Int J Biol Sci 2018; 14(4):406-417. doi:10.7150/ijbs.23542
Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis
1. Department of Thoracic Surgery, Harbin Medical University Cancer Hospital, Harbin, 150001, China
Pyroptosis is a form of caspase-1-dependent programmed cell death with anti-tumor properties, but the underlying molecular mechanisms are not fully understood. The results of our study showed that the antihyperlipidemic drug simvastatin induced pyroptosis in non-small cell lung cancer (NSCLC) cell lines and a xenograft mouse model. Inhibition of pyroptosis attenuated the effects of simvastatin on tumor cell viability and migration. These data suggest that simvastatin may induce pyroptosis, thereby potentially serving as a novel therapeutic agent for NSCLC.
Keywords: Simvastatin, NSCLC, pyroptosis, caspase-1, cancer therapy
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How to cite this article:
Wang F, Liu W, Ning J, Wang J, Lang Y, Jin X, Zhu K, Wang X, Li X, Yang F, Ma J, Xu S. Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis. Int J Biol Sci 2018; 14(4):406-417. doi:10.7150/ijbs.23542. Available from http://www.ijbs.com/v14p0406.htm