International Journal of Biological Sciences

Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

Impact factor is 4.057 according to 2018 release of Journal Citation Reports®. 5 Year Impact factor is 4.950. Congratulations!
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Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (full index information)
Full texts of articles in PubMed Central and Europe PMC.
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Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details

Top cited papers:

G Chen et al. TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation. Cited by 237
BF Zamarron & W Chen. Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression. Cited by 172
TM Thornton & M Rincon. Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival. Cited by 200
HB Shao et al. Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells. Cited by 247
JK Lunney. Advances in Swine Biomedical Model Genomics. Cited by 255
DP Siderovski & FS Willard. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Cited by 241

The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details

Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details

Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details

In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details

Research Paper
Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy
Fan Yang, Ying Qin, Yueqiu Wang, Songyan Meng, Huimin Xian, Hui Che, Jie Lv, Yang Li, Yahan Yu, Yunlong Bai, Lihong Wang
Int. J. Biol. Sci. 2019; 15(5): 1010-1019. doi:10.7150/ijbs.29680
[Abstract] [Full text] [PDF]

Research Paper
FePt/GO Nanosheets Suppress Proliferation, Enhance Radiosensitization and Induce Autophagy of Human Non-Small Cell Lung Cancer Cells
Shijing Ma, Hongtao Miao, Yuan Luo, Yingming Sun, Xiaoli Tian, Feng Wang, Chengcheng You, Shan Peng, Guiliang Tang, Cui Yang, Wenjie Sun, Shuying Li, Yanling Mao, Jieyu Xu, Yu Xiao, Yan Gong, Hong Quan, Conghua Xie
Int. J. Biol. Sci. 2019; 15(5): 999-1009. doi:10.7150/ijbs.29805
[Abstract] [Full text] [PDF]

Research Paper
Elevated CD163⁺/CD68⁺ Ratio at Tumor Invasive Front is Closely Associated with Aggressive Phenotype and Poor Prognosis in Colorectal Cancer
Chaogang Yang, Chen Wei, Shuyi Wang, Dongdong Shi, Chunxiao Zhang, Xiaobin Lin, Rongzhang Dou, Bin Xiong
Int. J. Biol. Sci. 2019; 15(5): 984-998. doi:10.7150/ijbs.29836
[Abstract] [Full text] [PDF]

Research Paper
A Comprehensive Study of High Cholesterol Diet-Induced Larval Zebrafish Model: A Short-Time In Vivo Screening Method for Non-Alcoholic Fatty Liver Disease Drugs
Ji Ma, Hongli Yin, Maoru Li, Yang Deng, Owais Ahmad, Guohong Qin, Qiangqiang He, Jiajing Li, Kai Gao, Junyi Zhu, Bing Wang, Susu Wu, Tao Wang, Jing Shang
Int. J. Biol. Sci. 2019; 15(5): 973-983. doi:10.7150/ijbs.30013
[Abstract] [Full text] [PDF]

Review
Prospect for Application of PARP Inhibitor in Patients with HER2 Negative Breast Cancer
Nan Shao, Yawei Shi, Liang Yu, Runyi Ye, Zhen Shan, Zhanqiang Zhang, Yunjian Zhang, Ying Lin
Int. J. Biol. Sci. 2019; 15(5): 962-972. doi:10.7150/ijbs.30721
[Abstract] [Full text] [PDF]

Research Paper
KLF4-Mediated CDH3 Upregulation Suppresses Human Hepatoma Cell Growth and Migration via GSK-3β Signaling
Li Li, Shijun Yu, Qiong Wu, Ning Dou, Yandong Li, Yong Gao
Int. J. Biol. Sci. 2019; 15(5): 953-961. doi:10.7150/ijbs.30857
[Abstract] [Full text] [PDF]

Research Paper
Estrogen Receptor Beta (ERβ) Mediated-CyclinD1 Degradation via Autophagy Plays an Anti-Proliferation Role in Colon Cells
Yong Wei, Can Huang, Haoyu Wu, Jian Huang
Int. J. Biol. Sci. 2019; 15(5): 942-952. doi:10.7150/ijbs.30930
[Abstract] [Full text] [PDF]

Research Paper
Feedback Activation of SGK3 and AKT Contributes to Rapamycin Resistance by Reactivating mTORC1/4EBP1 Axis via TSC2 in Breast Cancer
Hongtao Wang, Fang Huang, Zhe Zhang, Peng Wang, Yuan Luo, Hailiang Li, Na Li, Jian Wang, Jianguang Zhou, Yongan Wang, Shanhu Li
Int. J. Biol. Sci. 2019; 15(5): 929-941. doi:10.7150/ijbs.32489
[Abstract] [Full text] [PDF]

Research Paper
The Novel Combination of Nitroxoline and PD-1 Blockade, Exerts a Potent Antitumor Effect in a Mouse Model of Prostate Cancer
Naijin Xu, Linglong Huang, Xiezhao Li, Masami Watanabe, Chaoming Li, Abai Xu, Chunxiao Liu, Qiang Li, Motoo Araki, Koichiro Wada, Yasutomo Nasu, Peng Huang
Int. J. Biol. Sci. 2019; 15(5): 919-928. doi:10.7150/ijbs.32259
[Abstract] [Full text] [PDF]

Review
The Functions of DNA Damage Factor RNF8 in the Pathogenesis and Progression of Cancer
Tingting Zhou, Fei Yi, Zhuo Wang, Qiqiang Guo, Jingwei Liu, Ning Bai, Xiaoman Li, Xiang Dong, Ling Ren, Liu Cao, Xiaoyu Song
Int. J. Biol. Sci. 2019; 15(5): 909-918. doi:10.7150/ijbs.31972
[Abstract] [Full text] [PDF]

Research Paper
Systematic Analysis of tRNA-Derived Small RNAs Reveals Novel Potential Therapeutic Targets of Traditional Chinese Medicine (Buyang-Huanwu-Decoction) on Intracerebral Hemorrhage
Pengfei Li, Tao Tang, Tao Liu, Jing Zhou, Hanjin Cui, Zehui He, Yuanyuan Zhong, En Hu, Ali Yang, Gaohui Wei, Jiekun Luo, Yang Wang
Int. J. Biol. Sci. 2019; 15(4): 895-908. doi:10.7150/ijbs.29744
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Glycolytic Enzyme PKM2 Mediates Autophagic Activation to Promote Cell Survival in NPM1-Mutated Leukemia
Lu Wang, Liyuan Yang, Zailin Yang, Yuting Tang, Yao Tao, Qian Zhan, Li Lei, Yipei Jing, Xueke Jiang, Hongjun Jin, Qin Zou, Jingrong Xian, Ling Zhang
Int. J. Biol. Sci. 2019; 15(4): 882-894. doi:10.7150/ijbs.30290
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
BMI1 Deficiency Results in Female Infertility by Activating p16/p19 Signaling and Increasing Oxidative Stress
Rong Wang, Xian Xue, Yang Wang, Haiyang Zhao, Yuling Zhang, Hui Wang, Dengshun Miao
Int. J. Biol. Sci. 2019; 15(4): 870-881. doi:10.7150/ijbs.30488
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
MicroRNA-322 Regulates Self-renewal of Mouse Spermatogonial Stem Cells through Rassf8
Yinjuan Wang, Xiaoyong Li, Xiaowen Gong, Yongqiang Zhao, Ji Wu
Int. J. Biol. Sci. 2019; 15(4): 857-869. doi:10.7150/ijbs.30611
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
PCAT-1: A Novel Oncogenic Long Non-Coding RNA in Human Cancers
Tiefu Xiong, Jianfa Li, Fangfang Chen, Fangting Zhang
Int. J. Biol. Sci. 2019; 15(4): 847-856. doi:10.7150/ijbs.30970
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
The LIM-Only Protein FHL2 is involved in Autophagy to Regulate the Development of Skeletal Muscle Cell
Zihao Liu, Shunshun Han, Yan Wang, Can Cui, Qing Zhu, Xiaosong Jiang, Chaowu Yang, Huarui Du, Chunlin Yu, Qingyun Li, Haorong He, Xiaoxu Shen, Yuqi Chen, Yao Zhang, Lin Ye, Zhichao Zhang, Diyan Li, Xiaoling Zhao, Huadong Yin
Int. J. Biol. Sci. 2019; 15(4): 838-846. doi:10.7150/ijbs.31371
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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