Int J Biol Sci 2019; 15(10):2256-2264. doi:10.7150/ijbs.37467

Review

Salvianolic acid A & B: potential cytotoxic polyphenols in battle against cancer via targeting multiple signaling pathways

Tian Qin1, Azhar Rasul1,2, Ayesha Sarfraz2, Iqra Sarfraz2, Ghulam Hussain3, Haseeb Anwar3, Ammara Riaz2, Sitong Liu1,5, Wei Wei1,4, Jiang Li4✉, Xiaomeng Li1✉

1. The Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China
2. Department of Zoology, Faculty of Life Sciences, Government College University Faisalabad, 38000, Faisalabad, Pakistan
3. Neurochemicalbiology and Genetics Laboratory (NGL), Department of Physiology, Faculty of Life Sciences, Government College University Faisalabad, 38000, Faisalabad, Pakistan
4. Dental Hospital, Jilin University, Changchun 130021, China
5. College of Life Sciences, Jilin University, Changchun, 130012, China

Abstract

Nature has generously offered life-saving therapies to mankind by providing evolutionarily optimized drug-like entities in the form of natural products. These splendid gifts of nature have served as most suitable candidates for anti-cancer drug discovery due to their pleiotropic activity on target molecules. This review aims to provide an update on the natural sources and bioactivities of such gifts from nature, salvianolic acid A & B, which are major bioactive constituents of a traditional Chinses medicinal herb, Salvia miltiorrhiza. Salvianolic acid A & B have been reported to owe anti-cancer, anti-inflammatory and cardioprotective activities. Currently salvianolic acids have been emerged as potent anti-cancer molecules. Salvianolic acid A & B fight cancer progression by prompting apoptosis, halting cell cycle and adjourning metastasis by targeting multiple deregulated signaling networks of cancer. Moreover, salvianolic acid A & B display potency towards sensitizing cancer cells to chemo-drugs. The review purposes that salvianolic acid A & B supply a novel opportunity for drug discovery but further experimentation is mandatory to embellish the knowledge of their pharmacological usage and to access their toxicological limits in order to establish these compounds as potential multitarget future drugs.

Keywords: Salvianolic acids, natural products, anticancer activity

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How to cite this article:
Qin T, Rasul A, Sarfraz A, Sarfraz I, Hussain G, Anwar H, Riaz A, Liu S, Wei W, Li J, Li X. Salvianolic acid A & B: potential cytotoxic polyphenols in battle against cancer via targeting multiple signaling pathways. Int J Biol Sci 2019; 15(10):2256-2264. doi:10.7150/ijbs.37467. Available from http://www.ijbs.com/v15p2256.htm