Int J Biol Sci 2018; 14(9):1090-1098. doi:10.7150/ijbs.25996 This issue Cite

Review

The Nrf2 Signaling in Retinal Ganglion Cells under Oxidative Stress in Ocular Neurodegenerative Diseases

Xiu-Fen Liu1, Dan-Dan Zhou2, Tian Xie3, Ji-Long Hao1, Tayyab Hamid Malik4, Cheng-Bo Lu5, Jing Qi1, Om Prakash Pant1, Cheng-Wei Lu1✉

1. Department of Ophthalmology, The First Hospital of Jilin University, Jilin, China.
2. Department of Radiology, The First Hospital of Jilin University, Jilin, China.
3. Department of . Neurosurgery, The People's Hospital of Jilin Province, Jilin, China.
4. Department of Gastroenterology, The First Hospital of Jilin University, Jilin, China.
5. Department of Cardiology, The First Hospital of Jiamusi University, Heilongjiang, China.

Citation:
Liu XF, Zhou DD, Xie T, Hao JL, Malik TH, Lu CB, Qi J, Pant OP, Lu CW. The Nrf2 Signaling in Retinal Ganglion Cells under Oxidative Stress in Ocular Neurodegenerative Diseases. Int J Biol Sci 2018; 14(9):1090-1098. doi:10.7150/ijbs.25996. https://www.ijbs.com/v14p1090.htm
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Abstract

Graphic abstract

Retinal ganglion cells (RGCs) are one of the important cell types affected in many ocular neurodegenerative diseases. Oxidative stress is considered to be involved in retinal RGCs death in ocular neurodegenerative diseases. More and more attention has been focused on studying the agents that may have neuroprotective effects. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a key nuclear transcription factor for the systemic antioxidant defense system. This review elucidates the underlying mechanism of the Nrf2-mediated neuroprotective effects on RGCs in ocular neurodegenerative diseases, such as diabetic retinopathy and retinal ischemia-reperfusion injury. Several Nrf2 inducers that shield RGCs from oxidative stress-induced neurodegeneration via regulating Nrf2 signaling are discussed.

Keywords: retinal ganglion cells, neurodegenerative diseases, oxidative stress, Nrf2, Keap1


Citation styles

APA
Liu, X.F., Zhou, D.D., Xie, T., Hao, J.L., Malik, T.H., Lu, C.B., Qi, J., Pant, O.P., Lu, C.W. (2018). The Nrf2 Signaling in Retinal Ganglion Cells under Oxidative Stress in Ocular Neurodegenerative Diseases. International Journal of Biological Sciences, 14(9), 1090-1098. https://doi.org/10.7150/ijbs.25996.

ACS
Liu, X.F.; Zhou, D.D.; Xie, T.; Hao, J.L.; Malik, T.H.; Lu, C.B.; Qi, J.; Pant, O.P.; Lu, C.W. The Nrf2 Signaling in Retinal Ganglion Cells under Oxidative Stress in Ocular Neurodegenerative Diseases. Int. J. Biol. Sci. 2018, 14 (9), 1090-1098. DOI: 10.7150/ijbs.25996.

NLM
Liu XF, Zhou DD, Xie T, Hao JL, Malik TH, Lu CB, Qi J, Pant OP, Lu CW. The Nrf2 Signaling in Retinal Ganglion Cells under Oxidative Stress in Ocular Neurodegenerative Diseases. Int J Biol Sci 2018; 14(9):1090-1098. doi:10.7150/ijbs.25996. https://www.ijbs.com/v14p1090.htm

CSE
Liu XF, Zhou DD, Xie T, Hao JL, Malik TH, Lu CB, Qi J, Pant OP, Lu CW. 2018. The Nrf2 Signaling in Retinal Ganglion Cells under Oxidative Stress in Ocular Neurodegenerative Diseases. Int J Biol Sci. 14(9):1090-1098.

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