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Int J Biol Sci 2011; 7(7):1003-1015. doi:10.7150/ijbs.7.1003 This issue Cite

Review

The Link between the Metabolic Syndrome and Cancer

Sandra Braun, Keren Bitton-Worms, Derek LeRoith✉

Diabetes and Metabolism Clinical Research Center of Excellence, Legacy Heritage Clinical Research Institute at Rambam (LHCRIR), Haifa, Israel.

✉ Corresponding author: Derek LeRoith, M.D., Ph.D., Director, Diabetes and Metabolism Clinical Research Center of Excellence, Legacy Heritage Clinical Research Institute at Rambam (LHCRIR). Tel: 972-4-854-1260. d_leroithhealth.gov.il

Citation:
Braun S, Bitton-Worms K, LeRoith D. The Link between the Metabolic Syndrome and Cancer. Int J Biol Sci 2011; 7(7):1003-1015. doi:10.7150/ijbs.7.1003. https://www.ijbs.com/v07p1003.htm
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Abstract

Since the incidence of the metabolic syndrome is on the rise in the western world, its coherence to cancer is becoming more apparent. In this review we discuss the different potential factors involved in the increase of cancer in the metabolic syndrome including obesity, dyslipidemia and Type 2 Diabetes Mellitus (T2DM) as well as inflammation and hypoxia. We especially focus on the insulin and IGF systems with their intracellular signaling cascades mediated by different receptor subtypes, and suggest that they may play major roles in this process. Understanding the mechanisms involved will be helpful in developing potential therapeutics.

Keywords: metabolic syndrome, cancer

Citation styles

APA
Braun, S., Bitton-Worms, K., LeRoith, D. (2011). The Link between the Metabolic Syndrome and Cancer. International Journal of Biological Sciences, 7(7), 1003-1015. https://doi.org/10.7150/ijbs.7.1003.

ACS
Braun, S.; Bitton-Worms, K.; LeRoith, D. The Link between the Metabolic Syndrome and Cancer. Int. J. Biol. Sci. 2011, 7 (7), 1003-1015. DOI: 10.7150/ijbs.7.1003.

NLM
Braun S, Bitton-Worms K, LeRoith D. The Link between the Metabolic Syndrome and Cancer. Int J Biol Sci 2011; 7(7):1003-1015. doi:10.7150/ijbs.7.1003. https://www.ijbs.com/v07p1003.htm

CSE
Braun S, Bitton-Worms K, LeRoith D. 2011. The Link between the Metabolic Syndrome and Cancer. Int J Biol Sci. 7(7):1003-1015.

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