1. State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China 2. Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China 3. Department of Biotherapy Center, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China 4. Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China
✉ Corresponding author: Prof. J. Li. Department of Biotherapy Center & Department of Experimental Research, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060. Tel: +86-20-87343174; Fax: +86-20-87343392. E-mail: lijiang2sysu.edu.cn & Prof. Y.X. Zeng, Department of Experimental Research, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060. Tel: +86-20-87343333; Fax: +86-20-87343392; E-mail: zengyxorg.cnMore
Citation:
Peng RJ, Huang ZF, Zhang YL, Yuan ZY, Xia Y, Jiang WQ, Zeng YX, Li J. Circulating and Tumor-Infiltrating Foxp3+ Regulatory T Cell Subset in Chinese Patients with Extranodal NK/T Cell Lymphoma. Int J Biol Sci 2011; 7(7):1027-1036. doi:10.7150/ijbs.7.1027. https://www.ijbs.com/v07p1027.htm
Foxp3+ regulatory T lymphocytes (Tregs) usually act as an immune suppressor and correlate with poorer survival in malignancies. This study aims to investigate the distribution and characterization of Foxp3+ subset in peripheral blood mononuclear cells (PBMCs) and tumor tissues from extranodal NK/T cell lymphoma (ENKTL). Our study showed the percentage of Foxp3+ subset from PBMC was significantly higher than that of healthy individuals (P<0.001). The Foxp3+ subset from PBMCs expressed CD45RO, CTLA4, GITR, CCR7, and had an IL-10highIFNγ+TGFβ+IL-2lowIL-17low cytokine secreting phenotype. Interestingly, the existence of EBV antigen-specific CD8+Foxp3+ Tregs was discovered in ENKTL. Furthermore, the high density of Foxp3+ TILs was associated with improved progression-free survival (PFS) in ENKTL patients (P<0.05). Collectively, our study implicates that EBV antigens could induce antigen-specific CD8+Foxp3+ Tregs in ENKTL, and Foxp3+ TILs is an independent factor for PFS in ENKTL.
Peng, R.J., Huang, Z.F., Zhang, Y.L., Yuan, Z.Y., Xia, Y., Jiang, W.Q., Zeng, Y.X., Li, J. (2011). Circulating and Tumor-Infiltrating Foxp3+ Regulatory T Cell Subset in Chinese Patients with Extranodal NK/T Cell Lymphoma. International Journal of Biological Sciences, 7(7), 1027-1036. https://doi.org/10.7150/ijbs.7.1027.
ACS
Peng, R.J.; Huang, Z.F.; Zhang, Y.L.; Yuan, Z.Y.; Xia, Y.; Jiang, W.Q.; Zeng, Y.X.; Li, J. Circulating and Tumor-Infiltrating Foxp3+ Regulatory T Cell Subset in Chinese Patients with Extranodal NK/T Cell Lymphoma. Int. J. Biol. Sci. 2011, 7 (7), 1027-1036. DOI: 10.7150/ijbs.7.1027.
NLM
Peng RJ, Huang ZF, Zhang YL, Yuan ZY, Xia Y, Jiang WQ, Zeng YX, Li J. Circulating and Tumor-Infiltrating Foxp3+ Regulatory T Cell Subset in Chinese Patients with Extranodal NK/T Cell Lymphoma. Int J Biol Sci 2011; 7(7):1027-1036. doi:10.7150/ijbs.7.1027. https://www.ijbs.com/v07p1027.htm
CSE
Peng RJ, Huang ZF, Zhang YL, Yuan ZY, Xia Y, Jiang WQ, Zeng YX, Li J. 2011. Circulating and Tumor-Infiltrating Foxp3+ Regulatory T Cell Subset in Chinese Patients with Extranodal NK/T Cell Lymphoma. Int J Biol Sci. 7(7):1027-1036.