International Journal of Biological Sciences
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ISSN 1449-2288

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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

new Latest impact factor is 4.372. Congratulations!
new Cover suggestion ...details
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Most Cited Paper Award: Winners of this year are Guiqian Chen et al, for the paper "TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation". Details...
The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details
Top cited papers:
Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...
The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details
Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details
Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details
The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details
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Research Paper
Valproate Attenuates 25-kDa C-Terminal Fragment of TDP-43-Induced Neuronal Toxicity via Suppressing Endoplasmic Reticulum Stress and Activating Autophagy
Xuejing Wang, Mingming Ma, Junfang Teng, Xiangqian Che, Wenwen Zhang, Shuman Feng, Shuang Zhou, Ying Zhang, Erxi Wu, Xuebing Ding
Int. J. Biol. Sci. 2015; 11(7): 752-761. doi:10.7150/ijbs.11880
[Abstract] [Full text] [PDF]


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Research Paper
Identification and Expression Analysis of Putative Chemosensory Receptor Genes in Microplitis mediator by Antennal Transcriptome Screening
Shan-Ning Wang, Yong Peng, Zi-Yun Lu, Khalid Hussain Dhiloo, Shao-Hua Gu, Rui-Jun Li, Jing-Jiang Zhou, Yong-Jun Zhang, Yu-Yuan Guo
Int. J. Biol. Sci. 2015; 11(7): 737-751. doi:10.7150/ijbs.11786
[Abstract] [Full text] [PDF]


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Research Paper
Ionizing Radiation Impairs T Cell Activation by Affecting Metabolic Reprogramming
Heng-Hong Li, Yi-wen Wang, Renxiang Chen, Bin Zhou, Jonathan D. Ashwell, Albert J. Fornace
Int. J. Biol. Sci. 2015; 11(7): 726-736. doi:10.7150/ijbs.12009
[Abstract] [Full text] [PDF]


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Research Paper
Induction of Phosphoenolpyruvate Carboxykinase (PEPCK) during Acute Acidosis and Its Role in Acid Secretion by V-ATPase-Expressing Ionocytes
Fumiya Furukawa, Yung-Che Tseng, Sian-Tai Liu, Yi-Ling Chou, Ching-Chun Lin, Po-Hsuan Sung, Katsuhisa Uchida, Li-Yih Lin, Pung-Pung Hwang
Int. J. Biol. Sci. 2015; 11(6): 712-725. doi:10.7150/ijbs.11827
[Abstract] [Full text] [PDF]


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Research Paper
HOXB5 Promotes the Proliferation and Invasion of Breast Cancer Cells
Ji-Yeon Lee, Ho Hur, Hyo Jung Yun, Yeejeong Kim, Seoyeon Yang, Seung Il Kim, Myoung Hee Kim
Int. J. Biol. Sci. 2015; 11(6): 701-711. doi:10.7150/ijbs.11431
[Abstract] [Full text] [PDF]


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Research Paper
Zebrafish Lbh-like Is Required for Otx2-mediated Photoreceptor Differentiation
Wen-Hua Li, Li Zhou, Zhi Li, Yang Wang, Jian-Tao Shi, Yan-Jing Yang, Jian-Fang Gui
Int. J. Biol. Sci. 2015; 11(6): 688-700. doi:10.7150/ijbs.11244
[Abstract] [Full text] [PDF]


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Research Paper
P-Selectin-Mediated Adhesion between Platelets and Tumor Cells Promotes Intestinal Tumorigenesis in ApcMin/+ Mice
Cuiling Qi, Bin Li, Simei Guo, Bo Wei, Chunkui Shao, Jialin Li, Yang Yang, Qianqian Zhang, Jiangchao Li, Xiaodong He, Lijing Wang, Yajie Zhang
Int. J. Biol. Sci. 2015; 11(6): 679-687. doi:10.7150/ijbs.11589
[Abstract] [Full text] [PDF]


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Review
Functions of Autophagy in Pathological Cardiac Hypertrophy
Zhenhua Li, Jian Wang, Xiao Yang
Int. J. Biol. Sci. 2015; 11(6): 672-678. doi:10.7150/ijbs.11883
[Abstract] [Full text] [PDF]


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Research Paper
A Novel Role of OS-9 in the Maintenance of Intestinal Barrier Function from Hypoxia-induced Injury via p38-dependent Pathway
Lihua Sun, Chao Xu, Guoqing Chen, Min Yu, Songwei Yang, Yuan Qiu, Ke Peng, Wensheng Wang, Weidong Xiao, Hua Yang
Int. J. Biol. Sci. 2015; 11(6): 664-671. doi:10.7150/ijbs.10783
[Abstract] [Full text] [PDF]


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Research Paper
Role of the Renin-Angiotensin System, Renal Sympathetic Nerve System, and Oxidative Stress in Chronic Foot Shock-Induced Hypertension in Rats
Tao Dong, Jing-Wei Chen, Li-Li Tian, Lin-Hui Wang, Ren-Di Jiang, Zhe Zhang, Jian-Bing Xu, Xiao-Dong Zhao, Wei Zhu, Guo-Qing Wang, Wan-Ping Sun, Guo-Xing Zhang
Int. J. Biol. Sci. 2015; 11(6): 652-663. doi:10.7150/ijbs.10250
[Abstract] [Full text] [PDF]


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Research Paper
Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway
Cui-Li Zhang, Tao Zeng, Xiu-Lan Zhao, Ke-Qin Xie
Int. J. Biol. Sci. 2015; 11(6): 643-651. doi:10.7150/ijbs.10785
[Abstract] [Full text] [PDF]


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Research Paper
The Xanthine Derivative KMUP-1 Attenuates Serotonin-Induced Vasoconstriction and K+-Channel Inhibitory Activity via the PKC Pathway in Pulmonary Arteries
Zen-Kong Dai, Yu-Wei Liu, Jong-Hau Hsu, Jwu-Lai Yeh, Ing-Jun Chen, Jiunn-Ren Wu, Bin-Nan Wu
Int. J. Biol. Sci. 2015; 11(6): 633-642. doi:10.7150/ijbs.11127
[Abstract] [Full text] [PDF]


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Letter
The Promyelocytic Leukemia Protein Is Upregulated in Conditions of Obesity and Liver Steatosis
Arkaitz Carracedo, Déborah Rousseau, Nicholas Douris, Sonia Fernández-Ruiz, Natalia Martín-Martín, Dror Weiss, Kaitlyn Webster, Andrew C. Adams, Mercedes Vazquez-Chantada, Maria L. Martinez-Chantar, Rodolphe Anty, Albert Tran, Eleftheria Maratos-Flier, Philippe Gual, Pier Paolo Pandolfi
Int. J. Biol. Sci. 2015; 11(6): 629-632. doi:10.7150/ijbs.11615
[Abstract] [Full text] [PDF]


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Research Paper
Tamoxifen Inhibits ER-negative Breast Cancer Cell Invasion and Metastasis by Accelerating Twist1 Degradation
Gang Ma, Jianjun He, Yang Yu, Yixiang Xu, Xiaobin Yu, Jarrod Martinez, David M. Lonard, Jianming Xu
Int. J. Biol. Sci. 2015; 11(5): 618-628. doi:10.7150/ijbs.11380
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Review
DNA Methylation, Its Mediators and Genome Integrity
Huan Meng, Ying Cao, Jinzhong Qin, Xiaoyu Song, Qing Zhang, Yun Shi, Liu Cao
Int. J. Biol. Sci. 2015; 11(5): 604-617. doi:10.7150/ijbs.11218
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
1H NMR Based Serum Metabolic Profiles Associated with Pathological Progression of Pancreatic Islet β Cell Tumor in Rip1-Tag2 Mice
Yongxia Yang, Ying Liu, Lingyun Zheng, Qianqian Zhang, Quliang Gu, Linlin Wang, Lijing Wang
Int. J. Biol. Sci. 2015; 11(5): 595-603. doi:10.7150/ijbs.11058
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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