International Journal of Biological Sciences

Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

Impact factor is 4.057 according to 2018 release of Journal Citation Reports®. 5 Year Impact factor is 4.950. Congratulations!
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Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (full index information)
Full texts of articles in PubMed Central and Europe PMC.
(For NIH-funded researchers) Save time by submitting your paper to us - this journal is in full compliance with NIH Public Access Requirement.

Most Cited Paper Award: Winners of this year are Yan-Cun Liu, Xian-Biao Zou, Yan-Fen Chai, Yong-Ming Yao, for the paper "Macrophage Polarization in Inflammatory Diseases". Details...

The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details

Top cited papers:

G Chen et al. TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation. Cited by 237
BF Zamarron & W Chen. Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression. Cited by 172
TM Thornton & M Rincon. Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival. Cited by 200
HB Shao et al. Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells. Cited by 247
JK Lunney. Advances in Swine Biomedical Model Genomics. Cited by 255
DP Siderovski & FS Willard. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Cited by 241

Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...

The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details

Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details

Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details

The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details

Review
The PI3K/AKT pathway in obesity and type 2 diabetes
Xingjun Huang, Guihua Liu, Jiao Guo, Zhengquan Su
Int. J. Biol. Sci. 2018; 14(11): 1483-1496. doi:10.7150/ijbs.27173
[Abstract] [Full text] [PDF]

Research Paper
Ecdysone oxidase and 3-dehydroecdysone-3β-reductase contribute to the synthesis of ecdysone during early embryonic development of the silkworm
Cheng-Fang Wang, Ze Zhang, Wei Sun
Int. J. Biol. Sci. 2018; 14(11): 1472-1482. doi:10.7150/ijbs.26227
[Abstract] [Full text] [PDF]

Research Paper
Demonstrating the Potential of Using Transcutaneous Oxygen and Carbon Dioxide Tensions to Assess the Risk of Pressure Injuries
Mei Xue, Dandan Wang, Zhaozhi Zhang, Zhixin Cao, Zujin Luo, Yingying Zheng, Jingjing Lu, Qi Zhao, Xiaohua Douglas Zhang
Int. J. Biol. Sci. 2018; 14(11): 1466-1471. doi:10.7150/ijbs.26987
[Abstract] [Full text] [PDF]

Research Paper
MiR-490-3p inhibits osteogenic differentiation in thoracic ligamentum flavum cells by targeting FOXO1
Xiaoxi Yang, Xiaochen Qu, Xiangyu Meng, Mengtao Li, Dongwei Fan, Tianqi Fan, Ann Y Huang, Zhongqiang Chen, Chi Zhang
Int. J. Biol. Sci. 2018; 14(11): 1457-1465. doi:10.7150/ijbs.26686
[Abstract] [Full text] [PDF]

Research Paper
MicroRNA485-3p negatively regulates the transcriptional co-repressor CtBP1 to control the oncogenic process in osteosarcoma cells
Kaili Du, Xinliang Zhang, Zhenkai Lou, Peiyu Guo, Fan Zhang, Bing Wang, Lingqiang Chen, Chunqiang Zhang
Int. J. Biol. Sci. 2018; 14(11): 1445-1456. doi:10.7150/ijbs.26335
[Abstract] [Full text] [PDF]

Research Paper
Overexpression of human mitochondrial alanyl-tRNA synthetase suppresses biochemical defects of the mt-tRNA^Ala mutation in cybrids
Xiaoxu Zhao, Jiamin Han, Ling Zhu, Yun Xiao, Chenghui Wang, Fang Hong, Pingping Jiang, Min-Xin Guan
Int. J. Biol. Sci. 2018; 14(11): 1437-1444. doi:10.7150/ijbs.27043
[Abstract] [Full text] [PDF]

Research Paper
The Pro-angiogenesis Of Exosomes Derived From Umbilical Cord Blood Of Intrauterine Growth Restriction Pigs Was Repressed Associated With MiRNAs
Jia Luo, Yuan Fan, Linyuan Shen, LiLi Niu, Ye Zhao, Dongmei Jiang, Lin Zhu, An'an Jiang, Qianzi Tang, Jideng Ma, Long Jin, Jinyong Wang, Xuewei Li, Shunhua Zhang, Li Zhu
Int. J. Biol. Sci. 2018; 14(11): 1426-1436. doi:10.7150/ijbs.27029
[Abstract] [Full text] [PDF]

Research Paper
Polydatin attenuates diet-induced nonalcoholic steatohepatitis and fibrosis in mice
Rui Li, Jingzhi Li, Yiji Huang, Hui Li, Sishan Yan, Jiaxin Lin, Ying Chen, Limin Wu, Bing Liu, Genshu Wang, Tian Lan
Int. J. Biol. Sci. 2018; 14(11): 1411-1425. doi:10.7150/ijbs.26086
[Abstract] [Full text] [PDF]

Research Paper
Zeb1 Regulates the Symmetric Division of Mouse Lewis Lung Carcinoma Stem Cells through Numb mediated by miR-31
Jianyu Wang, Tiejun Zhou, Zhiwei Sun, Ting Ye, Shixia Zhou, Jingyuan Li, Yongli Liu, Liangsheng Kong, Junlin Tang, Doudou Liu, H.Rosie Xing
Int. J. Biol. Sci. 2018; 14(11): 1399-1410. doi:10.7150/ijbs.27446
[Abstract] [Full text] [PDF]

Research Paper
A novel FGFR1-binding peptide exhibits anti-tumor effect on lung cancer by inhibiting proliferation and angiogenesis
Qiaoyan Tan, Zuqiang Wang, Quan Wang, Yuanqiang Wang, Zhifeng Huang, Nan Su, Min Jin, Liang Kuang, Huabing Qi, Zhenhong Ni, Can Li, Ying Zhu, Wanling Jiang, Hangang Chen, Chuxia Deng, Xiaolan Du, Yangli Xie, Lin Chen
Int. J. Biol. Sci. 2018; 14(10): 1389-1398. doi:10.7150/ijbs.24739
[Abstract] [Full text] [PDF]

Research Paper
Antrodia cinnamomea Galactomannan Elicits Immuno-stimulatory Activity Through Toll-like Receptor 4
Namal Perera, Feng-Ling Yang, Yueh-Tung Lu, Lan-Hui Li, Kuo-Feng Hua, Shih-Hsiung Wu
Int. J. Biol. Sci. 2018; 14(10): 1378-1388. doi:10.7150/ijbs.24564
[Abstract] [Full text] [PDF]

Research Paper
Construction of implantation failure related lncRNA-mRNA network and identification of lncRNA biomarkers for predicting endometrial receptivity
Chun Feng, Jin-Ming Shen, Ping-Ping Lv, Min Jin, Li-Quan Wang, Jin-Peng Rao, Lei Feng
Int. J. Biol. Sci. 2018; 14(10): 1361-1377. doi:10.7150/ijbs.25081
[Abstract] [Full text] [PDF]

Review
Neutrophil Elastase Inhibitors and Chronic Kidney Disease
Elsa Bronze-da-Rocha, Alice Santos-Silva
Int. J. Biol. Sci. 2018; 14(10): 1343-1360. doi:10.7150/ijbs.26111
[Abstract] [Full text] [PDF]

Research Paper
Expression of VEGFR-3 in intrahepatic cholangiocarcinoma correlates with unfavorable prognosis through lymphangiogenesis
Meng Sha, Seogsong Jeong, Xiao-song Chen, Ying Tong, Jie Cao, Han-yong Sun, Lei Xia, Ning Xu, Xin Wang, Long-zhi Han, Zhi-feng Xi, Jian-jun Zhang, Xiao-ni Kong, Qiang Xia
Int. J. Biol. Sci. 2018; 14(10): 1333-1342. doi:10.7150/ijbs.26045
[Abstract] [Full text] [PDF]

Research Paper
Genome-wide Identification and Characterization of Enhancers Across 10 Human Tissues
Lili Xiong, Ran Kang, Ruofan Ding, Wenyuan Kang, Yiming Zhang, Wenrong Liu, Qingqing Huang, Junhua Meng, Zhiyun Guo
Int. J. Biol. Sci. 2018; 14(10): 1321-1332. doi:10.7150/ijbs.26605
[Abstract] [Full text] [PDF]

Research Paper
Preliminary Observation about Alteration of Proteins and Their Potential Functions in Spinal Cord of SOD1 G93A Transgenic Mice
Jie Zhang, Ping Huang, Chengsi Wu, Huiting Liang, Yue Li, Lei Zhu, Yi Lu, Chunyan Tang, Renshi Xu
Int. J. Biol. Sci. 2018; 14(10): 1306-1320. doi:10.7150/ijbs.26829
[Abstract] [Full text] [PDF]

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