International Journal of Biological Sciences
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ISSN 1449-2288

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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China
* Dr. Deng is serving in his personal capacity.
Editor-in-Chief's Profile


new Latest impact factor is 4.372. Congratulation!
new Most Cited Paper Award: Winners are Brian F. Zamarron and WanJun Chen from National Institute of Dental and Craniofacial Research, NIH, for the paper "Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression". A certificate and $US 1000 have been issued. Winners of previous years.
The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details
Top cited papers:
Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...
The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details
Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details
Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details
The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details
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Research Paper
Clinical Significance of a Point Mutation in DNA Polymerase Beta (POLB) Gene in Gastric Cancer
Xiaohui Tan, Hongyi Wang, Guangbin Luo, Shuyang Ren, Wenmei Li, Jiantao Cui, Harindarpal S. Gill, Sidney W. Fu, Youyong Lu
Int. J. Biol. Sci. 2015; 11(2): 144-155. doi:10.7150/ijbs.10692
[Abstract] [Full text] [PDF]


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Research Paper
Adipose-Derived Stromal Cells Protect Intervertebral Disc Cells in Compression: Implications for Stem Cell Regenerative Disc Therapy
Zhen Sun, Beier Luo, Zhi-Heng Liu, Dino Samartzis, Zhongyang Liu, Bo Gao, Liangliang Huang, Zhuo-Jing Luo
Int. J. Biol. Sci. 2015; 11(2): 133-143. doi:10.7150/ijbs.10598
[Abstract] [Full text] [PDF]


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Research Paper
Stanniocalcin-1 Controls Ion Regulation Functions of Ion-transporting Epithelium Other than Calcium Balance
Ming-Yi Chou, Chia-Hao Lin, Pei-Lin Chao, Jo-Chi Hung, Shelly A. Cruz, Pung-Pung Hwang
Int. J. Biol. Sci. 2015; 11(2): 122-132. doi:10.7150/ijbs.10773
[Abstract] [Full text] [PDF]


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Research Paper
MiR-467a is Upregulated in Radiation-Induced Mouse Thymic Lymphomas and Regulates Apoptosis by Targeting Fas and Bax
Fu Gao, Song Chen, Mingjuan Sun, Ronald E.J. Mitchel, Bailong Li, Zhiyong Chu, Jianming Cai, Cong Liu
Int. J. Biol. Sci. 2015; 11(1): 109-121. doi:10.7150/ijbs.10276
[Abstract] [Full text] [PDF]


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Research Paper
CEP2 Attenuates Myoblast Differentiation But Does Not Affect Proliferation
Ming Wu, Gongshe Yang, Yaosheng Chen, Xingyu Zhou, Hu Chen, Mingsen Li, Kaifan Yu, Xumeng Zhang, Shuihua Xie, Ying Zhang, Guiyan Chu, Delin Mo
Int. J. Biol. Sci. 2015; 11(1): 99-108. doi:10.7150/ijbs.8621
[Abstract] [Full text] [PDF]


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Research Paper
Integrative Genomic and Transcriptomic Characterization of Matched Primary and Metastatic Liver and Colorectal Carcinoma
Stephanie Roessler, Guoling Lin, Marshonna Forgues, Anuradha Budhu, Shelley Hoover, R. Mark Simpson, Xiaolin Wu, Ping He, Lun-Xiu Qin, Zhao-You Tang, Qing-Hai Ye, Xin Wei Wang
Int. J. Biol. Sci. 2015; 11(1): 88-98. doi:10.7150/ijbs.10583
[Abstract] [Full text] [PDF]


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Research Paper
Ligands Binding and Molecular Simulation: the Potential Investigation of a Biosensor Based on an Insect Odorant Binding Protein
Xin Yi, Yanbo Zhang, Peidan Wang, Jiangwei Qi, Meiying Hu, Guohua Zhong
Int. J. Biol. Sci. 2015; 11(1): 75-87. doi:10.7150/ijbs.9872
[Abstract] [Full text] [PDF]


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Research Paper
Silencing the HaAK Gene by Transgenic Plant-Mediated RNAi Impairs Larval Growth of Helicoverpa armigera
Feng Liu, Xiaodong Wang, Yiying Zhao, Yanjun Li, Yongchang Liu, Jie Sun
Int. J. Biol. Sci. 2015; 11(1): 67-74. doi:10.7150/ijbs.10468
[Abstract] [Full text] [PDF]


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Research Paper
Coenzyme Q10 Protects Astrocytes from ROS-Induced Damage through Inhibition of Mitochondria-Mediated Cell Death Pathway
Li Jing, Mao-Tao He, Yue Chang, Suresh L. Mehta, Qing-Ping He, Jian-Zhong Zhang, P. Andy Li
Int. J. Biol. Sci. 2015; 11(1): 59-66. doi:10.7150/ijbs.10174
[Abstract] [Full text] [PDF]


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Research Paper
Decrease of Let-7f in Low-Dose Metronomic Paclitaxel Chemotherapy Contributed to Upregulation of Thrombospondin-1 in Breast Cancer
Wei-Yang Tao, Xiao-Shuan Liang, Yang Liu, Chun-Yang Wang, Da Pang
Int. J. Biol. Sci. 2015; 11(1): 48-58. doi:10.7150/ijbs.9969
[Abstract] [Full text] [PDF]


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Research Paper
Decrease in Plasma Cyclophilin A Concentration at 1 Month after Myocardial Infarction Predicts Better Left Ventricular Performance and Synchronicity at 6 Months: A Pilot Study in Patients with ST Elevation Myocardial Infarction
Ching-Hui Huang, Chia-Chu Chang, Chen-Ling Kuo, Ching-Shan Huang, Chih-Sheng Lin, Chin-San Liu
Int. J. Biol. Sci. 2015; 11(1): 38-47. doi:10.7150/ijbs.10271
[Abstract] [Full text] [PDF]


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Review
Epithelial Cell Polarity Determinant CRB3 in Cancer Development
Pingping Li, Xiaona Mao, Yu Ren, Peijun Liu
Int. J. Biol. Sci. 2015; 11(1): 31-37. doi:10.7150/ijbs.10615
[Abstract] [Full text] [PDF]


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Research Paper
Differential Transcriptional Response in Macrophages Infected with Cell Wall Deficient versus Normal Mycobacterium Tuberculosis
Yu-Rong Fu, Kun-Shan Gao, Rui Ji, Zheng-Jun Yi
Int. J. Biol. Sci. 2015; 11(1): 22-30. doi:10.7150/ijbs.10217
[Abstract] [Full text] [PDF]


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Research Paper
Molecular Variation and Horizontal Gene Transfer of the Homocysteine Methyltransferase Gene mmuM and its Distribution in Clinical Pathogens
Jianchao Ying, Huifeng Wang, Bokan Bao, Ying Zhang, Jinfang Zhang, Cheng Zhang, Aifang Li, Junwan Lu, Peizhen Li, Jun Ying, Qi Liu, Teng Xu, Huiguang Yi, Jinsong Li, Li Zhou, Tieli Zhou, Zuyuan Xu, Liyan Ni, Qiyu Bao
Int. J. Biol. Sci. 2015; 11(1): 11-21. doi:10.7150/ijbs.10320
[Abstract] [Full text] [PDF]


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Research Paper
Bmi1 Drives Stem-Like Properties and is Associated with Migration, Invasion, and Poor Prognosis in Tongue Squamous Cell Carcinoma
Qianting He, Zhonghua Liu, Tingting Zhao, Luodan Zhao, Xiaofeng Zhou, Anxun Wang
Int. J. Biol. Sci. 2015; 11(1): 1-10. doi:10.7150/ijbs.10405
[Abstract] [Full text] [PDF]


Research Paper
SIRT1 Deacetylates TopBP1 and Modulates Intra-S-Phase Checkpoint and DNA Replication Origin Firing
Rui-Hong Wang, Tyler J. Lahusen, Qiang Chen, Xiaoling Xu, Lisa M. Miller Jenkins, Elisabetta Leo, Haiqing Fu, Mirit Aladjem, Yves Pommier, Ettore Appella, Chu-Xia Deng
Int. J. Biol. Sci. 2014; 10(10): 1193-1202. doi:10.7150/ijbs.11066
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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