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International Journal of Medical Sciences
Journal of Cancer
Theranostics
Journal of Genomics
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Editor-in-Chief: Chuxia Deng, PhD, National Institutes
of Health*, Bethesda, MD
* Dr. Deng is serving in his personal capacity.
Editor-in-Chief's Profile
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 Latest impact factor is 3.168; 5-year journal impact factor is 3.436. Congratulation! |
- Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (full index information)
- Full texts of articles in PubMed
Central, Europe PMC, and PMC Canada.
- Rapid review and publication.
- (For NIH-funded researchers) Save time by submitting your paper to us - this journal is in full compliance with NIH Public Access Requirement.
- High visibility of articles over the Internet.
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| Most Cited Paper Award in 2013: Winners of this year are Guan Yang and Xiao Yang from Institute of Biotechnology, AMMS, Beijing, for the paper "Smad4-mediated TGF-β signaling in tumorigenesis", cited by 42. Winners of previous years were Tina M. Thornton and Mercedes Rincon from University of Vermont (2012), Hong-Bo Shao et al. from Chinese Academy of Sciences (2011), and Joan K. Lunney from United States Department of Agriculture (2010). ...details |
| The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details |
| Top cited papers:
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| Our previous results have demonstrated that km23-2 has functions in TGFß signaling that are distinct from those for km23-1. In the current report, we demonstrate that blockade of km23-2 decreased TGFß activation of the human Smad7 promoter Smad7-Luc, an endogenous Smad3-target promoter. Luminescence-based mammalian interaction mapping (LUMIER) analyses showed that TGFß stimulated the interaction of km23-2 preferentially with Smad3, relative to that with Smad2. Size exclusion chromatography experiments revealed that km23-2 and Smad3 were recruited into the same complex after TGFß treatment. Moreover, in the presence of TGFß, but not in the absence, km23-2 was present in early endosomes with the TGFß receptors (TßRs) and Smad3. Collectively, our data indicate that km23-2 is a critical signaling intermediate in a Smad3-dependent TGFß signaling pathway. We also provide evidence of the novel finding that TGFß stimulates the rapid recruitment of the km23-2 dimer to the dynein intermediate chain (DIC) of the dynein complex, whereas a kinase-deficient form of TßRII prevented this interaction. ...details |
| The stemborer Sesamia nonagrioides is an important pest of maize in the Mediterranean Basin. Like other moths, this noctuid uses its chemosensory system to efficiently interact with its environment. However, very little is known on the molecular mechanisms that underlie chemosensation in this species. Here, we used next-generation sequencing (454 and Illumina) on different tissues from adult and larvae, including chemosensory organs and female ovipositors, to describe the chemosensory transcriptome of S. nonagrioides and identify key molecular components of the pheromone production and detection systems. We identified a total of 68 candidate chemosensory genes in this species, including 31 candidate binding-proteins and 23 chemosensory receptors... ...details |
| Anthracyclines, such as doxorubicin (Adriamycin), are highly effective chemotherapeutic agents, but are well known to cause myocardial dysfunction and life-threatening congestive heart failure (CHF) in some patients.
Methods: To generate new hypotheses about its etiology, genome-wide transcript analysis was performed on whole blood RNA from women that received doxorubicin-based chemotherapy and either did, or did not develop CHF, as defined by ejection fractions (EF)≤40%. Women with non-ischemic cardiomyopathy unrelated to chemotherapy were compared to breast cancer patients prior to chemo with normal EF to identify heart failure-related transcripts in women not receiving chemotherapy. Byproducts of oxidative stress in plasma were measured in a subset of patients.... ...details |
Research Paper
C1q-like Factor, a Target of miR-430, Regulates Primordial Germ Cell Development in Early Embryos of Carassius auratus
Jie Mei, Hua-Mei Yue, Zhi Li, Bo Chen, Jian-Xiang Zhong, Cheng Dan, Li Zhou, Jian-Fang Gui
Int. J. Biol. Sci. 2014; 10(1): 15-24. doi:10.7150/ijbs.7490
[Abstract]
[Full text]
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Variant Ionotropic Receptors Are Expressed in Olfactory Sensory Neurons of Coeloconic Sensilla on the Antenna of the Desert Locust (Schistocerca gregaria)
Mei Guo, Jürgen Krieger, Ewald-Große Wilde, Christine Mißbach, Long Zhang, Heinz Breer
Int. J. Biol. Sci. 2014; 10(1): 1-14. doi:10.7150/ijbs.7624
[Abstract]
[Full text]
[PDF] Review
The Epigenomics of Embryonic Stem Cell Differentiation
Daniel C. Kraushaar, Keji Zhao
Int. J. Biol. Sci. 2013; 9(10): 1134-1144. doi:10.7150/ijbs.7998
[Abstract]
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[PDF] Review
The Regulation of the Autophagic Network and Its Implications for Human Disease
Jing Yang, Serena Carra, Wei-Guo Zhu, Harm H. Kampinga
Int. J. Biol. Sci. 2013; 9(10): 1121-1133. doi:10.7150/ijbs.6666
[Abstract]
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Macrophage Migration Inhibitory Factor Promotes Proliferation and Neuronal Differentiation of Neural Stem/Precursor Cells through Wnt/β-Catenin Signal Pathway
Xijing Zhang, Liangwei Chen, Yazhou Wang, Yinxiu Ding, Zhengwu Peng, Li Duan, Gong Ju, Yi Ren, Xi Wang
Int. J. Biol. Sci. 2013; 9(10): 1108-1120. doi:10.7150/ijbs.7232
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Development of a Rapid Streptavidin Capture-Based Assay for the Tyrosine Phosphorylated CSF-1R in Peripheral Blood Mononuclear Cells
Shalini Chaturvedi, Elayne Dell, Derick Siegel, Gregory Brittingham, Shobha Seetharam
Int. J. Biol. Sci. 2013; 9(10): 1099-1107. doi:10.7150/ijbs.7268
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Genistein Promotion of Osteogenic Differentiation through BMP2/SMAD5/RUNX2 Signaling
Jin Dai, Yalin Li, Honghao Zhou, Jie Chen, Minhu Chen, Zhousheng Xiao
Int. J. Biol. Sci. 2013; 9(10): 1089-1098. doi:10.7150/ijbs.7367
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Gender Differences in Histamine-Induced Depolarization and Inward Currents in Vagal Ganglion Neurons in Rats
Jun-Nan Li, Zhao Qian, Wen-Xiao Xu, Bing Xu, Xiao-Long Lu, Zhen-Yu Yan, Li-Min Han, Yang Liu, Mei Yuan, John Schild, Guo-Fen Qiao, Bai-Yan Li
Int. J. Biol. Sci. 2013; 9(10): 1079-1088. doi:10.7150/ijbs.7595
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Cells Isolated from Human Periapical Cysts Express Mesenchymal Stem Cell-like Properties
Massimo Marrelli, Francesco Paduano, Marco Tatullo
Int. J. Biol. Sci. 2013; 9(10): 1070-1078. doi:10.7150/ijbs.6662
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[PMC] Review
The Vascular Endothelium and Human Diseases
Peramaiyan Rajendran, Thamaraiselvan Rengarajan, Jayakumar Thangavel, Yutaka Nishigaki, Dhanapal Sakthisekaran, Gautam Sethi, Ikuo Nishigaki
Int. J. Biol. Sci. 2013; 9(10): 1057-1069. doi:10.7150/ijbs.7502
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[PMC] Research Paper
Simulation of Interstitial Fluid Flow in Ligaments: Comparison among Stokes, Brinkman and Darcy Models
Wei Yao, Zhoufeng Shen, Guanghong Ding
Int. J. Biol. Sci. 2013; 9(10): 1050-1056. doi:10.7150/ijbs.7242
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[PMC] Research Paper
Genetic Differentiation and Efficient Sex-specific Marker Development of a Pair of Y- and X-linked Markers in Yellow Catfish
Cheng Dan, Jie Mei, Da Wang, Jian-Fang Gui
Int. J. Biol. Sci. 2013; 9(10): 1043-1049. doi:10.7150/ijbs.7203
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[PMC] Research Paper
Asiatic Acid Isolated From Centella Asiatica Inhibits TGF-β1-induced Collagen Expression in Human Keloid Fibroblasts via PPAR-γ Activation
Difei Bian, Jizhou Zhang, Xin Wu, Yannong Dou, Yan Yang, Qian Tan, Yufeng Xia, Zhunan Gong, Yue Dai
Int. J. Biol. Sci. 2013; 9(10): 1032-1042. doi:10.7150/ijbs.7273
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Isolation and Quantification of MicroRNAs from Urinary Exosomes/Microvesicles for Biomarker Discovery
Lin-Li Lv, Yuhan Cao, Dan Liu, Min Xu, Hong Liu, Ri-Ning Tang, Kun-Ling Ma, Bi-Cheng Liu
Int. J. Biol. Sci. 2013; 9(10): 1021-1031. doi:10.7150/ijbs.6100
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[PMC] Review
Roles of Eukaryotic Initiation Factor 5A2 in Human Cancer
Feng-wei Wang, Xin-yuan Guan, Dan Xie
Int. J. Biol. Sci. 2013; 9(10): 1013-1020. doi:10.7150/ijbs.7191
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[PMC] Research Paper
Identification and Expression Profile Analysis of Antimicrobial Peptide/Protein in Asian Corn Borer, Ostrinia furnacalis (Guenée)
Mingming Zhang, Fan Zhou, Yuan Chu, Zhangwu Zhao, Chunju An
Int. J. Biol. Sci. 2013; 9(9): 1004-1012. doi:10.7150/ijbs.6813
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