Roles for the Backdoor Pathway of Androgen Metabolism in Prostate Cancer Response to Castration and Drug Treatment

Fiandalo, Michael V.; Wilton, John; Mohler, James L.

doi:10.7150/ijbs.8780

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Theranostics

International Journal of Medical Sciences

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Int J Biol Sci 2014; 10(6):596-601. doi:10.7150/ijbs.8780 This issue Cite

Review

Roles for the Backdoor Pathway of Androgen Metabolism in Prostate Cancer Response to Castration and Drug Treatment

Michael V. Fiandalo, John Wilton, James L. Mohler^✉

Department of Urology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

Citation:

Fiandalo MV, Wilton J, Mohler JL. Roles for the Backdoor Pathway of Androgen Metabolism in Prostate Cancer Response to Castration and Drug Treatment. Int J Biol Sci 2014; 10(6):596-601. doi:10.7150/ijbs.8780. https://www.ijbs.com/v10p0596.htm

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Abstract

Almost all men who present with advanced prostate cancer (CaP) and many men who fail potentially curative therapy are treated with androgen deprivation therapy (ADT). ADT is not curative and CaP recurs as the lethal phenotype. The goal of this review is to describe the evolution of adrenal androgen blockade, how new androgen measurement methods have furthered understanding of androgen metabolism, and how further understanding of the backdoor pathway of androgen metabolism may lead to interventions that extend survival even more.

Keywords: Adrenal androgens, "Backdoor" Pathway, Prostate cancer, Dihydrotestosterone, CYP17A1.

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APA

Fiandalo, M.V., Wilton, J., Mohler, J.L. (2014). Roles for the Backdoor Pathway of Androgen Metabolism in Prostate Cancer Response to Castration and Drug Treatment. International Journal of Biological Sciences, 10(6), 596-601. https://doi.org/10.7150/ijbs.8780.

ACS

Fiandalo, M.V.; Wilton, J.; Mohler, J.L. Roles for the Backdoor Pathway of Androgen Metabolism in Prostate Cancer Response to Castration and Drug Treatment. Int. J. Biol. Sci. 2014, 10 (6), 596-601. DOI: 10.7150/ijbs.8780.

NLM

CSE

Fiandalo MV, Wilton J, Mohler JL. 2014. Roles for the Backdoor Pathway of Androgen Metabolism in Prostate Cancer Response to Castration and Drug Treatment. Int J Biol Sci. 10(6):596-601.

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