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Int J Biol Sci 2016; 12(4):446-453. doi:10.7150/ijbs.12937 This issue Cite

Research Paper

A Phase II Clinical Trial of Concurrent Helical Tomotherapy plus Cetuximab Followed by Adjuvant Chemotherapy with Cisplatin and Docetaxel for Locally Advanced Nasopharyngeal Carcinoma

Xinxin Zhang1✉, Lei Du2, Feifang Zhao1, Qiuju Wang1, Shiming Yang1, Lin Ma2✉

1. Department of Otolaryngology, Head and Neck Surgery, Chinese People Liberation Army (PLA) General Hospital, Beijing, China.
2. Department of Radiation Oncology, Chinese People Liberation Army (PLA) General Hospital, Beijing, China.

✉ Corresponding authors: Dr. Xinxin Zhang, Department of Otolaryngology, Head and Neck Surgery, PLA General Hospital, 28 Fuxing Road, Beijing100853, China. Tel: +86-15910520109; FAX: +86-010-68241383; E-mail: zhangxinxincom.cn; xinxinzhan More

Citation:
Zhang X, Du L, Zhao F, Wang Q, Yang S, Ma L. A Phase II Clinical Trial of Concurrent Helical Tomotherapy plus Cetuximab Followed by Adjuvant Chemotherapy with Cisplatin and Docetaxel for Locally Advanced Nasopharyngeal Carcinoma. Int J Biol Sci 2016; 12(4):446-453. doi:10.7150/ijbs.12937. https://www.ijbs.com/v12p0446.htm
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Abstract

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Purpose: The present clinical trial was designed to evaluate the efficacy and safety of concurrent helical tomotherapy (HT) with cetuximab followed by adjuvant chemotherapy with docetaxel and cisplatin (TP) in the treatment of patients with locoregionally advanced nasopharyngeal carcinoma.

Materials and Methods: This phase II clinical trial included 43 patients with Stage III/IV LANC (33 Stage III and 10 Stage IV). The treatment consisted of concurrent HT with cetuximab (400 mg/m2 loading dose and weekly 250mg/m2), followed by four cycles of chemotherapy [docetaxel (70 mg/m2 on Day 1) and cisplatin (40 mg/m2 on Days 1 and 2 every 3 weeks). Side effects were evaluated with CTCAE criteria (Common Terminology Criteria for Adverse Events 3.0).

Results: The median follow-up duration was 48.0 months [95% confidence interval (CI) 41.7-58.0 months], the 2-year locoregional failure-free rate (LFFR), progression-free survival (PFS), distant failure-free rate (DFFR) and overall survival (OS) were 95.2%, 79.1%, 88.1% and 93.0% respectively; the 3-year LFFR, DFFR, PFS and OS were 92.7%, 85.6%, 72.0% and 85.7% respectively. The most common grade 3 toxicities were oropharyngeal mucositis (81.4%) and RT-related dermatitis (7.0%). No patients had more than grade 3 radiation related toxicities and no patients required nasogastric feeding. One patient experienced grade 3 osteonecrosis at 18 months after treatment.

Conclusions: Concurrent HT with cetuximab followed by adjuvant chemotherapy with TP is an effective strategy for the treatment of LANC with encouraging survival rates and minimal side effects.

Keywords: Locally advanced nasopharyngeal carcinoma, Helical tomotherapy, Cetuximab, Adjuvant chemotherapy, adverse event.

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APA
Zhang, X., Du, L., Zhao, F., Wang, Q., Yang, S., Ma, L. (2016). A Phase II Clinical Trial of Concurrent Helical Tomotherapy plus Cetuximab Followed by Adjuvant Chemotherapy with Cisplatin and Docetaxel for Locally Advanced Nasopharyngeal Carcinoma. International Journal of Biological Sciences, 12(4), 446-453. https://doi.org/10.7150/ijbs.12937.

ACS
Zhang, X.; Du, L.; Zhao, F.; Wang, Q.; Yang, S.; Ma, L. A Phase II Clinical Trial of Concurrent Helical Tomotherapy plus Cetuximab Followed by Adjuvant Chemotherapy with Cisplatin and Docetaxel for Locally Advanced Nasopharyngeal Carcinoma. Int. J. Biol. Sci. 2016, 12 (4), 446-453. DOI: 10.7150/ijbs.12937.

NLM
Zhang X, Du L, Zhao F, Wang Q, Yang S, Ma L. A Phase II Clinical Trial of Concurrent Helical Tomotherapy plus Cetuximab Followed by Adjuvant Chemotherapy with Cisplatin and Docetaxel for Locally Advanced Nasopharyngeal Carcinoma. Int J Biol Sci 2016; 12(4):446-453. doi:10.7150/ijbs.12937. https://www.ijbs.com/v12p0446.htm

CSE
Zhang X, Du L, Zhao F, Wang Q, Yang S, Ma L. 2016. A Phase II Clinical Trial of Concurrent Helical Tomotherapy plus Cetuximab Followed by Adjuvant Chemotherapy with Cisplatin and Docetaxel for Locally Advanced Nasopharyngeal Carcinoma. Int J Biol Sci. 12(4):446-453.

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