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Int J Biol Sci 2018; 14(4):406-417. doi:10.7150/ijbs.23542

Research Paper

Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis

Fengjiao Wang1#, Wei Liu2#, Jinfeng Ning1, Junfeng Wang1, Yaoguo Lang1, Xiangyuan Jin1, Kaibin Zhu1, Xiuyun Wang3, Xiaoguang Li4, Fan Yang5, Jianqun Ma1✉, Shidong Xu1✉

1. Department of Thoracic Surgery, Harbin Medical University Cancer Hospital, Harbin, 150001, China
2. The Fourth Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, 150001, China
3. Department of Abdominal Ultrasound, First Hospital of Harbin Medical University, Harbin, 150001, China
4. Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
5. Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, China
#These authors contributed equally to this work and should be considered co-first authors

Abstract

Pyroptosis is a form of caspase-1-dependent programmed cell death with anti-tumor properties, but the underlying molecular mechanisms are not fully understood. The results of our study showed that the antihyperlipidemic drug simvastatin induced pyroptosis in non-small cell lung cancer (NSCLC) cell lines and a xenograft mouse model. Inhibition of pyroptosis attenuated the effects of simvastatin on tumor cell viability and migration. These data suggest that simvastatin may induce pyroptosis, thereby potentially serving as a novel therapeutic agent for NSCLC.

Keywords: Simvastatin, NSCLC, pyroptosis, caspase-1, cancer therapy

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Wang F, Liu W, Ning J, Wang J, Lang Y, Jin X, Zhu K, Wang X, Li X, Yang F, Ma J, Xu S. Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis. Int J Biol Sci 2018; 14(4):406-417. doi:10.7150/ijbs.23542. Available from http://www.ijbs.com/v14p0406.htm