International Journal of Biological Sciences

Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

Impact factor is 4.057 according to 2018 release of Journal Citation Reports®. 5 Year Impact factor is 4.950. Congratulations!
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Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (full index information)
Full texts of articles in PubMed Central and Europe PMC.
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The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details

Top cited papers:

G Chen et al. TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation. Cited by 237
BF Zamarron & W Chen. Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression. Cited by 172
TM Thornton & M Rincon. Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival. Cited by 200
HB Shao et al. Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells. Cited by 247
JK Lunney. Advances in Swine Biomedical Model Genomics. Cited by 255
DP Siderovski & FS Willard. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Cited by 241

Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...

The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details

Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details

Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details

The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details

Research Paper
DJ-1 Deficiency Protects Hepatic Steatosis by Enhancing Fatty Acid Oxidation in Mice
Min Xu, Hailong Wu, Meng Li, Yankai Wen, Chang Yu, Lei Xia, Qiang Xia, Xiaoni Kong
Int. J. Biol. Sci. 2018; 14(13): 1892-1900. doi:10.7150/ijbs.28620
[Abstract] [Full text] [PDF]

Research Paper
PKM2 Inhibitor Shikonin Overcomes the Cisplatin Resistance in Bladder Cancer by Inducing Necroptosis
Yonggang Wang, Fangshi Hao, Yonghao Nan, Licheng Qu, Wanli Na, Chunshu Jia, Xiaoliang Chen
Int. J. Biol. Sci. 2018; 14(13): 1883-1891. doi:10.7150/ijbs.27854
[Abstract] [Full text] [PDF]

Research Paper
SIRT3 Activation by Dihydromyricetin Suppresses Chondrocytes Degeneration via Maintaining Mitochondrial Homeostasis
Jianle Wang, Ke Wang, Chongan Huang, Dongdong Lin, Yifei Zhou, Yaosen Wu, Naifeng Tian, Pei Fan, Xiangxiang Pan, Daoliang Xu, Jianing Hu, Ying Zhou, Xiangyang Wang, Xiaolei Zhang
Int. J. Biol. Sci. 2018; 14(13): 1873-1882. doi:10.7150/ijbs.27746
[Abstract] [Full text] [PDF]

Research Paper
Effect of RIF1 on response of non-small-cell lung cancer patients to platinum-based chemotherapy by regulating MYC signaling pathway
Ying Mei, Yong-Bin Liu, Dong-Li Hu, Hong-Hao Zhou
Int. J. Biol. Sci. 2018; 14(13): 1859-1872. doi:10.7150/ijbs.27710
[Abstract] [Full text] [PDF]

Research Paper
The HDAC Inhibitor Quisinostat (JNJ-26481585) Supresses Hepatocellular Carcinoma alone and Synergistically in Combination with Sorafenib by G0/G1 phase arrest and Apoptosis induction
Bin He, Longfei Dai, Xiaoqian Zhang, Diyu Chen, Jingbang Wu, Xiaode Feng, Yanpeng Zhang, Haiyang Xie, Lin Zhou, Jian Wu, Shusen Zheng
Int. J. Biol. Sci. 2018; 14(13): 1845-1858. doi:10.7150/ijbs.27661
[Abstract] [Full text] [PDF]

Research Paper
Copper Nanoparticles Show Obvious in vitro and in vivo Reproductive Toxicity via ERK Mediated Signaling Pathway in Female Mice
Cai-Hong Zhang, Ye Wang, Qian-Qian Sun, Lei-Lei Xia, Jing-Jing Hu, Kai Cheng, Xia Wang, Xin-Xin Fu, Hang Gu
Int. J. Biol. Sci. 2018; 14(13): 1834-1844. doi:10.7150/ijbs.27640
[Abstract] [Full text] [PDF]

Research Paper
Prior Knowledge Driven Joint NMF Algorithm for ceRNA Co-Module Identification
Jin Deng, Wei Kong, Shuaiqun Wang, Xiaoyang Mou, Weiming Zeng
Int. J. Biol. Sci. 2018; 14(13): 1822-1833. doi:10.7150/ijbs.27555
[Abstract] [Full text] [PDF]

Research Paper
Prognostic Dynamic Nomogram Integrated with Inflammation-Based Factors for Non-Small Cell Lung Cancer Patients with Chronic Hepatitis B Viral Infection
Shulin Chen, Xiaohui Li, Hui Lv, Xiaoyan Wen, Qiuying Ding, Ning Xue, Hongkai Su, Hao Chen
Int. J. Biol. Sci. 2018; 14(13): 1813-1821. doi:10.7150/ijbs.27260
[Abstract] [Full text] [PDF]

Review
Evaluating the Remote Control of Programmed Cell Death, with or without a Compensatory Cell Proliferation
Xixi Dou, Lichan Chen, Mingjuan Lei, Lucas Zellmer, Qingwen Jia, Peixue Ling, Yan He, Wenxiu Yang, Dezhong Joshua Liao
Int. J. Biol. Sci. 2018; 14(13): 1800-1812. doi:10.7150/ijbs.26962
[Abstract] [Full text] [PDF]

Research Paper
miR-186-5p Promotes Apoptosis by Targeting IGF-1 in SH-SY5Y OGD/R Model
Rui Wang, Hongbo Bao, Shihua Zhang, Ruiyan Li, Lijie Chen, Yulan Zhu
Int. J. Biol. Sci. 2018; 14(13): 1791-1799. doi:10.7150/ijbs.25352
[Abstract] [Full text] [PDF]

Review
Novel CD44-downstream signaling pathways mediating breast tumor invasion
Allal Ouhtit, Balsam Rizeq, Haissam Abou Saleh, MD Mizanur Rahman, Hatem Zayed
Int. J. Biol. Sci. 2018; 14(13): 1782-1790. doi:10.7150/ijbs.23586
[Abstract] [Full text] [PDF]

Research Paper
Inhibition of AKT suppresses the initiation and progression of BRCA1-associated mammary tumors
Hye Jung Baek, Sun Eui Kim, Jong Kwang Kim, Dong Hoon Shin, Tae Hyun Kim, Kwang Gi Kim, Chu-Xia Deng, Sang Soo Kim
Int. J. Biol. Sci. 2018; 14(13): 1769-1781. doi:10.7150/ijbs.29242
[Abstract] [Full text] [PDF]

Research Paper
Inhibition of Estrogen Signaling Reduces the Incidence of BRCA1-associated Mammary Tumor Formation
Hye Jung Baek, Sun Eui Kim, Eun Kyung Choi, Jong Kwang Kim, Dong Hoon Shin, Eun Jung Park, Tae Hyun Kim, Joo-Young Kim, Kwang Gi Kim, Chu-Xia Deng, Sang Soo Kim
Int. J. Biol. Sci. 2018; 14(12): 1755-1768. doi:10.7150/ijbs.28142
[Abstract] [Full text] [PDF]

Review
Targeting phosphodiesterase 4 as a potential therapeutic strategy for enhancing neuroplasticity following ischemic stroke
Haitao Wang, Uma Gaur, Jiao Xiao, Bingtian Xu, Jiangping Xu, Wenhua Zheng
Int. J. Biol. Sci. 2018; 14(12): 1745-1754. doi:10.7150/ijbs.26230
[Abstract] [Full text] [PDF]

Research Paper
The small molecule NSM00191 specifically represses the TNF-α/NF-кB axis in foot and ankle rheumatoid arthritis
Xiaodong Wen, Xun Chen, Xiaojun Liang, Hongmou Zhao, Yi Li, Xiangxiang Sun, Jun Lu
Int. J. Biol. Sci. 2018; 14(12): 1732-1744. doi:10.7150/ijbs.24232
[Abstract] [Full text] [PDF]

Research Paper
TFmapper: A Tool for Searching Putative Factors Regulating Gene Expression Using ChIP-seq Data
Jianming Zeng, Gang Li
Int. J. Biol. Sci. 2018; 14(12): 1724-1731. doi:10.7150/ijbs.28850
[Abstract] [Full text] [PDF]

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