International Journal of Biological Sciences
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ISSN 1449-2288

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Journal of Genomics now in PubMed/PubMed Central. Submit manuscript...

International Journal of Medical Sciences

Journal of Cancer

Theranostics

Journal of Genomics

PubMed Central Indexed in Journal Impact Factor
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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

new Latest impact factor is 4.509. Congratulations!
new Cover suggestion ...details
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Most Cited Paper Award: Winners of this year are Guiqian Chen et al, for the paper "TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation". Details...
The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details
Top cited papers:
Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...
The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details
Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details
Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details
The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details
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Research Paper
Activation of ER Stress and Autophagy Induced by TDP-43 A315T as Pathogenic Mechanism and the Corresponding Histological Changes in Skin as Potential Biomarker for ALS with the Mutation
Xuejing Wang, Shuang Zhou, Xuebing Ding, Mingming Ma, Jiewen Zhang, Yue Zhou, Erxi Wu, Junfang Teng
Int. J. Biol. Sci. 2015; 11(10): 1140-1149. doi:10.7150/ijbs.12657
[Abstract] [Full text] [PDF]


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Research Paper
Persistence of CD34 Stem Marker in Human Lipoma: Searching for Cancer Stem Cells
Barbara Zavan, Francesco De Francesco, Francesco D'Andrea, Letizia Ferroni, Chiara Gardin, Rosa Salzillo, Gianfranco Nicoletti, Giuseppe A. Ferraro
Int. J. Biol. Sci. 2015; 11(10): 1127-1139. doi:10.7150/ijbs.11946
[Abstract] [Full text] [PDF]


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Research Paper
Norisoboldine, an Anti-Arthritis Alkaloid Isolated from Radix Linderae, Attenuates Osteoclast Differentiation and Inflammatory Bone Erosion in an Aryl Hydrocarbon Receptor-Dependent Manner
Zhi-feng Wei, Qi Lv, Ying Xia, Meng-fan Yue, Can Shi, Yu-feng Xia, Gui-xin Chou, Zheng-tao Wang, Yue Dai
Int. J. Biol. Sci. 2015; 11(9): 1113-1126. doi:10.7150/ijbs.12152
[Abstract] [Full text] [PDF]


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Review
Targeting Apoptosis and Multiple Signaling Pathways with Icariside II in Cancer Cells
Muhammad Khan, Amara Maryam, Javed Iqbal Qazi, Tonghui Ma
Int. J. Biol. Sci. 2015; 11(9): 1100-1112. doi:10.7150/ijbs.11595
[Abstract] [Full text] [PDF]


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Research Paper
The Small Molecule R-(-)-β-O-Methylsynephrine Binds to Nucleoporin 153 kDa and Inhibits Angiogenesis
Nam Hee Kim, Ngoc Bich Pham, Ronald J. Quinn, Joong Sup Shim, Hee Cho, Sung Min Cho, Sung Wook Park, Jeong Hun Kim, Seung Hyeok Seok, Jong-Won Oh, Ho Jeong Kwon
Int. J. Biol. Sci. 2015; 11(9): 1088-1099. doi:10.7150/ijbs.10603
[Abstract] [Full text] [PDF]


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Research Paper
Cathepsin B Cysteine Proteinase is Essential for the Development and Pathogenesis of the Plant Parasitic Nematode Radopholus similis
Yu Li, Ke Wang, Hui Xie, Dong-Wei Wang, Chun-Ling Xu, Xin Huang, Wen-Jia Wu, Dan-Lei Li
Int. J. Biol. Sci. 2015; 11(9): 1073-1087. doi:10.7150/ijbs.12065
[Abstract] [Full text] [PDF]


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Research Paper
Knockout of SRC-1 and SRC-3 in Mice Decreases Cardiomyocyte Proliferation and Causes a Noncompaction Cardiomyopathy Phenotype
Xian Chen, Li Qin, Zhaoliang Liu, Lan Liao, James F. Martin, Jianming Xu
Int. J. Biol. Sci. 2015; 11(9): 1056-1072. doi:10.7150/ijbs.12408
[Abstract] [Full text] [PDF]


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Research Paper
Higher Frequency of Circulating PD-1high CXCR5+CD4+ Tfh Cells in Patients with Chronic Schistosomiasis
Yumei Zhang, Yanyan Jiang, Yanjuan Wang, Hua Liu, Yujuan Shen, Zhongying Yuan, Yuan Hu, Yuxin Xu, Jianping Cao
Int. J. Biol. Sci. 2015; 11(9): 1049-1055. doi:10.7150/ijbs.12023
[Abstract] [Full text] [PDF]


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Research Paper
Identification and Characterization of Candidate Chemosensory Gene Families from Spodoptera exigua Developmental Transcriptomes
Nai-Yong Liu, Ting Zhang, Zhan-Feng Ye, Fei Li, Shuang-Lin Dong
Int. J. Biol. Sci. 2015; 11(9): 1036-1048. doi:10.7150/ijbs.12020
[Abstract] [Full text] [PDF]


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Research Paper
DNA-PKcs Negatively Regulates Cyclin B1 Protein Stability through Facilitating Its Ubiquitination Mediated by Cdh1-APC/C Pathway
Zeng-Fu Shang, Wei Tan, Xiao-Dan Liu, Lan Yu, Bing Li, Ming Li, Man Song, Yu Wang, Bei-Bei Xiao, Cai-Gao Zhong, Hua Guan, Ping-Kun Zhou
Int. J. Biol. Sci. 2015; 11(9): 1026-1035. doi:10.7150/ijbs.12443
[Abstract] [Full text] [PDF]


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Research Paper
Evolutionary History of Cathepsin L (L-like) Family Genes in Vertebrates
Jin Zhou, Yao-Yang Zhang, Qing-Yun Li, Zhong-Hua Cai
Int. J. Biol. Sci. 2015; 11(9): 1016-1025. doi:10.7150/ijbs.11751
[Abstract] [Full text] [PDF]


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Research Paper
Identification and Functional Characterization of Cis-Regulatory Elements Controlling Expression of the Porcine ADRB2 Gene
Alexandra Jaeger, Stephan Fritschka, Siriluck Ponsuksili, Klaus Wimmers, Eduard Muráni
Int. J. Biol. Sci. 2015; 11(9): 1006-1015. doi:10.7150/ijbs.12456
[Abstract] [Full text] [PDF]


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Research Paper
MDC1 Enhances Estrogen Receptor-mediated Transactivation and Contributes to Breast Cancer Suppression
Renlong Zou, Xinping Zhong, Chunyu Wang, Hongmiao Sun, Shengli Wang, Lin Lin, Shiying Sun, Changci Tong, Hao Luo, Peng Gao, Yanshu Li, Tingting Zhou, Da Li, Liu Cao, Yue Zhao
Int. J. Biol. Sci. 2015; 11(9): 992-1005. doi:10.7150/ijbs.10918
[Abstract] [Full text] [PDF]


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Review
Significance of Antioxidant Potential of Plants and its Relevance to Therapeutic Applications
Deepak M. Kasote, Surendra S. Katyare, Mahabaleshwar V. Hegde, Hanhong Bae
Int. J. Biol. Sci. 2015; 11(8): 982-991. doi:10.7150/ijbs.12096
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
The saponin DT-13 Attenuates Tumor Necrosis Factor-α-induced Vascular Inflammation Associated with Src/NF-кB/MAPK Pathway Modulation
Yuanyuan Zhang, Minhui Sun, Yuwei Han, Kefeng Zhai, Youmei Tang, Xiaoying Qin, Zhengyu Cao, Boyang Yu, Junping Kou
Int. J. Biol. Sci. 2015; 11(8): 970-981. doi:10.7150/ijbs.11635
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Exosomal Transfer of Vasorin Expressed in Hepatocellular Carcinoma Cells Promotes Migration of Human Umbilical Vein Endothelial Cells
Aixue Huang, Jie Dong, Shaohua Li, Chaonan Wang, Hongmei Ding, Hui Li, Xueting Su, Xingfeng Ge, Leqiao Sun, Chenjun Bai, Xuelian Shen, Tao Fang, Jie Li, Ningsheng Shao
Int. J. Biol. Sci. 2015; 11(8): 961-969. doi:10.7150/ijbs.11943
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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