International Journal of Biological Sciences

Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

Impact factor is 3.873 according to 2017 release of Journal Citation Reports®. Congratulations!

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Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (full index information)
Full texts of articles in PubMed Central, Europe PMC, and PMC Canada.
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Most Cited Paper Award: Winners of this year are Yan-Cun Liu, Xian-Biao Zou, Yan-Fen Chai, Yong-Ming Yao, for the paper "Macrophage Polarization in Inflammatory Diseases". Details...

Special Issue on Computational Resources and Methods in Biological Sciences. Guest editors:
Prof. Jian Huang, Dr. Hao Lin, Prof. Shaoliang Peng.

The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details

Top cited papers:

G Chen et al. TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation. Cited by 237
BF Zamarron & W Chen. Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression. Cited by 172
TM Thornton & M Rincon. Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival. Cited by 200
HB Shao et al. Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells. Cited by 247
JK Lunney. Advances in Swine Biomedical Model Genomics. Cited by 255
DP Siderovski & FS Willard. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Cited by 241

Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...

The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details

Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details

Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details

The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details

Research Paper
Clenbuterol Induces Cell Cycle Arrest in C2C12 Myoblasts by Delaying p27 Degradation through β-arrestin 2 Signaling
Min Chen, Chuncheng Liu, Meng Wang, Hong Wang, Kuo Zhang, Yu Zheng, Zhengquan Yu, Xiangdong Li, Wei Guo, Ning Li, Qingyong Meng
Int. J. Biol. Sci. 2017; 13(10): 1341-1350. doi:10.7150/ijbs.17948
[Abstract] [Full text] [PDF]

Research Paper
Erythropoietin Reduces Insulin Resistance via Regulation of Its Receptor-Mediated Signaling Pathways in db/db Mice Skeletal Muscle
Yu Pan, Xiu Hong Yang, Li Li Guo, Yan Hong Gu, Qing Yan Qiao, Hui Min Jin
Int. J. Biol. Sci. 2017; 13(10): 1329-1340. doi:10.7150/ijbs.19752
[Abstract] [Full text] [PDF]

Review
Complexity Change in Cardiovascular Disease
Chang Chen, Yu Jin, Iek Long Lo, Hansen Zhao, Baoqing Sun, Qi Zhao, Jun Zheng, Xiaohua Douglas Zhang
Int. J. Biol. Sci. 2017; 13(10): 1320-1328. doi:10.7150/ijbs.19462
[Abstract] [Full text] [PDF]

Research Paper
Diabetes Induces Abnormal Ovarian Function via Triggering Apoptosis of Granulosa Cells and Suppressing Ovarian Angiogenesis
Yanqing Wu, Yiyang Li, Xinghui Liao, Zhengchao Wang, Rui Li, Shuang Zou, Ting Jiang, Bingbing Zheng, Ping Duan, Jian Xiao
Int. J. Biol. Sci. 2017; 13(10): 1297-1308. doi:10.7150/ijbs.21172
[Abstract] [Full text] [PDF]

Research Paper
Exosomal miR-7 Mediates Bystander Autophagy in Lung after Focal Brain Irradiation in Mice
Shang Cai, Geng-Sheng Shi, Hui-Ying Cheng, Ya-Nan Zeng, Gen Li, Meng Zhang, Man Song, Ping-Kun Zhou, Ye Tian, Feng-Mei Cui, Qiu Chen
Int. J. Biol. Sci. 2017; 13(10): 1287-1296. doi:10.7150/ijbs.18890
[Abstract] [Full text] [PDF]

Review
Pathogenic Role of Exosomes in Epstein-Barr Virus (EBV)-Associated Cancers
Sin-Yeang Teow, Kitson Liew, Alan Soo-Beng Khoo, Suat-Cheng Peh
Int. J. Biol. Sci. 2017; 13(10): 1276-1286. doi:10.7150/ijbs.19531
[Abstract] [Full text] [PDF]

Research Paper
Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway
Fei Han, Mei Xue, Yunpeng Chang, Xiaoyu Li, Yang Yang, Bei Sun, Liming Chen
Int. J. Biol. Sci. 2017; 13(10): 1266-1275. doi:10.7150/ijbs.20485
[Abstract] [Full text] [PDF]

Research Paper
PTH 1-34 Ameliorates the Osteopenia and Delayed Healing of Stabilized Tibia Fracture in Mice with Achondroplasia Resulting from Gain-Of-Function Mutation of FGFR3
Hangang Chen, Xianding Sun, Liangjun Yin, Shuai Chen, Ying Zhu, Junlan Huang, Wanling Jiang, Bo Chen, Ruobin Zhang, Lin Chen, Mao Nie, Yangli Xie, Zhongliang Deng
Int. J. Biol. Sci. 2017; 13(10): 1254-1265. doi:10.7150/ijbs.21258
[Abstract] [Full text] [PDF]

Research Paper
Distinct Effects of Ca²⁺Sparks on Cerebral Artery and Airway Smooth Muscle Cell Tone in Mice and Humans
Qing-Yang Zhao, Yong-Bo Peng, Xiao-Jing Luo, Xi Luo, Hao Xu, Ming-Yu Wei, Qiu-Ju Jiang, Wen-Er Li, Li-Qun Ma, Jin-Chao Xu, Xiao-Cao Liu, Dun-An Zang, Yu-San She, He Zhu, Jinhua Shen, Ping Zhao, Lu Xue, Meng-Fei Yu, Weiwei Chen, Ping Zhang, Xiangning Fu, Jingyu Chen, Xiaowei Nie, Chenyou Shen, Shu Chen, Shanshan Chen, Jingcao Chen, Sheng Hu, Chunbin Zou, Gangjian Qin, Ying Fang, Jiuping Ding, Guangju Ji, Yun-Min Zheng, Tengyao Song, Yong-Xiao Wang, Qing-Hua Liu
Int. J. Biol. Sci. 2017; 13(10): 1242-1253. doi:10.7150/ijbs.21475
[Abstract] [Full text] [PDF]

Research Paper
Transarterial Chemoembolization: A Favorable Postoperative Management to Improve Prognosis of Hepatitis B Virus-associated Intrahepatic Cholangiocarcinoma after Surgical Resection
Seogsong Jeong, Bo Zheng, Jian Wang, Jiachang Chi, Ying Tong, Lei Xia, Ning Xu, Jianjun Zhang, Xiaoni Kong, Jinyang Gu, Qiang Xia
Int. J. Biol. Sci. 2017; 13(10): 1234-1241. doi:10.7150/ijbs.21149
[Abstract] [Full text] [PDF]

Review
Structural Principles in the Development of Cyclic Peptidic Enzyme Inhibitors
Peng Xu, Peter A. Andreasen, Mingdong Huang
Int. J. Biol. Sci. 2017; 13(10): 1222-1233. doi:10.7150/ijbs.21597
[Abstract] [Full text] [PDF]

Research Paper
Identification and Analysis of P53-Mediated Competing Endogenous RNA Network in Human Hepatocellular Carcinoma
Yiming Zhang, Ran Kang, Wenrong Liu, Yalan Yang, Ruofan Ding, Qingqing Huang, Junhua Meng, Lili Xiong, Zhiyun Guo
Int. J. Biol. Sci. 2017; 13(9): 1213-1221. doi:10.7150/ijbs.21502
[Abstract] [Full text] [PDF]

Research Paper
ATP2B1 gene Silencing Increases Insulin Sensitivity through Facilitating Akt Activation via the Ca²⁺/calmodulin Signaling Pathway and Ca²⁺-associated eNOS Activation in Endothelial Cells
Yang Long, Ji-yi Xia, Shao-wei Chen, Chen-lin Gao, Guan-nan Liang, Xue-mei He, Jian Wu, Chun-xia Jiang, Xin Liu, Wei Huang, Qin Wan, Yong Xu
Int. J. Biol. Sci. 2017; 13(9): 1203-1212. doi:10.7150/ijbs.19666
[Abstract] [Full text] [PDF]

Research Paper
Chronic Osteomyelitis Increases the Incidence of Type 2 Diabetes in Humans and Mice
Yicun Wang, Jun Wang, Zhantao Deng, Jiewen Jin, Hui Jiang, Jia Meng, Haidong Xu, Jianning Zhao, Guojing Sun, Hongbo Qian
Int. J. Biol. Sci. 2017; 13(9): 1192-1202. doi:10.7150/ijbs.21379
[Abstract] [Full text] [PDF]

Research Paper
Antisense lncRNA FOXF1-AS1 Promotes Migration and Invasion of Osteosarcoma Cells Through the FOXF1/MMP-2/-9 Pathway
Zhu Kun-Peng, Zhang Chun-Lin, Ma Xiao-Long
Int. J. Biol. Sci. 2017; 13(9): 1180-1191. doi:10.7150/ijbs.21722
[Abstract] [Full text] [PDF]

Research Paper
High PD-L1 Expression Is Closely Associated With Tumor-Infiltrating Lymphocytes and Leads to Good Clinical Outcomes in Chinese Triple Negative Breast Cancer Patients
NiJiati AiErken, Hui-juan Shi, Yu Zhou, Nan Shao, Jin Zhang, Yawei Shi, Zhong-yu Yuan, Ying Lin
Int. J. Biol. Sci. 2017; 13(9): 1172-1179. doi:10.7150/ijbs.20868
[Abstract] [Full text] [PDF]

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