International Journal of Biological Sciences
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ISSN 1449-2288

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Journal of Genomics now in PubMed/PubMed Central. Submit manuscript...

International Journal of Medical Sciences

Journal of Cancer

Theranostics

Journal of Genomics

PubMed Central Indexed in Journal Impact Factor
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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

new Latest impact factor is 4.509. Congratulations!
new Cover suggestion ...details
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Most Cited Paper Award: Winners of this year are Guiqian Chen et al, for the paper "TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation". Details...
The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details
Top cited papers:
Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...
The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details
Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details
Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details
The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details
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Research Paper
Identification and Functional Characterization of Cis-Regulatory Elements Controlling Expression of the Porcine ADRB2 Gene
Alexandra Jaeger, Stephan Fritschka, Siriluck Ponsuksili, Klaus Wimmers, Eduard Muráni
Int. J. Biol. Sci. 2015; 11(9): 1006-1015. doi:10.7150/ijbs.12456
[Abstract] [Full text] [PDF]


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Research Paper
MDC1 Enhances Estrogen Receptor-mediated Transactivation and Contributes to Breast Cancer Suppression
Renlong Zou, Xinping Zhong, Chunyu Wang, Hongmiao Sun, Shengli Wang, Lin Lin, Shiying Sun, Changci Tong, Hao Luo, Peng Gao, Yanshu Li, Tingting Zhou, Da Li, Liu Cao, Yue Zhao
Int. J. Biol. Sci. 2015; 11(9): 992-1005. doi:10.7150/ijbs.10918
[Abstract] [Full text] [PDF]


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Review
Significance of Antioxidant Potential of Plants and its Relevance to Therapeutic Applications
Deepak M. Kasote, Surendra S. Katyare, Mahabaleshwar V. Hegde, Hanhong Bae
Int. J. Biol. Sci. 2015; 11(8): 982-991. doi:10.7150/ijbs.12096
[Abstract] [Full text] [PDF]


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Research Paper
The saponin DT-13 Attenuates Tumor Necrosis Factor-α-induced Vascular Inflammation Associated with Src/NF-кB/MAPK Pathway Modulation
Yuanyuan Zhang, Minhui Sun, Yuwei Han, Kefeng Zhai, Youmei Tang, Xiaoying Qin, Zhengyu Cao, Boyang Yu, Junping Kou
Int. J. Biol. Sci. 2015; 11(8): 970-981. doi:10.7150/ijbs.11635
[Abstract] [Full text] [PDF]


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Research Paper
Exosomal Transfer of Vasorin Expressed in Hepatocellular Carcinoma Cells Promotes Migration of Human Umbilical Vein Endothelial Cells
Aixue Huang, Jie Dong, Shaohua Li, Chaonan Wang, Hongmei Ding, Hui Li, Xueting Su, Xingfeng Ge, Leqiao Sun, Chenjun Bai, Xuelian Shen, Tao Fang, Jie Li, Ningsheng Shao
Int. J. Biol. Sci. 2015; 11(8): 961-969. doi:10.7150/ijbs.11943
[Abstract] [Full text] [PDF]


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Research Paper
Overexpression of FGF9 in Prostate Epithelial Cells Augments Reactive Stroma Formation and Promotes Prostate Cancer Progression
Yanqing Huang, Chengliu Jin, Tomoaki Hamana, Junchen Liu, Cong Wang, Lei An, Wallace L. McKeehan, Fen Wang
Int. J. Biol. Sci. 2015; 11(8): 948-960. doi:10.7150/ijbs.12468
[Abstract] [Full text] [PDF]


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Research Paper
Yes-Associated Protein (Yap) Is Necessary for Ciliogenesis and Morphogenesis during Pronephros Development in Zebrafish (Danio Rerio)
Liangliang He, Wenyan Xu, Ying Jing, Ming Wu, Shuwei Song, Ying Cao, Changlin Mei
Int. J. Biol. Sci. 2015; 11(8): 935-947. doi:10.7150/ijbs.11346
[Abstract] [Full text] [PDF]


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Research Paper
Sensitization of Chemo-Resistant Human Chronic Myeloid Leukemia Stem-Like Cells to Hsp90 Inhibitor by SIRT1 Inhibition
Hak-Bong Kim, Su-Hoon Lee, Jee-Hyun Um, Mi-Ju Kim, Suh-Kyung Hyun, Eun-Ji Gong, Won Keun Oh, Chi-Dug Kang, Sun-Hee Kim
Int. J. Biol. Sci. 2015; 11(8): 923-934. doi:10.7150/ijbs.10896
[Abstract] [Full text] [PDF]


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Research Paper
Transmissible Gastroenteritis Virus (TGEV) Infection Alters the Expression of Cellular MicroRNA Species That Affect Transcription of TGEV Gene 7
Xiangjun Song, Xiaomin Zhao, Yong Huang, Hailing Xiang, Wenlong Zhang, Dewen Tong
Int. J. Biol. Sci. 2015; 11(8): 913-922. doi:10.7150/ijbs.11585
[Abstract] [Full text] [PDF]


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Research Paper
Sleep Deprivation Induces Changes in Immunity in Trichinella spiralis-Infected Rats
Elizabeth G. Ibarra-Coronado, Javier Velazquéz-Moctezuma, Daniel Diaz, Luis Enrique Becerril-Villanueva, Lenin Pavón, Jorge Morales-Montor
Int. J. Biol. Sci. 2015; 11(8): 901-912. doi:10.7150/ijbs.11907
[Abstract] [Full text] [PDF]


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Research Paper
Mild ischemic Injury Leads to Long-Term Alterations in the Kidney: Amelioration by Spironolactone Administration
Jonatan Barrera-Chimal, Rosalba Pérez-Villalva, Juan Antonio Ortega, Andrea Sánchez, Roxana Rodríguez-Romo, Marta Durand, Frederic Jaisser, Norma A. Bobadilla
Int. J. Biol. Sci. 2015; 11(8): 892-900. doi:10.7150/ijbs.11729
[Abstract] [Full text] [PDF]


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Research Paper
Magnolia Bioactive Constituent 4-O-Methylhonokiol Prevents the Impairment of Cardiac Insulin Signaling and the Cardiac Pathogenesis in High-Fat Diet-Induced Obese Mice
Zhiguo Zhang, Jing Chen, Shanshan Zhou, Shudong Wang, Xiaohong Cai, Daniel J. Conklin, Ki-Soo Kim, Ki Ho Kim, Yi Tan, Yang Zheng, Young Heui Kim, Lu Cai
Int. J. Biol. Sci. 2015; 11(8): 879-891. doi:10.7150/ijbs.12101
[Abstract] [Full text] [PDF]


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Research Paper
Regulation of β-Adrenergic Receptor Trafficking and Lung Microvascular Endothelial Cell Permeability by Rab5 GTPase
Junjun Yang, Huan Sun, Jihang Zhang, Mingdong Hu, Jianchun Wang, Guangyu Wu, Guansong Wang
Int. J. Biol. Sci. 2015; 11(8): 868-878. doi:10.7150/ijbs.12045
[Abstract] [Full text] [PDF]


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Research Paper
Silver Nanoparticle Exposure Induced Mitochondrial Stress, Caspase-3 Activation and Cell Death: Amelioration by Sodium Selenite
Wanrui Ma, Li Jing, Alexandra Valladares, Suresh L. Mehta, Zhizhong Wang, P. Andy Li, John J. Bang
Int. J. Biol. Sci. 2015; 11(8): 860-867. doi:10.7150/ijbs.12059
[Abstract] [Full text] [PDF]


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Research Paper
bFGF Promotes the Migration of Human Dermal Fibroblasts under Diabetic Conditions through Reactive Oxygen Species Production via the PI3K/Akt-Rac1- JNK Pathways
Hongxue Shi, Yi Cheng, Jingjing Ye, Pingtao Cai, Jinjing Zhang, Rui Li, Ying Yang, Zhouguang Wang, Hongyu Zhang, Cai Lin, Xianghong Lu, Liping Jiang, Aiping Hu, Xinbo Zhu, Qiqiang Zeng, Xiaobing Fu, Xiaokun Li, Jian Xiao
Int. J. Biol. Sci. 2015; 11(7): 845-859. doi:10.7150/ijbs.11921
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
ROS/Autophagy/Nrf2 Pathway Mediated Low-Dose Radiation Induced Radio-Resistance in Human Lung Adenocarcinoma A549 Cell
Ni Chen, Lijun Wu, Hang Yuan, Jun Wang
Int. J. Biol. Sci. 2015; 11(7): 833-844. doi:10.7150/ijbs.10564
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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