International Journal of Biological Sciences
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ISSN 1449-2288

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Journal of Genomics now in PubMed/PubMed Central. Submit manuscript...

International Journal of Medical Sciences

Journal of Cancer

Theranostics

Journal of Genomics

Journal of Bone and Joint Infection (JBJI)

PubMed Central Indexed in Journal Impact Factor
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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

new Latest impact factor is 4.509. Congratulations!
new Cover suggestion ...details
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Most Cited Paper Award: Winners of this year are Guiqian Chen et al, for the paper "TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation". Details...
The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details
Top cited papers:
Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...
The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details
Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details
Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details
The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details
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Research Paper
MiR-487a Promotes TGF-β1-induced EMT, the Migration and Invasion of Breast Cancer Cells by Directly Targeting MAGI2
Mengtao Ma, Miao He, Qian Jiang, Yuanyuan Yan, Shu Guan, Jing Zhang, Zhaojin Yu, Qiuchen Chen, Mingli Sun, Weifan Yao, Haishan Zhao, Feng Jin, Minjie Wei
Int. J. Biol. Sci. 2016; 12(4): 397-408. doi:10.7150/ijbs.13475
[Abstract] [Full text] [PDF]


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Research Paper
Proton-sensing GPCR-YAP Signalling Promotes Cancer-associated Fibroblast Activation of Mesenchymal Stem Cells
Hongyi Zhu, Shangchun Guo, Yuelei Zhang, Junhui Yin, Wenjing Yin, Shicong Tao, Yang Wang, Changqing Zhang
Int. J. Biol. Sci. 2016; 12(4): 389-396. doi:10.7150/ijbs.13688
[Abstract] [Full text] [PDF]


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Research Paper
Targeting Oncogenes into a Defined Subset of Mammary Cells Demonstrates That the Initiating Oncogenic Mutation Defines the Resulting Tumor Phenotype
Kimberly R. Holloway, Vidya C. Sinha, Wen Bu, Michael Toneff, Jie Dong, Yi Peng, Yi Li
Int. J. Biol. Sci. 2016; 12(4): 381-388. doi:10.7150/ijbs.12947
[Abstract] [Full text] [PDF]


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Research Paper
Lyophilized Powder of Catalpol and Puerarin Protects Neurovascular Unit from Stroke
Qiang XUE, Yang LIU, Ran HE, Sheng YANG, Jie TONG, Xu LI, Yi CHEN, Xiaoyu XU
Int. J. Biol. Sci. 2016; 12(4): 367-380. doi:10.7150/ijbs.14059
[Abstract] [Full text] [PDF]


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Review
CPT-cGMP Is A New Ligand of Epithelial Sodium Channels
Hong-Long Ji, Hong-Guang Nie, Yongchang Chang, Qizhou Lian, Shan-Lu Liu
Int. J. Biol. Sci. 2016; 12(4): 359-366. doi:10.7150/ijbs.13764
[Abstract] [Full text] [PDF]


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Research Paper
Vitamin K2 Prevents Glucocorticoid-induced Osteonecrosis of the Femoral Head in Rats
Yue-Lei Zhang, Jun-Hui Yin, Hao Ding, Wei Zhang, Chang-Qing Zhang, You-Shui Gao
Int. J. Biol. Sci. 2016; 12(4): 347-358. doi:10.7150/ijbs.13269
[Abstract] [Full text] [PDF]


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Review
The Significance of Ras Activity in Pancreatic Cancer Initiation
Craig D. Logsdon, Weiqin Lu
Int. J. Biol. Sci. 2016; 12(3): 338-346. doi:10.7150/ijbs.15020
[Abstract] [Full text] [PDF]


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Review
MicroRNA Targeted Therapeutic Approach for Pancreatic Cancer
Yiwei Li, Fazlul H. Sarkar
Int. J. Biol. Sci. 2016; 12(3): 326-337. doi:10.7150/ijbs.15017
[Abstract] [Full text] [PDF]


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Review
Pancreatic Cancer Genetics
Laufey T. Amundadottir
Int. J. Biol. Sci. 2016; 12(3): 314-325. doi:10.7150/ijbs.15001
[Abstract] [Full text] [PDF]


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Review
Neutrophil-Derived Proteases in the Microenvironment of Pancreatic Cancer -Active Players in Tumor Progression
Klaus Felix, Matthias M. Gaida²
Int. J. Biol. Sci. 2016; 12(3): 302-313. doi:10.7150/ijbs.14996
[Abstract] [Full text] [PDF]


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Review
Molecular Biomarkers of Pancreatic Intraepithelial Neoplasia and Their Implications in Early Diagnosis and Therapeutic Intervention of Pancreatic Cancer
Junli Guo, Keping Xie, Shaojiang Zheng
Int. J. Biol. Sci. 2016; 12(3): 292-301. doi:10.7150/ijbs.14995
[Abstract] [Full text] [PDF]


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Review
The Role of Gastrin and CCK Receptors in Pancreatic Cancer and other Malignancies
Jill P. Smith, Lionel K. Fonkoua, Terry W. Moody
Int. J. Biol. Sci. 2016; 12(3): 283-291. doi:10.7150/ijbs.14952
[Abstract] [Full text] [PDF]


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Review
The Landscape of Pancreatic Cancer Therapeutic Resistance Mechanisms
Saswati Chand, Kevin O'Hayer, Fernando F. Blanco, Jordan M. Winter, Jonathan R. Brody
Int. J. Biol. Sci. 2016; 12(3): 273-282. doi:10.7150/ijbs.14951
[Abstract] [Full text] [PDF]


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Editorial
Pancreatic Cancer: Current Progress and Future Challenges
S. Perwez Hussain
Int. J. Biol. Sci. 2016; 12(3): 270-272. doi:10.7150/ijbs.14950
[Abstract] [Full text] [PDF]


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Research Paper
Wheat Transcription Factor TaAREB3 Participates in Drought and Freezing Tolerances in Arabidopsis
Jingyi Wang, Qian Li, Xinguo Mao, Ang Li, Ruilian Jing
Int. J. Biol. Sci. 2016; 12(2): 257-269. doi:10.7150/ijbs.13538
[Abstract] [Full text] [PDF]


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Research Paper
A Group of Novel Serum Diagnostic Biomarkers for Multidrug-Resistant Tuberculosis by iTRAQ-2D LC-MS/MS and Solexa Sequencing
Chong Wang, Chang-Ming Liu, Li-Liang Wei, Li-Ying Shi, Zhi-Fen Pan, Lian-Gen Mao, Xiao-Chen Wan, Ze-Peng Ping, Ting-Ting Jiang, Zhong-Liang Chen, Zhong-Jie Li, Ji-Cheng Li
Int. J. Biol. Sci. 2016; 12(2): 246-256. doi:10.7150/ijbs.13805
[Abstract] [Full text] [PDF]

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