International Journal of Biological Sciences
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ISSN 1449-2288

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Theranostics

International Journal of Medical Sciences

Journal of Cancer

Oncomedicine

Journal of Genomics

Journal of Bone and Joint Infection (JBJI)

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Journal of Genomics now in PubMed/PubMed Central. Submit manuscript...

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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

new Latest impact factor is 3.982. 5 year IF is 4.454.
new Cover suggestion ...details
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Most Cited Paper Award: Winners of this year are Yan-Cun Liu, Xian-Biao Zou, Yan-Fen Chai, Yong-Ming Yao, for the paper "Macrophage Polarization in Inflammatory Diseases". Details...
The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details
Top cited papers:
Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...
The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details
Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details
Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details
The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details
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Research Paper
Dipalmitoylphosphatidic acid inhibits tumor growth in triple-negative breast cancer
Qian-Qian Zhang, Jian Chen, Da-Lei Zhou, You-Fa Duan, Cui-Ling Qi, Jiang-Chao Li, Xiao-Dong He, Min Zhang, Yong-Xia Yang, Lijing Wang
Int. J. Biol. Sci. 2017; 13(4): 471-479. doi:10.7150/ijbs.16290
[Abstract] [Full text] [PDF]


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Research Paper
Characterization of Cytosine Methylation and the DNA Methyltransferases of Toxoplasma gondii
Haixia Wei, Shichen Jiang, Longfei Chen, Cheng He, Shuizhen Wu, Hongjuan Peng
Int. J. Biol. Sci. 2017; 13(4): 458-470. doi:10.7150/ijbs.18644
[Abstract] [Full text] [PDF]


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Review
The role of germ cell loss during primordial follicle assembly: a review of current advances
Yuan-Chao Sun, Xiao-Feng Sun, Paul W. Dyce, Wei Shen, Hong Chen
Int. J. Biol. Sci. 2017; 13(4): 449-457. doi:10.7150/ijbs.18836
[Abstract] [Full text] [PDF]


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Research Paper
Estradiol Suppresses TLR4-triggered Apoptosis of Decidual Stromal Cells and Drives an Anti-inflammatory TH2 Shift by Activating SGK1
Yiyun Lou, Minhao Hu, Qijing Wang, Mu Yuan, Ning Wang, Fang Le, Lejun Li, Shisi Huang, Liya Wang, Xiangrong Xu, Fan Jin
Int. J. Biol. Sci. 2017; 13(4): 434-448. doi:10.7150/ijbs.18278
[Abstract] [Full text] [PDF]


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Review
Role of Epigenetics in Uveal Melanoma
Yongyun Li, Renbing Jia, Shengfang Ge
Int. J. Biol. Sci. 2017; 13(4): 426-433. doi:10.7150/ijbs.18331
[Abstract] [Full text] [PDF]


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Research Paper
MiR-696 Regulates C2C12 Cell Proliferation and Differentiation by Targeting CNTFRα
Han Wang, Lei Shi, Tingting Liang, BinBin Wang, WangJun Wu, Guosheng Su, Julong Wei, Pinghua Li, Ruihua Huang
Int. J. Biol. Sci. 2017; 13(4): 413-425. doi:10.7150/ijbs.17508
[Abstract] [Full text] [PDF]


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Review
Photoacoustic-Based Multimodal Nanoprobes: from Constructing to Biological Applications
Duyang Gao, Zhen Yuan
Int. J. Biol. Sci. 2017; 13(4): 401-412. doi:10.7150/ijbs.18750
[Abstract] [Full text] [PDF]


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Research Paper
Novel approaches to vitiligo treatment via modulation of mTOR and NF-κB pathways in human skin melanocytes
Jerry Wan, Fuquan Lin, Wei Zhang, Aie Xu, Joseph DeGiorgis, Hongguang Lu, Yinsheng Wan
Int. J. Biol. Sci. 2017; 13(3): 391-400. doi:10.7150/ijbs.17318
[Abstract] [Full text] [PDF]


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Research Paper
Inhibition of Proteasome Activity Induces Aggregation of IFIT2 in the Centrosome and Enhances IFIT2-Induced Cell Apoptosis
Limin Chen, Shuyuan Liu, Fen Xu, Yunyuan Kong, Lagen Wan, Yonglu zhang, Zhanglin Zhang
Int. J. Biol. Sci. 2017; 13(3): 383-390. doi:10.7150/ijbs.17236
[Abstract] [Full text] [PDF]


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Research Paper
Comparative Mitogenomic Analyses of Praying Mantises (Dictyoptera, Mantodea): Origin and Evolution of Unusual Intergenic Gaps
Hong-Li Zhang, Fei Ye
Int. J. Biol. Sci. 2017; 13(3): 367-382. doi:10.7150/ijbs.17035
[Abstract] [Full text] [PDF]


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Research Paper
PADI4 Epigenetically Suppresses p21 Transcription and Inhibits Cell Apoptosis in Fibroblast-like Synoviocytes from Rheumatoid Arthritis Patients
Lieying Fan, Ming Zong, Ruhan Gong, Dongyi He, Niu Li, Li shan Sun, Qin Ye, Shanshan Yu
Int. J. Biol. Sci. 2017; 13(3): 358-366. doi:10.7150/ijbs.16879
[Abstract] [Full text] [PDF]


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Research Paper
Identification of a novel human long non-coding RNA that regulates hepatic lipid metabolism by inhibiting SREBP-1c
Duan Li, Min Cheng, Yuqiang Niu, Xiaojing Chi, Xiuying Liu, Jingjing Fan, Heng Fan, Yongsheng Chang, Wei Yang
Int. J. Biol. Sci. 2017; 13(3): 349-357. doi:10.7150/ijbs.16635
[Abstract] [Full text] [PDF]


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Review
Small role with big impact: miRNAs as communicators in the cross-talk between cancer-associated fibroblasts and cancer cells
Zhanhuai Wang, Yinuo Tan, Wei Yu, Shu Zheng, Suzhan Zhang, Lifeng Sun, Kefeng Ding
Int. J. Biol. Sci. 2017; 13(3): 339-348. doi:10.7150/ijbs.17680
[Abstract] [Full text] [PDF]


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Research Paper
Lyophilized Powder of Catalpol and Puerarin Protected Cerebral Vessels from Ischemia by Its Anti-apoptosis on Endothelial Cells
Yang Liu, Qing Tang, Siying Shao, Yi Chen, Weihai Chen, Xiaoyu Xu
Int. J. Biol. Sci. 2017; 13(3): 327-338. doi:10.7150/ijbs.17751
[Abstract] [Full text] [PDF]


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Research Paper
Effects of Photodynamic Therapy Using Yellow LED-light with Concomitant Hypocrellin B on Apoptotic Signaling in Keloid Fibroblasts
Yongqing Hu, Chunmin Zhang, Shengli Li, Ya Jiao, Tonggang Qi, Guo Wei, Gangwen Han
Int. J. Biol. Sci. 2017; 13(3): 319-326. doi:10.7150/ijbs.17920
[Abstract] [Full text] [PDF]


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Research Paper
High Production of 2,3-butanediol by a Mutant Strain of the Newly Isolated Klebsiella pneumoniae SRP2 with Increased Tolerance Towards Glycerol
Md. Shafiqur Rahman, Chunbao (Charles) Xu, Kesen Ma, Malaya Nanda, Wensheng Qin
Int. J. Biol. Sci. 2017; 13(3): 308-318. doi:10.7150/ijbs.17594
[Abstract] [Full text] [PDF]

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