Int J Biol Sci 2016; 12(11):1309-1318. doi:10.7150/ijbs.16564
Epstein-Barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis
1. Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha 410078, China
Epstein-Barr virus (EBV) has been associated with several types of human cancers. In the host, EBV can establish two alternative modes of life cycle, known as latent or lytic and the switch from latency to the lytic cycle is known as EBV reactivation. Although EBV in cancer cells is found mostly in latency, a small number of lytically-infected cells promote carcinogenesis through the release of growth factors and oncogenic cytokines. This review focuses on the mechanisms by which EBV reactivation is controlled by cellular and viral factors, and discusses how EBV lytic infection contributes to human malignancies.
Keywords: Zta, Rta, Epstein-Barr virus, latency, reactivation, carcinogenesis
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How to cite this article:
Li H, Liu S, Hu J, Luo X, Li N, M.Bode A, Cao Y. Epstein-Barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis. Int J Biol Sci 2016; 12(11):1309-1318. doi:10.7150/ijbs.16564. Available from http://www.ijbs.com/v12p1309.htm