Int J Biol Sci 2014; 10(4):396-403. doi:10.7150/ijbs.8193
SRC-1 and Twist1 Expression Positively Correlates with a Poor Prognosis in Human Breast Cancer
1. Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing, China.
To evaluate the possible prognostic value of Steroid Receptor Coactivator-1 (SRC-1) and Twist1 expression in human breast cancer, we examined SRC-1 and Twist1 expression using immunohistochemistry on tissue microarray sections containing 137 breast cancer specimens. All patients were followed up for a median of 5 years following surgery. Survival curves were generated using the Kaplan-Meier method. Multivariate analysis was performed using the Cox proportional hazard regression model to assess the prognostic values. The results showed a positive correlation between SRC-1 and Twist1 expression at protein levels (P < 0.001). Also, SRC-1 expression positively correlated with HER2 expression (P = 0.024). The protein expression of Twist1 positively associated with lymph node metastasis (P < 0.001), but inversely correlated with PR status (P = 0.041). Patients with SRC-1 or Twist1-positive expression exhibited poorer overall survival (OS) and disease-free survival (DFS) than did those with SRC-1 or Twist1-negative expression (P < 0.05 for all). In addition, SRC-1-negativeive/Twist1-negative patients had the best OS and DFS (P < 0.01 for both). In multivariate survival analysis, SRC-1 expression, tumor stage, and PR were found to be independent prognostic factors related to OS (P = 0.019, < 0.001 and 0.02, respectively) and Twist1 expression, lymph node status and PR were independent predictors of DFS (P = 0.006, 0.001 and 0.029, respectively). These results suggest that a combined SRC-1/Twist1 expression status could improve the prognostic judgment for breast cancer patients.
Keywords: SRC-1, Twist1, Correlation, Breast cancer, Prognosis.
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How to cite this article:
Xu Y, Hu B, Qin L, Zhao L, Wang Q, Wang Q, Xu Y, Jiang J. SRC-1 and Twist1 Expression Positively Correlates with a Poor Prognosis in Human Breast Cancer. Int J Biol Sci 2014; 10(4):396-403. doi:10.7150/ijbs.8193. Available from http://www.ijbs.com/v10p0396.htm