Int J Biol Sci 2019; 15(5):1072-1079. doi:10.7150/ijbs.31277 This issue Cite

Research Paper

Cryptotanshinone Suppresses Non-Small Cell Lung Cancer via microRNA-146a-5p/EGFR Axis

Pengfei Qi1*, Yanli Li1*, Xiaomin Liu1, Fatemeh A. Jafari1, Xinju Zhang1, Qiangling Sun2✉, Zhongliang Ma1✉

1. Lab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai, China
2. Department of Thoracic Surgery, Shanghai Chest Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China
*Co-first authors with equal contribution to the manuscript

Citation:
Qi P, Li Y, Liu X, Jafari FA, Zhang X, Sun Q, Ma Z. Cryptotanshinone Suppresses Non-Small Cell Lung Cancer via microRNA-146a-5p/EGFR Axis. Int J Biol Sci 2019; 15(5):1072-1079. doi:10.7150/ijbs.31277. https://www.ijbs.com/v15p1072.htm
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Abstract

Graphic abstract

Epidermal growth factor receptor (EGFR), a cancer-driven gene, plays an important role in tumorigenesis of lung cancer. Cryptotanshinone (CT) is the main constituent of salia miltiorrhiza and has been found to affect tumor progression. However, the mechanism of CT on lung cancer is still not clear. Here we found that CT could suppress the proliferation of non-small cell lung cancer (NSCLC) by inhibiting EGFR. We further confirmed that knockdown of EGFR also suppressed cell proliferation and arrested cell cycle progression. Furthermore, we evaluated EGFR was a direct target gene of miR-146a-5p which was upregulated by CT. In general, our results proved that CT could restrain NSCLC via miR-146a-5p/EGFR axis. CT and miR-146a-5p have the potential to be positive candidates in drug development of NSCLC.

Keywords: NSCLC, cryptotanshinone, EGFR, miR-146a-5p


Citation styles

APA
Qi, P., Li, Y., Liu, X., Jafari, F.A., Zhang, X., Sun, Q., Ma, Z. (2019). Cryptotanshinone Suppresses Non-Small Cell Lung Cancer via microRNA-146a-5p/EGFR Axis. International Journal of Biological Sciences, 15(5), 1072-1079. https://doi.org/10.7150/ijbs.31277.

ACS
Qi, P.; Li, Y.; Liu, X.; Jafari, F.A.; Zhang, X.; Sun, Q.; Ma, Z. Cryptotanshinone Suppresses Non-Small Cell Lung Cancer via microRNA-146a-5p/EGFR Axis. Int. J. Biol. Sci. 2019, 15 (5), 1072-1079. DOI: 10.7150/ijbs.31277.

NLM
Qi P, Li Y, Liu X, Jafari FA, Zhang X, Sun Q, Ma Z. Cryptotanshinone Suppresses Non-Small Cell Lung Cancer via microRNA-146a-5p/EGFR Axis. Int J Biol Sci 2019; 15(5):1072-1079. doi:10.7150/ijbs.31277. https://www.ijbs.com/v15p1072.htm

CSE
Qi P, Li Y, Liu X, Jafari FA, Zhang X, Sun Q, Ma Z. 2019. Cryptotanshinone Suppresses Non-Small Cell Lung Cancer via microRNA-146a-5p/EGFR Axis. Int J Biol Sci. 15(5):1072-1079.

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