International Journal of Biological Sciences

Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

Impact factor is 4.057 according to 2018 release of Journal Citation Reports®. 5 Year Impact factor is 4.950. Congratulations!
Cover suggestion ...details

Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (full index information)
Full texts of articles in PubMed Central and Europe PMC.
(For NIH-funded researchers) Save time by submitting your paper to us - this journal is in full compliance with NIH Public Access Requirement.

The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details

Top cited papers:

G Chen et al. TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation. Cited by 237
BF Zamarron & W Chen. Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression. Cited by 172
TM Thornton & M Rincon. Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival. Cited by 200
HB Shao et al. Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells. Cited by 247
JK Lunney. Advances in Swine Biomedical Model Genomics. Cited by 255
DP Siderovski & FS Willard. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Cited by 241

Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...

The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details

Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details

Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details

The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details

Research Paper
Exosomes Derived from Hypoxic Colorectal Cancer Cells Transfer Wnt4 to Normoxic Cells to Elicit a Prometastatic Phenotype
Zhe Huang, Mingli Yang, Yunze Li, Fan Yang, Yong Feng
Int. J. Biol. Sci. 2018; 14(14): 2094-2102. doi:10.7150/ijbs.28288
[Abstract] [Full text] [PDF]

Review
Effect of Stromal Cells in Tumor Microenvironment on Metastasis Initiation
Sen Guo, Chu-Xia Deng
Int. J. Biol. Sci. 2018; 14(14): 2083-2093. doi:10.7150/ijbs.25720
[Abstract] [Full text] [PDF]

Research Paper
TRIM59 Is a Novel Marker of Poor Prognosis and Promotes Malignant Progression of Ovarian Cancer by Inducing Annexin A2 Expression
You Wang, Zhicheng Zhou, Xinran Wang, Xuping Zhang, Yansu Chen, Jin Bai, Wen Di
Int. J. Biol. Sci. 2018; 14(14): 2073-2082. doi:10.7150/ijbs.28757
[Abstract] [Full text] [PDF]

Research Paper
Comparison of Prognostic Indices in NSCLC Patients with Brain Metastases after Radiosurgery
Hong Xiang Gao, Shi Gao Huang, Jian Fei Du, Xue Cheng Zhang, Nan Jiang, Wen Xing Kang, Jian Mao, Qi Zhao
Int. J. Biol. Sci. 2018; 14(14): 2065-2072. doi:10.7150/ijbs.28608
[Abstract] [Full text] [PDF]

Research Paper
SRC-3 protects intestine from DSS-induced colitis by inhibiting inflammation and promoting goblet cell differentiation through enhancement of KLF4 expression
Wenbo Chen, Minghui Zhuo, Xuqiang Lu, Xiaochun Xia, Yang Zhao, Zhengrong Huang, Jianming Xu, Weihua Li, Chundong Yu
Int. J. Biol. Sci. 2018; 14(14): 2051-2064. doi:10.7150/ijbs.28576
[Abstract] [Full text] [PDF]

Research Paper
Hepatoprotective effects of limb ischemic post-conditioning in hepatic ischemic rat model and liver cancer patients via PI3K/ERK pathways
Yanfeng Gao, Shuang Zhou, Fengfei Wang, Yue Zhou, Sen Sheng, Dan Qi, Jason H. Huang, Erxi Wu, Yi Lv, Xiongwei Huo
Int. J. Biol. Sci. 2018; 14(14): 2037-2050. doi:10.7150/ijbs.28435
[Abstract] [Full text] [PDF]

Research Paper
The intracellular NADH level regulates atrophic nonunion pathogenesis through the CtBP2-p300-Runx2 transcriptional complex
Wentao Zhang, Ning Duan, Qian Zhang, Tao Song, Zhong Li, Xun Chen, Kunzheng Wang
Int. J. Biol. Sci. 2018; 14(14): 2023-2036. doi:10.7150/ijbs.28302
[Abstract] [Full text] [PDF]

Research Paper
Seven Genes Based Novel Signature Predicts Clinical Outcome and Platinum Sensitivity of High Grade IIIc Serous Ovarian Carcinoma
Gang Liu, Lihua Chen, He Ren, Fei Liu, Chuanpeng Dong, Aosen Wu, Zhenhao Liu, Yu Zheng, Xi Cheng, Lei Liu
Int. J. Biol. Sci. 2018; 14(14): 2012-2022. doi:10.7150/ijbs.28249
[Abstract] [Full text] [PDF]

Review
The roles of Wnt/β-catenin signaling pathway related lncRNAs in cancer
Xiao-Yi Hu, Ping-Fu Hou, Teng-Teng Li, Hao-Yu Quan, Min-Le Li, Tian Lin, Jin-Jin Liu, Jin Bai, Jun-Nian Zheng
Int. J. Biol. Sci. 2018; 14(14): 2003-2011. doi:10.7150/ijbs.27977
[Abstract] [Full text] [PDF]

Research Paper
SAK-HV Promotes RAW264.7 cells Migration Mediated by MCP-1 via JNK and NF-κB Pathways
Yao Chen, Wen-Liang Fu, Xiang-Dong Gan, Wei-Wei Xing, Wen-Rong Xia, Min-Ji Zou, Qing Liu, Yuan-Yuan Wang, Chao Zhang, Dong-Gang Xu
Int. J. Biol. Sci. 2018; 14(14): 1993-2002. doi:10.7150/ijbs.27459
[Abstract] [Full text] [PDF]

Research Paper
Androgen action augments ischemia-induced, bone marrow progenitor cell-mediated vasculogenesis
Yuen Ting Lam, Laura Lecce, Gloria S.C. Yuen, Steven G. Wise, David J. Handelsman, Martin K.C. Ng
Int. J. Biol. Sci. 2018; 14(14): 1985-1992. doi:10.7150/ijbs.27378
[Abstract] [Full text] [PDF]

Research Paper
Nitric oxide prevents H₂O₂-induced apoptosis in SK-N-MC human neuroblastoma cells
Yeong-Min Yoo, Eui-Man Jung, Changhwan Ahn, Eui-Bae Jeung
Int. J. Biol. Sci. 2018; 14(14): 1974-1984. doi:10.7150/ijbs.28050
[Abstract] [Full text] [PDF]

Research Paper
Exosomal Metastasis‑Associated Lung Adenocarcinoma Transcript 1 Promotes Angiogenesis and Predicts Poor Prognosis in Epithelial Ovarian Cancer
Jun-Jun Qiu, Xiao-Jing Lin, Xiao-Yan Tang, Ting-Ting Zheng, Ying-Ying Lin, Ke-Qin Hua
Int. J. Biol. Sci. 2018; 14(14): 1960-1973. doi:10.7150/ijbs.28048
[Abstract] [Full text] [PDF]

Research Paper
Prediction of CircRNA-Disease Associations Using KATZ Model Based on Heterogeneous Networks
Chunyan Fan, Xiujuan Lei, Fang-Xiang Wu
Int. J. Biol. Sci. 2018; 14(14): 1950-1959. doi:10.7150/ijbs.28260
[Abstract] [Full text] [PDF]

Research Paper
A chemosensory protein MsepCSP5 involved in chemoreception of oriental armyworm Mythimna separata
Aneela Younas, Muhammad Irfan Waris, Xiang-Qian Chang, Muhammad Shaaban, Hazem Abdelnabby, Muhammad Tahir ul Qamar, Man-Qun Wang
Int. J. Biol. Sci. 2018; 14(14): 1935-1949. doi:10.7150/ijbs.27315
[Abstract] [Full text] [PDF]

Research Paper
Saikosaponin A Protects From Pressure Overload-Induced Cardiac Fibrosis via Inhibiting Fibroblast Activation or Endothelial Cell EndMT
Yuan Liu, Lu Gao, Xiaoyan Zhao, Sen Guo, Yuzhou Liu, Ran Li, Cui Liang, Ling Li, Jianzeng Dong, Lina Li, Haibo Yang
Int. J. Biol. Sci. 2018; 14(13): 1923-1934. doi:10.7150/ijbs.27022
[Abstract] [Full text] [PDF]

More ...