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Volume 22 (7); 2026
Research Papers
Macrophage NEDD4L restrains liver fibrosis by preventing scar-associated macrophage expansion via ubiquitination of phospho-SMAD3 Yanghuan He, Shujun Ge, Shijia Ling, Siting Yang, Feiran Yang, Xinyi Liu, Siyue Dong, Yingfen Chen, Ziling Zhang, Yue Zhou, Seonghwan Hwang, Seung-Jin Kim, Peng Wang, Yong He, Yuanwen Chen
Int. J. Biol. Sci. 2026; 22(7): 3304-3321. doi:10.7150/ijbs.126649
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TIMP1 Derived from Mesenchymal Stem Cells Promotes Bladder Cancer Progression by Regulating the Formation of VDIMs through the RAP1 Pathway Pan Li, Enguang Yang, Xinyu Zhang, Yibo Shi, Chaohu Chen, Guangrui Fan, Yuhan Wang, Hanzhang Wang, Nan Liu, Hong Zhou, Junqiang Tian, Liang Cheng, Zhilong Dong, Zhiping Wang
Int. J. Biol. Sci. 2026; 22(7): 3322-3341. doi:10.7150/ijbs.130720
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OTUB2/ALYREF axis modulates the docetaxel resistance of castration-resistant prostate cancer via upregulating ABCG4-mediated drug efflux Zhi-Bin Ke, Jia-Yin Chen, Bin Lin, Chao-Ran Chen, Yu-Ting Xue, Jiang-Bo Sun, Zi-Heng Yan, Yu-Xuan Zhao, Meng-Xin Liu, Zhen Wang, Xue-Yi Xue, Qing-Shui Zheng, Yong Wei, Ning Xu
Int. J. Biol. Sci. 2026; 22(7): 3342-3366. doi:10.7150/ijbs.126319
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LINC-EPS Protects Against Neurodegeneration by Driving a PGC-1α-Mediated Anti-Ferroptosis Program in Parkinson's Disease Ziqi Liu, Ruoxun Wang, Xinrui Lan, Min Shen, Mingfeng Jiang, Rongqing Li, Jie Zhao, Jing Li, Sainan Wang, Qicheng Wang, Xinyi Xu, Wei Li, Weijuan Gong, Li Qian
Int. J. Biol. Sci. 2026; 22(7): 3367-3388. doi:10.7150/ijbs.128204
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CCT2 Orchestrates Glycolysis and Exosome-Mediated M2 Macrophage Polarization in HCC tumorigenesis Wing-Wa Guo, Cairang Dongzhi, Tianyin Ma, Minghe Zhang, Meng Gao, Xiaomian Li, Jitong Zhou, Xi Chen, Wenzhi He, Ming Tian, Yufeng Yuan, Weijie Ma
Int. J. Biol. Sci. 2026; 22(7): 3389-3410. doi:10.7150/ijbs.122859
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Kinesin Family Member 26A Disrupts DNA-Dependent Protein Kinase Complex Formation to Enhance Chemoradiotherapy Sensitivity in Colorectal Cancer Mengjie Li, Ningxin Ren, Shaosen Zhang, Hongxia Chen, Ruoqing Yan, Ying Huang, Jing Jin, Linlin Zheng, Shuangmei Zou, Yexiong Li, Wen Tan, Dongxin Lin
Int. J. Biol. Sci. 2026; 22(7): 3411-3431. doi:10.7150/ijbs.127218
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TIM-4+ skeletal muscle Resident Tissue Macrophages Ferroptosis mediated Rhabdomyolysis in Exertional Heatstroke Youyong Tang, Qiyuan An, Keying Zhang, Chenxin Liu, Riqing Wei, Ru Li, Zhiqing Wang, Sixiao He, Fudi Wang, Li Ma, Qiang Ma
Int. J. Biol. Sci. 2026; 22(7): 3432-3450. doi:10.7150/ijbs.114815
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DHCR24 Drives Ovarian Cancer Chemoresistance Through Lipid Raft-mediated P-gp Stabilization and STAT3 Activation Xin Fu, Zhaosong Wang, Zhining Yang, Yue Xu, Qiuping Dong, Yanfen Cui, Ke Wang
Int. J. Biol. Sci. 2026; 22(7): 3451-3469. doi:10.7150/ijbs.128173
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Exosomal Long Noncoding RNA H19 as a Biomarker and Therapeutic Target in Atrial Fibrillation Ji-Young Kang, Dasom Mun, Malgeum Park, Gyeongseo Yoo, Nuri Yun, Boyoung Joung
Int. J. Biol. Sci. 2026; 22(7): 3470-3487. doi:10.7150/ijbs.123108
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Oligodendrocyte-secreted ERBB3 Mediates the Competitive Uptake of Copper Ions by Tumor Cells to Promote Brain Metastasis in Lung Cancer Yuechao Yang, Yang Gao, Huanhuan Cui, Sen Li, Zhe Qi, Zhisu Wang, Deheng Li, Lei Chen, Mingtao Feng, Xiaojun Wu, Xin Chen, Bin Hao, Changshuai Zhou, Liangdong Li, Yiqun Cao
Int. J. Biol. Sci. 2026; 22(7): 3580-3599. doi:10.7150/ijbs.127108
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ZCCHC4 Orchestrates Hepatocellular Carcinoma Metastasis by Regulating Lipid biosynthesis and TMEM97/LCN2/Twist1 Pathway Juan Ye, Xinyi Wen, Ruiyang Liu, Caini Huang, Zhijie Xu, Yi Zhan, Fuyuan Xu, Hongbin Huang, Chunhui Qi, Yao Tang, Peirong Li, Jianzhong He, Zhiju Zhao, Gang Lu, Fei Xiao
Int. J. Biol. Sci. 2026; 22(7): 3600-3616. doi:10.7150/ijbs.120086
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Nebivolol Inhibits Hepatocellular Carcinoma via RHOQ and Enhances the Efficacy of Lenvatinib Saihua Zhang, Hechun Lin, Junming Yu, Yunyu Wu, Changbing Wang, Lin Mao, Yizi Jin, Qin Geng, Shuqing Jiang, Xin Shen, Chao Ge, Taoyang Chen, Jinjun Li, Jing Li, Xiuying Xiao, Hong Li
Int. J. Biol. Sci. 2026; 22(7): 3617-3634. doi:10.7150/ijbs.127395
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Microglial PGC-1α alleviates synaptic damage and cognitive impairments following anesthesia and surgery by suppressing excessive synaptic pruning in aged mice Xuyang Wu, Maokai Xu, Yongxin Huang, Pinzhong Chen, Liang Wu, Andi Chen, Jianjie Wei, Yingjie Chen, Yongbao Lin, Yingceng Lin, Zhe Lin, Ying Lin, Fushan Xue, Xiaohui Chen, Xiaochun Zheng
Int. J. Biol. Sci. 2026; 22(7): 3635-3657. doi:10.7150/ijbs.121472
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The ANXA2P1-hnRNP F-HK2/c-Myc Positive Feedback Loop Promotes Proliferation and Glycolytic Metabolism in Gastric Cancer Ping Yang, Yanci Xie, Yuting Lei, Xiaodong Huang, Jieke Wu, Jiaxing Zhang, Siyang Peng, Yidong Chen, Xiangyang Wei, Jieming Zhang, Qiong Yang, Jiaying Li, Weiyu Dai, Xiaosheng Wu, Xinpeng Shi, Yanfeng Hu, Side Liu, Aimin Li, Weimei Tang, Jide Wang
Int. J. Biol. Sci. 2026; 22(7): 3658-3681. doi:10.7150/ijbs.126842
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Multi-Omics Profiling of Long Noncoding RNAs in Clear Cell Renal Cell Carcinoma for Characterization and Clinical Applications Yuhong Ding, Yang Li, Zhenghao Liu, Yaxin Hou, Zhipeng Yao, Pengjie Shi, Jinxu Li, Yingchun Kuang, Yiting Liu, Junyi Hu, Lilong Liu, Ke Chen
Int. J. Biol. Sci. 2026; 22(7): 3682-3700. doi:10.7150/ijbs.127291
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Polycystin-1 Orchestrates Tumor Context-Dependent Mechanotransduction Programs Driving Epithelial-to-Mesenchymal Transition and Invasion in Solid Cancers Antonios N. Gargalionis, Kostas A. Papavassiliou, Angeliki-Ioanna Giannopoulou, Panagiotis Sarantis, Christina Piperi, Eleftheria Lakiotaki, Anastasios Stofas, Christos Adamopoulos, Panagiota Kontou, Efstathios Boviatsis, Stefanos Korfias, Nikolaos Kavantzas, Penelope Korkolopoulou, Efthimia K. Basdra, Athanasios G. Papavassiliou
Int. J. Biol. Sci. 2026; 22(7): 3701-3713. doi:10.7150/ijbs.131646
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eEF2K-Mediated Stabilization of PCBP2 Promotes Oncogenic mRNA Programs in Triple-Negative Breast Cancer Yueying Cheng, Ting Jiang, Wenqian Zhu, Linhao He, Zongling Chen, Hang Li, Ruigang Zhao, Shilong Jiang, Yan Cheng
Int. J. Biol. Sci. 2026; 22(7): 3714-3730. doi:10.7150/ijbs.127111
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Luteolin enhances antitumor immunity of B7-H3-targeted bispecific natural killer cell engagers against non-small cell lung cancer Shuo Yang, Zhenfeng Zhang, Xi He, Zilu Ouyang, Shuzhen Tang, Manshan Liang, Zhuowen Chen, Yinghua Liu, Yang Huang, Yeneng Dai, Shengfeng Huang, Bihui Cao, Zhe-sheng Chen, Xiyong Yu, Qi Zhao
Int. J. Biol. Sci. 2026; 22(7): 3731-3748. doi:10.7150/ijbs.125834
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PUS1 Drives Renal Cancer Progression by Preventing Formation of Endogenous Double-stranded RNAs Ziwei Zhu, Zeyi Lu, Fan Li, Zhehao Xu, Ruyue Wang, Yang Li, Haohua Lu, Yiming Ding, Wenqin Luo, Yudong Lin, Yi Lu, Xudong Mao, Mengxuan Li, Ziyuan Wang, Lifeng Ding, Liqun Xia, Gonghui Li
Int. J. Biol. Sci. 2026; 22(7): 3749-3768. doi:10.7150/ijbs.130175
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OSBPL10 Drives Lipophagy-Mediated Lipid Mobilization to Promote Pancreatic Ductal Adenocarcinoma Progression Zonghao Duan, Xueshiyu Ma, Feng Yu, Junfeng Zhang, Rong Hua, Wei Liu, Dejun Liu, Jianyu Yang, Xueliang Fu, Minwei Yang, Hongfei Yao, Shuheng Jiang, Lipeng Hu, Musitaba Mutailifu, Xiaomei Yang, Yongwei Sun, Linli Yao, Yanmiao Huo
Int. J. Biol. Sci. 2026; 22(7): 3769-3787. doi:10.7150/ijbs.125552
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Monocyte Preprogramming by Tobacco Carcinogens and Fructose Intake Accelerates Lung Cancer Progression via Metabolic and Epigenetic Pathways Jee Hwan Ahn, Hye-Young Min, Jisung Kim, Xuan Wei, Namwon Kim, Ho-Young Lee
Int. J. Biol. Sci. 2026; 22(7): 3788-3806. doi:10.7150/ijbs.125622
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Exosomal transfer of macrophage-derived NEAT1 enhances DNA damage response and confers cisplatin resistance in lung adenocarcinoma via the MAD1L1/p53 axis Yi Yang, Min Meng, Yi Zhao, Fangyuan Yu, Harsh Patel, Zhe-Sheng Chen
Int. J. Biol. Sci. 2026; 22(7): 3807-3825. doi:10.7150/ijbs.128214
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SphK1/S1P signaling-mediated crosstalk between pancreatic acinar cell and macrophage M1 polarization aggravates acute pancreatitis progression Jie Wang, Guangyu Zhao, Ping Hu, Shengbo Han, Yuhang Hu, Zhu Zeng, Yang Li, Yong Zhao, Yan Huang, Wenfeng Zhuo, Guozheng Lv, Hongda Wang, Gang Zhao
Int. J. Biol. Sci. 2026; 22(7): 3826-3842. doi:10.7150/ijbs.120627
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Loss of Frmd5 Inhibits Jak2-Stat3 Signalling Pathway and Impairs Cell Apoptosis During Vagina Luminal Formation in Puberty Mice Tiantian Su, Zhenbin Wang, Yunjiao Wu, Qianchen Li, Li Tian, Xiaowei Li, Jing Zhang, Miao Yu, Yuqi Xing, Juan Du, Lijun Zhao, Jun Zhan, Hongquan Zhang
Int. J. Biol. Sci. 2026; 22(7): 3843-3859. doi:10.7150/ijbs.126669
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Single-cell Deciphering of the Progression Trajectories of the Tumor Ecosystem in Laryngeal Squamous Cell Carcinoma Zhimou Cai, Yun Li, Jinhong Zhang, Shiyun Luo, Zhiwei Qiang, Zhaoyue Lu, Lin Chen, Wenbin Lei
Int. J. Biol. Sci. 2026; 22(7): 3862-3885. doi:10.7150/ijbs.129291
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DHCR24 Deficiency Drives Age-Related Meibomian Gland Dysfunction by Regulating Lipid Metabolic Imbalance and Cytosolic mtDNA-Induced cGAS-STING Activation Yuchen Cai, Tianyi Zhou, Jiaming Sun, Xueyao Cai, Wenjun Shi, Junzhao Chen, Christos C. Zouboulis, Hao Sun, Yao Fu, Liangbo Chen
Int. J. Biol. Sci. 2026; 22(7): 3886-3908. doi:10.7150/ijbs.129636
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RUNX2 enhances vascular remodeling to promote endothelial proliferation in acute liver injury Jong-Min Lee, Yoon-Su Ha, Seung-Jun Lee, Hyun-Yi Kim, Anish Ashok Adpaikar, Eun-Jung Kim, Keishi Otsu, Xiangguo Che, Dai Hoon Han, Young Her, Je-Yong Choi, Seung-Jin Kim, Han-Sung Jung
Int. J. Biol. Sci. 2026; 22(7): 3909-3924. doi:10.7150/ijbs.123366
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Reviews
The Implications of Radiotherapy-Induced Cellular Senescence for Cancer Treatment and Tumor Microenvironment Modulation Chao Jiang, Zhouting Tuo, Dilinaer Wusiman, Jie Wang, Haohao Yao, William C. Cho, Zhaojie Lyu, Qi Zhang, Dechao Feng
Int. J. Biol. Sci. 2026; 22(7): 3488-3508. doi:10.7150/ijbs.130683
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Natural Killer Cell Therapy in Ovarian Cancer: From Preclinical Potentials to Clinical Applications and Combination Strategies Tian Chen, Jiaqi Lu, Haiou Liu
Int. J. Biol. Sci. 2026; 22(7): 3509-3521. doi:10.7150/ijbs.130260
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Deciphering Uncoupling Proteins in Cellular Homeostasis and Metabolic Health Yu-Ting Liu, Ya-Jia Ding, Hong-Liang Qiu, Yan Che, Qi-Zhu Tang
Int. J. Biol. Sci. 2026; 22(7): 3522-3543. doi:10.7150/ijbs.129896
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Amino Acid Metabolism in Chronic Liver Disease: from Pathogenic Driver to Therapeutic Target Yingchen Huang, Yao Jiang, Wenkai Ye, Xin Hu, Nuerbiye Abudurexiti, Jiarui Li, Chuang Li, Ronggao Chen, Xiao Xu
Int. J. Biol. Sci. 2026; 22(7): 3544-3563. doi:10.7150/ijbs.128644
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The Quartet of Core Oncogenic Drivers in Neuroendocrine Prostate Cancer: Multi-Omics Dataset Integration to Forge a Translational Link Between Biology and Precision Therapy Youzhi Wang, Ning Wu, Junbo Li, Qian Cao, Jianfei Ye, Shudong Zhang
Int. J. Biol. Sci. 2026; 22(7): 3564-3579. doi:10.7150/ijbs.129521
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Erratum
FTO-induced APOE promotes the malignant progression of pancreatic neuroendocrine neoplasms through FASN-mediated lipid metabolism: Erratum Jinhao Chen, Mujie Ye, Danyang Gu, Ping Yu, Lin Xu, Bingyang Xue, Lijun Yan, Feiyu Lu, Chunhua Hu, Yanling Xu, Xiaoting Shi, Lingyi Chen, Yan Wang, Jianan Bai, Ye Tian, Qiyun Tang
Int. J. Biol. Sci. 2026; 22(7): 3860-3861. doi:10.7150/ijbs.132859
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