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ISSN 1449-2288 |
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International Journal of Medical Sciences Journal of Bone and Joint Infection (JBJI) ![]() ![]() |
Int J Biol Sci 2017; 13(7):935-948. doi:10.7150/ijbs.18953 Research Paper Structure elucidation and antitumor activity of a new polysaccharide from Maerkang Tricholoma matsutake 1. Key Laboratory of Southwest China Wildlife Resources Conservation, College of Life Sciences, China West Normal University, 1# Shida Road, Nanchong, Sichuan Province 637009, China A new heteropolysaccharide was isolated from the fruiting bodies of Tricholoma matsutake which had a molecular weight of 12078 Da. The results of structural features analysis showed that T. matsutake polysaccharide, here named TMP-B, was mainly composed of α - D - glucose and α - D - galactose which ratios were 7:2 and had a backbone of 1, 4 - linked α - D - glucose which branches were mainly composed of two 6 - linked α - D - galactose residue, and the α - D - galactose was 1, 6 - linked. Antitumor activity results showed that heteropolysaccharide TMP-B could inhibit the growth of S180 tumor in vivo and promote the apoptosis of L929 cells in vitro. Immunoregulatory activity results showed that TMP-B could promote the proliferation of macrophages by affecting G0/G1 phase, S phases and G2/M phases and promote cytokines release and gene expression. The result of this study introduced Maerkang T. matsutake as a possible valuable source which helped to exhibit unique antitumor and immunoregulatory properties. Keywords: structure elucidation, biological activity, polysaccharide, Maerkang Tricholoma matsutake This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
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to cite this article:
Hou Y, Ding X, Hou W, Song B, Yan X. Structure elucidation and antitumor activity of a new polysaccharide from Maerkang Tricholoma matsutake. Int J Biol Sci 2017; 13(7):935-948. doi:10.7150/ijbs.18953. Available from http://www.ijbs.com/v13p0935.htm |