Int J Biol Sci 2013; 9(10):1121-1133. doi:10.7150/ijbs.6666
The Regulation of the Autophagic Network and Its Implications for Human Disease
1. Department of Cell Biology; University Medical Center Groningen, University of Groningen; Groningen, The Netherlands.
Autophagy has attracted a lot of attention in recent years. More and more proteins and signaling pathways have been discovered that somehow feed into the autophagy regulatory pathways. Regulation of autophagy is complex and condition-specific, and in several diseases, autophagic fluxes are changed. Here, we review the most well-established concepts in this field as well as the reported signaling pathways or components which steer the autophagy machinery. Furthermore, we will highlight how autophagic fluxes are changed in various diseases either as cause for or as response to deal with an altered cellular homeostasis and how modulation of autophagy might be used as potential therapy for such diseases.
Keywords: Autophagy, ATGs, mTOR, UPR, FOXO1, HSF1, Heat Shock Proteins (HSP), Human diseases.
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How to cite this article:
Yang J, Carra S, Zhu WG, Kampinga HH. The Regulation of the Autophagic Network and Its Implications for Human Disease. Int J Biol Sci 2013; 9(10):1121-1133. doi:10.7150/ijbs.6666. Available from http://www.ijbs.com/v09p1121.htm