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Int J Biol Sci 2011; 7(2):147-153. doi:10.7150/ijbs.7.147

Research Paper

The Myoepithelial Cell Layer May Serve As a Potential Trigger Factor for Different Outcomes of Stage-Matched Invasive Lobular and Ductal Breast Cancers

Yi-Hsuan Hsiao1,2, Horng-Der Tsai2, Ming-Chih Chou3 , Yan-gao Man4

1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
2. Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan
3. Department of Surgery, Chung Shan Medical University, Taichung, Taiwan
4. Armed Forces Institute of Pathology and American Registry of Pathology, Washington DC, USA

Abstract

Invasive lobular cancer (ILC) tends to be significantly larger in size with significantly more positive lymph nodes, whereas ILC has a significantly more favorable outcome, compared to stage-matched invasive ductal carcinoma (IDC). The mechanism accounting for such differences remains elusive. Based on morphological, immunohistochemical, and molecular studies of over 1,000 cases of human breast cancers, we hypothesize that the differences may result from the structural and/or functional differences of their surrounding myoepithelial cell layers, which dictate lobular and ductal tumor cells to follow different pathways of invasion or metastasis. The background, rationale, supportive data, and implications of our hypothesis are presented and discussed.

Keywords: Invasive lobular cancer, invasive ductal carcinoma, human breast cancers, myoepithelial cell layers

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Hsiao YH, Tsai HD, Chou MC, Man Yg. The Myoepithelial Cell Layer May Serve As a Potential Trigger Factor for Different Outcomes of Stage-Matched Invasive Lobular and Ductal Breast Cancers. Int J Biol Sci 2011; 7(2):147-153. doi:10.7150/ijbs.7.147. Available from http://www.ijbs.com/v07p0147.htm