International Journal of Biological Sciences

Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

Impact factor is 3.873 (five year impact factor 4.689) according to 2017 release of Journal Citation Reports®.
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Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (full index information)
Full texts of articles in PubMed Central and Europe PMC.
(For NIH-funded researchers) Save time by submitting your paper to us - this journal is in full compliance with NIH Public Access Requirement.

Most Cited Paper Award: Winners of this year are Yan-Cun Liu, Xian-Biao Zou, Yan-Fen Chai, Yong-Ming Yao, for the paper "Macrophage Polarization in Inflammatory Diseases". Details...

Special Issue on Computational Resources and Methods in Biological Sciences. Guest editors:
Prof. Jian Huang, Dr. Hao Lin, Prof. Shaoliang Peng.

The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details

Top cited papers:

G Chen et al. TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation. Cited by 237
BF Zamarron & W Chen. Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression. Cited by 172
TM Thornton & M Rincon. Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival. Cited by 200
HB Shao et al. Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells. Cited by 247
JK Lunney. Advances in Swine Biomedical Model Genomics. Cited by 255
DP Siderovski & FS Willard. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Cited by 241

Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...

The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details

Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details

Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details

The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details

Review
Epstein-Barr virus-encoded microRNAs as regulators in host immune responses
Man Wang, Fei Yu, Wei Wu, Yu Wang, Han Ding, Lili Qian
Int. J. Biol. Sci. 2018; 14(5): 565-576. doi:10.7150/ijbs.24562
[Abstract] [Full text] [PDF]

Research Paper
PM2.5 induces autophagy-mediated cell death via NOS2 signaling in human bronchial epithelium cells
Xiao-Ming Zhu, Qin Wang, Wei-Wei Xing, Min-Hui Long, Wen-Liang Fu, Wen-Rong Xia, Chen Jin, Ning Guo, Dong-Qun Xu, Dong-Gang Xu
Int. J. Biol. Sci. 2018; 14(5): 557-564. doi:10.7150/ijbs.24546
[Abstract] [Full text] [PDF]

Research Paper
Prognostic nomogram for patients with Nasopharyngeal Carcinoma incorporating hematological biomarkers and clinical characteristics
Jianpei Li, Shulin Chen, Songguo Peng, Yijun Liu, Shan Xing, Xia He, Hao Chen
Int. J. Biol. Sci. 2018; 14(5): 549-556. doi:10.7150/ijbs.24374
[Abstract] [Full text] [PDF]

Short Research Communication
Generation of Smurf2 Conditional Knockout Mice
Yi Tang, Liu-Ya Tang, Xuan Xu, Cuiling Li, Chuxia Deng, Ying E. Zhang
Int. J. Biol. Sci. 2018; 14(5): 542-548. doi:10.7150/ijbs.24303
[Abstract] [Full text] [PDF]

Research Paper
PARI functions as a new transcriptional target of FOXM1 involved in gastric cancer development
Yi Zhang, Xiaojuan Ye, Lizhi Chen, Qiong Wu, Yong Gao, Yandong Li
Int. J. Biol. Sci. 2018; 14(5): 531-541. doi:10.7150/ijbs.23945
[Abstract] [Full text] [PDF]

Research Paper
Elongator promotes the migration and invasion of hepatocellular carcinoma cell by the phosphorylation of AKT
Yi Xu, Wei Zhou, Yuan Ji, Jian Shen, Xiaxia Zhu, Huijun Yu, Jingchun Guo, Zhi Pang, Wenxiang Wei
Int. J. Biol. Sci. 2018; 14(5): 518-530. doi:10.7150/ijbs.23511
[Abstract] [Full text] [PDF]

Research Paper
DNA damage checkpoint pathway modulates the regulation of skeletal growth and osteoblastic bone formation by parathyroid hormone-related peptide
Ying Zhang, Guangpei Chen, Zhen Gu, Haijian Sun, Andrew Karaplis, David Goltzman, Dengshun Miao
Int. J. Biol. Sci. 2018; 14(5): 508-517. doi:10.7150/ijbs.23318
[Abstract] [Full text] [PDF]

Research Paper
Low-intensity pulsed ultrasound promotes Schwann cell viability and proliferation via the GSK-3β/β-catenin signaling pathway
Cong Ren, Xiaohui Chen, Ning Du, Shuo Geng, Yingying Hu, Xin Liu, Xianxian Wu, Yuan Lin, Xue Bai, Wenzhe Yin, Shi Cheng, Lei Yang, Yong Zhang
Int. J. Biol. Sci. 2018; 14(5): 497-507. doi:10.7150/ijbs.22409
[Abstract] [Full text] [PDF]

Research Paper
The Suppression of Medium Acidosis Improves the Maintenance and Differentiation of Human Pluripotent Stem Cells at High Density in Defined Cell Culture Medium
Weiwei Liu, Zhili Ren, Kai Lu, Chengcheng Song, Edwin Chong Wing Cheung, Zhou Zhou, Guokai Chen
Int. J. Biol. Sci. 2018; 14(5): 485-496. doi:10.7150/ijbs.24681
[Abstract] [Full text] [PDF]

Research Paper
Mesoporous bioactive glass-coated 3D printed borosilicate bioactive glass scaffolds for improving repair of bone defects
Xin Qi, Hui Wang, Yadong Zhang, Libin Pang, Wei Xiao, Weitao Jia, Shichang Zhao, Deping Wang, Wenhai Huang, Qiugen Wang
Int. J. Biol. Sci. 2018; 14(4): 471-484. doi:10.7150/ijbs.23872
[Abstract] [Full text] [PDF]

Research Paper
Identification of Functional mimotopes of human Vasorin Ectodomain by Biopanning
Da Li, Tan Zhang, Xiqin Yang, Jie Geng, Shaohua Li, Hongmei Ding, Hui Li, Aixue Huang, Chaonan Wang, Leqiao Sun, Chenjun Bai, Heqiu Zhang, Jie Li, Jie Dong, Ningsheng Shao
Int. J. Biol. Sci. 2018; 14(4): 461-470. doi:10.7150/ijbs.22692
[Abstract] [Full text] [PDF]

Research Paper
Repair of Critical-Sized Mandible Defects in Aged Rat Using Hypoxia Preconditioned BMSCs with Up-regulation of Hif-1α
Jiankang Zhang, Zhuozhuo Feng, Junjun Wei, Yunbo Yu, Jie Luo, Jing Zhou, Yi Li, Xiaohui Zheng, Wei Tang, Lei Liu, Jie Long, Xiaoyu Li, Wei Jing
Int. J. Biol. Sci. 2018; 14(4): 449-460. doi:10.7150/ijbs.24158
[Abstract] [Full text] [PDF]

Research Paper
CTGF Contributes to the Development of Posterior Capsule Opacification: an in vitro and in vivo study
Bo Ma, Ruihua Jing, Jie Liu, Lan Yang, Jingming Li, Li Qin, Lijun Cui, Cheng Pei
Int. J. Biol. Sci. 2018; 14(4): 437-448. doi:10.7150/ijbs.23946
[Abstract] [Full text] [PDF]

Research Paper
Generation of Cashmere Goats Carrying an EDAR Gene Mutant Using CRISPR-Cas9-Mediated Genome Editing
Fei Hao, Wei Yan, Xiaocong Li, Hui Wang, Yingmin Wang, Xiao Hu, Xu Liu, Hao Liang, Dongjun Liu
Int. J. Biol. Sci. 2018; 14(4): 427-436. doi:10.7150/ijbs.23890
[Abstract] [Full text] [PDF]

Research Paper
Glaucocalyxin A induces G2/M cell cycle arrest and apoptosis through the PI3K/Akt pathway in human bladder cancer cells
Wenfeng Lin, Jinlin Xie, Naijin Xu, Linglong Huang, Abai Xu, Hulin Li, Chaoming Li, Yubo Gao, Masami Watanabe, Chunxiao Liu, Peng Huang
Int. J. Biol. Sci. 2018; 14(4): 418-426. doi:10.7150/ijbs.23602
[Abstract] [Full text] [PDF]

Research Paper
Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis
Fengjiao Wang, Wei Liu, Jinfeng Ning, Junfeng Wang, Yaoguo Lang, Xiangyuan Jin, Kaibin Zhu, Xiuyun Wang, Xiaoguang Li, Fan Yang, Jianqun Ma, Shidong Xu
Int. J. Biol. Sci. 2018; 14(4): 406-417. doi:10.7150/ijbs.23542
[Abstract] [Full text] [PDF]

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