International Journal of Biological Sciences

Impact factor
3.873

ISSN 1449-2288

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Journal of Biomedicinenew

Theranostics

International Journal of Medical Sciences

Journal of Cancer

Oncomedicine

Journal of Genomics

Journal of Bone and Joint Infection (JBJI)

Nanotheranostics

PubMed Central Indexed in Journal Impact Factor
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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

new Impact factor is 3.873 (five year impact factor 4.689) according to 2017 release of Journal Citation ReportsĀ®. Congratulations!
new Cover suggestion ...details
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Most Cited Paper Award: Winners of this year are Yan-Cun Liu, Xian-Biao Zou, Yan-Fen Chai, Yong-Ming Yao, for the paper "Macrophage Polarization in Inflammatory Diseases". Details...
Special Issue on Computational Resources and Methods in Biological Sciences. Guest editors:
Prof. Jian Huang, Dr. Hao Lin, Prof. Shaoliang Peng.
The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details
Top cited papers:
Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...
The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details
Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details
Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details
The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details
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Review
Circular RNAs: A novel type of non-coding RNA and their potential implications in antiviral immunity
Man Wang, Fei Yu, Wei Wu, Yuan Zhang, Wenguang Chang, Murugavel Ponnusamy, Kun Wang, Peifeng Li
Int. J. Biol. Sci. 2017; 13(12): 1497-1506. doi:10.7150/ijbs.22531
[Abstract] [Full text] [PDF]


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Review
The Molecular Mechanisms of Regulation on USP2's Alternative Splicing and the Significance of Its Products
Han-Qing Zhu, Feng-Hou Gao
Int. J. Biol. Sci. 2017; 13(12): 1489-1496. doi:10.7150/ijbs.21637
[Abstract] [Full text] [PDF]


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Review
Fibroblast Growth Factor Receptor 2 (FGFR2) Mutation Related Syndromic Craniosynostosis
Saïd C. Azoury, Sashank Reddy, Vivek Shukla, Chu-Xia Deng
Int. J. Biol. Sci. 2017; 13(12): 1479-1488. doi:10.7150/ijbs.22373
[Abstract] [Full text] [PDF]


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Research Paper
CRISPR-offinder: a CRISPR guide RNA design and off-target searching tool for user-defined protospacer adjacent motif
Changzhi Zhao, Xiaoguo Zheng, Wubin Qu, Guanglei Li, Xinyun Li, Yi-Liang Miao, Xiaosong Han, Xiangdong Liu, Zhenhua Li, Yunlong Ma, Qianzhi Shao, Haiwei Li, Fei Sun, Shengsong Xie, Shuhong Zhao
Int. J. Biol. Sci. 2017; 13(12): 1470-1478. doi:10.7150/ijbs.21312
[Abstract] [Full text] [PDF]


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Research Paper
Overexpression of selenoprotein H prevents mitochondrial dynamic imbalance induced by glutamate exposure
Yan-Mei Ma, Yong-Zhen Guo, Gordon Ibeanu, Li-Yao Wang, Jian-Da Dong, Juan Wang, Li Jing, Jian-Zhong Zhang, P. Andy Li
Int. J. Biol. Sci. 2017; 13(11): 1458-1469. doi:10.7150/ijbs.21300
[Abstract] [Full text] [PDF]


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Research Paper
Human colorectal cancer progression correlates with LOX-induced ECM stiffening
Bo Wei, Xueling Zhou, Chenghua Liang, Xiaoming Zheng, Purun Lei, Jiafeng Fang, Xiaoyan Han, Lijing Wang, Cuiling Qi, Hongbo Wei
Int. J. Biol. Sci. 2017; 13(11): 1450-1457. doi:10.7150/ijbs.21230
[Abstract] [Full text] [PDF]


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Research Paper
Transcriptome integration analysis in hepatocellular carcinoma reveals discordant intronic miRNA-host gene pairs in expression
Yulin Sun, Fubo Ji, Mia R Kumar, Xin Zheng, Yi Xiao, Niya Liu, Jiong Shi, Linda Wong, Marshonna Forgues, Lun-Xiu Qin, Zhao-You Tang, Xiaohang Zhao, Xin Wei Wang, Junfang Ji
Int. J. Biol. Sci. 2017; 13(11): 1438-1449. doi:10.7150/ijbs.20836
[Abstract] [Full text] [PDF]


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Research Paper
Adhesion Regulating Molecule 1 Mediates HAP40 Overexpression-Induced Mitochondrial Defects
Zih-Ning Huang, Her Min Chung, Su-Chiung Fang, Lu-Shiun Her
Int. J. Biol. Sci. 2017; 13(11): 1420-1437. doi:10.7150/ijbs.20742
[Abstract] [Full text] [PDF]


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Review
Altered Neuroendocrine Immune Responses, a Two-Sword Weapon against Traumatic Inflammation
Ce Yang, Jie Gao, Juan Du, Xuetao Yang, Jianxin Jiang
Int. J. Biol. Sci. 2017; 13(11): 1409-1419. doi:10.7150/ijbs.21916
[Abstract] [Full text] [PDF]


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Research Paper
Targeting the long noncoding RNA MALAT1 blocks the pro-angiogenic effects of osteosarcoma and suppresses tumour growth
Zhi-Chang Zhang, Chun Tang, Yang Dong, Jing Zhang, Ting Yuan, Shi-Cong Tao, Xiao-Lin Li
Int. J. Biol. Sci. 2017; 13(11): 1398-1408. doi:10.7150/ijbs.22249
[Abstract] [Full text] [PDF]


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Review
Risk Factors and Preventions of Breast Cancer
Yi-Sheng Sun, Zhao Zhao, Zhang-Nv Yang, Fang Xu, Hang-Jing Lu, Zhi-Yong Zhu, Wen Shi, Jianmin Jiang, Ping-Ping Yao, Han-Ping Zhu
Int. J. Biol. Sci. 2017; 13(11): 1387-1397. doi:10.7150/ijbs.21635
[Abstract] [Full text] [PDF]


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Research Paper
Clinical and in vitro analysis of Osteopontin as a prognostic indicator and unveil its potential downstream targets in bladder cancer
Janet P.C. Wong, Ran Wei, Peng Lyu, Olivia L.H. Tong, Shu Dong Zhang, Qing Wen, Hiu Fung Yuen, Mohamed El-Tanani, Hang Fai Kwok
Int. J. Biol. Sci. 2017; 13(11): 1373-1386. doi:10.7150/ijbs.21457
[Abstract] [Full text] [PDF]


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Research Paper
Co-expression network analysis identified FCER1G in association with progression and prognosis in human clear cell renal cell carcinoma
Liang Chen, Lushun Yuan, Yongzhi Wang, Gang Wang, Yuan Zhu, Rui Cao, Guofeng Qian, Conghua Xie, Xuefeng Liu, Yu Xiao, Xinghuan Wang
Int. J. Biol. Sci. 2017; 13(11): 1361-1372. doi:10.7150/ijbs.21657
[Abstract] [Full text] [PDF]


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Research Paper
Role of matrix metalloproteinase-2/9 (MMP2/9) in lead-induced changes in an in vitro blood-brain barrier model
Xinqin Liu, Peng Su, Shanshan Meng, Michael Aschner, Yupeng Cao, Wenjing Luo, Gang Zheng, Mingchao Liu
Int. J. Biol. Sci. 2017; 13(11): 1351-1360. doi:10.7150/ijbs.20670
[Abstract] [Full text] [PDF]


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Research Paper
Clenbuterol Induces Cell Cycle Arrest in C2C12 Myoblasts by Delaying p27 Degradation through β-arrestin 2 Signaling
Min Chen, Chuncheng Liu, Meng Wang, Hong Wang, Kuo Zhang, Yu Zheng, Zhengquan Yu, Xiangdong Li, Wei Guo, Ning Li, Qingyong Meng
Int. J. Biol. Sci. 2017; 13(10): 1341-1350. doi:10.7150/ijbs.17948
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Erythropoietin Reduces Insulin Resistance via Regulation of Its Receptor-Mediated Signaling Pathways in db/db Mice Skeletal Muscle
Yu Pan, Xiu Hong Yang, Li Li Guo, Yan Hong Gu, Qing Yan Qiao, Hui Min Jin
Int. J. Biol. Sci. 2017; 13(10): 1329-1340. doi:10.7150/ijbs.19752
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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