International Journal of Biological Sciences

Impact factor
4.057

ISSN 1449-2288

News feeds of IJBS published articles
Manuscript login
Account
Submit

open access Global reach, higher impact

Journal of Genomics in PubMed Central. Submit manuscript now...

Theranostics

International Journal of Medical Sciences

Journal of Cancer

Journal of Genomics

Journal of Bone and Joint Infection (JBJI)

Nanotheranostics

PubMed Central Indexed in Journal Impact Factor

Int J Biol Sci 2018; 14(9):1090-1098. doi:10.7150/ijbs.25996

Review

The Nrf2 Signaling in Retinal Ganglion Cells under Oxidative Stress in Ocular Neurodegenerative Diseases

Xiu-Fen Liu1, Dan-Dan Zhou2, Tian Xie3, Ji-Long Hao1, Tayyab Hamid Malik4, Cheng-Bo Lu5, Jing Qi1, Om Prakash Pant1, Cheng-Wei Lu1✉

1. Department of Ophthalmology, The First Hospital of Jilin University, Jilin, China.
2. Department of Radiology, The First Hospital of Jilin University, Jilin, China.
3. Department of . Neurosurgery, The People's Hospital of Jilin Province, Jilin, China.
4. Department of Gastroenterology, The First Hospital of Jilin University, Jilin, China.
5. Department of Cardiology, The First Hospital of Jiamusi University, Heilongjiang, China.

Abstract

Retinal ganglion cells (RGCs) are one of the important cell types affected in many ocular neurodegenerative diseases. Oxidative stress is considered to be involved in retinal RGCs death in ocular neurodegenerative diseases. More and more attention has been focused on studying the agents that may have neuroprotective effects. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a key nuclear transcription factor for the systemic antioxidant defense system. This review elucidates the underlying mechanism of the Nrf2-mediated neuroprotective effects on RGCs in ocular neurodegenerative diseases, such as diabetic retinopathy and retinal ischemia-reperfusion injury. Several Nrf2 inducers that shield RGCs from oxidative stress-induced neurodegeneration via regulating Nrf2 signaling are discussed.

Keywords: retinal ganglion cells, neurodegenerative diseases, oxidative stress, Nrf2, Keap1

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Liu XF, Zhou DD, Xie T, Hao JL, Malik TH, Lu CB, Qi J, Pant OP, Lu CW. The Nrf2 Signaling in Retinal Ganglion Cells under Oxidative Stress in Ocular Neurodegenerative Diseases. Int J Biol Sci 2018; 14(9):1090-1098. doi:10.7150/ijbs.25996. Available from http://www.ijbs.com/v14p1090.htm