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Int J Biol Sci 2010; 6(7):796-805. doi:10.7150/ijbs.6.796

Review

Applications of Patient-Specific Induced Pluripotent Stem Cells; Focused on Disease Modeling, Drug Screening and Therapeutic Potentials for Liver Disease

Yong Soon Chun, Pooja Chaudhari, Yoon-Young Jang

Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Abstract

The recent advances in the induced pluripotent stem cell (iPSC) research have significantly changed our perspectives on regenerative medicine by providing researchers with a unique tool to derive disease-specific stem cells for study. In this review, we describe the human iPSC generation from developmentally diverse origins (i.e. endoderm-, mesoderm-, and ectoderm- tissue derived human iPSCs) and multistage hepatic differentiation protocols, and discuss both basic and clinical applications of these cells including disease modeling, drug toxicity screening/drug discovery, gene therapy and cell replacement therapy.

Keywords: Stem Cell, Disease Modeling, Drug Screening, Liver Disease

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Chun YS, Chaudhari P, Jang YY. Applications of Patient-Specific Induced Pluripotent Stem Cells; Focused on Disease Modeling, Drug Screening and Therapeutic Potentials for Liver Disease. Int J Biol Sci 2010; 6(7):796-805. doi:10.7150/ijbs.6.796. Available from http://www.ijbs.com/v06p0796.htm