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Int J Biol Sci 2015; 11(10):1181-1189. doi:10.7150/ijbs.12500 This issue Cite

Research Paper

Proton-sensing GPCR-YAP Signalling Promotes Cell Proliferation and Survival

Hongyi Zhu1, Xiangguo Cheng1,2, Xin Niu2, Yuelei Zhang1, Junjie Guan1, Xiaolin Liu1, Shicong Tao1, Yang Wang1,2, ✉, Changqing Zhang1,2,✉

1. Department of Orthopaedic Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
2. Institute of Microsurgery on Extremities, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, China.

✉ Corresponding authors: Tel: +86 21 64369181; Fax: +86 21 6470 1361; Email: zhangcqedu.cn (Changqing Zhang); Tel: +86 18930174249; Fax: +86 21 6470 1361; Email: wangy63cncom (Yang Wang)

Citation:
Zhu H, Cheng X, Niu X, Zhang Y, Guan J, Liu X, Tao S, Wang Y, Zhang C. Proton-sensing GPCR-YAP Signalling Promotes Cell Proliferation and Survival. Int J Biol Sci 2015; 11(10):1181-1189. doi:10.7150/ijbs.12500. https://www.ijbs.com/v11p1181.htm
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Abstract

Graphic abstract

The pHs of extracellular fluids (ECFs) in humans are consistently maintained at 7.35 to 7.45 in physiological conditions. Pathological changes, including infarction, tumourigenesis and inflammation, commonly result in decreases in the ECF pH in the affected tissues. In this study, we report that proliferation is promoted and apoptosis is inhibited by decreases in extracellular pH. Furthermore, we demonstrated that proton-sensing G-protein-coupled receptors (GPCRs) are required for the pH-dependent regulation of proliferation and apoptosis through the G protein α subunit 12/13 (G12/13) and Rho GTPases. Next, we identified Yes-associated protein 1 (YAP) as a downstream effector of Rho signalling. Together, the results from our study demonstrate that extracellular pH can modulate cell proliferation and apoptosis by regulating the proton-sensing GPCR-YAP pathway.

Keywords: pH, YAP, proton-sensing, GPCR, proliferation, apoptosis

Citation styles

APA
Zhu, H., Cheng, X., Niu, X., Zhang, Y., Guan, J., Liu, X., Tao, S., Wang, Y., Zhang, C. (2015). Proton-sensing GPCR-YAP Signalling Promotes Cell Proliferation and Survival. International Journal of Biological Sciences, 11(10), 1181-1189. https://doi.org/10.7150/ijbs.12500.

ACS
Zhu, H.; Cheng, X.; Niu, X.; Zhang, Y.; Guan, J.; Liu, X.; Tao, S.; Wang, Y.; Zhang, C. Proton-sensing GPCR-YAP Signalling Promotes Cell Proliferation and Survival. Int. J. Biol. Sci. 2015, 11 (10), 1181-1189. DOI: 10.7150/ijbs.12500.

NLM
Zhu H, Cheng X, Niu X, Zhang Y, Guan J, Liu X, Tao S, Wang Y, Zhang C. Proton-sensing GPCR-YAP Signalling Promotes Cell Proliferation and Survival. Int J Biol Sci 2015; 11(10):1181-1189. doi:10.7150/ijbs.12500. https://www.ijbs.com/v11p1181.htm

CSE
Zhu H, Cheng X, Niu X, Zhang Y, Guan J, Liu X, Tao S, Wang Y, Zhang C. 2015. Proton-sensing GPCR-YAP Signalling Promotes Cell Proliferation and Survival. Int J Biol Sci. 11(10):1181-1189.

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