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Volume 22 (5); 2026

Research Papers

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Metabolic Adaptation of CD8⁺ T Cells Limits the Efficacy of Fatty Acid Oxidation Inhibition in Type 1 Diabetes
Manuel Salzmann, Laura Boccuni, Patrizia Gibler, Mira Brekalo, Tamara S. Trimmel, Elena T. Pichler, Patrick Haider, Julia L. Blesch, Christian Hengstenberg, Michael B. Fischer, Bruno K. Podesser, Remi J. Creusot, Julia B. Kral-Pointner, Philipp J. Hohensinner
Int. J. Biol. Sci. 2026; 22(5): 2196-2214. doi:10.7150/ijbs.125649
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Triptonide-mediated PTGS2 Inhibition Induces Autophagic Cell Death to Suppress the Progression of Triple-negative Breast Cancer and Epithelial Ovarian Cancer
Kunxiang Gong, Kai Song, Haotian Wang, Linye Li, Xiaomin Sun, Lingling Sun, Wenbo Hao, Zhe-Sheng Chen, Yinger Huang
Int. J. Biol. Sci. 2026; 22(5): 2215-2232. doi:10.7150/ijbs.127562
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PTPN1 Regulation via YBX1-PTBP1 Interaction Promotes Fibroblast Activation and Fibrotic Remodeling in the Lung
Huibing Liu, Cong Xia, Yingying Zhang, Yulong Gan, Lianhui Cheng, Xuqian Wang, Airu Chang, Wenyu Zhao, Bin Li, Yaxuan Wang, Yajun Li, Ivan Rosas, Juntang Yang, Guoying Yu, Lan Wang
Int. J. Biol. Sci. 2026; 22(5): 2233-2246. doi:10.7150/ijbs.123875
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MYC-Mediated Functional Manifestation of IDH1 Mutations in Intrahepatic Cholangiocarcinoma Confers Sensitivity to (+)-JQ1
Fangyanni Wang, Xinyu Liu, Ning Zhang, Ruirui Kong
Int. J. Biol. Sci. 2026; 22(5): 2247-2264. doi:10.7150/ijbs.123085
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CXCL8 Drives MMP1 Upregulation and Promotes Metastatic Progression in Oral Cancer Through CXCR1/2-Mediated JAK1/STAT3 Activation
Kuan-Chou Lin, Tsung-Ming Chang, Ying-Sui Sun, Yu-Rou Lin, Chih-Hsin Tang, Ju-Fang Liu
Int. J. Biol. Sci. 2026; 22(5): 2285-2301. doi:10.7150/ijbs.115990
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Interaction between m6A and YAP1 mechanotransduction pathways is essential for mechanical memory and matrix remodeling in pancreatic cancer
Jiaoshun Chen, Gengqiao Wang, Haoxiang Zhang, Qingyi Hu, Jun Zhao, Qiang Shen, Qingke Duan, Tao Yin
Int. J. Biol. Sci. 2026; 22(5): 2302-2323. doi:10.7150/ijbs.125330
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GFPT2 drives sunitinib resistance of renal cell carcinoma via enzyme-dependent and -independent manners
Songbo Wang, Jiajun Xing, Xiaoyi Wang, Zengjun Wang, Pengfei Shao, Chenkui Miao
Int. J. Biol. Sci. 2026; 22(5): 2324-2342. doi:10.7150/ijbs.118985
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ANXA1-mediated mTOR/FABP4 Inhibition Drives Antifibrotic Macrophage Reprogramming in Lupus Nephritis
Juan Tao, Qingyu Cheng, Pinjie Zhang, Guizhen Yu, Qi Chen, Manwen Yang, Qiqin Wu, Haopeng Fang, Haibo Wu, Xiaoyuan Song, Zhu Chen, Min Chen, Xiaoming Meng, Mingxing Lei, Tengchuan Jin
Int. J. Biol. Sci. 2026; 22(5): 2343-2360. doi:10.7150/ijbs.118613
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Targeting Macrophage-to-Myofibroblast Transition Mitigates Progression from Inflammation to Fibrosis in Rosacea
Chengqian Chen, Peiru Wang, Yajing Cao, Dongbin Sung, Yutong Yang, Jin Yang, Jia Liu, Yu Yan, Zhijie Ruan, Jie Dong, Jia Yan, Qihang Chang, Chunying Li, Xiaojing Liu, Xiuli Wang, Qingyu Zeng
Int. J. Biol. Sci. 2026; 22(5): 2361-2382. doi:10.7150/ijbs.128841
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BMP2-induced Adam12+ Fibroblasts Dictate Wound-associated Skin Scarring and Fibrosis
Jun-Yi Chen, Jin-Ru Song, Ke-Ai Li, Xue-Yan Xu, Ding-Heng Zhu, Lian Zhang, Zi-Shuo Chen, Qing Cheng, Liu-Yi Yao, Yi-Qi Shen, Zhili Rong, Bin Yang, Cheng-Cheng Deng
Int. J. Biol. Sci. 2026; 22(5): 2383-2397. doi:10.7150/ijbs.123725
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Neutrophil extracellular traps prime the ZBP1-cGAS sensor complex, triggering necroptosis and inflammatory injury in acute pancreatitis
Haoyu Zhang, Zheng Wang, Jiongdi Lu, Jie Li, Yuchen Jia, Xiaozhou Xie, Yixuan Ding, Feng Cao, Fei Li
Int. J. Biol. Sci. 2026; 22(5): 2398-2417. doi:10.7150/ijbs.122290
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O-GlcNAcylation stabilizes RSK4 by antagonizing GSK3β-mediated phosphorylation to enhance radioresistance in esophageal squamous cell carcinoma
Jin Liu, Duo Cao, Tianqi Xu, Junpeng Xu, Bowen Zhang, Xinya Yang, Pusong Zhao, Peng Wang, Ligang Chen, Qingge Jia, Mingyang Li
Int. J. Biol. Sci. 2026; 22(5): 2418-2434. doi:10.7150/ijbs.128078
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DNA Polymerase Gamma Acetylation Governs Mitochondrial Homeostasis and Vascular Cell Senescence
Pengbo Wang, Liming Yu, Kexin Cao, Xiaofan Guo, Lufan Sun, Shu Zhang, Tong Zhao, Yao Yu, Mengyao Xiong, Chang Liu, Naijin Zhang, Yingxian Sun, Guozhe Sun, Liu Cao
Int. J. Biol. Sci. 2026; 22(5): 2435-2451. doi:10.7150/ijbs.122298
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VCAN Is Essential for ERK5-Driven Tumorigenesis in Soft Tissue Sarcoma
Jaime Jiménez-Suárez, Francisco J. Cimas, José Joaquín Paricio, Borja Belandia, Yosra Berrouayel, Elena Arconada-Luque, Sofía Matilla-Almazán, Cesare Soffientini, Stefano Percio, Silvia Redondo-García, Natalia García-Flores, Cristina Garnés-García, Pablo Fernández-Aroca, Juan Jesús Martínez-Gómez, Antonio Fernández-Aramburo, Syong Hyun Nam-Cha, Elisabetta Rovida, Atanasio Pandiella, Azucena Esparís-Ogando, Sandro Pasquali, Juan Carlos Rodríguez-Manzaneque, Luis Del Peso, María José Ruiz-Hidalgo, Ricardo Sánchez-Prieto
Int. J. Biol. Sci. 2026; 22(5): 2452-2468. doi:10.7150/ijbs.121402
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Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
Xiaoya Jin, Hetian Xue, Xiaolin Shi, Yuchuan Zhou, Jialing Zhang, Liang Zeng, Xinglong Liu, Yuqi Xiao, Han Wang, Yue Zheng, Lina Wang, Yang Bai, Yan Pan, Jianghong Zhang, Yanwu Xu, Chunlin Shao
Int. J. Biol. Sci. 2026; 22(5): 2469-2491. doi:10.7150/ijbs.126269
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CD44/POU2F2/BCL9L axis mediates MIF-driven SPP1+TAM activation in colorectal cancer metastasis
Fan Zhang, Bingquan Zhao, Xueying Fan, Zhiqiang Shi, Peilan Guo, Haibo Zhang, Hiu-Yee Kwan, Zhongqiu Liu, Tao Su
Int. J. Biol. Sci. 2026; 22(5): 2492-2511. doi:10.7150/ijbs.116575
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Exploring Host-driven Immunopathological Factors Developing Severe Tuberculosis: Insights from Comparative Mouse Models
Hongmin Kim, Kee Woong Kwon, Hagyu Kim, WeonSeok Jung, Kyungmin Kim, Jung Joo Hong, Sung Jae Shin
Int. J. Biol. Sci. 2026; 22(5): 2512-2532. doi:10.7150/ijbs.124878
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Gut Microbiota-driven Tryptophan Metabolism Towards the Indole Pathway Mediates Schisandra Chinensis Polysaccharide's Alleviation of Ulcerative Colitis and Comorbid Depression via Aryl Hydrocarbon Receptor
Jiuba Zhang, Shuai Yan, Ting Gao, Mingxuan Li, Yu Li, Lin Li, De Ji, Zhenhua Bian, Wei Huang, Jinjun Hou, Tulin Lu, Lianlin Su
Int. J. Biol. Sci. 2026; 22(5): 2557-2580. doi:10.7150/ijbs.125012
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β-Cryptoxanthin Confers Radioprotection against Intestinal Injury via NRF2-Mediated Antioxidant Response and Gut Microbiota Reprogramming
Manman Zhang, Yingshuang Liu, Wenbo Ma, Jinhan Wang, Ningning He, Huijuan Song, Yeqing Gu, Mengmeng Yang, Xinran Lu, Jingxing Sun, Chang Xu, Liqing Du, Yayi Yuan, Yan Wang, Kaihua Ji, Qiang Liu
Int. J. Biol. Sci. 2026; 22(5): 2581-2602. doi:10.7150/ijbs.125307
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Itaconate Modulates Neutrophil Homeostasis to Ameliorate Airway Inflammation in Diesel Exhaust Particles-exacerbated Asthma via Inhibiting NETs Formation
Guiping Zhu, Ling Ye, Yansha Song, Yu Chen, Hui Cai, Zilinuer Abuduxukuer, Liping Zhu, Yingying Zeng, Wenjiao Zhu, Dan Ye, Yuanlin Song, Pu Wang, Meiling Jin, Jian Wang
Int. J. Biol. Sci. 2026; 22(5): 2603-2621. doi:10.7150/ijbs.124927
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ARID1A deficiency activates OSM-STAT3 axis in endometrial cancer, creating vulnerability to JAK/STAT3 inhibition
Li-Jie Chen, Changxiang Shi, Eun Ju Yang, Guowen Ren, Shishi Tao, Yue Pu, Xiumei Zhang, Xin Shen, Changjie Wu, Joong Sup Shim
Int. J. Biol. Sci. 2026; 22(5): 2638-2653. doi:10.7150/ijbs.129142
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USP20, a Super-enhancer Regulated Gene, Promotes Acute Myeloid Leukemia Progression through CTNNB1 Deubiquitination
Jia Cheng, Fang Fang, Zhiheng Li, Jianwei Wang, Linbo Cai, Ling Xu, Yanfang Tao, Juanjuan Yu, Gen Li, Zimu Zhang, Zexi Cui, Yang Yang, Tiandan Li, Di Wu, Xiaolu Li, Yifang Ding, Zong Zhai, Mengmeng Gu, Xue Li, Xingxing Wu, Pengju Yang, Chunxia Shi, Huike Bai, Xiaodong Wang, Lanlan Han, Lei Shi, Jianqin Li, Jian Pan
Int. J. Biol. Sci. 2026; 22(5): 2665-2686. doi:10.7150/ijbs.122898
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NPLOC4 Inhibition Remodels Tumor Microenvironment via M2-to-M1 Macrophage Reprogramming and Boosts Anti-PD-1 Response in Liver Cancer
Xingxing Gao, Hechen Huang, Caixu Pan, Jiacheng Huang, Junru Chen, Shengyong Yin, Lin Zhou, Shusen Zheng
Int. J. Biol. Sci. 2026; 22(5): 2687-2701. doi:10.7150/ijbs.125201
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APP Deficiency Ameliorates FAD Presenilin 1 F105C and A246E Mutations-induced Mitochondrial Dysfunction in Human Cortical Neurons
Yu-Hsin Yen, Fang Yuan, Daijiao Tang, Jing-Fang Luo, Chen Ming, Phil-Jun Kang, Huanxing Su, Cheong-Meng Chong, Su-Chun Zhang
Int. J. Biol. Sci. 2026; 22(5): 2720-2735. doi:10.7150/ijbs.120062
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Dual Targeting of FAP-Directed Nanoparticles and FRα-Specific CAR-T Cells Induces Additive Anti-Tumor Effects in Triple-Negative Breast Cancer
Tanva Thongkleang, Suyanee Thongchot, Kamonlatth Rodponthukwaji, Piriya Luangwattananun, Kwanruthai Tadpetch, Pa-thai Yenchitsomanus, Peti Thuwajit, Primana Punnakitikashem, Chanitra Thuwajit
Int. J. Biol. Sci. 2026; 22(5): 2736-2753. doi:10.7150/ijbs.122417
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Reviews

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Gut-Lung Microbiota Axis Shapes the Immune Microenvironment and Immunotherapeutic Response in Lung Cancer
Yao Liu, Sidao Wang, Xuan Xiang, Yiheng Du, Qianqian Xue, Yiran Niu, Wenbei Peng, Linlin Ye, Qiong Zhou
Int. J. Biol. Sci. 2026; 22(5): 2265-2284. doi:10.7150/ijbs.126977
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Tumor-Induced Rewiring of Splenic Niches: from Immune Organ to Cancer Accomplice
Tong Yuan, Junjie Liu, Chunyu Zhang, Xing Lv, Guan Tan, Lin Xue, Erlei Zhang, Huifang Liang, Zhiyong Huang
Int. J. Biol. Sci. 2026; 22(5): 2533-2556. doi:10.7150/ijbs.127169
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Metabolic Dysfunction-Associated Steatotic Liver Disease and Emerging Oligonucleotide Therapies
Qionghui Chen, Jing Jiang, Zhixin Chiang, Xiangyu Li, LiWen Zhang, Lian Wang, Hung-fat Tse, Shihua Wang, Qizhou Lian
Int. J. Biol. Sci. 2026; 22(5): 2622-2637. doi:10.7150/ijbs.127996
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New Insights into the Role of NF-κB in Hepatitis B Virus Infection
Shana Halemubieke, Xinru Liu, Ying Yan, Huimin Ji, Huizhen Sun, Jie Ma, Le Chang, Lunan Wang
Int. J. Biol. Sci. 2026; 22(5): 2654-2664. doi:10.7150/ijbs.126968
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The Yin-Yang balance of SIRT1 and SIRT2 in cancer metabolic remodeling
Fei Yi, Li Shen, Xindi Yang, Zhuo Wang, Xue Li, Zishi Shen, Wenting Liu, Qi Miao, Shuang Jiang, Eryan Kong, Xiaoyu Song, Tingting Zhou, Ning Bai, Liu Cao
Int. J. Biol. Sci. 2026; 22(5): 2702-2719. doi:10.7150/ijbs.127696
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