Int J Biol Sci 2019; 15(10):2170-2181. doi:10.7150/ijbs.33310

Research Paper

Influence of hyperproteinemia on reproductive development in an invertebrate model

Yong-Feng Wang1,2*, Xue-Dong Chen1,2*, Guang Wang1,2, Qiu-Ying Li1,2, Xin-Yin Liang1,2, Yang-Hu Sima1,2, Shi-Qing Xu1,2✉

1. School of Biology and Basic Medical Sciences, Medical College, Soochow University, Suzhou 215123, China.
2. Institute of Agricultural Biotechnology & Ecology (IABE), Soochow University, Suzhou 215123, China.
* Yong-Feng Wang and Xue-Dong Chen contributed equally to this work.

Abstract

Hyperproteinemia is a severe metabolic disease characterized by abnormally elevated plasma protein concentrations (PPC). However, there is currently no reliable animal model for PPC, and the pathological mechanism of hyperproteinemia thus remains unclear. In this study, we evaluated the effects of hyperproteinemia on reproductive development in an invertebrate silkworm model with a controllable PPC and no primary disease effects. High PPC inhibited the synthesis of vitellogenin and 30K protein essential for female ovarian development in the fat body of metabolic tissues, and inhibited their transport through the hemolymph to the ovary. High PPC also induced programmed cell death in testis and ovary cells, slowed the development of germ cells, and significantly reduced the reproductive coefficient. Furthermore, the intensities and mechanisms of high-PPC-induced reproductive toxicity differed between sexes in this silkworm model.

Keywords: hyperproteinemia, animal model, reproductive development, vitellogenin, programmed cell death

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How to cite this article:
Wang YF, Chen XD, Wang G, Li QY, Liang XY, Sima YH, Xu SQ. Influence of hyperproteinemia on reproductive development in an invertebrate model. Int J Biol Sci 2019; 15(10):2170-2181. doi:10.7150/ijbs.33310. Available from http://www.ijbs.com/v15p2170.htm