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International Journal of Medical Sciences
Journal of Cancer
Theranostics
Journal of Genomics
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Editor-in-Chief: Chuxia Deng, PhD, National Institutes
of Health*, Bethesda, MD
* Dr. Deng is serving in his personal capacity.
Editor-in-Chief's Profile
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 Latest impact factor is 3.168; 5-year journal impact factor is 3.436. Congratulation! |
- Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (full index information)
- Full texts of articles in PubMed
Central, Europe PMC, and PMC Canada.
- Rapid review and publication.
- (For NIH-funded researchers) Save time by submitting your paper to us - this journal is in full compliance with NIH Public Access Requirement.
- High visibility of articles over the Internet.
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Most Cited Paper Award: Winners are Brian F. Zamarron and WanJun Chen from National Institute of Dental and Craniofacial Research, NIH, for the paper "Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression". A certificate and $US 1000 have been issued.
Winners of previous years details. |
| The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details |
| Top cited papers:
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| Our previous results have demonstrated that km23-2 has functions in TGFß signaling that are distinct from those for km23-1. In the current report, we demonstrate that blockade of km23-2 decreased TGFß activation of the human Smad7 promoter Smad7-Luc, an endogenous Smad3-target promoter. Luminescence-based mammalian interaction mapping (LUMIER) analyses showed that TGFß stimulated the interaction of km23-2 preferentially with Smad3, relative to that with Smad2. Size exclusion chromatography experiments revealed that km23-2 and Smad3 were recruited into the same complex after TGFß treatment. Moreover, in the presence of TGFß, but not in the absence, km23-2 was present in early endosomes with the TGFß receptors (TßRs) and Smad3. Collectively, our data indicate that km23-2 is a critical signaling intermediate in a Smad3-dependent TGFß signaling pathway. We also provide evidence of the novel finding that TGFß stimulates the rapid recruitment of the km23-2 dimer to the dynein intermediate chain (DIC) of the dynein complex, whereas a kinase-deficient form of TßRII prevented this interaction. ...details |
| The stemborer Sesamia nonagrioides is an important pest of maize in the Mediterranean Basin. Like other moths, this noctuid uses its chemosensory system to efficiently interact with its environment. However, very little is known on the molecular mechanisms that underlie chemosensation in this species. Here, we used next-generation sequencing (454 and Illumina) on different tissues from adult and larvae, including chemosensory organs and female ovipositors, to describe the chemosensory transcriptome of S. nonagrioides and identify key molecular components of the pheromone production and detection systems. We identified a total of 68 candidate chemosensory genes in this species, including 31 candidate binding-proteins and 23 chemosensory receptors... ...details |
| Anthracyclines, such as doxorubicin (Adriamycin), are highly effective chemotherapeutic agents, but are well known to cause myocardial dysfunction and life-threatening congestive heart failure (CHF) in some patients.
Methods: To generate new hypotheses about its etiology, genome-wide transcript analysis was performed on whole blood RNA from women that received doxorubicin-based chemotherapy and either did, or did not develop CHF, as defined by ejection fractions (EF)≤40%. Women with non-ischemic cardiomyopathy unrelated to chemotherapy were compared to breast cancer patients prior to chemo with normal EF to identify heart failure-related transcripts in women not receiving chemotherapy. Byproducts of oxidative stress in plasma were measured in a subset of patients.... ...details |
Review
STAMPing into Mitochondria
Seong Keun Yoo, Jaehun Cheong, Hye Young Kim
Int. J. Biol. Sci. 2014; 10(3): 321-326. doi:10.7150/ijbs.8456
[Abstract]
[Full text]
[PDF] Research Paper
CARP, a Myostatin-downregulated Gene in CFM Cells, Is a Novel Essential Positive Regulator of Myogenesis
Guoda Ma, Haiyang Wang, Xuefeng Gu, Wen Li, Xingli Zhang, Lili Cui, You Li, Yong Zhang, Bin Zhao, Keshen Li
Int. J. Biol. Sci. 2014; 10(3): 309-320. doi:10.7150/ijbs.7475
[Abstract]
[Full text]
[PDF] Review
The Soldiers in Societies: Defense, Regulation, and Evolution
Li Tian, Xuguo Zhou
Int. J. Biol. Sci. 2014; 10(3): 296-308. doi:10.7150/ijbs.6847
[Abstract]
[Full text]
[PDF] Research Paper
Capsaicin Mediates Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells via Stabilizing and Activating p53
Junzhe Jin, Guofu Lin, Hong Huang, Dong Xu, Hao Yu, Xu Ma, Lisi Zhu, Dongyan Ma, Honglei Jiang
Int. J. Biol. Sci. 2014; 10(3): 285-295. doi:10.7150/ijbs.7730
[Abstract]
[Full text]
[PDF] Research Paper
Study on the Expressions of PHD and HIF in Placentas from Normal Pregnant Women and Patients with Preeclampsia
Wei Liu, Shu-Jun Wang, Qi-De Lin
Int. J. Biol. Sci. 2014; 10(3): 278-284. doi:10.7150/ijbs.6375
[Abstract]
[Full text]
[PDF] Research Paper
Metformin Plays a Dual Role in MIN6 Pancreatic β Cell Function through AMPK-dependent Autophagy
Yingling Jiang, Wei Huang, Jing Wang, Zhipeng Xu, Jieyu He, Xiaohong Lin, Zhiguang Zhou, Jingjing Zhang
Int. J. Biol. Sci. 2014; 10(3): 268-277. doi:10.7150/ijbs.7929
[Abstract]
[Full text]
[PDF] Research Paper
Gene Expression Profiling in Winged and Wingless Cotton Aphids, Aphis gossypii (Hemiptera: Aphididae)
Xiaowei Yang, Xiaoxia Liu, Xiangli Xu, Zhen Li, Yisong Li, Dongyan Song, Tian Yu, Fang Zhu, Qingwen Zhang, Xuguo Zhou
Int. J. Biol. Sci. 2014; 10(3): 257-267. doi:10.7150/ijbs.7629
[Abstract]
[Full text]
[PDF] Research Paper
ZIP4, a Novel Determinant of Tumor Invasion in Hepatocellular Carcinoma, Contributes to Tumor Recurrence after Liver Transplantation
Xiao Xu, Hai-Jun Guo, Hai-Yang Xie, Jie Li, Run-Zhou Zhuang, Qi-Ling, Lin Zhou, Xu-Yong Wei, Zhi-Kun Liu, Song-Ming Ding, Kang-Jie Chen, Zhi-Yuan Xu, Shu-Sen Zheng
Int. J. Biol. Sci. 2014; 10(3): 245-256. doi:10.7150/ijbs.7401
[Abstract]
[Full text]
[PDF] Short Research Communication
Genome Wide Screening of Candidate Genes for Improving Piglet Birth Weight Using High and Low Estimated Breeding Value Populations
Lifan Zhang, Xiang Zhou, Jennifer J. Michal, Bo Ding, Rui Li, Zhihua Jiang
Int. J. Biol. Sci. 2014; 10(3): 236-244. doi:10.7150/ijbs.7744
[Abstract]
[Full text]
[PDF] Research Paper
Vasa Identifies Germ Cells and Critical Stages of Oogenesis in the Asian Seabass
Hongyan Xu, Menghuat Lim, Manali Dwarakanath, Yunhan Hong
Int. J. Biol. Sci. 2014; 10(2): 225-235. doi:10.7150/ijbs.6797
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[Full text]
[PDF] [PubMed]
[PMC] Research Paper
Bufalin Induces the Interplay between Apoptosis and Autophagy in Glioma Cells through Endoplasmic Reticulum Stress
Shuying Shen, Yi Zhang, Zhen Wang, Rui Zhang, Xingguo Gong
Int. J. Biol. Sci. 2014; 10(2): 212-224. doi:10.7150/ijbs.8056
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[Full text]
[PDF] [PubMed]
[PMC] Research Paper
A Cryptic Species of the Tylonycteris pachypus Complex (Chiroptera: Vespertilionidae) and Its Population Genetic Structure in Southern China and nearby Regions
Chujing HUANG, Wenhua YU, Zhongxian XU, Yuanxiong QIU, Miao CHEN, Bing QIU, Masaharu MOTOKAWA, Masashi HARADA, Yuchun LI, Yi WU
Int. J. Biol. Sci. 2014; 10(2): 200-211. doi:10.7150/ijbs.7301
[Abstract]
[Full text]
[PDF] [PubMed]
[PMC] Research Paper
CDK5 and Its Activator P35 in Normal Pituitary and in Pituitary Adenomas: Relationship to VEGF Expression
Weiyan Xie, Hongyun Wang, Yue He, Dan Li, Lei Gong, Yazhuo Zhang
Int. J. Biol. Sci. 2014; 10(2): 192-199. doi:10.7150/ijbs.7770
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[Full text]
[PDF] [PubMed]
[PMC] Research Paper
Icariin Decreases the Expression of APP and BACE-1 and Reduces the β-amyloid Burden in an APP Transgenic Mouse Model of Alzheimer's Disease
Lan Zhang, Cong Shen, Jin Chu, Ruyi Zhang, Yali Li, Lin Li
Int. J. Biol. Sci. 2014; 10(2): 181-191. doi:10.7150/ijbs.6232
[Abstract]
[Full text]
[PDF] [PubMed]
[PMC] Research Paper
Fatty Acid Synthase Mediates the Epithelial-Mesenchymal Transition of Breast Cancer Cells
Junqin Li, Lihua Dong, Dapeng Wei, Xiaodong Wang, Shuo Zhang, Hua Li
Int. J. Biol. Sci. 2014; 10(2): 171-180. doi:10.7150/ijbs.7357
[Abstract]
[Full text]
[PDF] [PubMed]
[PMC] Research Paper
Inhibition of Lymphangiogenesis of Endothelial Progenitor Cells with VEGFR-3 siRNA Delivered with PEI-alginate Nanoparticles
Ting Li, Guo-dong Wang, Yu-zhen Tan, Hai-jie Wang
Int. J. Biol. Sci. 2014; 10(2): 160-170. doi:10.7150/ijbs.6719
[Abstract]
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[PDF] [PubMed]
[PMC] More ...
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