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Int J Biol Sci 2016; 12(8):1022-1031. doi:10.7150/ijbs.15438

Review

A Review of Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer

Yi Li2, Ji Wang3, Xiaowei Ma4, Li Tan4, Yanli Yan4, Chaofan Xue4, Beina Hui1, Rui Liu1, Hailin Ma1, Juan Ren1, ✉

1. Department of Radiotherapy, Oncology Department, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
2. Department of Chemotherapy, Oncology Department, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China,
3. Intensive Care Unit, China Mei Tan General Hospital, ChaoYang, Beijing 100028, P.R. China,
4. Medical School, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.

Abstract

Neoadjuvant chemoradiotherapy has become the standard treatment for locally advanced rectal cancer. Neoadjuvant chemoradiotherapy not only can reduce tumor size and recurrence, but also increase the tumor resection rate and anus retention rate with very slight side effect. Comparing with preoperative chemotherapy, preoperative chemoradiotherapy can further reduce the local recurrence rate and downstage. Middle and low rectal cancers can benefit more from neoadjuvant chemradiotherapy than high rectal cancer. It needs to refine the selection of appropriate patients and irradiation modes for neoadjuvant chemoradiotherapy. Different therapeutic reactions to neoadjuvant chemoradiotherapy affect the type of surgical techniques, hence calling for the need of much attention. Furthermore, many problems such as accurate staging before surgery, selection of suitable neoadjuvant chemoradiotherapy method, and sensitivity prediction to preoperative radiotherapy need to be well settled.

Keywords: Rectal cancer, preoperative concurrent chemoradiotherapy

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How to cite this article:
Li Y, Wang J, Ma X, Tan L, Yan Y, Xue C, Hui B, Liu R, Ma H, Ren J. A Review of Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer. Int J Biol Sci 2016; 12(8):1022-1031. doi:10.7150/ijbs.15438. Available from http://www.ijbs.com/v12p1022.htm