International Journal of Biological Sciences

Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

Impact factor is 4.057 according to 2018 release of Journal Citation Reports®. 5 Year Impact factor is 4.950. Congratulations!
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Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (full index information)
Full texts of articles in PubMed Central and Europe PMC.
(For NIH-funded researchers) Save time by submitting your paper to us - this journal is in full compliance with NIH Public Access Requirement.

Most Cited Paper Award: Winners of this year are Yan-Cun Liu, Xian-Biao Zou, Yan-Fen Chai, Yong-Ming Yao, for the paper "Macrophage Polarization in Inflammatory Diseases". Details...

Special Issue on Computational Resources and Methods in Biological Sciences. Guest editors:
Prof. Jian Huang, Dr. Hao Lin, Prof. Shaoliang Peng.

The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details

Top cited papers:

G Chen et al. TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation. Cited by 237
BF Zamarron & W Chen. Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression. Cited by 172
TM Thornton & M Rincon. Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival. Cited by 200
HB Shao et al. Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells. Cited by 247
JK Lunney. Advances in Swine Biomedical Model Genomics. Cited by 255
DP Siderovski & FS Willard. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Cited by 241

Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...

The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details

Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details

Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details

The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details

Research Paper
Alcohol accumulation promotes esophagitis via pyroptosis activation
Fengjiao Wang, Gang Li, Jinfeng Ning, Lantao Chen, Hai Xu, Xianglong Kong, Jianlong Bu, Weiwei Zhao, Zhengtian Li, Xiuyun Wang, Xiaoguang Li, Jianqun Ma
Int. J. Biol. Sci. 2018; 14(10): 1245-1255. doi:10.7150/ijbs.24347
[Abstract] [Full text] [PDF]

Review
Review of Drug Repositioning Approaches and Resources
Hanqing Xue, Jie Li, Haozhe Xie, Yadong Wang
Int. J. Biol. Sci. 2018; 14(10): 1232-1244. doi:10.7150/ijbs.24612
[Abstract] [Full text] [PDF]

Research Paper
Simultaneously targeting DNA damage repair pathway and mTORC1/2 results in small cell lung cancer growth arrest via ER stress-induced apoptosis
Bin Fang, Aarthi Kannan, Tao Guo, Ling Gao
Int. J. Biol. Sci. 2018; 14(10): 1221-1231. doi:10.7150/ijbs.25488
[Abstract] [Full text] [PDF]

Research Paper
Adapted HCV JFH1 variant is capable of accommodating a large foreign gene insert and allows lower level HCV replication and viral production
Qi Wang, Curt Hagedorn, Shuanghu Liu
Int. J. Biol. Sci. 2018; 14(10): 1211-1220. doi:10.7150/ijbs.27411
[Abstract] [Full text] [PDF]

Research Paper
Scalable Generation of Mesenchymal Stem Cells from Human Embryonic Stem Cells in 3D
Li Yan, Bin Jiang, Enqin Li, Xiaoyan Wang, Qinjie Ling, Dejin Zheng, Jung Woo Park, Xin Chen, Edwin Cheung, Xin Du, Yingcui Li, Gregory Cheng, Erxing He, Ren-He Xu
Int. J. Biol. Sci. 2018; 14(10): 1196-1210. doi:10.7150/ijbs.25023
[Abstract] [Full text] [PDF]

Research Paper
Hepatic Ischemic Preconditioning Alleviates Ischemia-Reperfusion Injury by Decreasing TIM4 Expression
Yu Zhang, Qiang Shen, Yuanxing Liu, Hui Chen, Xiaoxiao Zheng, Shangzhi Xie, Haofeng Ji, Shusen Zheng
Int. J. Biol. Sci. 2018; 14(10): 1186-1195. doi:10.7150/ijbs.24898
[Abstract] [Full text] [PDF]

Research Paper
Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking
Junfang Lyu, Eun Ju Yang, Sarah A. Head, Nana Ai, Baoyuan Zhang, Changjie Wu, Ruo-Jing Li, Yifan Liu, Harapriya Chakravarty, Shaolin Zhang, Kin Yip Tam, Yongjun Dang, Ho Jeong Kwon, Wei Ge, Jun O. Liu, Joong Sup Shim
Int. J. Biol. Sci. 2018; 14(10): 1175-1185. doi:10.7150/ijbs.26011
[Abstract] [Full text] [PDF]

Research Paper
Topical Application of Tat-Rac1 Promotes Cutaneous Wound Healing in Normal and Diabetic Mice
Bin Fan, Tao Wang, Li Bian, Zhe Jian, Dongyan D. Wang, Fulun Li, Fanglong Wu, Tao Bai, Gongyi Zhang, Nik Muller, Barry Holwerda, Gangwen Han, Xiao-Jing Wang
Int. J. Biol. Sci. 2018; 14(10): 1163-1174. doi:10.7150/ijbs.25920
[Abstract] [Full text] [PDF]

Research Paper
Combined Effects of PVT1 and MiR-146a Single Nucleotide Polymorphism on the Lung Function of Smokers with Chronic Obstructive Pulmonary Disease
Sijing Zhou, Yi Liu, Min Li, Peipei Wu, Gengyun Sun, Guanghe Fei, Xuan Xu, Xuexin Zhou, Luqian Zhou, Ran Wang
Int. J. Biol. Sci. 2018; 14(10): 1153-1162. doi:10.7150/ijbs.25420
[Abstract] [Full text] [PDF]

Research Paper
An investigation of the distribution and location of mast cells affected by the stiffness of substrates as a mechanical niche
Hong-Wei Yang, Xin-Yue Liu, Zhou-Feng Shen, Wei Yao, Xiao-Bo Gong, Hua-Xiong Huang, Guang-Hong Ding
Int. J. Biol. Sci. 2018; 14(9): 1142-1152. doi:10.7150/ijbs.26738
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
Non-coding RNA-linked epigenetic regulation in cardiac hypertrophy
Yanhan Dong, Sheng Xu, Jing Liu, Murugavel Ponnusamy, Yanfang Zhao, Yanhui Zhang, Qi Wang, Peifeng Li, Kun Wang
Int. J. Biol. Sci. 2018; 14(9): 1133-1141. doi:10.7150/ijbs.26215
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
KDM5B demethylates H3K4 to recruit XRCC1 and promote chemoresistance
Wenxia Xu, Bingluo Zhou, Xiaoya Zhao, Liyuan Zhu, Jinye Xu, Zhinong Jiang, Dingwei Chen, Qi Wei, Mengjiao Han, Lifeng Feng, Shouyu Wang, Xian Wang, Jianwei Zhou, Hongchuan Jin
Int. J. Biol. Sci. 2018; 14(9): 1122-1132. doi:10.7150/ijbs.25881
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Apoptosis Induction by Iron Radiation via Inhibition of Autophagy in Trp53^+/- Mouse Testes: Is Chronic Restraint-Induced Stress a Modifying Factor?
Hongyan Li, Bing Wang, Hong Zhang, Takanori Katsube, Yi Xie, Lu Gan
Int. J. Biol. Sci. 2018; 14(9): 1109-1121. doi:10.7150/ijbs.22805
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Zika Virus Envelope Protein induces G2/M Cell Cycle Arrest and Apoptosis via an Intrinsic Cell Death Signaling Pathway in Neuroendocrine PC12 Cells
Jun Liu, Qingqing Li, Xiaoxin Li, Zhenzhen Qiu, Andrew Li, Wenhan Liang, Huangyao Chen, Xiangsheng Cai, Xinglu Chen, Xinyue Duan, Jingjing Li, Wangsheng Wu, Mingyu Xu, Yingying Mao, Huiying Chen, Jinlong Li, Weiwang Gu, Hongwei Li
Int. J. Biol. Sci. 2018; 14(9): 1099-1108. doi:10.7150/ijbs.26400
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
The Nrf2 Signaling in Retinal Ganglion Cells under Oxidative Stress in Ocular Neurodegenerative Diseases
Xiu-Fen Liu, Dan-Dan Zhou, Tian Xie, Ji-Long Hao, Tayyab Hamid Malik, Cheng-Bo Lu, Jing Qi, Om Prakash Pant, Cheng-Wei Lu
Int. J. Biol. Sci. 2018; 14(9): 1090-1098. doi:10.7150/ijbs.25996
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Phosphorylation of SMC1A promotes hepatocellular carcinoma cell proliferation and migration
Ying Zhang, Fei Yi, Liang Wang, Zhuo Wang, Naijin Zhang, Zhijun Wang, Ziwei Li, Xiaoyu Song, Shi Wei, Liu Cao
Int. J. Biol. Sci. 2018; 14(9): 1081-1089. doi:10.7150/ijbs.24692
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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