International Journal of Biological Sciences
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ISSN 1449-2288

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Journal of Biomedicinenew

Theranostics

International Journal of Medical Sciences

Journal of Cancer

Oncomedicine

Journal of Genomics

Journal of Bone and Joint Infection (JBJI)

Nanotheranostics

PubMed Central Indexed in Journal Impact Factor
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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

new Latest impact factor is 3.982. 5 year IF is 4.454.
new Cover suggestion ...details
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Most Cited Paper Award: Winners of this year are Zhi-Yuan Xu et al, for the paper "Knockdown of Long Non-coding RNA HOTAIR Suppresses Tumor Invasion and Reverses Epithelial-mesenchymal Transition in Gastric Cancer". Details...
The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details
Top cited papers:
Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...
The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details
Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details
Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details
The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details
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Review
Epithelial Sodium Channels in Pulmonary Epithelial Progenitor and Stem Cells
Yang Liu, Bi-Jie Jiang, Run-Zhen Zhao, Hong-Long Ji
Int. J. Biol. Sci. 2016; 12(9): 1150-1154. doi:10.7150/ijbs.15747
[Abstract] [Full text] [PDF]


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Research Paper
The Overexpression of TDP-43 Protein in the Neuron and Oligodendrocyte Cells Causes the Progressive Motor Neuron Degeneration in the SOD1 G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
Yi Lu, Chunyan Tang, Lei Zhu, Jiao Li, Huiting Liang, Jie Zhang, Renshi Xu
Int. J. Biol. Sci. 2016; 12(9): 1140-1149. doi:10.7150/ijbs.15938
[Abstract] [Full text] [PDF]


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Research Paper
Selection of Reference Genes for Expression Studies of Xenobiotic Adaptation in Tetranychus urticae
Mariany Ashanty Morales, Bianca Marie Mendoza, Laura Corley Lavine, Mark Daniel Lavine, Douglas Bruce Walsh, Fang Zhu
Int. J. Biol. Sci. 2016; 12(9): 1129-1139. doi:10.7150/ijbs.16319
[Abstract] [Full text] [PDF]


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Review
Role of Osteopontin in Liver Diseases
Yankai Wen, Seogsong Jeong, Qiang Xia, Xiaoni Kong
Int. J. Biol. Sci. 2016; 12(9): 1121-1128. doi:10.7150/ijbs.16445
[Abstract] [Full text] [PDF]


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Research Paper
Novel FOXC2 Mutation in Hereditary Distichiasis Impairs DNA-Binding Activity and Transcriptional Activation
Leilei Zhang, Jie He, Bing Han, Linna Lu, Jiayan Fan, He Zhang, Shengfang Ge, Yixiong Zhou, Renbing Jia, Xianqun Fan
Int. J. Biol. Sci. 2016; 12(9): 1114-1120. doi:10.7150/ijbs.13774
[Abstract] [Full text] [PDF]


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Research Paper
An Effective Molecular Target Site in Hepatitis B Virus S Gene for Cas9 Cleavage and Mutational Inactivation
Hao Li, Chunyu Sheng, Hongbo Liu, Guangze Liu, Xinying Du, Juan Du, Linsheng Zhan, Peng Li, Chaojie Yang, Lihua Qi, Jian Wang, Xiaoxia Yang, Leili Jia, Jing Xie, Ligui Wang, Rongzhang Hao, Dongping Xu, Yigang Tong, Yusen Zhou, Jianjun Zhou, Yansong Sun, Qiao Li, Shaofu Qiu, Hongbin Song
Int. J. Biol. Sci. 2016; 12(9): 1104-1113. doi:10.7150/ijbs.16064
[Abstract] [Full text] [PDF]


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Research Paper
Cooperation of Doxycycline with Phytochemicals and Micronutrients Against Active and Persistent Forms of Borrelia sp
Anna Goc, Alexandra Niedzwiecki, Matthias Rath
Int. J. Biol. Sci. 2016; 12(9): 1093-1103. doi:10.7150/ijbs.16060
[Abstract] [Full text] [PDF]


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Review
Cytoskeleton Molecular Motors: Structures and Their Functions in Neuron
Qingpin Xiao, Xiaohui Hu, Zhiyi Wei, Kin Yip Tam
Int. J. Biol. Sci. 2016; 12(9): 1083-1092. doi:10.7150/ijbs.15633
[Abstract] [Full text] [PDF]


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Research Paper
Analysis of PBase Binding Profile Indicates an Insertion Target Selection Mechanism Dependent on TTAA, But Not Transcriptional Activity
Dong Yang, Ruiqi Liao, Yun Zheng, Ling Sun, Tian Xu
Int. J. Biol. Sci. 2016; 12(9): 1074-1082. doi:10.7150/ijbs.15589
[Abstract] [Full text] [PDF]


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Research Paper
Gamma-secretase Inhibitor Prevents Proliferation and Migration of Ductus Arteriosus Smooth Muscle Cells through the Notch3-HES1/2/5 Pathway
Jiunn-Ren Wu, Jwu-Lai Yeh, Shu-Fen Liou, Zen-Kong Dai, Bin-Nan Wu, Jong-Hau Hsu
Int. J. Biol. Sci. 2016; 12(9): 1063-1073. doi:10.7150/ijbs.16430
[Abstract] [Full text] [PDF]


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Research Paper
Alcohol Increases Liver Progenitor Populations and Induces Disease Phenotypes in Human IPSC-Derived Mature Stage Hepatic Cells
Lipeng Tian, Abhijeet Deshmukh, Neha Prasad, Yoon-Young Jang
Int. J. Biol. Sci. 2016; 12(9): 1052-1062. doi:10.7150/ijbs.15811
[Abstract] [Full text] [PDF]


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Research Paper
Multiple Growth Factors, But Not VEGF, Stimulate Glycosaminoglycan Hyperelongation in Retinal Choroidal Endothelial Cells
Othman Al Gwairi, Narin Osman, Robel Getachew, Wenhua Zheng, X-L. Liang, Danielle Kamato, Lyna Thach, Peter J. Little
Int. J. Biol. Sci. 2016; 12(8): 1041-1051. doi:10.7150/ijbs.16134
[Abstract] [Full text] [PDF]


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Research Paper
Rapamycin Reduced Ischemic Brain Damage in Diabetic Animals Is Associated with Suppressions of mTOR and ERK1/2 Signaling
Ping Liu, Xiao Yang, Changchun Hei, Yvonne Meli, Jianguo Niu, Tao Sun, P. Andy Li
Int. J. Biol. Sci. 2016; 12(8): 1032-1040. doi:10.7150/ijbs.15624
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Review
A Review of Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer
Yi Li, Ji Wang, Xiaowei Ma, Li Tan, Yanli Yan, Chaofan Xue, Beina Hui, Rui Liu, Hailin Ma, Juan Ren
Int. J. Biol. Sci. 2016; 12(8): 1022-1031. doi:10.7150/ijbs.15438
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Cis-Natural Antisense Transcripts Are Mainly Co-expressed with Their Sense Transcripts and Primarily Related to Energy Metabolic Pathways during Muscle Development
Yunxia Zhao, Ye Hou, Changzhi Zhao, Fei Liu, Yu Luan, Lu Jing, Xinyun Li, Mengjin Zhu, Shuhong Zhao
Int. J. Biol. Sci. 2016; 12(8): 1010-1021. doi:10.7150/ijbs.14825
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Carbon Monoxide Improves Neurologic Outcomes by Mitochondrial Biogenesis after Global Cerebral Ischemia Induced by Cardiac Arrest in Rats
Peng Wang, Lan Yao, Li-li Zhou, Yuan-shan Liu, Ming-di Chen, Hai-dong Wu, Rui-ming Chang, Yi Li, Ming-gen Zhou, Xiang-shao Fang, Tao Yu, Long-yuan Jiang, Zi-tong Huang
Int. J. Biol. Sci. 2016; 12(8): 1000-1009. doi:10.7150/ijbs.13222
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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