International Journal of Biological Sciences

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ISSN 1449-2288

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PERK/eIF-2α/CHOP Pathway Dependent ROS Generation Mediates Butein-induced Non-small-cell Lung Cancer Apoptosis and G2/M Phase Arrest
Shouyin Di, Chongxi Fan, Zhiqiang Ma, Mingyang Li, Kai Guo, Donghui Han, Xiaofei Li, Deguang Mu, Xiaolong Yan
Int. J. Biol. Sci. online date 2019-5-8; doi:10.7150/ijbs.33790; accepted
[Author manuscript]

Dietary glycine decreases both tumor volume and vascularization in a combined colorectal liver metastasis and chemotherapy model
Juste Maneikyte, Augustinas Bausys, Bettina Leber, Angela Horvath, Nicole Feldbacher, Gerald Hoefler, Kestutis Strupas, Philipp Stiegler, Peter Schemmer
Int. J. Biol. Sci. online date 2019-5-8; doi:10.7150/ijbs.35513; accepted
[Author manuscript]

miR-424-5p represses the metastasis and invasion of intrahepatic cholangiocarcinoma by targeting ARK5
Jingbang Wu, Beng Yang, Yanpeng Zhang, Xiaode Feng, Bin He, Haiyang Xie, Lin Zhou, Jian Wu, Shusen Zheng
Int. J. Biol. Sci. online date 2019-5-8; doi:10.7150/ijbs.34113; accepted
[Author manuscript]

Exosomes derived from Wharton’s jelly of human umbilical cord mesenchymal stem cells reduce osteocyte apoptosis in glucocorticoid-induced osteonecrosis of the femoral head in rats via the miR-21–PTEN–AKT signalling pathway
Ming-jie Kuang, Ying Huang, Xi-ge Zhao, Rui Zhang, Jian-xiong Ma, Da-chuan Wang, Xin-long Ma
Int. J. Biol. Sci. online date 2019-5-8; doi:10.7150/ijbs.32262; accepted
[Author manuscript]

Nuclear localization of Desmoplakin and its involvement in telomere maintenance
Peipei Li, Yuan Meng, Yuan Wang, Jingjing Li, Manting Lam, Li Wang, Li-jun Di
Int. J. Biol. Sci. online date 2019-5-1; doi:10.7150/ijbs.34450; accepted
[Author manuscript]

Caffeine Inhibits NLRP3 Inflammasome Activation via Suppression of MAPK/NF-κB and A2aR Signaling in LPS-Induced THP-1 Macrophages
Weiming Zhao, Li Ma, Cheng Cai, Xiaohui Gong
Int. J. Biol. Sci. online date 2019-5-8; doi:10.7150/ijbs.34211; accepted
[Author manuscript]

The Structural Function of Nestin in Cell Body Softening is Correlated with Cancer Cell Metastasis
Ayana Yamagishi, Moe Susaki, Yuta Takano, Mei Mizusawa, Mari Mishima, Masumi Iijima, Shun’ichi Kuroda, Tomoko Okada, Chikashi Nakamura
Int. J. Biol. Sci. online date 2019-5-8; doi:10.7150/ijbs.33423; accepted
[Author manuscript]

Inhibition of Super enhancer downregulates the expression of KLF5 in basal-like breast cancers
Chuan-Huizi Chen, Nong Yang, Yongchang Zhang, Jiancheng Ding, Wenjuan Zhang, Rong Liu, Wen Liu, Ceshi Chen
Int. J. Biol. Sci. online date 2019-5-1; doi:10.7150/ijbs.35138; accepted
[Author manuscript]

TLX3 repressed SNAI1-induced epithelial-mesenchymal transition by directly constraining STAT3 phosphorylation and functionally sensitized 5-FU chemotherapy in hepatocellular carcinoma
Cong Wang, Changwei Dou, Yufeng Wang, Zhikui Liu, Lewis Roberts, Xin Zheng
Int. J. Biol. Sci. online date 2019-5-8; doi:10.7150/ijbs.33844; accepted
[Author manuscript]

Curcumol: From plant roots to cancer roots
Wei Wei, Azhar Rasul, Ayesha Sadiqa, Iqra Sarfraz, Ghulam Hussain, Bushra Nageen, Xintong Liu, Nobumoto Watanabe, Zeliha Selamoglu, Muhammad Ali, Xiaomeng Li and Jiang Li
Int. J. Biol. Sci. online date 2019-5-8; doi:10.7150/ijbs.34716; accepted
[Author manuscript]

Hypoxia preconditioned renal tubular epithelial cell-derived extracellular vesicles alleviate renal ischaemia-reperfusion injury mediated by the HIF-1α/Rab22 pathway and potentially affected by microRNAs
Lei Zhang, Han Liu, Kai Xu, Zhixin Ling, Yeqing Huang, Qiang Hu, Kai Lu, Chunhui Liu, Yiduo Wang, Ning Liu, Xiaowen Zhang, Bin Xu, Jianping Wu, Shuqiu Chen, Guangyuan Zhang, Ming Chen
Int. J. Biol. Sci. online date 2019-4-21; doi:10.7150/ijbs.32004; in press
[Author manuscript]

Amorphous solid dispersion of Berberine mitigates apoptosis via iPLA2β/Cardiolipin/Opa1 pathway in db/db mice and in Palmitate-treated MIN6 β-cells
Junnan Li, Hongwei Du, Meishuang Zhang, Zhi Zhang, Fei Teng, Yali Zhao, Wenyou Zhang, Yang Yu, Linjing Feng, Xinming Cui, Ming Zhang, Tzongshi Lu, Fengying Guan, Li Chen
Int. J. Biol. Sci. online date 2019-4-21; doi:10.7150/ijbs.32020; accepted
[Author manuscript]

Scutellaria flavonoids effectively inhibit the malignant phenotypes of non-small cell lung cancer in an Id1-dependent manner
Zhengxiao Zhao, Baojun Liu, Jing Sun, Linwei Lu, Lumei Liu, Jian Qiu, Qiuping Li, Chen Yan, Shan Jiang, Nabijan Mohammadtursun, Wenjuan Ma, Mihui Li, Jingcheng Dong, Weiyi Gong
Int. J. Biol. Sci. online date 2019-4-23; doi:10.7150/ijbs.33146; in press
[Author manuscript]

The landscape of DNA methylation associated with the transcriptomic network in layers and broilers generates insight into embryonic muscle development in chicken
Zihao Liu£, Shunshun Han£, Xiaoxu Shen£, Yan Wang£, Can Cui, Haorong He, Yuqi Chen, Jing Zhao, Diyan Li, Qing Zhu and Huadong Yin
Int. J. Biol. Sci. online date 2019-5-1; doi:10.7150/ijbs.35073; in press
[Author manuscript]

Lichen Sclerosus: An autoimmunopathogenic and genomic enigma with emerging genetic and immune targets
Davis A. Tran, Xiaohui Tan, Charles J. Macri, Andrew T. Goldstein and Sidney W. Fu
Int. J. Biol. Sci. online date 2019-4-15; doi:10.7150/ijbs.34613; accepted
[Author manuscript]

Hypericin promotes PDX1 expression by activating the Erk pathway and protects islet β-cells against glucotoxicity and lipotoxicity in vitro and in vivo
Chen Liang, Fang Hao, Xinlei Yao, Ye Qiu, Lei Liu, Shuyue Wang, Chunlei Yu, Zhenbo Song, Yongli Bao, Jingwen Yi, Yanxin Huang, Yin Wu, Lihua Zheng, Ying Sun, Guannan Wang, Xiaoguang Yang, Shaonian Yang, Luguo SunYuxin Li
Int. J. Biol. Sci. online date 2019-5-8; doi:10.7150/ijbs.33817; accepted
[Author manuscript]

A kind of integrated serial algorithms for noise reduction and characteristics expanding in respiratory sound
Meng Fei, Wang Yixuan, Shi Yan, Zhao Hongmei
Int. J. Biol. Sci. online date 2019-5-8; doi:10.7150/ijbs.33274; accepted
[Author manuscript]

SWPepNovo: An Efficient De Novo Peptide Sequencing Tool for Large-scale MS/MS Spectra Analysis
Chuang Li, Kenli Li, Keqin Li, Xianghui Xie, Feng Lin
Int. J. Biol. Sci. online date 2019-4-10; doi:10.7150/ijbs.32142; accepted
[Author manuscript]

The CtBP1-HDAC1/2-IRF1 transcriptional complex represses the expression of the long noncoding RNA GAS5 in human osteosarcoma cells
Xinliang Zhang, Kaili Du, Zhenkai Lou, Keyuan Ding, Fan Zhang, Jinwen Zhu, Zheng Cang
Int. J. Biol. Sci. online date 2019-5-8; doi:10.7150/ijbs.33529; accepted
[Author manuscript]

Reactive versus Constitutive: Reconcile the Controversial Results about the Prognostic Value of PD-L1 Expression in cancer
Dapeng Hao, Guangyu Wang, Weiwei Yang, Xingmin Li, Mingming Xiao, Ruo Zhang, Lijie He, Li Wang, Xiaobo Li, and Lijun Di
Int. J. Biol. Sci. online date 2019-4-21; doi:10.7150/ijbs.33297; accepted
[Author manuscript]

TFAP2A Induced KRT16 As An Oncogene In Lung Adenocarcinoma Via EMT
Liu Yuanhua, Qian Pudong, Zhu Wei, Wu Yuan, Liu Delin, Zhang Yan, Liang Geyu, Shen Bo
Int. J. Biol. Sci. online date 2019-4-10; doi:10.7150/ijbs.34076; accepted
[Author manuscript]

Potential Mechanisms of Action of Curcumin for Cancer Prevention: Focus on Cellular Signaling Pathways and miRNAs
Man Wang, Shuai Jiang, Li Zhou, Fei Yu, Han Ding, Peifeng Li, Meng Zhou, Kun Wang
Int. J. Biol. Sci. online date 2019-4-21; doi:10.7150/ijbs.33710; in press
[Author manuscript]

A Synthetic Light-switchable System based on CRISPR Cas13a Regulates the Expression of LncRNA MALAT1 and Affects the Malignant Phenotype of Bladder Cancer Cells
Fuming Qi, Bo Tan, Fujun Ma, Bo Zhu, Li Zhang, Xiaoyun Liu, Honglei Li, Jinhui Yang, Bo Cheng
Int. J. Biol. Sci. online date 2019-4-21; doi:10.7150/ijbs.33772; accepted
[Author manuscript]

The antipsychotic agent flupentixol is a new PI3K inhibitor and potential anticancer drug for lung cancer
Chao Dong, Yin Chen, Hongjian Li, Yi Yang, Hongtao Zhang, Kunbin Ke Xi-Nan Shi, Xu Liu, Ling Li, Jing Ma, Hsiang-Fu Kung, Ceshi Chen, Marie Chia-mi Lin
Int. J. Biol. Sci. online date 2019-4-21; doi:10.7150/ijbs.32625; in press
[Author manuscript]

Osimertinib and pterostilbene in EGFR-mutation-positive non-small cell lung cancer (NSCLC)
Jillian Wilhelmina Paulina Bracht, Niki Karachaliou, Jordi Berenguer, Carlos Pedraz-Valdunciel, Martyna Filipska, Carles Codony-Servat, Jordi Codony-Servat, Rafael Rosell
Int. J. Biol. Sci. online date 2019-4-21; doi:10.7150/ijbs.32889; accepted
[Author manuscript]

Review: Recent Advances in Studies of Molecular Hydrogen against Sepsis
Peng Qiu, Yang Liu, and Jin Zhang
Int. J. Biol. Sci. online date 2019-3-31; doi:10.7150/ijbs.30741; in press
[Author manuscript]

PCBP1 inhibits the expression of oncogenic STAT3 isoform by targeting alternative splicing of STAT3 exon 23
Xiaole Wang, Jihua Guo, Xiaoxuan Che, Rong Jia
Int. J. Biol. Sci. 2019; doi:10.7150/ijbs.33103; in press
[Author manuscript]

miR-155-5p Promotes Dorsal Root Ganglion Neuron Axonal Growth in an Inhibitory Microenvironment via the cAMP/PKA Pathway
Tianyi Wang, Bo Li, Zhijie Wang, Xin Yuan, Chuanjie Chen, Yanjun Zhang, Ziwei Xia, Xin Wang, Mei Yu, Wen Tao, Liang Zhang, Xu Wang, Zheng Zhang, Xiaoling Guo, Guangzhi Ning, Shiqing Feng, Xueming Chen
Int. J. Biol. Sci. online date 2019-5-1; doi:10.7150/ijbs.31904; accepted
[Author manuscript]

miR-1204 promotes hepatocellular carcinoma progression through activating MAPK and c-Jun/AP1 signaling by targeting ZNF418
Liang Wang, Liankang Sun, Yufeng Wang, Bowen Yao, Runkun Liu, Tianxiang Chen, Kangsheng Tu, Qingguang Liu, Zhikui Liu
Int. J. Biol. Sci. online date 2019-4-10; doi:10.7150/ijbs.33658; in press
[Author manuscript]

Role of pyroptosis in cardiovascular diseases and its therapeutic implications
Cheng Zeng, Renqing Wang, Hongmei Tan
Int. J. Biol. Sci. online date 2019-4-10; doi:10.7150/ijbs.33568; in press
[Author manuscript]

Increased expression of TRIP13 drives tumorigenesis of bladder cancer in association with the EGFR signaling pathway
Yanjun Gao, Shanhui Liu, Qi Guo, Su Zhang, Youli Zhao, Hanzhang Wang, Tianbao Li, Yuwen Gong, Yuhan Wang, Tao Zhang, Dean Bacich, Wasim H. Chowdhury, Ronald Rodriguez, Zhilong Dong, Zhiping Wang
Int. J. Biol. Sci. online date 2019-4-10; doi:10.7150/ijbs.32718; in press
[Author manuscript]

Novel role of Heterogeneous nuclear ribonucleoprotein E1 in regulation of apoptosis and autophagy by a small molecule in vascular endothelial cells
Ning Meng, Yan Gong, Xin Mu, Yan Hong Wang, Le Su, Cheng Shi Jiang and Hua Zhang
Int. J. Biol. Sci. online date 2019-4-10; doi:10.7150/ijbs.32677; in press
[Author manuscript]

Causal cortical network for arithmetic problem-solving represents brain’s planning rather than reasoning
Zhishan Hu; Keng-Fong Lam; Yu-Tao Xiang; Zhen Yuan
Int. J. Biol. Sci. online date 2019-4-10; doi:10.7150/ijbs.33400; in press
[Author manuscript]

Exosomal Micro RNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation
Hailong Yan, Ye Gao, Qiang Ding, Jiao Liu, Yan Li, Miaohan Jin, Han Xu, Sen Ma, Xiaolong Wang, Wenxian Zen, Yulin Chen
Int. J. Biol. Sci. online date 2019-3-31; doi:10.7150/ijbs.33233; in press
[Author manuscript]

Huaier polysaccharide inhibits the stem-like characteristics of triple negative breast cancer cells via inactivation of the ERα-36 signaling pathway
Baoquan Hu, Wenting Yan, Minghao Wang, Xiang Cui, Xiaowei Qi, Ying Hu, Qingqiu Chen, Yi Zhang, Jun Jiang
Int. J. Biol. Sci. online date 2019-4-23; doi:10.7150/ijbs.27360; in press
[Author manuscript]

HJURP Promotes Epithelial-to-Mesenchymal Transition via Upregulating SPHK1 in Hepatocellular Carcinoma
Tianchi Chen, Lingfeng Zhou, Yuan Zhou, Wuhua Zhou, Hechen Huang, Shengyong Yin, Haiyang Xie, Lin Zhou, Shusen Zheng
Int. J. Biol. Sci. online date 2019-4-10; doi:10.7150/ijbs.30904; in press
[Author manuscript]

SAROTUP: a suite of tools for finding potential target-unrelated peptides from phage display data
Bifang He, Heng Chen, Ning Li, Jian Huang
Int. J. Biol. Sci. online date 2019-4-10; doi:10.7150/ijbs.31957; accepted
[Author manuscript]

Prognostic score predicts survival in HPV-negative head and neck squamous cell cancer patients
Xu Qian, Duc T. Nguyen, Yue Dong, Branko Sinikovic, Andreas M. Kaufmann, Jeffrey N. Myers, Andreas E. Albers, Edward A. Graviss
Int. J. Biol. Sci. online date 2019-3-22; doi:10.7150/ijbs.33329; in press
[Author manuscript]

CHL1 suppresses tumor growth and metastasis in nasopharyngeal carcinoma by repressing PI3K/AKT signaling pathway via interaction with Integrin β1 and Merlin
Juan Chen, Chen Jiang, Li Fu, Cai-Lei Zhu, Yan-Qun Xiang, Ling-Xi Jiang, Qian Chen, Wai Man Liu, Jin-Na Chen, Li-Yi Zhang, Ming Liu, Chao Chen, Hong Tang, Bo Wang, Sai Wah Tsao, Dora Lai-Wan Kwong, Xin-Yuan Guan
Int. J. Biol. Sci. online date 2019-4-21; doi:10.7150/ijbs.34785; accepted
[Author manuscript]

Nuclear CD44 Mediated by Importin β Participated in Naïve Genes Transcriptional Regulation in C3A-iCSCs
Ming Su; Peipei Wang; Xuan Wang; Mingzhi Zhang; Shiruo Wei; Kaiyu Liu; Shuo Han;Xu Han; Yue Deng; Li Shen
Int. J. Biol. Sci. online date 2019-3-22; doi:10.7150/ijbs.28235; in press
[Author manuscript]

Aplnra/b Sequentially Regulate Organ Left-right Patterning via Distinct Mechanisms
Chengke Zhu, Zhenghua Guo, Yu Zhang, Min Liu, Bingyu Chen, Kang Cao, Yongmei Wu, Wenqing Yin, Min Yang, Haixia Zhao, Haoran Tai, Yu Ou, Xiaoping Yu, Chi Liu, Shurong Li, Binying Su, Yi Feng, Sizhou Huang
Int. J. Biol. Sci. online date 2019-3-22; doi:10.7150/ijbs.30100; in press
[Author manuscript]

Metabolic intermediates in tumorigenesis and progression
Yuchen He; Menghui Gao; Haosheng Tang; Yiqu Cao; Shuang Liu; Yongguang Tao
Int. J. Biol. Sci. online date 2019-3-22; doi:10.7150/ijbs.33496; in press
[Author manuscript]

A CRISPR interference of CBP and p300 selectively induced synthetic lethality in bladder cancer cells in vitro
Jianfa Li, Tiefu Xiong, Changshui Zhuang, Chengle Zhuang, Yawen Li, Jing Ye, Yaoting Gui
Int. J. Biol. Sci. online date 2019-3-22; doi:10.7150/ijbs.32332; in press
[Author manuscript]

P11 loss-of-function is associated with decreased cell proliferation and neurobehavioral disorders in mice
Guosheng Liu, Yabo Wang, Weixin Zheng, Hanhua Cheng, Rongjia Zhou
Int. J. Biol. Sci. online date 2019-3-22; doi:10.7150/ijbs.33773; in press
[Author manuscript]

A mathematical modelling of initiation of dendritic cells-induced T cell immune response
Wen-zhu Huang, Wen-hui Hu, Yun Wang, Jin Chen, Zu-quan Hu, Jing Zhou, Lina Liu, Wei Qiu, Fu-zhou Tang, Shi-chao Zhang, Yan Ouyang, Yuan-nong Ye, Jin-hua Long, Zhu Zeng
Int. J. Biol. Sci. online date 2019-3-22; doi:10.7150/ijbs.33412; in press
[Author manuscript]

Combined Features Based on Preoperative Controlling Nutritional Status Score and Circulating Tumor Cell Status Predict Prognosis for Colorectal Cancer Patients Treated with Curative Resection
Chaogang Yang, Chen Wei, Shuyi Wang, Song Han, Dongdong Shi, Chunxiao Zhang, Xiaobin Lin, Rongzhang Dou, Bin Xiong
Int. J. Biol. Sci. online date 2019-3-22; doi:10.7150/ijbs.33671; in press
[Author manuscript]

CSN6 promotes the migration and invasion of cervical cancer cells by inhibiting autophagic degradation of cathepsin L
Zun Mao, Miao-Miao Sang, Cheng Chen, Wen-Tao Zhu, Yu-Sen Gong, Dong Sheng Pei
Int. J. Biol. Sci. online date 2019-3-22; doi:10.7150/ijbs.32987; in press
[Author manuscript]

The nuclear export and ubiquitin-proteasome-dependent degradation of PPARg induced by angiotensin II
Li Sun, Ka Bian
Int. J. Biol. Sci. online date 2019-3-22; doi:10.7150/ijbs.29741; in press
[Author manuscript]

Epigenetic down-regulation of Sirt 1 via DNA methylation and oxidative stress signing contributes to the gestational diabetes mellitus-induced fetal programming of heart ischemia-sensitive phenotype in late life
Zewen, Lei Gong, Peng Zhang, Yong Li, Bailin Liu, Lubo Zhang, Jian Zhuang, DaLiao Xiao
Int. J. Biol. Sci. online date 2019-3-13; doi:10.7150/ijbs.33044; in press
[Author manuscript]

Emerging roles of p53 related lncRNAs in cancer progression: A systematic review
Tian Lin, Ping-Fu Hou, Sen Meng, Fang Chen, Tao Jiang, Min-Le Li, Mei-Lin Shi, Jin-Jin Liu, Jun-Nian Zheng, Jin Bai
Int. J. Biol. Sci. online date 2019-3-22; doi:10.7150/ijbs.33218; in press
[Author manuscript]

Synthetic-evolution reveals narrow paths to regulation of the Saccharomyces cerevisiae mitotic kinesin-5 Cin8
Alina Goldstein, Darya Goldman, Ervin Valk, Mart Loog, Liam J. Holt, and Larisa Gheber
Int. J. Biol. Sci. 2019; doi:10.7150/ijbs.30543; in press
[Author manuscript]

Specifically blocking the fatty acid synthesis to inhibit the malignant phenotype of bladder cancer
Aolin Li, Mengting Ding, Hengji Zhan, Yuchen Liu, Weiren Huang, Zhiming Cai
Int. J. Biol. Sci. online date 2019-5-1; doi:10.7150/ijbs.32518; accepted
[Author manuscript]

Ciliary IFT80 regulates dental pulp stem cells differentiation by FGF/FGFR1 and Hh/BMP2 signaling
Xue Yuan, Min Liu, Xu Cao, Shuying Yang
Int. J. Biol. Sci. online date 2019-2-20; doi:10.7150/ijbs.27231; accepted
[Author manuscript]

The Antioxidant MitoQ Protects Against CSE-Induced Endothelial Barrier Injury and Inflammation by Inhibiting ROS and Autophagy in Human Umbilical Vein Endothelial Cells
Sha Chen, Yu wang, Hailin Zhang, Ran Chen, Fangfang Lu, Zhengmao Li, Ting Jiang, Daopeng Lin, Hongyu Zhang, Li Yang, Xiaoxia Kong
Int. J. Biol. Sci. online date 2019-1-25; doi:10.7150/ijbs.30193; accepted
[Author manuscript]


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