International Journal of Biological Sciences

Impact factor
3.873

ISSN 1449-2288

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Journal of Biomedicinenew

Theranostics

International Journal of Medical Sciences

Journal of Cancer

Oncomedicine

Journal of Genomics

Journal of Bone and Joint Infection (JBJI)

Nanotheranostics

PubMed Central Indexed in Journal Impact Factor
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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

Impact factor is 3.873 (five year impact factor 4.689) according to 2017 release of Journal Citation ReportsĀ®.
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Most Cited Paper Award: Winners of this year are Yan-Cun Liu, Xian-Biao Zou, Yan-Fen Chai, Yong-Ming Yao, for the paper "Macrophage Polarization in Inflammatory Diseases". Details...
Special Issue on Computational Resources and Methods in Biological Sciences. Guest editors:
Prof. Jian Huang, Dr. Hao Lin, Prof. Shaoliang Peng.
The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details
Top cited papers:
Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...
The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details
Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details
Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details
The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details
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Research Paper
Overexpressed circPVT1, a potential new circular RNA biomarker, contributes to doxorubicin and cisplatin resistance of osteosarcoma cells by regulating ABCB1
Zhu Kun-Peng, Ma Xiao-Long, Zhang Chun-Lin
Int. J. Biol. Sci. 2018; 14(3): 321-330. doi:10.7150/ijbs.24360
[Abstract] [Full text] [PDF]


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Research Paper
Environmental adaptation of Acanthamoeba castellanii and Entamoeba histolytica at genome level as seen by comparative genomic analysis
Victoria Shabardina, Tabea Kischka, Hanna Kmita, Yutaka Suzuki, Wojciech Makałowski
Int. J. Biol. Sci. 2018; 14(3): 306-320. doi:10.7150/ijbs.23869
[Abstract] [Full text] [PDF]


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Research Paper
Mycotoxin zearalenone exposure impairs genomic stability of swine follicular granulosa cells in vitro
Xue-Lian Liu, Rui-Ying Wu, Xiao-Feng Sun, Shun-Feng Cheng, Rui-Qian Zhang, Tian-Yu Zhang, Xi-Feng Zhang, Yong Zhao, Wei Shen, Lan Li
Int. J. Biol. Sci. 2018; 14(3): 294-305. doi:10.7150/ijbs.23898
[Abstract] [Full text] [PDF]


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Research Paper
Frizzled7 Promotes Epithelial-to-mesenchymal Transition and Stemness Via Activating Canonical Wnt/β-catenin Pathway in Gastric Cancer
Guanman Li, Qiao Su, Haibo Liu, Dong Wang, Wenhui Zhang, Zhenhai Lu, Yu Chen, Xiaohui Huang, Wen Li, Changhua Zhang, Yulong He, Li Fu, Jiong Bi
Int. J. Biol. Sci. 2018; 14(3): 280-293. doi:10.7150/ijbs.23756
[Abstract] [Full text] [PDF]


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Research Paper
Identification of key genes and pathways in human clear cell renal cell carcinoma (ccRCC) by co-expression analysis
Lushun Yuan, Guang Zeng, Liang Chen, Gang Wang, Xiaolong Wang, Xinyue Cao, Mengxin Lu, Xuefeng Liu, Guofeng Qian, Yu Xiao, Xinghuan Wang
Int. J. Biol. Sci. 2018; 14(3): 266-279. doi:10.7150/ijbs.23574
[Abstract] [Full text] [PDF]


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Research Paper
Instillation of particulate matter 2.5 induced acute lung injury and attenuated the injury recovery in ACE2 knockout mice
Chung-I Lin, Chin-Hung Tsai, Yu-Ling Sun, Wen-Yeh Hsieh, Yi-Chang Lin, Cheng-Yi Chen, Chih-Sheng Lin
Int. J. Biol. Sci. 2018; 14(3): 253-265. doi:10.7150/ijbs.23489
[Abstract] [Full text] [PDF]


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Research Paper
Molecular Networks of Postia placenta Involved in Degradation of Lignocellulosic Biomass Revealed from Metadata Analysis of Open Access Gene Expression Data
Ayyappa Kumar Sista Kameshwar, Wensheng Qin
Int. J. Biol. Sci. 2018; 14(3): 237-252. doi:10.7150/ijbs.22868
[Abstract] [Full text] [PDF]


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Research Paper
MiR-519d suppresses breast cancer tumorigenesis and metastasis via targeting MMP3
Chengling Chu, Xin Liu, Xue Bai, Tong Zhao, Mengxue Wang, Ranchen Xu, Mingqi Li, Yingying Hu, Weihua Li, Lida Yang, Youyou Qin, Meng Yang, Chaoqi Yan, Yong Zhang
Int. J. Biol. Sci. 2018; 14(2): 228-236. doi:10.7150/ijbs.22849
[Abstract] [Full text] [PDF]


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Research Paper
Trichosanthin enhances sensitivity of non-small cell lung cancer (NSCLC) TRAIL-resistance cells
Chengcheng You, Yingming Sun, Shiyu Zhang, Guiliang Tang, Nannan Zhang, Chunyang Li, Xiaoli Tian, Shijing Ma, Yuan Luo, Wenjie Sun, Feng Wang, Xuefeng Liu, Yu Xiao, Yan Gong, Junhong Zhang, Conghua Xie
Int. J. Biol. Sci. 2018; 14(2): 217-227. doi:10.7150/ijbs.22811
[Abstract] [Full text] [PDF]


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Review
Combination Strategies Using EGFR-TKi in NSCLC Therapy: Learning from the Gap between Pre-Clinical Results and Clinical Outcomes
Zheng Yang, Kin Yip Tam
Int. J. Biol. Sci. 2018; 14(2): 204-216. doi:10.7150/ijbs.22955
[Abstract] [Full text] [PDF]


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Review
The Role of G Protein-coupled Receptor Kinases in Cancer
Shan Yu, Litao Sun, Yufei Jiao, Leo Tsz On Lee
Int. J. Biol. Sci. 2018; 14(2): 189-203. doi:10.7150/ijbs.22896
[Abstract] [Full text] [PDF]


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Research Paper
MicroRNA-21-5p mediates TGF-β-regulated fibrogenic activation of spinal fibroblasts and the formation of fibrotic scars after spinal cord injury
Wenzhao Wang, Ronghan Liu, Yanlin Su, Hongfei Li, Wei Xie, Bin Ning
Int. J. Biol. Sci. 2018; 14(2): 178-188. doi:10.7150/ijbs.24074
[Abstract] [Full text] [PDF]


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Research Paper
Loss of p21 promoted tumorigenesis in the background of telomere dysfunctions induced by TRF2 and Wrn deficiency
Xiaoyu Si, Chihao Shao, Jing Li, Shuting Jia, Wenru Tang, Jihong Zhang, Julun Yang, Xiaoming Wu, Ying Luo
Int. J. Biol. Sci. 2018; 14(2): 165-177. doi:10.7150/ijbs.23477
[Abstract] [Full text] [PDF]


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Research Paper
Analysis of early stage osteonecrosis of the human femoral head and the mechanism of femoral head collapse
Cheng Wang, Haoye Meng, Yu Wang, Bin Zhao, Chenyang Zhao, Weijia Sun, Yun Zhu, Bingxing Han, Xueling Yuan, Ruoxi Liu, Xin Wang, Aiyuan Wang, Quanyi Guo, Jiang Peng, Shibi Lu
Int. J. Biol. Sci. 2018; 14(2): 156-164. doi:10.7150/ijbs.18334
[Abstract] [Full text] [PDF]


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Research Paper
NLRP12 Promotes Mouse Neutrophil Differentiation through Regulation of Non-canonical NF-κB and MAPKERK1/2 Signaling
Qian Wang, Furao Liu, Meichao Zhang, Pingting Zhou, Ci Xu, Yanyan Li, Lei Bian, Yuanhua Liu, Yuan Yao, Fei Wang, Yong Fang, Dong Li
Int. J. Biol. Sci. 2018; 14(2): 147-155. doi:10.7150/ijbs.23231
[Abstract] [Full text] [PDF]


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Research Paper
A Prognostic Model Based on Circulating Tumour Cells is Useful for Identifying the Poorest Survival Outcome in Patients with Metastatic Colorectal Cancer
Wen-Chi Chou, Min-Hsien Wu, Pei-Hung Chang, Hung-Chih Hsu, Gwo-jyh Chang, Wen-Kuan Huang, Chiao-En Wu, Jason Chia-Hsun Hsieh
Int. J. Biol. Sci. 2018; 14(2): 137-146. doi:10.7150/ijbs.23182
[Abstract] [Full text] [PDF]

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