International Journal of Biological Sciences
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ISSN 1449-2288

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Journal of Genomics now in PubMed/PubMed Central. Submit manuscript...

International Journal of Medical Sciences

Journal of Cancer

Theranostics

Journal of Genomics

Journal of Bone and Joint Infection (JBJI)

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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

new Latest impact factor is 4.509. Congratulations!
new Cover suggestion ...details
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Most Cited Paper Award: Winners of this year are Guiqian Chen et al, for the paper "TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation". Details...
The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details
Top cited papers:
Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...
The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details
Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details
Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details
The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details
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Research Paper
Defective Initiation of Liver Regeneration in Osteopontin-Deficient Mice after Partial Hepatectomy due to Insufficient Activation of IL-6/Stat3 Pathway
Yankai Wen, Dechun Feng, Hailong Wu, Wenjun Liu, Hongjie Li, Fang Wang, Qiang Xia, Wei-Qiang Gao, Xiaoni Kong
Int. J. Biol. Sci. 2015; 11(10): 1236-1247. doi:10.7150/ijbs.12118
[Abstract] [Full text] [PDF]


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Review
DAZ Family Proteins, Key Players for Germ Cell Development
Xia-Fei Fu, Shun-Feng Cheng, Lin-Qing Wang, Shen Yin, Massimo De Felici, Wei Shen
Int. J. Biol. Sci. 2015; 11(10): 1226-1235. doi:10.7150/ijbs.11536
[Abstract] [Full text] [PDF]


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Research Paper
Toxoplasma gondii Rhoptry Protein ROP16 Mediates Partially SH-SY5Y Cells Apoptosis and Cell Cycle Arrest by Directing Ser15/37 Phosphorylation of p53
Shuang Chang, Xiumei Shan, Xingliang Li, Weiwei Fan, Steven Qian Zhang, Jin Zhang, Nan Jiang, Duan Ma, Zuohua Mao
Int. J. Biol. Sci. 2015; 11(10): 1215-1225. doi:10.7150/ijbs.10516
[Abstract] [Full text] [PDF]


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Research Paper
Triterpenoid Saponin W3 from Anemone flaccida Suppresses Osteoclast Differentiation through Inhibiting Activation of MAPKs and NF-κB Pathways
Xiangying Kong, Yue Yang, Wenbin Wu, Hongye Wan, Xiaomin Li, Michun Zhong, Xiaohui Su, Shiwei Jia, Na Lin
Int. J. Biol. Sci. 2015; 11(10): 1204-1214. doi:10.7150/ijbs.12296
[Abstract] [Full text] [PDF]


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Research Paper
Molecular Physiology of an Extra-renal Cl- Uptake Mechanism for Body Fluid Cl- Homeostasis
Yi-Fang Wang, Jia-Jiun Yan, Yung-Che Tseng, Ruo-Dong Chen, Pung-Pung Hwang
Int. J. Biol. Sci. 2015; 11(10): 1190-1203. doi:10.7150/ijbs.11737
[Abstract] [Full text] [PDF]


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Research Paper
Proton-sensing GPCR-YAP Signalling Promotes Cell Proliferation and Survival
Hongyi Zhu, Xiangguo Cheng, Xin Niu, Yuelei Zhang, Junjie Guan, Xiaolin Liu, Shicong Tao, Yang Wang, Changqing Zhang
Int. J. Biol. Sci. 2015; 11(10): 1181-1189. doi:10.7150/ijbs.12500
[Abstract] [Full text] [PDF]


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Research Paper
Effects of Mild Chronic Intermittent Cold Exposure on Rat Organs
Xiaohui Wang, Honglei Che, Wenbin Zhang, Jiye Wang, Tao Ke, Rui Cao, Shanshan Meng, Dan Li, Ouyang Weiming, Jingyuan Chen, Wenjing Luo
Int. J. Biol. Sci. 2015; 11(10): 1171-1180. doi:10.7150/ijbs.12161
[Abstract] [Full text] [PDF]


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Review
Insights into Chemoresistance of Prostate Cancer
Wei Zhang, Yan Meng, Na Liu, Xiao-Fei Wen, Tao Yang
Int. J. Biol. Sci. 2015; 11(10): 1160-1170. doi:10.7150/ijbs.11439
[Abstract] [Full text] [PDF]


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Research Paper
Beneficial Effects of Highly Palatable Food on the Behavioral and Neural Adversities induced by Early Life Stress Experience in Female Rats
Jin Young Kim, Jong-Ho Lee, Doyun Kim, Soung-Min Kim, JaeHyung Koo, Jeong Won Jahng
Int. J. Biol. Sci. 2015; 11(10): 1150-1159. doi:10.7150/ijbs.12044
[Abstract] [Full text] [PDF]


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Research Paper
Activation of ER Stress and Autophagy Induced by TDP-43 A315T as Pathogenic Mechanism and the Corresponding Histological Changes in Skin as Potential Biomarker for ALS with the Mutation
Xuejing Wang, Shuang Zhou, Xuebing Ding, Mingming Ma, Jiewen Zhang, Yue Zhou, Erxi Wu, Junfang Teng
Int. J. Biol. Sci. 2015; 11(10): 1140-1149. doi:10.7150/ijbs.12657
[Abstract] [Full text] [PDF]


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Research Paper
Persistence of CD34 Stem Marker in Human Lipoma: Searching for Cancer Stem Cells
Barbara Zavan, Francesco De Francesco, Francesco D'Andrea, Letizia Ferroni, Chiara Gardin, Rosa Salzillo, Gianfranco Nicoletti, Giuseppe A. Ferraro
Int. J. Biol. Sci. 2015; 11(10): 1127-1139. doi:10.7150/ijbs.11946
[Abstract] [Full text] [PDF]


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Research Paper
Norisoboldine, an Anti-Arthritis Alkaloid Isolated from Radix Linderae, Attenuates Osteoclast Differentiation and Inflammatory Bone Erosion in an Aryl Hydrocarbon Receptor-Dependent Manner
Zhi-feng Wei, Qi Lv, Ying Xia, Meng-fan Yue, Can Shi, Yu-feng Xia, Gui-xin Chou, Zheng-tao Wang, Yue Dai
Int. J. Biol. Sci. 2015; 11(9): 1113-1126. doi:10.7150/ijbs.12152
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Review
Targeting Apoptosis and Multiple Signaling Pathways with Icariside II in Cancer Cells
Muhammad Khan, Amara Maryam, Javed Iqbal Qazi, Tonghui Ma
Int. J. Biol. Sci. 2015; 11(9): 1100-1112. doi:10.7150/ijbs.11595
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
The Small Molecule R-(-)-β-O-Methylsynephrine Binds to Nucleoporin 153 kDa and Inhibits Angiogenesis
Nam Hee Kim, Ngoc Bich Pham, Ronald J. Quinn, Joong Sup Shim, Hee Cho, Sung Min Cho, Sung Wook Park, Jeong Hun Kim, Seung Hyeok Seok, Jong-Won Oh, Ho Jeong Kwon
Int. J. Biol. Sci. 2015; 11(9): 1088-1099. doi:10.7150/ijbs.10603
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Cathepsin B Cysteine Proteinase is Essential for the Development and Pathogenesis of the Plant Parasitic Nematode Radopholus similis
Yu Li, Ke Wang, Hui Xie, Dong-Wei Wang, Chun-Ling Xu, Xin Huang, Wen-Jia Wu, Dan-Lei Li
Int. J. Biol. Sci. 2015; 11(9): 1073-1087. doi:10.7150/ijbs.12065
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Knockout of SRC-1 and SRC-3 in Mice Decreases Cardiomyocyte Proliferation and Causes a Noncompaction Cardiomyopathy Phenotype
Xian Chen, Li Qin, Zhaoliang Liu, Lan Liao, James F. Martin, Jianming Xu
Int. J. Biol. Sci. 2015; 11(9): 1056-1072. doi:10.7150/ijbs.12408
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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