International Journal of Biological Sciences

Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

Impact factor is 3.873 (five year impact factor 4.689) according to 2017 release of Journal Citation Reports®.
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Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (full index information)
Full texts of articles in PubMed Central and Europe PMC.
(For NIH-funded researchers) Save time by submitting your paper to us - this journal is in full compliance with NIH Public Access Requirement.

Most Cited Paper Award: Winners of this year are Yan-Cun Liu, Xian-Biao Zou, Yan-Fen Chai, Yong-Ming Yao, for the paper "Macrophage Polarization in Inflammatory Diseases". Details...

Special Issue on Computational Resources and Methods in Biological Sciences. Guest editors:
Prof. Jian Huang, Dr. Hao Lin, Prof. Shaoliang Peng.

The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details

Top cited papers:

G Chen et al. TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation. Cited by 237
BF Zamarron & W Chen. Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression. Cited by 172
TM Thornton & M Rincon. Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival. Cited by 200
HB Shao et al. Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells. Cited by 247
JK Lunney. Advances in Swine Biomedical Model Genomics. Cited by 255
DP Siderovski & FS Willard. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Cited by 241

Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...

The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details

Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details

Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details

The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details

Research Paper
Atg7 inhibits Warburg effect by suppressing PKM2 phosphorylation resulting reduced epithelial-mesenchymal transition
Yanling Feng, Jingwei Liu, Wendong Guo, Yi Guan, Hongde Xu, Qiqiang Guo, Xiaoyu Song, Fei Yi, Ting Liu, Wenyu Zhang, Xiang Dong, Longyue L. Cao, Brian P. O'Rourke, Liu Cao
Int. J. Biol. Sci. 2018; 14(7): 775-783. doi:10.7150/ijbs.26077
[Abstract] [Full text] [PDF]

Research Paper
miR-487b-3p Suppresses the Proliferation and Differentiation of Myoblasts by Targeting IRS1 in Skeletal Muscle Myogenesis
Jian Wang, Jiaoyan Tan, Qi Qi, Lingzhi Yang, Yanhong Wang, Chunlei Zhang, Linyong Hu, Hong Chen, Xingtang Fang
Int. J. Biol. Sci. 2018; 14(7): 760-774. doi:10.7150/ijbs.25052
[Abstract] [Full text] [PDF]

Research Paper
Activation of Central Alpha 7 Nicotinic Acetylcholine Receptor Reverses Suppressed Immune Function of T Lymphocytes and Protects Against Sepsis Lethality
Chao Ren, Xiu-hua Li, Shi-bin Wang, Li-xue Wang, Ning Dong, Yao Wu, Yong-ming Yao
Int. J. Biol. Sci. 2018; 14(7): 748-759. doi:10.7150/ijbs.24576
[Abstract] [Full text] [PDF]

Research Paper
Improvement of Animal Feed Additives of Ginkgo Leaves through Solid-state Fermentation using Aspergillus niger
Jiahong Wang, Fuliang Cao, Erzheng Su, Linguo Zhao, Wensheng Qin
Int. J. Biol. Sci. 2018; 14(7): 736-747. doi:10.7150/ijbs.24523
[Abstract] [Full text] [PDF]

Research Paper
FBW7 suppresses metastasis of colorectal cancer by inhibiting HIF1α/CEACAM5 functional axis
Qingguo Li, Yaqi Li, Jing Li, Yanlei Ma, Weixing Dai, Shaobo Mo, Ye Xu, Xinxiang Li, Sanjun Cai
Int. J. Biol. Sci. 2018; 14(7): 726-735. doi:10.7150/ijbs.24505
[Abstract] [Full text] [PDF]

Research Paper
The prevalence of autism spectrum disorders in China: a comprehensive meta-analysis
Fei Wang, Li Lu, Shi-Bin Wang, Ling Zhang, Chee H. Ng, Gabor S. Ungvari, Xiao-Lan Cao, Jian-Ping Lu, Cai-Lan Hou, Fu-Jun Jia, Yu-Tao Xiang
Int. J. Biol. Sci. 2018; 14(7): 717-725. doi:10.7150/ijbs.24063
[Abstract] [Full text] [PDF]

Research Paper
Eaf1 and Eaf2 mediate zebrafish dorsal-ventral axis patterning via suppressing Wnt/β-Catenin activity
Jing-Xia Liu, Qin-Han Xu, XueDong Yu, Ting Zhang, XunWei Xie, Gang Ouyang
Int. J. Biol. Sci. 2018; 14(7): 705-716. doi:10.7150/ijbs.18997
[Abstract] [Full text] [PDF]

Research Paper
Dentinal mineralization is not limited in the mineralization front but occurs along with the entire odontoblast process
C. Li, Y. Jing, K. Wang, Y. Ren, X. Liu, X. Wang, Z. Wang, H. Zhao, J.Q. Feng
Int. J. Biol. Sci. 2018; 14(7): 693-704. doi:10.7150/ijbs.25712
[Abstract] [Full text] [PDF]

Research Paper
Berberine suppresses apoptosis and extracellular matrix (ECM) degradation in nucleus pulposus cells and ameliorates disc degeneration in a rodent model
Yu Chen, Zengming Zheng, Jianle Wang, Chengxuan Tang, Sinan Khor, Jian Chen, Xibang Chen, Zengjie Zhang, Qian Tang, Chenggui Wang, Yiting Lou, Zhouguang Wang, Jian Xiao, Xiangyang Wang
Int. J. Biol. Sci. 2018; 14(6): 682-692. doi:10.7150/ijbs.24081
[Abstract] [Full text] [PDF]

Research Paper
VRTN is Required for the Development of Thoracic Vertebrae in Mammals
Yanyu Duan, Hui Zhang, Zhen Zhang, Jun Gao, Jie Yang, Zhongping Wu, Yin Fan, Yuyun Xing, Lin Li, Shijun Xiao, Yong Hou, Jun Ren, Lusheng Huang
Int. J. Biol. Sci. 2018; 14(6): 667-681. doi:10.7150/ijbs.23815
[Abstract] [Full text] [PDF]

Research Paper
Incorporation of DDR2 clusters into collagen matrix via integrin-dependent posterior remnant tethering
Tingting Li, Jin'e Liu, Hao Cai, Baomei Wang, Yunfeng Feng, Jun Liu
Int. J. Biol. Sci. 2018; 14(6): 654-666. doi:10.7150/ijbs.24765
[Abstract] [Full text] [PDF]

Research Paper
MiR-152-5p as a microRNA passenger strand special functions in human gastric cancer cells
Wendao You, Xing Zhang, Mengyue Ji, Yang Yu, Chen Chen, Yujia Xiong, Yiting Liu, Yibin Sun, Chenhuan Tan, Hanshuo Zhang, Jie Li, Weichang Chen, Rui Li
Int. J. Biol. Sci. 2018; 14(6): 644-653. doi:10.7150/ijbs.25272
[Abstract] [Full text] [PDF]

Review
Salivary Exosomes: Emerging Roles in Systemic Disease
Yineng Han, Lingfei Jia, Yunfei Zheng, Weiran Li
Int. J. Biol. Sci. 2018; 14(6): 633-643. doi:10.7150/ijbs.25018
[Abstract] [Full text] [PDF]

Research Paper
miR-433 inhibits breast cancer cell growth via the MAPK signaling pathway by targeting Rap1a
Tao Zhang, Kangfeng Jiang, Xinying Zhu, Gan Zhao, Haichong Wu, Ganzhen Deng, Changwei Qiu
Int. J. Biol. Sci. 2018; 14(6): 622-632. doi:10.7150/ijbs.24223
[Abstract] [Full text] [PDF]

Review
Role of DKK4 in Tumorigenesis and Tumor Progression
Xinjia Cai, Zhigang Yao, Long Li, Junhui Huang
Int. J. Biol. Sci. 2018; 14(6): 616-621. doi:10.7150/ijbs.24329
[Abstract] [Full text] [PDF]

Research Paper
Screening of multimeric β-xylosidases from the gut microbiome of a higher termite, Globitermes brachycerastes
Chunyan Liu, Gen Zou, Xing Yan, Xuguo Zhou
Int. J. Biol. Sci. 2018; 14(6): 608-615. doi:10.7150/ijbs.22763
[Abstract] [Full text] [PDF]

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