Online advance articles

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The role of WT1 in breast cancer: clinical implications, biological effects and molecular mechanisms
Ye Zhang, Wen-Ting Yan, Ze-Yu Yang, Yan-Ling Li, Jun Jiang, Yi Zhang, Xiao-Wei Qi
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.39958; accepted
[Author manuscript]

Development and validation of a prognostic nomogram for gastric cancer based on DNA methylation-driven differentially expressed genes
Yi Bai, Chunlian Wei, Yuxin Zhong, Junyu Long, Shan Huang, Fucun Xie, Yantao Tian, Xi Wang, and Haitao Zhao
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.41587; in press
[Author manuscript]

Potential Crosstalk between Liver and Extra-liver Organs in Mouse Models of Acute Liver Injury
Yufan Zheng, Baiping Cui, Wenrui Sun, Sining Wang, Xu Huang, Han Gao, Fei Gao, Yanpeng An, Xiaobo Li, Ning Sun
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.41293; in press
[Author manuscript]

MiR-139-5p negatively regulates PMP22 to repress cell proliferation by targeting the NF-κB signaling pathway in gastric cancer
MiR-139-, p negatively regulates PMP22 to repress cell proliferation by targeting the NF-κB signaling pathway in gastric cancer
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.40338; accepted
[Author manuscript]

ATM Expression Is Elevated in Established Radiation-Resistant Breast Cancer Cells and Improves DNA Repair Efficiency
Lei Bian, Yiling Meng, Meichao Zhang, Zhuying Guo, Furao Liu, Weiwen Zhang, Xue Ke, Yuxuan Su, Meng Wang, Yuan Yao, Lizhong Wu, Dong Li
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.41246; in press
[Author manuscript]

Superparamagnetic iron oxide nanoparticles drive miR-485-5p inhibition in glioma stem cells by silencing Tie1 expression
Zhiguang Pan, Yongyi Huang, Haiyang Qian, Xiling Du, Wenxing Qin, Te Liu
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.42887; accepted
[Author manuscript]

(Submission39125g3, resubmitted by corresponding author) Quercetin reverses docetaxel resistance in prostate cancer via androgen receptor and PI3K/Akt signaling pathways
Xinxing Lu| Feiya Yang| Dexi Chen| Qinxin Zhao| Dong Chen| Hao Ping| Nianzeng Xing
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.41686; in press
[Author manuscript]

Aldehyde Dehydrogenase, Liver Disease and Cancer
Wenjun Wang, Chunguang Wang, Hongxin Xu, Yanhang Gao
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.42300; in press
[Author manuscript]

The CARM1-p300-c-Myc-Max (CPCM) transcriptional complex specifically regulates the expression of CUL4A/4B and affects the stability of CRL4 E3 ligases in colorectal cancer
Wenzhu Lu, Jing Wu, Hongbo He, Hong Liu
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.41230; in press
[Author manuscript]

LncRNAs regulate metabolism in cancer
Wenyu Lin, Qiyin Zhou, Chao-Qun Wang, Liyuan Zhu, Chao Bi, Shuzhen Zhang, Xian Wang, Hongchuan Jin
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.40769; accepted
[Author manuscript]

Wnt5a/CaMKII/ERK/CCL2 axis is required for tumor-associated macrophages to promote colorectal cancer progression
Qing Liu, Jialin Song, Yue Pan, Dongdong Shi, chaogang Yang, Shuyi Wang, and Bin Xiong
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.40535; in press
[Author manuscript]

ALDH 2 conferred neuroprotection on cerebral ischemic injury by alleviating mitochondria-related apoptosis though JNK/caspase-3 signing pathway
Pingping Xia, Fan Zhang, Yajing Yuan, Cheng Chen, Yan Huang, Longyan, Li, E Wang, Qulian Guo, Zhi Ye
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.38962; in press
[Author manuscript]

Small molecule NSC1892 targets the CUL4A/4B-DDB1 interactions and causes impairment of CRL4DCAF4 E3 ligase to inhibit colorectal cancer cell growth
Hong Liu
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.40235; in press
[Author manuscript]

Vitamin A deficiency causes islet dysfunction by inducing islet stellate cell activation via cellular retinol binding protein 1
Yunting Zhou, Junming Zhou, Ming Zhong, Bo Sun, Wei Xu, Yumin Li, Cong He, Yang Chen, Xiaohang Wang, Min Zha, Peter M Jones, Zilin Sun
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.37861; in press
[Author manuscript]

MicroRNA-148b enhances the radiosensitivity of B-cell lymphoma cells by targeting Bcl-w to promote apoptosis
Si-hong Liu, Pei-pei Wang, Cun-te Chen, Dan Li, Qiong-yao Liu, Lin Lv, Xia Liu, Li-na Wang, Bao-xiu Li, Cheng-yin Weng, Xi-sheng Fang, Xiao-fei Cao, Hai-bo Mao, Xiao-jun Chen, Shao-li Luo, Shu-xiang Zheng, Guo-long Liu, Yong Wu
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.40756; in press
[Author manuscript]

Quantitative determination of niraparib and olaparib tumor distribution by mass spectrometry imaging
Lavinia Morosi, Cristina Matteo, Tommaso Ceruti, Silvia Giordano, Marianna Ponzo, Roberta Frapolli, Massimo Zucchetti, Enrico Davoli, Maurizio D’Incalci, and Paolo Ubezio
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.41395; accepted
[Author manuscript]

Circular RNA in Lung Cancer Research: Biogenesis, Functions and Roles
Congcong Zhang, Lifang Ma, Yongjie Niu, Zhixian Wang, Xin Xu, Yan Li, Yongchun Yu
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.39212; in press
[Author manuscript]

The Effect of HMGA1 in LPS-induced Myocardial Inflammation
Zhu-Lan Cai, Yuan Yuan, Bo Shen, Chen Liu, Qing-Wen Xie, Tong-Tong Hu, Qi Yao, Qing-Qing Wu, Qi-Zhu Tang
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.39947; accepted
[Author manuscript]

CRISPR/Cas9-related technologies in liver diseases: from feasibility to future diversity
Tao Xu, Li Li, Yu-chen Liu, Wei Cao, Jia-si Chen, Shuang Hu, Ying Liu, Huan Zhou, Yun-liang Li, Hong Zhou, Xiao-ming Meng, Cheng Huang, Lei Zhang, Xiang-peng Hu, Jun Li
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.33481; accepted
[Author manuscript]

TAF1L promotes development of oral squamous cell carcinoma via decreasing autophagy-depended apoptosis
Daiwei Wang, Yanpeng Li, Hong Qi, Wei Zhou, Haoxing Zhang, Qiong Liu, Ang Li, Yun Wang
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.41148; accepted
[Author manuscript]

Crystal structures of human C4.4A reveal the unique association of Ly6/uPAR/α-neurotoxin domain
Yunbin Jiang, Lin Lin, Shanli Chen, Longguang Jiang, Mette C. Kriegbaum, Henrik Gårdsvoll, Line V. Hansen, Jinyu Li, Michael Ploug, Cai Yuan, Mingdong Huang
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.39919; in press
[Author manuscript]

Therapeutic Targeting of CDK7 Suppresses Tumor Progression in Intrahepatic Cholangiocarcinoma
Hua-Dong Chen, Chen-Song Huang, Qiong-Cong Xu, Fuxi Li, Xi-Tai Huang, Jie-Qin Wang, Shi-Jin Li, Wei Zhao, and Xiao-Yu Yin
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.39779; accepted
[Author manuscript]

F2r negatively regulates osteoclastogenesis through inhibiting the Akt and NFκB signaling pathways
Yan Zhang, He Wang, Guochun Zhu, Airong Qian, Wei Chen
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.41867; accepted
[Author manuscript]

EHMT2/G9a Inhibits Aortic Smooth Muscle Cells Death by Suppressing Autophagy Activation
Tai-Qiang Chen, Nan Hu, Bo Huo, Jackson Ferdinand Masau, Xin Yi, Xiao-Xuan Zhong, Yong-Jie Chen, Xian Guo, Xue-Hai Zhu, Xiang Wei, Ding-Sheng Jiang
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.38835; in press
[Author manuscript]

Knockdown of SMAD3 inhibits the growth and enhances the radiosensitivity of lung adenocarcinoma via p21/cell cycle in vitro and in vivo
Hao Niu, Yiwei Huang, Li Yan, Li Zhang, Mengnan Zhao, Tao Lu, Xiaodong Yang, Zhengcong Chen, Cheng Zhan, Yu Shi, Qun Wang
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.40173; in press
[Author manuscript]

Exosomes Transmit Viral Genetic Information and Immune Signals may Causing Immunosuppression and Immune Tolerance in ALV-J Infected HD11 cells
Fei Ye, a, Yan Wang, a, Qijian He, a, Heling Yu, Yuxiang Lu, Shiliang Zhu, Hengyong Xu, Xiaoling Zhao, Huadong Yin, Diyan Li, Hua Li, Qing Zhu
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.35839; in press
[Author manuscript]

DNA methylation is involved in the pathogenesis of osteoarthritis by inducing CtBP expression and CtBP-mediated signaling
Xiangxiang Sun, Lin Xiao, Juan Chen, Xun Chen, Xinlin Chen, Shuxin Yao, Hui Li, Guanghui Zhao, and Jianbing Ma
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.39945; in press
[Author manuscript]

Functional Passenger-Strand miRNAs in Exosomes Derived from Human Colon Cancer Cells and Their Heterogeneous Paracrine Effects
Qingkun Gao, Fuming Lei, Qingmin Zeng, Zhaoya Gao, Pengfei Niu, Junnan, Ning, Jie Li, Jun Zhang
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.40787; in press
[Author manuscript]

SASH1 promotes melanin synthesis and migration via suppression of TGF-β1 secretion in melanocytes resulting in pathologic hyperpigmentation
Cui Hongzhou, Guo Shuping, He Hongxia, Guo Huina, Zhang Yuliang, Wang Binquan
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.38415; in press
[Author manuscript]

Development and validation of a novel nomogram to predict overall survival in gastric cancer with lymph node metastasis
Minjie Mao, Ao Zhang, Yi He, Lin Zhang, Wen Liu, Yiling Song, Shuqi Chen, Guanmin Jiang and Xueping Wang
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.39161; accepted
[Author manuscript]

Improvement of cognitive and motor performance with mitotherapy in aged mice
Zizhen Zhao, Yuzhen Yao, Yixue Hou, Le Zhang, Ailing Fu
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.40886; in press
[Author manuscript]

Innate Lymphoid Cells at the Maternal-Fetal Interface in Human Pregnancy
Rui-Qi Chang, Wen-Jie Zhou, Da-Jin Li, Ming-Qing Li
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.38264; in press
[Author manuscript]

Acute Synovitis after Trauma Precedes and is Associated with Osteoarthritis Onset and Progression
Lifan Liao, Shanxing Zhang, Lan Zhao, Xiaofeng Chang, Lin Han, Jian Huang, Di Chen
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.39015; in press
[Author manuscript]

IC261, a specific inhibitor of CK1δ/ε, promotes aerobic glycolysis through p53-dependent mechanisms in colon cancer
Min Liu, Yuhan Hu, Shuya Lu, Manman Lu, Jingsong Li, Haimin Chang, Huijie Jia, Min Zhou, Feng Ren, Jiateng Zhong
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.40960; in press
[Author manuscript]

Revised for 40219s PARKINSON’S DISEASE: A COMPREHENSIVE ANALYSIS OF FUNGI AND BACTERIA IN BRAIN TISSUE
Diana Pisa, Ruth Alonso and Luis Carrasco
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.42257; in press
[Author manuscript]

A novel versatile vehicle-like drug delivery 3D printing scaffold and its application for a rat femoral bone repairing in vitro and in vivo
Hui Wang, Zhengwei Deng, Lianfeng Dong, Xin Qi, Yiwei Hu, Bocai Lin, Deping Wang, Jiusheng Li, Xiangqiong Zeng, Yadong Zhang
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.37552; accepted
[Author manuscript]

Molecular mechanisms underlying increased radiosensitivity in human papillomavirus-associated oropharyngeal squamous cell carcinoma
Huanhuan Wang, Bin Wang, Jinlong Wei, Lingbin Meng, Qihe Zhang, Chao Qu, Ying Xin, Xin Jiang
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.40880; in press
[Author manuscript]

C-terminal binding proteins 1 and 2 in traumatic brain injury-induced inflammation and their inhibition as an approach for anti-inflammatory treatment
Hong Li, Caiguo Zhang, Chunxia Yang, Melanie Blevins, David Norris, Rui Zhao, and Mingxia Huang
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.42109; in press
[Author manuscript]

Mesenchymal stromal cells promote liver regeneration through regulation of immune cells
Chenxia Hu, Zhongwen Wu and Lanjuan Li
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.39725; in press
[Author manuscript]

Axl-148b chimeric aptamers inhibit breast cancer and melanoma progression
Lorena Quirico, Francesca Orso, Carla L. Esposito, Sofia Bertone, Roberto Coppo, Laura Conti, Silvia Catuogno, Federica Cavallo, Vittorio de Franciscis and Daniela Taverna
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.39768; accepted
[Author manuscript]

Clinical and Molecular Characterization and Discovery of Novel Genetic Mutations of Chinese Patients with COL2A1-related Dysplasia
Yang Xu, Li Li, Chun Wang, Hua Yue, Hao Zhang, Jiemei Gu, Weiwei Hu, Lianyong Liu, Zhenlin Zhang
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.38811; in press
[Author manuscript]

Overexpression of microRNA-9 enhances cisplatin sensitivity in hepatocellular carcinoma by regulating EIF5A2-mediated epithelial–mesenchymal transition
Ying Bao, Yibo Zhang, Yongliang Lu, Huihui Guo, Zhaohuo Dong, Qiuqiang Chen, Xilin Zhang, Weiyun Shen, Wei Chen, Xiang Wang
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.32460; in press
[Author manuscript]

ROBO4 deletion ameliorates PAF-mediated skin inflammation via regulating the mRNA translation efficiency of LPCAT1/LPCAT2 and the expression of PAF receptor
Xiaoqiang Xiao, Xi Zhuang, Ciyan Xue, Haoyu Chen, ChiPui Pang, Mingzhi Zhang
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.35797; in press
[Author manuscript]

Contents, Construction Methods, Data Resources, and Functions Comparative Analysis of Bacteria Databases
Jie Li, Zhuo Chen, Yadong Wang
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.39289; in press
[Author manuscript]

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Prognostic value of a novel multi-mRNA signature for predicting relapse of cholangiocarcinoma

Han Guo, Jie Cai, Bingrui Wang, Bijun Qiu, Xiang Li, Xiaoye Qu, Hongting Huang, Xianming Kong, Xuehua Sun, Yueqiu Gao, Qiang Xia, †, Hailong Wu, †, Xiaoni Kong, †
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.38846; in press
[Author manuscript]

Integrin α1 promote tumorigenicity and progressive capacity of human colorectal cancer cells
Hai Li, Yong Wang, Shi-kuo Rong, Ling Li, Tuo Chen, Ya-yun Fan, Yu-feng Wang, Chun-rong Yang Chun Yang, William C. Cho, Jiali Yang
Int. J. Biol. Sci. 2020; doi:10.7150/ijbs.37275; in press
[Author manuscript]


Note: This page contains manuscripts that have been accepted by this journal. They haven't been typeset by the journal and the content may change before final publication.