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Int J Biol Sci 2013; 9(10):1121-1133. doi:10.7150/ijbs.6666

Review

The Regulation of the Autophagic Network and Its Implications for Human Disease

Jing Yang1,2, Serena Carra1, Wei-Guo Zhu2, Harm H. Kampinga1✉

1. Department of Cell Biology; University Medical Center Groningen, University of Groningen; Groningen, The Netherlands.
2. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education); Department of Biochemistry and Molecular Biology; Peking University Health Science Center, Beijing 100191, China;
3. University of Modena and Reggio Emilia, Department of Biomedical, Metabolic and Neuronal Sciences, Giuseppe Campi 287, 41125 Modena, Italy

Abstract

Autophagy has attracted a lot of attention in recent years. More and more proteins and signaling pathways have been discovered that somehow feed into the autophagy regulatory pathways. Regulation of autophagy is complex and condition-specific, and in several diseases, autophagic fluxes are changed. Here, we review the most well-established concepts in this field as well as the reported signaling pathways or components which steer the autophagy machinery. Furthermore, we will highlight how autophagic fluxes are changed in various diseases either as cause for or as response to deal with an altered cellular homeostasis and how modulation of autophagy might be used as potential therapy for such diseases.

Keywords: Autophagy, ATGs, mTOR, UPR, FOXO1, HSF1, Heat Shock Proteins (HSP), Human diseases.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Yang J, Carra S, Zhu WG, Kampinga HH. The Regulation of the Autophagic Network and Its Implications for Human Disease. Int J Biol Sci 2013; 9(10):1121-1133. doi:10.7150/ijbs.6666. Available from http://www.ijbs.com/v09p1121.htm