Global reach, higher impact
Research Paper
CHL1 suppresses tumor growth and metastasis in nasopharyngeal carcinoma by repressing PI3K/AKT signaling pathway via interaction with Integrin β1 and Merlin
Juan Chen, Chen Jiang, Li Fu, Cai-Lei Zhu, Yan-Qun Xiang, Ling-Xi Jiang, Qian Chen, Wai Man Liu, Jin-Na Chen, Li-Yi Zhang, Ming Liu, Chao Chen, Hong Tang, Bo Wang, Sai Wah Tsao, Dora Lai-Wan Kwong, Xin-Yuan Guan
Int. J. Biol. Sci. 2019; 15(9): 1802-1815. doi:10.7150/ijbs.34785
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Research Paper
SWPepNovo: An Efficient De Novo Peptide Sequencing Tool for Large-scale MS/MS Spectra Analysis
Chuang Li, Kenli Li, Keqin Li, Xianghui Xie, Feng Lin
Int. J. Biol. Sci. 2019; 15(9): 1787-1801. doi:10.7150/ijbs.32142
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Research Paper
Combined Aberrant Expression of NDRG2 and LDHA Predicts Hepatocellular Carcinoma Prognosis and Mediates the Anti-tumor Effect of Gemcitabine
Yan Guo, Xi'an Li, Xiang Sun, Jiancai Wang, Xu Yang, Xin Zhou, Xinping Liu, Wenchao Liu, Jianlin Yuan, Libo Yao, Xia Li, Lan Shen
Int. J. Biol. Sci. 2019; 15(9): 1771-1786. doi:10.7150/ijbs.35094
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Research Paper
Molecular Mechanism for Selective Cytotoxicity towards Cancer Cells of Diselenide-Containing Paclitaxel Nanoparticles
Jing Li, Yue Gu, Wei Zhang, Cui-Yu Bao, Cai-Rong Li, Jing-Yi Zhang, Tao Liu, Shuai Li, Jia-Xi Huang, Zhi-Gang Xie, Shu-Cheng Hua, Ying Wan
Int. J. Biol. Sci. 2019; 15(8): 1755-1770. doi:10.7150/ijbs.34878
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Research Paper
Generation of Tβ4 knock-in Cashmere goat using CRISPR/Cas9
Xiaocong Li, Fei Hao, Xiao Hu, Hui Wang, Bai Dai, Xiao Wang, Hao Liang, Ming Cang, Dongjun Liu
Int. J. Biol. Sci. 2019; 15(8): 1743-1754. doi:10.7150/ijbs.34820
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Research Paper
Inhibition of super enhancer downregulates the expression of KLF5 in basal-like breast cancers
Chuan-Huizi Chen, Nong Yang, Yongchang Zhang, Jiancheng Ding, Wenjuan Zhang, Rong Liu, Wen Liu, Ceshi Chen
Int. J. Biol. Sci. 2019; 15(8): 1733-1742. doi:10.7150/ijbs.35138
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Research Paper
Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2
Wenhui Zhou, Huan Fang, Qiuju Wu, Xinye Wang, Rong Liu, Fubin Li, Ji Xiao, Lin Yuan, Zhongmei Zhou, Junying Ma, Lulu Wang, Weiwei Zhao, Hua You, Jianhua Ju, Jing Feng, Ceshi Chen
Int. J. Biol. Sci. 2019; 15(8): 1723-1732. doi:10.7150/ijbs.35284
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Research Paper
Serum microRNA Signature Is Capable of Early Diagnosis for Non-Small Cell Lung Cancer
Xia Yang, Qiuhong Zhang, Ming Zhang, Wenmei Su, Zhuwen Wang, Yali Li, Jie Zhang, David G. Beer, Shuanying Yang, Guoan Chen
Int. J. Biol. Sci. 2019; 15(8): 1712-1722. doi:10.7150/ijbs.33986
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Research Paper
TLX3 repressed SNAI1-induced epithelial-mesenchymal transition by directly constraining STAT3 phosphorylation and functionally sensitized 5-FU chemotherapy in hepatocellular carcinoma
Cong Wang, Changwei Dou, Yufeng Wang, Zhikui Liu, Lewis Roberts, Xin Zheng
Int. J. Biol. Sci. 2019; 15(8): 1696-1711. doi:10.7150/ijbs.33844
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Research Paper
CXXC5 Mediates P. gingivalis-suppressed Cementoblast Functions Partially via MAPK Signaling Network
Li Ma, Xiaoxuan Wang, Huan Liu, Chenxi Jiang, Haiqing Liao, Shihan Xu, Yi Guo, Zhengguo Cao
Int. J. Biol. Sci. 2019; 15(8): 1685-1695. doi:10.7150/ijbs.35419
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Research Paper
Enhancement of oxaliplatin-induced colon cancer cell apoptosis by alantolactone, a natural product inducer of ROS
Peihai Cao, Yiqun Xia, Wei He, Tingting Zhang, Lin Hong, Peisen Zheng, Xin Shen, Guang Liang, Ri Cui, Peng Zou
Int. J. Biol. Sci. 2019; 15(8): 1676-1684. doi:10.7150/ijbs.35265
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Research Paper
CD44 3'-Untranslated Region Functions as a Competing Endogenous RNA to Enhance NK Sensitivity of Liver Cancer Stem Cell by Regulating ULBP2 Expression
Jun Weng, Xu Han, Kaiyu Liu, Jiong Yang, Shiruo Wei, Yue Zhang, Fanhong Zeng, Yang Li, Li Shen, Yi Gao
Int. J. Biol. Sci. 2019; 15(8): 1664-1675. doi:10.7150/ijbs.35216
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Review
Treatment implications of natural compounds targeting lipid metabolism in nonalcoholic fatty liver disease, obesity and cancer
Can Cheng, Songming Zhuo, Bo Zhang, Xu Zhao, Ying Liu, Chaoliang Liao, Jing Quan, Zhenzhen Li, Ann M. Bode, Ya Cao, Xiangjian Luo
Int. J. Biol. Sci. 2019; 15(8): 1654-1663. doi:10.7150/ijbs.33837
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Research Paper
PERK/eIF-2α/CHOP Pathway Dependent ROS Generation Mediates Butein-induced Non-small-cell Lung Cancer Apoptosis and G2/M Phase Arrest
Shouyin Di, Chongxi Fan, Zhiqiang Ma, Mingyang Li, Kai Guo, Donghui Han, Xiaofei Li, Deguang Mu, Xiaolong Yan
Int. J. Biol. Sci. 2019; 15(8): 1637-1653. doi:10.7150/ijbs.33790
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Research Paper
A Synthetic Light-switchable System based on CRISPR Cas13a Regulates the Expression of LncRNA MALAT1 and Affects the Malignant Phenotype of Bladder Cancer Cells
Fuming Qi, Bo Tan, Fujun Ma, Bo Zhu, Li Zhang, Xiaoyun Liu, Honglei Li, Jinhui Yang, Bo Cheng
Int. J. Biol. Sci. 2019; 15(8): 1630-1636. doi:10.7150/ijbs.33772
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Research Paper
Tripartite Motif 8 Deficiency Relieves Hepatic Ischaemia/reperfusion Injury via TAK1-dependent Signalling Pathways
Qiu Tao, Wang Tianyu, Zhou Jiangqiao, Chen Zhongbao, Ma Xiaoxiong, Zhang Long, Zou Jilin
Int. J. Biol. Sci. 2019; 15(8): 1618-1629. doi:10.7150/ijbs.33323
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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor,
Faculty of Health Sciences, University of Macau
Editor-in-Chief's Profile Impact factor is 4.067 according to 2019 release of Journal Citation Reports®. |
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 Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details |
Top cited papers:
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| The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details |
| Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details |
| Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details |
| In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details |