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Int J Biol Sci 2018; 14(12):1630-1635. doi:10.7150/ijbs.26932

Review

The Biological Roles of Translation Initiation Factor 3b

Xuefei Feng1,2, Juan Li1,2, Peijun Liu1,2✉

1. Center for Translational Medicine, the First Affiliated Hospital of Xi'an Jiaotong University
2. Key Laboratory for Tumor Precision Medicine of Shaanxi Province, the First Affiliated Hospital of Xi'an Jiaotong University

Abstract

Translation has important roles in almost all physiological and pathological processes, and translation initiation factors are particularly relevant to the translation initiation step, which is the most important step in translation regulation. Translation initiation factor 3b (eIF3b), a key subunit of the largest translation initiation factor 3 (eIF3), is widely considered a scaffold protein that acts to ensure the accuracy of translation initiation. A series of recent finds has revealed that eIF3 is closely related to oncogenesis. However, the concrete mechanism by which eIF3b is involve in carcinogenesis remains elusive. Here, we summarize a series of research findings regarding the relationship between eIF3b, translation and cancer.

Keywords: eIF3b, translation initiation, cancer.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Feng X, Li J, Liu P. The Biological Roles of Translation Initiation Factor 3b. Int J Biol Sci 2018; 14(12):1630-1635. doi:10.7150/ijbs.26932. Available from http://www.ijbs.com/v14p1630.htm