1. Department of Biotechnology, School of Biology and Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China 2. Department of Immunology, School of Basic Medical Science, Guizhou Medical University, Guiyang, 550004, P.R. China 3. Immune Cells and Antibody Engineering Research Center of Guizhou Province/Key Laboratory of Biology and Medical Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China 4. Department of Head & Neck, Affiliated Tumor Hospital, Guizhou Medical University, Guiyang, 550004, P.R. China 5. Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, 550025, P.R. China * These authors are equal contributors
✉ Corresponding authors: : Zhu Zeng, School of Biology and Engineering / School of Basic Medical Science, Guizhou Medical University, University City, Guian New District, 550025, Guizhou Province, China. Tel.: +86-851-8817-4045, E-mail: zengzhuedu.cn; or Jinhua Long, Department of Head & Neck, Affiliated Tumor Hospital, Guizhou Medical University, No.1 Beijingxi Road, Yunyan District, Guiyang, 550004, P.R. China. Tel.: +86-851-8651-2802, E-mail: longjinhua100cn.More
Citation:
Huang Wz, Hu Wh, Wang Y, Chen J, Hu Zq, Zhou J, Liu L, Qiu W, Tang Fz, Zhang Sc, Ouyang Y, Ye Yn, Xu Gq, Long Jh, Zeng Z. A Mathematical Modelling of Initiation of Dendritic Cells-Induced T Cell Immune Response. Int J Biol Sci 2019; 15(7):1396-1403. doi:10.7150/ijbs.33412. https://www.ijbs.com/v15p1396.htm
Dendritic cells (DCs) are the most potent specialized antigen-presenting cells as now known, which play a crucial role in initiating and amplifying both the innate and adaptive immune responses. Immunologically, the motilities and T cell activation capabilities of DCs are closely related to the resulting immune responses. However, due to the complexity of the immune system, the dynamic changes in the number of cells during the peripheral tissue (e.g. skin and mucosa) immune response induced by DCs are still poorly understood. Therefore, this study simulated dynamic number changes of DCs and T cells in this process by constructing several ordinary differential equations and setting the initial conditions of the functions and parameters. The results showed that these equations could simulate dynamic numerical changes of DCs and T cells in peripheral tissue and lymph node, which was in accordance with the physiological conditions such as the duration of immune response, the proliferation rates and the motilities of DCs and T cells. This model provided a theoretical reference for studying the immunologic functions of DCs and practical guidance for the clinical DCs-based therapy against immune-related diseases.
Huang, W.z., Hu, W.h., Wang, Y., Chen, J., Hu, Z.q., Zhou, J., Liu, L., Qiu, W., Tang, F.z., Zhang, S.c., Ouyang, Y., Ye, Y.n., Xu, G.q., Long, J.h., Zeng, Z. (2019). A Mathematical Modelling of Initiation of Dendritic Cells-Induced T Cell Immune Response. International Journal of Biological Sciences, 15(7), 1396-1403. https://doi.org/10.7150/ijbs.33412.
ACS
Huang, W.z.; Hu, W.h.; Wang, Y.; Chen, J.; Hu, Z.q.; Zhou, J.; Liu, L.; Qiu, W.; Tang, F.z.; Zhang, S.c.; Ouyang, Y.; Ye, Y.n.; Xu, G.q.; Long, J.h.; Zeng, Z. A Mathematical Modelling of Initiation of Dendritic Cells-Induced T Cell Immune Response. Int. J. Biol. Sci. 2019, 15 (7), 1396-1403. DOI: 10.7150/ijbs.33412.
NLM
Huang Wz, Hu Wh, Wang Y, Chen J, Hu Zq, Zhou J, Liu L, Qiu W, Tang Fz, Zhang Sc, Ouyang Y, Ye Yn, Xu Gq, Long Jh, Zeng Z. A Mathematical Modelling of Initiation of Dendritic Cells-Induced T Cell Immune Response. Int J Biol Sci 2019; 15(7):1396-1403. doi:10.7150/ijbs.33412. https://www.ijbs.com/v15p1396.htm
CSE
Huang Wz, Hu Wh, Wang Y, Chen J, Hu Zq, Zhou J, Liu L, Qiu W, Tang Fz, Zhang Sc, Ouyang Y, Ye Yn, Xu Gq, Long Jh, Zeng Z. 2019. A Mathematical Modelling of Initiation of Dendritic Cells-Induced T Cell Immune Response. Int J Biol Sci. 15(7):1396-1403.
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