International Journal of Biological Sciences

Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

Impact factor is 4.057 according to 2018 release of Journal Citation Reports®. 5 Year Impact factor is 4.950. Congratulations!
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Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (full index information)
Full texts of articles in PubMed Central and Europe PMC.
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Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details

Top cited papers:

G Chen et al. TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation. Cited by 237
BF Zamarron & W Chen. Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression. Cited by 172
TM Thornton & M Rincon. Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival. Cited by 200
HB Shao et al. Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells. Cited by 247
JK Lunney. Advances in Swine Biomedical Model Genomics. Cited by 255
DP Siderovski & FS Willard. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Cited by 241

The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details

Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details

Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details

In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details

Research Paper
Upregulated MMP28 in Hepatocellular Carcinoma Promotes Metastasis via Notch3 Signaling and Predicts Unfavorable Prognosis
Jiangfan Zhou, Xixi Zheng, Mei Feng, Zhichao Mo, Yunfeng Shan, Yilin Wang, Jing Jin
Int. J. Biol. Sci. 2019; 15(4): 812-825. doi:10.7150/ijbs.31335
[Abstract] [Full text] [PDF]

Research Paper
Dendropanax morbifera Ameliorates Thioacetamide-Induced Hepatic Fibrosis via TGF-β1/Smads Pathways
Hun Yong Yang, Kyeong Seok Kim, Yong Hee Lee, Jae Hyeon Park, Jung-Hwan Kim, Seok-Yong Lee, Young-Mi Kim, In Su Kim, Sam Kacew, Byung Mu Lee, Jong Hwan Kwak, Kyungsil Yoon, Hyung Sik Kim
Int. J. Biol. Sci. 2019; 15(4): 800-811. doi:10.7150/ijbs.30356
[Abstract] [Full text] [PDF]

Research Paper
Farrerol Ameliorates APAP-induced Hepatotoxicity via Activation of Nrf2 and Autophagy
Lidong Wang, Wei Wei, Qingfei Xiao, Huahong Yang, Xinxin Ci
Int. J. Biol. Sci. 2019; 15(4): 788-799. doi:10.7150/ijbs.30677
[Abstract] [Full text] [PDF]

Review
Bone function, dysfunction and its role in diseases including critical illness
Nan Su, Jing Yang, Yangli Xie, Xiaolan Du, Hangang Chen, Zhou Hong, Lin Chen
Int. J. Biol. Sci. 2019; 15(4): 776-787. doi:10.7150/ijbs.27063
[Abstract] [Full text] [PDF]

Research Paper
Contributions of suboolemmal acidic vesicles and microvilli to the intracellular Ca²⁺ increase in the sea urchin eggs at fertilization
F Vasilev, N Limatola, JT Chun, L Santella
Int. J. Biol. Sci. 2019; 15(4): 757-775. doi:10.7150/ijbs.28461
[Abstract] [Full text] [PDF]

Research Paper
Prevalence of sexual harassment of nurses and nursing students in China: a meta-analysis of observational studies
Liang-Nan Zeng, Qian-Qian Zong, Ji-Wen Zhang, Li Lu, Feng-Rong An, Chee H. Ng, Gabor S. Ungvari, Fang-Yu Yang, Teris Cheung, Ligang Chen, Yu-Tao Xiang
Int. J. Biol. Sci. 2019; 15(4): 749-756. doi:10.7150/ijbs.28144
[Abstract] [Full text] [PDF]

Research Paper
USP17 Suppresses Tumorigenesis and Tumor Growth through Deubiquitinating AEP
Xi Chen, Chen Wang, Keman Liao, Sunhai Zhou, Lu Cao, Jiayi Chen, Cheng Xu, Yingying Lin
Int. J. Biol. Sci. 2019; 15(4): 738-748. doi:10.7150/ijbs.30106
[Abstract] [Full text] [PDF]

Review
Autophagy in Ovarian Follicular Development and Atresia
Jiawei Zhou, Xianwen Peng, Shuqi Mei
Int. J. Biol. Sci. 2019; 15(4): 726-737. doi:10.7150/ijbs.30369
[Abstract] [Full text] [PDF]

Research Paper
Differential Expression Patterns of Glycolytic Enzymes and Mitochondria-Dependent Apoptosis in PCOS Patients with Endometrial Hyperplasia, an Early Hallmark of Endometrial Cancer, In Vivo and the Impact of Metformin In Vitro
Tao Wang, Jiao Zhang, Min Hu, Yuehui Zhang, Peng Cui, Xin Li, Juan Li, Edvin Vestin, Mats Brännström, Linus R Shao, Håkan Billig
Int. J. Biol. Sci. 2019; 15(3): 714-725. doi:10.7150/ijbs.31425
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Sirt6 Suppresses High Glucose-Induced Mitochondrial Dysfunction and Apoptosis in Podocytes through AMPK Activation
Yanqin Fan, Qian Yang, Yingjie Yang, Zhao Gao, Yiqiong Ma, Lu Zhang, Wei Liang, Guohua Ding
Int. J. Biol. Sci. 2019; 15(3): 701-713. doi:10.7150/ijbs.29323
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Andrographolide Enhances TRAIL-Induced Apoptosis via p53-Mediated Death Receptors Up-Regulation and Suppression of the NF-кB Pathway in Bladder Cancer Cells
Yuyou Deng, Ran Bi, Haoran Guo, Jiaxin Yang, Yujun Du, Chunxi Wang, Wei Wei
Int. J. Biol. Sci. 2019; 15(3): 688-700. doi:10.7150/ijbs.30847
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
Reactive Oxygen Species Related Noncoding RNAs as Regulators of Cardiovascular Diseases
Yanhan Dong, Wenhua Xu, Cuiyun Liu, Peijun Liu, Peifeng Li, Kun Wang
Int. J. Biol. Sci. 2019; 15(3): 680-687. doi:10.7150/ijbs.30464
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Attenuation of STAT3 Phosphorylation Promotes Apoptosis and Chemosensitivity in Human Osteosarcoma Induced by Raddeanin A
Zhuoying Wang, Chongren Wang, Dongqing Zuo, Tao Zhang, Fei Yin, Zifei Zhou, Hongsheng Wang, Jing Xu, Min Mao, Gangyang Wang, Yingqi Hua, Wei Sun, Zhengdong Cai
Int. J. Biol. Sci. 2019; 15(3): 668-679. doi:10.7150/ijbs.30168
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
EBV miR-BART10-3p Promotes Cell Proliferation and Migration by Targeting DKK1
Kyoungmi Min, Suk Kyeong Lee
Int. J. Biol. Sci. 2019; 15(3): 657-667. doi:10.7150/ijbs.30099
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
FBXO22 Suppresses Metastasis in Human Renal Cell Carcinoma via Inhibiting MMP-9-Mediated Migration and Invasion and VEGF-Mediated Angiogenesis
Feng Guo, Jinjin Liu, Xiao Han, Xuping Zhang, Tian Lin, You Wang, Jin Bai, Junqing Han
Int. J. Biol. Sci. 2019; 15(3): 647-656. doi:10.7150/ijbs.31293
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
SMARCAD1 Promotes Pancreatic Cancer Cell Growth and Metastasis through Wnt/β-catenin-Mediated EMT
Furao Liu, Zebin Xia, Meichao Zhang, Jiping Ding, Yang Feng, Jianwei Wu, Yun Dong, Wei Gao, Zengwei Han, Yuanhua Liu, Yuan Yao, Dong Li
Int. J. Biol. Sci. 2019; 15(3): 636-646. doi:10.7150/ijbs.29562
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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