International Journal of Biological Sciences

Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

Impact factor is 3.873 (five year impact factor 4.689) according to 2017 release of Journal Citation Reports®.
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Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (full index information)
Full texts of articles in PubMed Central and Europe PMC.
(For NIH-funded researchers) Save time by submitting your paper to us - this journal is in full compliance with NIH Public Access Requirement.

Most Cited Paper Award: Winners of this year are Yan-Cun Liu, Xian-Biao Zou, Yan-Fen Chai, Yong-Ming Yao, for the paper "Macrophage Polarization in Inflammatory Diseases". Details...

Special Issue on Computational Resources and Methods in Biological Sciences. Guest editors:
Prof. Jian Huang, Dr. Hao Lin, Prof. Shaoliang Peng.

The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details

Top cited papers:

G Chen et al. TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation. Cited by 237
BF Zamarron & W Chen. Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression. Cited by 172
TM Thornton & M Rincon. Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival. Cited by 200
HB Shao et al. Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells. Cited by 247
JK Lunney. Advances in Swine Biomedical Model Genomics. Cited by 255
DP Siderovski & FS Willard. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Cited by 241

Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...

The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details

Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details

Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details

The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details

Research Paper
Improving Prediction of Self-interacting Proteins Using Stacked Sparse Auto-Encoder with PSSM profiles
Yan-Bin Wang, Zhu-Hong You, Li-Ping Li, De-Shuang Huang, Feng-Feng Zhou, Shan Yang
Int. J. Biol. Sci. 2018; 14(8): 983-991. doi:10.7150/ijbs.23817
[Abstract] [Full text] [PDF]

Research Paper
Predicting Potential Drugs for Breast Cancer based on miRNA and Tissue Specificity
Liang Yu, Jin Zhao, Lin Gao
Int. J. Biol. Sci. 2018; 14(8): 971-982. doi:10.7150/ijbs.23350
[Abstract] [Full text] [PDF]

Research Paper
RicyerDB: A Database For Collecting Rice Yield-related Genes with Biological Analysis
Jing Jiang, Fei Xing, Xiangxiang Zeng, Quan Zou
Int. J. Biol. Sci. 2018; 14(8): 965-970. doi:10.7150/ijbs.23328
[Abstract] [Full text] [PDF]

Research Paper
HBPred: a tool to identify growth hormone-binding proteins
Hua Tang, Ya-Wei Zhao, Ping Zou, Chun-Mei Zhang, Rong Chen, Po Huang, Hao Lin
Int. J. Biol. Sci. 2018; 14(8): 957-964. doi:10.7150/ijbs.24174
[Abstract] [Full text] [PDF]

Research Paper
PTM-ssMP: A Web Server for Predicting Different Types of Post-translational Modification Sites Using Novel Site-specific Modification Profile
Yu Liu, Minghui Wang, Jianing Xi, Fenglin Luo, Ao Li
Int. J. Biol. Sci. 2018; 14(8): 946-956. doi:10.7150/ijbs.24121
[Abstract] [Full text] [PDF]

Research Paper
Classification of Sputum Sounds Using Artificial Neural Network and Wavelet Transform
Yan Shi, Guoliang Wang, Jinglong Niu, Qimin Zhang, Maolin Cai, Baoqing Sun, Dandan Wang, Mei Xue, Xiaohua Douglas Zhang
Int. J. Biol. Sci. 2018; 14(8): 938-945. doi:10.7150/ijbs.23855
[Abstract] [Full text] [PDF]

Research Paper
Computational Design of Antiangiogenic Peptibody by Fusing Human IgG1 Fc Fragment and HRH Peptide: Structural Modeling, Energetic Analysis, and Dynamics Simulation of Its Binding Potency to VEGF Receptor
Lin Ning, Zhongyan Li, Zhengya Bai, Shasha Hou, Bifang He, Jian Huang, Peng Zhou
Int. J. Biol. Sci. 2018; 14(8): 930-937. doi:10.7150/ijbs.24582
[Abstract] [Full text] [PDF]

Review
Translational Bioinformatics for Cholangiocarcinoma: Opportunities and Challenges
Fuliang Qian, Junping Guo, Zhi Jiang, Bairong Shen
Int. J. Biol. Sci. 2018; 14(8): 920-929. doi:10.7150/ijbs.24622
[Abstract] [Full text] [PDF]

Research Paper
MicroShare: Privacy-Preserved Medical Resource Sharing through MicroService Architecture
Yilong Yang, Quan Zu, Peng Liu, Defang Ouyang, Xiaoshan Li
Int. J. Biol. Sci. 2018; 14(8): 907-919. doi:10.7150/ijbs.24617
[Abstract] [Full text] [PDF]

Research Paper
A Sequential Segment Based Alpha-Helical Transmembrane Protein Alignment Method
Han Wang, Jingru Wang, Li Zhang, Pingping Sun, Ning Du, Yanwen Li
Int. J. Biol. Sci. 2018; 14(8): 901-906. doi:10.7150/ijbs.24327
[Abstract] [Full text] [PDF]

Research Paper
Identifying differentially expressed genes from cross-site integrated data based on relative expression orderings
Hao Cai, Xiangyu Li, Jing Li, Qirui Liang, Weicheng Zheng, Qingzhou Guan, Zheng Guo, Xianlong Wang
Int. J. Biol. Sci. 2018; 14(8): 892-900. doi:10.7150/ijbs.24548
[Abstract] [Full text] [PDF]

Research Paper
iRSpot-Pse6NC: Identifying recombination spots in Saccharomyces cerevisiae by incorporating hexamer composition into general PseKNC
Hui Yang, Wang-Ren Qiu, Guoqing Liu, Feng-Biao Guo, Wei Chen, Kuo-Chen Chou, Hao Lin
Int. J. Biol. Sci. 2018; 14(8): 883-891. doi:10.7150/ijbs.24616
[Abstract] [Full text] [PDF]

Research Paper
Research on folding diversity in statistical learning methods for RNA secondary structure prediction
Yu Zhu, ZhaoYang Xie, YiZhou Li, Min Zhu, Yi-Ping Phoebe Chen
Int. J. Biol. Sci. 2018; 14(8): 872-882. doi:10.7150/ijbs.24595
[Abstract] [Full text] [PDF]

Research Paper
Identification of Inhibitors of MMPS Enzymes via a Novel Computational Approach
Jian Song, Jijun Tang, Fei Guo
Int. J. Biol. Sci. 2018; 14(8): 863-871. doi:10.7150/ijbs.24588
[Abstract] [Full text] [PDF]

Research Paper
CRISPRMatch: An Automatic Calculation and Visualization Tool for High-throughput CRISPR Genome-editing Data Analysis
Qi You, Zhaohui Zhong, Qiurong Ren, Fakhrul Hassan, Yong Zhang, Tao Zhang
Int. J. Biol. Sci. 2018; 14(8): 858-862. doi:10.7150/ijbs.24581
[Abstract] [Full text] [PDF]

Research Paper
PRWHMDA: Human Microbe-Disease Association Prediction by Random Walk on the Heterogeneous Network with PSO
Chuanyan Wu, Rui Gao, Daoliang Zhang, Shiyun Han, Yusen Zhang
Int. J. Biol. Sci. 2018; 14(8): 849-857. doi:10.7150/ijbs.24539
[Abstract] [Full text] [PDF]

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