Int J Biol Sci 2015; 11(3):345-352. doi:10.7150/ijbs.10921

Review

MiR-206, a Key Modulator of Skeletal Muscle Development and Disease

Guoda Ma1, 2, Yajun Wang3, You Li1, Lili Cui1, Yujuan Zhao4, Bin Zhao2✉, Keshen Li1✉

1. Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China;
2. Institute of Neurology, Guangdong Medical College, Zhanjiang 524001, China;
3. Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China;
4. Department of Cardiology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.

Abstract

MicroRNAs (miRNAs) have recently emerged as fundamental post-transcriptional regulators inhibit gene expression linked to various biological processes. MiR-206 is one of the most studied and best characterized miRNA to date, which specifically expressed in skeletal muscle. In this review, we summarized the results of studies of miR-206 with emphasis on its function in skeletal muscle development. Importantly, dysregulation of miR-206 has been linked to many disorders in skeletal muscle such as Duchenne muscular dystrophy (DMD) and amyotrophic lateral sclerosis (ALS), and circulating miR-206 has highlighted its potential as a diagnose biomarker. In addition, a mutation in the 3' untranslated region (3'-UTR) of the myostatin gene in the Texel sheep creating a target site for the miR-206 and miR-1 leads to inhibition of myostatin expression, which likely to cause the muscular hypertrophy phenotype of this breed of sheep. Therefore, miR-206 may become novel target for ameliorating skeletal muscle-related disorders and optimization of muscle quantity of domestic animals.

Keywords: miR-206, skeletal muscle, development, disease

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How to cite this article:
Ma G, Wang Y, Li Y, Cui L, Zhao Y, Zhao B, Li K. MiR-206, a Key Modulator of Skeletal Muscle Development and Disease. Int J Biol Sci 2015; 11(3):345-352. doi:10.7150/ijbs.10921. Available from http://www.ijbs.com/v11p0345.htm