International Journal of Biological Sciences
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ISSN 1449-2288

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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

new Latest impact factor is 4.372. Congratulations!
new Cover suggestion ...details
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Most Cited Paper Award: Winners of this year are Guiqian Chen et al, for the paper "TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation". Details...
The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details
Top cited papers:
Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...
The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details
Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details
Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details
The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details
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Research Paper
Brain-Derived Neurotrophic Factor Regulates TRPC3/6 Channels and Protects Against Myocardial Infarction in Rodents
Pengzhou Hang, Jing Zhao, Benzhi Cai, Shanshan Tian, Wei Huang, Jing Guo, Chuan Sun, Yue Li, Zhimin Du
Int. J. Biol. Sci. 2015; 11(5): 536-545. doi:10.7150/ijbs.10754
[Abstract] [Full text] [PDF]


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Research Paper
NOD2 is Involved in the Inflammatory Response after Cerebral Ischemia-Reperfusion Injury and Triggers NADPH Oxidase 2-Derived Reactive Oxygen Species
Huiqing Liu, Xinbing Wei, Lingjun Kong, Xiaoqian Liu, Li Cheng, Shi Yan, Xiumei Zhang, Lin Chen
Int. J. Biol. Sci. 2015; 11(5): 525-535. doi:10.7150/ijbs.10927
[Abstract] [Full text] [PDF]


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Review
Modulation of Glucose Transporter Protein by Dietary Flavonoids in Type 2 Diabetes Mellitus
Fatemeh Hajiaghaalipour, Manizheh Khalilpourfarshbafi, Aditya Arya
Int. J. Biol. Sci. 2015; 11(5): 508-524. doi:10.7150/ijbs.11241
[Abstract] [Full text] [PDF]


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Research Paper
The Histone H3K9 Demethylase Kdm3b Is Required for Somatic Growth and Female Reproductive Function
Zhaoliang Liu, Xian Chen, Suoling Zhou, Lan Liao, Rui Jiang, Jianming Xu
Int. J. Biol. Sci. 2015; 11(5): 494-507. doi:10.7150/ijbs.11849
[Abstract] [Full text] [PDF]


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Research Paper
Activation of TLR3 Induces Osteogenic Responses in Human Aortic Valve Interstitial Cells through the NF-κB and ERK1/2 Pathways
Qiong Zhan, Rui Song, Qingchun Zeng, Qingzhou Yao, Lihua Ao, Dingli Xu, David A. Fullerton, Xianzhong Meng
Int. J. Biol. Sci. 2015; 11(4): 482-493. doi:10.7150/ijbs.10905
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Stem Cell Transplantation Upregulates Sirt1 and Antioxidant Expression, Ameliorating Fatty Liver in Type 2 Diabetic Mice
Ming Li, Kequan Guo, Luca Vanella, Shigeru Taketani, Yasushi Adachi, Susumu Ikehara
Int. J. Biol. Sci. 2015; 11(4): 472-481. doi:10.7150/ijbs.10809
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Hints for Metal-Preference Protein Sequence Determinants: Different Metal Binding Features of the Five Tetrahymena thermophila Metallothioneins
Anna Espart, Maribel Marín, Selene Gil-Moreno, Òscar Palacios, Francisco Amaro, Ana Martín-González, Juan C. Gutiérrez, Mercè Capdevila, Sílvia Atrian
Int. J. Biol. Sci. 2015; 11(4): 456-471. doi:10.7150/ijbs.11060
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Review
Signal Transducer and Activator of Transcription 4 in Liver Diseases
Yan Wang, Aijuan Qu, Hua Wang
Int. J. Biol. Sci. 2015; 11(4): 448-455. doi:10.7150/ijbs.11164
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Tetratricopeptide Repeat Domain 9A Negatively Regulates Estrogen Receptor Alpha Activity
Smeeta Shrestha, Yang Sun, Thomas Lufkin, Petra Kraus, Yuzuan Or, Yenni A. Garcia, Naihsuan Guy, Paola Ramos, Marc B. Cox, Fiona Tay, Valerie CL Lin
Int. J. Biol. Sci. 2015; 11(4): 434-447. doi:10.7150/ijbs.9311
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Biased Signaling in Naturally Occurring Mutations in Human Melanocortin-3 Receptor Gene
Fan Yang, Hui Huang, Ya-Xiong Tao
Int. J. Biol. Sci. 2015; 11(4): 423-433. doi:10.7150/ijbs.11032
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
MEK Inhibitor PD-0325901 Overcomes Resistance to CK2 Inhibitor CX-4945 and Exhibits Anti-Tumor Activity in Head and Neck Cancer
Yansong Bian, Jiawei Han, Vishnu Kannabiran, Suresh Mohan, Hui Cheng, Jay Friedman, Luo Zhang, Carter VanWaes, Zhong Chen
Int. J. Biol. Sci. 2015; 11(4): 411-422. doi:10.7150/ijbs.10745
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Short Research Communication
Identification of Novel Focal Adhesion Kinase Substrates: Role for FAK in NFκB Signaling
Sheila Figel Dwyer, Lingqiu Gao, Irwin H. Gelman
Int. J. Biol. Sci. 2015; 11(4): 404-410. doi:10.7150/ijbs.10273
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
MicroRNA-23a Participates in Estrogen Deficiency Induced Gap Junction Remodeling of Rats by Targeting GJA1
Ning Wang, Lu-Yao Sun, Shou-Chen Zhang, Ran Wei, Fang Xie, Jing Liu, Yan Yan, Ming-Jing Duan, Lin-Lin Sun, Ying-Hui Sun, Hui-Fang Niu, Rong Zhang, Jing Ai
Int. J. Biol. Sci. 2015; 11(4): 390-403. doi:10.7150/ijbs.10930
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Review
Lethal (2) Giant Larvae: An Indispensable Regulator of Cell Polarity and Cancer Development
Fang Cao, Yi Miao, Kedong Xu, Peijun Liu
Int. J. Biol. Sci. 2015; 11(4): 380-389. doi:10.7150/ijbs.11243
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Caveolin-1 is a Modulator of Fibroblast Activation and a Potential Biomarker for Gastric Cancer
Xiao-Jun Shen, Hao Zhang, Gu-Sheng Tang, Xu-Dong Wang, Rui Zheng, Yang Wang, Yan Zhu, Xu-Chao Xue, Jian-Wei Bi
Int. J. Biol. Sci. 2015; 11(4): 370-379. doi:10.7150/ijbs.10666
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
PKD1 Mono-Allelic Knockout Is Sufficient to Trigger Renal Cystogenesis in a Mini-Pig Model
Jin He, Qiuyan Li, Suyun Fang, Ying Guo, Tongxin Liu, Jianhua Ye, Zhengquan Yu, Ran Zhang, Yaofeng Zhao, Xiaoxiang Hu, Xueyuan Bai, Xiangmei Chen, Ning Li
Int. J. Biol. Sci. 2015; 11(4): 361-369. doi:10.7150/ijbs.10858
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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