International Journal of Biological Sciences
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ISSN 1449-2288

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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China
* Dr. Deng is serving in his personal capacity.
Editor-in-Chief's Profile

new Latest impact factor is 4.372. Congratulation!
new Cover suggestion ...details
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Most Cited Paper Award: Winners of this year are Guiqian Chen et al, for the paper "TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation". Details...
The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details
Top cited papers:
Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...
The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details
Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details
Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details
The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details
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Research Paper
Molecular Docking and Site-directed Mutagenesis of a Bacillus thuringiensis Chitinase to Improve Chitinolytic, Synergistic Lepidopteran-larvicidal and Nematicidal Activities
Hong Ni, Siquan Zeng, Xu Qin, Xiaowen Sun, Shan Zhang, Xiuyun Zhao, Ziniu Yu, Lin Li
Int. J. Biol. Sci. 2015; 11(3): 304-315. doi:10.7150/ijbs.10632
[Abstract] [Full text] [PDF]


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Research Paper
Hydroferrate Fluid, MRN-100, Provides Protection against Chemical-Induced Gastric and Esophageal Cancer in Wistar Rats
Mamdooh H. Ghoneum, Nariman K. Badr El-Din, Salma M. Abdel Fattah, Deyu Pan, Lucilene Tolentino
Int. J. Biol. Sci. 2015; 11(3): 295-303. doi:10.7150/ijbs.10586
[Abstract] [Full text] [PDF]


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Research Paper
5-Fluorouracil Chemotherapy of Gastric Cancer Generates Residual Cells with Properties of Cancer Stem Cells
Zhi-Yuan Xu, Jia-Ning Tang, Hua-Xia Xie, Yi-An Du, Ling Huang, Peng-Fei Yu, Xiang-Dong Cheng
Int. J. Biol. Sci. 2015; 11(3): 284-294. doi:10.7150/ijbs.10248
[Abstract] [Full text] [PDF]


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Research Paper
Protracted Upregulation of Leptin and IGF1 is Associated with Activation of PI3K/Akt and JAK2 Pathway in Mouse Intestine after Ionizing Radiation Exposure
Shubhankar Suman, Bhaskar V. S. Kallakury, Albert J. Fornace Jr., Kamal Datta
Int. J. Biol. Sci. 2015; 11(3): 274-283. doi:10.7150/ijbs.10684
[Abstract] [Full text] [PDF]


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Research Paper
Peripheral Blood Mononuclear Cell Traffic Plays a Crucial Role in Mother-to-Infant Transmission of Hepatitis B Virus
Yuan-Yong Xu, Hui-Hui Liu, Yan-Wei Zhong, Chang Liu, Yong Wang, Lei-Li Jia, Fei Qiao, Xin-Xin Li, Chuan-Fu Zhang, Shen-Long Li, Peng Li, Hong-Bin Song, Qiao Li
Int. J. Biol. Sci. 2015; 11(3): 266-273. doi:10.7150/ijbs.10813
[Abstract] [Full text] [PDF]


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Research Paper
High-density Lipoprotein Increases the Uptake of Oxidized Low Density Lipoprotein via PPARγ/CD36 Pathway in Inflammatory Adipocytes
Qiaoqing Zhong, Shuiping Zhao, Bilian Yu, Xing Wang, Robina Matyal, Yunping Li, Zhisheng Jiang
Int. J. Biol. Sci. 2015; 11(3): 256-265. doi:10.7150/ijbs.10258
[Abstract] [Full text] [PDF]


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Research Paper
MicroRNA-1 Participates in Nitric Oxide-Induced Apoptotic Insults to MC3T3-E1 Cells by Targeting Heat-Shock Protein-70
Yong-Eng Lee, Chung-Ye Hong, Yi-Ling Lin, Ruei-Ming Chen
Int. J. Biol. Sci. 2015; 11(3): 246-255. doi:10.7150/ijbs.11138
[Abstract] [Full text] [PDF]


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Review
Exosomes in Mesenchymal Stem Cells, a New Therapeutic Strategy for Cardiovascular Diseases?
Lina Huang, Wenya Ma, Yidi Ma, Dan Feng, Hongyang Chen, Benzhi Cai
Int. J. Biol. Sci. 2015; 11(2): 238-245. doi:10.7150/ijbs.10725
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Efficient Inhibition of Human Glioma Development by RNA Interference-Mediated Silencing of PAK5
Xuefeng Gu, Ce Wang, Xuefeng Wang, Guoda Ma, You Li, Lili Cui, Yanyan Chen, Bin Zhao, Keshen Li
Int. J. Biol. Sci. 2015; 11(2): 230-237. doi:10.7150/ijbs.9193
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Changes in Follicular Helper T Cells in Idiopathic Thrombocytopenic Purpura Patients
Jue Xie, Dawei Cui, Yan Liu, Jie Jin, Hongyan Tong, Lei Wang, Guoxiang Ruan, Yun Lu, Huiming Yuan
Int. J. Biol. Sci. 2015; 11(2): 220-229. doi:10.7150/ijbs.10178
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Identification and Functional Analysis of a Novel Tryptophyllin Peptide from the Skin of the Red-eye Leaf Frog, Agalychnis callidryas
Ran Wang, Yu Zhou, Tianbao Chen, Mei Zhou, Lei Wang, Chris Shaw
Int. J. Biol. Sci. 2015; 11(2): 209-219. doi:10.7150/ijbs.10143
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
A Soluble Activin Receptor Type IIB Does Not Improve Blood Glucose in Streptozotocin-Treated Mice
Qian Wang, Tingqing Guo, Jennifer Portas, Alexandra C. McPherron
Int. J. Biol. Sci. 2015; 11(2): 199-208. doi:10.7150/ijbs.10430
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
FOXM1 Promotes Lung Adenocarcinoma Invasion and Metastasis by Upregulating SNAIL
Ping Wei, Nu Zhang, Yiqin Wang, Dawei Li, Lisha Wang, Xiangjie Sun, Chen Shen, Yusi Yang, Xiaoyan Zhou, Xiang Du
Int. J. Biol. Sci. 2015; 11(2): 186-198. doi:10.7150/ijbs.10634
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Enhancement of Larval RNAi Efficiency by Over-expressing Argonaute2 in Bombyx mori
Zhiqian Li, Baosheng Zeng, Lin Ling, Jun Xu, Lang You, Abu F.M. Aslam, Anjiang Tan, Yongping Huang
Int. J. Biol. Sci. 2015; 11(2): 176-185. doi:10.7150/ijbs.10235
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Review
Biology of IL-27 and its Role in the Host Immunity against Mycobacterium Tuberculosis
Abualgasim Elgaili Abdalla, Qiming Li, Longxiang Xie, Jianping Xie
Int. J. Biol. Sci. 2015; 11(2): 168-175. doi:10.7150/ijbs.10464
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Effects of Nitric Oxide on Notexin-Induced Muscle Inflammatory Responses
XingHui Liu, Gang Wu, DanDan Shi, Rong Zhu, HuiJun Zeng, Biao Cao, MeiXian Huang, Hua Liao
Int. J. Biol. Sci. 2015; 11(2): 156-167. doi:10.7150/ijbs.10283
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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