International Journal of Biological Sciences

Research Paper
Inhibition of super enhancer downregulates the expression of KLF5 in basal-like breast cancers
Chuan-Huizi Chen, Nong Yang, Yongchang Zhang, Jiancheng Ding, Wenjuan Zhang, Rong Liu, Wen Liu, Ceshi Chen
Int. J. Biol. Sci. 2019; 15(8): 1733-1742. doi:10.7150/ijbs.35138
[Abstract] [Full text] [PDF]

Research Paper
Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2
Wenhui Zhou, Huan Fang, Qiuju Wu, Xinye Wang, Rong Liu, Fubin Li, Ji Xiao, Lin Yuan, Zhongmei Zhou, Junying Ma, Lulu Wang, Weiwei Zhao, Hua You, Jianhua Ju, Jing Feng, Ceshi Chen
Int. J. Biol. Sci. 2019; 15(8): 1723-1732. doi:10.7150/ijbs.35284
[Abstract] [Full text] [PDF]

Research Paper
Serum microRNA Signature Is Capable of Early Diagnosis for Non-Small Cell Lung Cancer
Xia Yang, Qiuhong Zhang, Ming Zhang, Wenmei Su, Zhuwen Wang, Yali Li, Jie Zhang, David G. Beer, Shuanying Yang, Guoan Chen
Int. J. Biol. Sci. 2019; 15(8): 1712-1722. doi:10.7150/ijbs.33986
[Abstract] [Full text] [PDF]

Research Paper
TLX3 repressed SNAI1-induced epithelial-mesenchymal transition by directly constraining STAT3 phosphorylation and functionally sensitized 5-FU chemotherapy in hepatocellular carcinoma
Cong Wang, Changwei Dou, Yufeng Wang, Zhikui Liu, Lewis Roberts, Xin Zheng
Int. J. Biol. Sci. 2019; 15(8): 1696-1711. doi:10.7150/ijbs.33844
[Abstract] [Full text] [PDF]

Research Paper
CXXC5 Mediates P. gingivalis-suppressed Cementoblast Functions Partially via MAPK Signaling Network
Li Ma, Xiaoxuan Wang, Huan Liu, Chenxi Jiang, Haiqing Liao, Shihan Xu, Yi Guo, Zhengguo Cao
Int. J. Biol. Sci. 2019; 15(8): 1685-1695. doi:10.7150/ijbs.35419
[Abstract] [Full text] [PDF]

Research Paper
Enhancement of oxaliplatin-induced colon cancer cell apoptosis by alantolactone, a natural product inducer of ROS
Peihai Cao, Yiqun Xia, Wei He, Tingting Zhang, Lin Hong, Peisen Zheng, Xin Shen, Guang Liang, Ri Cui, Peng Zou
Int. J. Biol. Sci. 2019; 15(8): 1676-1684. doi:10.7150/ijbs.35265
[Abstract] [Full text] [PDF]

Research Paper
CD44 3'-Untranslated Region Functions as a Competing Endogenous RNA to Enhance NK Sensitivity of Liver Cancer Stem Cell by Regulating ULBP2 Expression
Jun Weng, Xu Han, Kaiyu Liu, Jiong Yang, Shiruo Wei, Yue Zhang, Fanhong Zeng, Yang Li, Li Shen, Yi Gao
Int. J. Biol. Sci. 2019; 15(8): 1664-1675. doi:10.7150/ijbs.35216
[Abstract] [Full text] [PDF]

Review
Treatment implications of natural compounds targeting lipid metabolism in nonalcoholic fatty liver disease, obesity and cancer
Can Cheng, Songming Zhuo, Bo Zhang, Xu Zhao, Ying Liu, Chaoliang Liao, Jing Quan, Zhenzhen Li, Ann M. Bode, Ya Cao, Xiangjian Luo
Int. J. Biol. Sci. 2019; 15(8): 1654-1663. doi:10.7150/ijbs.33837
[Abstract] [Full text] [PDF]

Research Paper
PERK/eIF-2α/CHOP Pathway Dependent ROS Generation Mediates Butein-induced Non-small-cell Lung Cancer Apoptosis and G2/M Phase Arrest
Shouyin Di, Chongxi Fan, Zhiqiang Ma, Mingyang Li, Kai Guo, Donghui Han, Xiaofei Li, Deguang Mu, Xiaolong Yan
Int. J. Biol. Sci. 2019; 15(8): 1637-1653. doi:10.7150/ijbs.33790
[Abstract] [Full text] [PDF]

Research Paper
A Synthetic Light-switchable System based on CRISPR Cas13a Regulates the Expression of LncRNA MALAT1 and Affects the Malignant Phenotype of Bladder Cancer Cells
Fuming Qi, Bo Tan, Fujun Ma, Bo Zhu, Li Zhang, Xiaoyun Liu, Honglei Li, Jinhui Yang, Bo Cheng
Int. J. Biol. Sci. 2019; 15(8): 1630-1636. doi:10.7150/ijbs.33772
[Abstract] [Full text] [PDF]

Research Paper
Tripartite Motif 8 Deficiency Relieves Hepatic Ischaemia/reperfusion Injury via TAK1-dependent Signalling Pathways
Qiu Tao, Wang Tianyu, Zhou Jiangqiao, Chen Zhongbao, Ma Xiaoxiong, Zhang Long, Zou Jilin
Int. J. Biol. Sci. 2019; 15(8): 1618-1629. doi:10.7150/ijbs.33323
[Abstract] [Full text] [PDF]

Research Paper
Specifically blocking the fatty acid synthesis to inhibit the malignant phenotype of bladder cancer
Aolin Li, Lin Yao, Yuan Fang, Kang Yang, Wei Jiang, Weiren Huang, Zhiming Cai
Int. J. Biol. Sci. 2019; 15(8): 1610-1617. doi:10.7150/ijbs.32518
[Abstract] [Full text] [PDF]

Review
Curcumol: From Plant Roots to Cancer Roots
Wei Wei, Azhar Rasul, Ayesha Sadiqa, Iqra Sarfraz, Ghulam Hussain, Bushra Nageen, Xintong Liu, Nobumoto Watanabe, Zeliha Selamoglu, Muhammad Ali, Xiaomeng Li, Jiang Li
Int. J. Biol. Sci. 2019; 15(8): 1600-1609. doi:10.7150/ijbs.34716
[Abstract] [Full text] [PDF]

Research Paper
miR-424-5p represses the metastasis and invasion of intrahepatic cholangiocarcinoma by targeting ARK5
Jingbang Wu, Beng Yang, Yanpeng Zhang, Xiaode Feng, Bin He, Haiyang Xie, Lin Zhou, Jian Wu, Shusen Zheng
Int. J. Biol. Sci. 2019; 15(8): 1591-1599. doi:10.7150/ijbs.34113
[Abstract] [Full text] [PDF]

Research Paper
Dietary glycine decreases both tumor volume and vascularization in a combined colorectal liver metastasis and chemotherapy model
Juste Maneikyte, Augustinas Bausys, Bettina Leber, Angela Horvath, Nicole Feldbacher, Gerald Hoefler, Kestutis Strupas, Philipp Stiegler, Peter Schemmer
Int. J. Biol. Sci. 2019; 15(8): 1582-1590. doi:10.7150/ijbs.35513
[Abstract] [Full text] [PDF]

Research Paper
Caffeine Inhibits NLRP3 Inflammasome Activation by Suppressing MAPK/NF-κB and A2aR Signaling in LPS-Induced THP-1 Macrophages
Weiming Zhao, Li Ma, Cheng Cai, Xiaohui Gong
Int. J. Biol. Sci. 2019; 15(8): 1571-1581. doi:10.7150/ijbs.34211
[Abstract] [Full text] [PDF]

Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau

Editor-in-Chief's Profile

Impact factor is 4.057 according to 2018 release of Journal Citation Reports®. 5 Year Impact factor 4.950.

Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (full index information)
Full texts of articles in PubMed Central and Europe PMC.
(For NIH-funded researchers) Save time by submitting your paper to us - this journal is in full compliance with NIH Public Access Requirement.

Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details

Top cited papers:

G Chen et al. TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation. Cited by 237
BF Zamarron & W Chen. Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression. Cited by 172
TM Thornton & M Rincon. Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival. Cited by 200
HB Shao et al. Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells. Cited by 247
JK Lunney. Advances in Swine Biomedical Model Genomics. Cited by 255
DP Siderovski & FS Willard. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Cited by 241

The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details

Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details

Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details

In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details