International Journal of Biological Sciences
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ISSN 1449-2288

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Journal of Genomics now in PubMed/PubMed Central. Submit manuscript...

International Journal of Medical Sciences

Journal of Cancer

Theranostics

Journal of Genomics

Journal of Bone and Joint Infection (JBJI)

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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

new Latest impact factor is 4.509. Congratulations!
new Cover suggestion ...details
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Most Cited Paper Award: Winners of this year are Guiqian Chen et al, for the paper "TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation". Details...
The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details
Top cited papers:
Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...
The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details
Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details
Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details
The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details
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Research Paper
Glycosphingolipid GM3 is Indispensable for Dengue Virus Genome Replication
Kezhen Wang, Juanjuan Wang, Ta Sun, Gang Bian, Wen Pan, Tingting Feng, Penghua Wang, Yunsen Li, Jianfeng Dai
Int. J. Biol. Sci. 2016; 12(7): 872-883. doi:10.7150/ijbs.15641
[Abstract] [Full text] [PDF]


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Research Paper
Asiatic Acid Protects against Cardiac Hypertrophy through Activating AMPKα Signalling Pathway
Zhen-Guo Ma, Jia Dai, Wen-Ying Wei, Wen-Bin Zhang, Si-Chi Xu, Hai-Han Liao, Zheng Yang, Qi-Zhu Tang
Int. J. Biol. Sci. 2016; 12(7): 861-871. doi:10.7150/ijbs.14213
[Abstract] [Full text] [PDF]


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Research Paper
Deguelin Induces the Apoptosis of Lung Squamous Cell Carcinoma Cells through Regulating the Expression of Galectin-1
Bing Yan, Dejian Zhao, Yinan Yao, Zhang Bao, Guohua Lu, Jianying Zhou
Int. J. Biol. Sci. 2016; 12(7): 850-860. doi:10.7150/ijbs.14773
[Abstract] [Full text] [PDF]


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Research Paper
Exosomes Secreted by Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Repair Critical-Sized Bone Defects through Enhanced Angiogenesis and Osteogenesis in Osteoporotic Rats
Xin Qi, Jieyuan Zhang, Hong Yuan, Zhengliang Xu, Qing Li, Xin Niu, Bin Hu, Yang Wang, Xiaolin Li
Int. J. Biol. Sci. 2016; 12(7): 836-849. doi:10.7150/ijbs.14809
[Abstract] [Full text] [PDF]


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Research Paper
A Novel Malaria Pf/Pv Ab Rapid Diagnostic Test Using a Differential Diagnostic Marker Identified by Network Biology
Sung Jin Cho, Jihoo Lee, Hyun Jae Lee, Hyun-Young Jo, Mangalam Sinniah, Hak-Yong Kim, Chom-Kyu Chong, Hyun-Ok Song
Int. J. Biol. Sci. 2016; 12(7): 824-835. doi:10.7150/ijbs.14408
[Abstract] [Full text] [PDF]


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Research Paper
Transient Receptor Potential Ankyrin 1 Channel Involved in Atherosclerosis and Macrophage-Foam Cell Formation
Jin-Feng Zhao, Song-Kun Shyue, Yu Ru Kou, Tse-Min Lu, Tzong-Shyuan Lee
Int. J. Biol. Sci. 2016; 12(7): 812-823. doi:10.7150/ijbs.15229
[Abstract] [Full text] [PDF]


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Research Paper
Global Identification and Differential Distribution Analysis of Glycans in Subcellular Fractions of Bladder Cells
Ganglong Yang, Luyu Huang, Jiaxu Zhang, Hanjie Yu, Zheng Li, Feng Guan
Int. J. Biol. Sci. 2016; 12(7): 799-811. doi:10.7150/ijbs.13310
[Abstract] [Full text] [PDF]


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Research Paper
Fenofibrate Suppresses Oral Tumorigenesis via Reprogramming Metabolic Processes: Potential Drug Repurposing for Oral Cancer
Chia-Ing Jan, Ming-Hsui Tsai, Chang-Fang Chiu, Yi-Ping Huang, Chia Jen Liu, Nai Wen Chang
Int. J. Biol. Sci. 2016; 12(7): 786-798. doi:10.7150/ijbs.13851
[Abstract] [Full text] [PDF]


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Research Paper
Vitamin K2 Ameliorates Damage of Blood Vessels by Glucocorticoid: a Potential Mechanism for Its Protective Effects in Glucocorticoid-induced Osteonecrosis of the Femoral Head in a Rat Model
Yuelei Zhang, Junhui Yin, Hao Ding, Changqing Zhang, You-Shui Gao
Int. J. Biol. Sci. 2016; 12(7): 776-785. doi:10.7150/ijbs.15248
[Abstract] [Full text] [PDF]


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Research Paper
Inhibition of wnt/β-catenin Signaling in Hepatocellular Carcinoma by an Antipsychotic Drug Pimozide
Valerie Fako, Zhipeng Yu, Curtis J. Henrich, Tanya Ransom, Anuradha S. Budhu, Xin W. Wang
Int. J. Biol. Sci. 2016; 12(7): 768-775. doi:10.7150/ijbs.14718
[Abstract] [Full text] [PDF]


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Research Paper
A Novel Protein Elicitor (PeBA1) from Bacillus amyloliquefaciens NC6 Induces Systemic Resistance in Tobacco
Ningbo Wang, Mengjie Liu, Lihua Guo, Xiufen Yang, Dewen Qiu
Int. J. Biol. Sci. 2016; 12(6): 757-767. doi:10.7150/ijbs.14333
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Chemoprevention of Low-Molecular-Weight Citrus Pectin (LCP) in Gastrointestinal Cancer Cells
Shi Wang, Pei Li, Sheng-Min Lu, Zhi-Qiang Ling
Int. J. Biol. Sci. 2016; 12(6): 746-756. doi:10.7150/ijbs.13988
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Different Modulatory Mechanisms of Renal FXYD12 for Na+-K+-ATPase between Two Closely Related Medakas upon Salinity Challenge
Wen-Kai Yang, Chao-Kai Kang, An-Di Hsu, Chia-Hao Lin, Tsung-Han Lee
Int. J. Biol. Sci. 2016; 12(6): 730-745. doi:10.7150/ijbs.15066
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Review
New Strategies for the Treatment of Solid Tumors with CAR-T Cells
Hao Zhang, Zhen-long Ye, Zhen-gang Yuan, Zheng-qiang Luo, Hua-jun Jin, Qi-jun qian
Int. J. Biol. Sci. 2016; 12(6): 718-729. doi:10.7150/ijbs.14405
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Review
Interleukin-10 Family and Tuberculosis: An Old Story Renewed
Abualgasim Elgaili Abdalla, Nzungize Lambert, Xiangke Duan, Jianping Xie
Int. J. Biol. Sci. 2016; 12(6): 710-717. doi:10.7150/ijbs.13881
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Ribose Accelerates Gut Motility and Suppresses Mouse Body Weight Gaining
Yan Liu, Tong-Ruei R Li, Cong Xu, Tian Xu
Int. J. Biol. Sci. 2016; 12(6): 701-709. doi:10.7150/ijbs.13635
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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