International Journal of Biological Sciences

Impact factor
4.057

ISSN 1449-2288

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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

new Impact factor is 4.057 according to 2018 release of Journal Citation Reports®. 5 Year Impact factor is 4.950. Congratulations!
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new Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details
Top cited papers:
The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details
Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details
Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details
In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details
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Research Paper
Hypoxia-Mimicking Cobalt-Doped Borosilicate Bioactive Glass Scaffolds with Enhanced Angiogenic and Osteogenic Capacity for Bone Regeneration
Zhengwei Deng, Bocai Lin, Zenghui Jiang, Wenhai Huang, Jiusheng Li, Xiangqiong Zeng, Hui Wang, Deping Wang, Yadong Zhang
Int. J. Biol. Sci. 2019; 15(6): 1113-1124. doi:10.7150/ijbs.32358
[Abstract] [Full text] [PDF]


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Research Paper
Taurine Transporter Regulates Adipogenic Differentiation of Human Adipose-Derived Stem Cells through Affecting Wnt/β-catenin Signaling Pathway
Xiaodan Hou, Zhixue Wang, Fang Ding, Yang He, Pengyuan Wang, Xia Liu, Feng Xu, Jun Wang, Yili Yang
Int. J. Biol. Sci. 2019; 15(5): 1104-1112. doi:10.7150/ijbs.31794
[Abstract] [Full text] [PDF]


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Research Paper
Circular RNA CircCACTIN Promotes Gastric Cancer Progression by Sponging MiR-331-3p and Regulating TGFBR1 Expression
Luo Zhang, Xing Song, Xin Chen, Qi Wang, Xiao Zheng, Changping Wu, Jingting Jiang
Int. J. Biol. Sci. 2019; 15(5): 1091-1103. doi:10.7150/ijbs.31533
[Abstract] [Full text] [PDF]


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Research Paper
ASB6 Promotes the Stemness Properties and Sustains Metastatic Potential of Oral Squamous Cell Carcinoma Cells by Attenuating ER Stress
Kai-Feng Hung, Po-Chen Liao, Chih-Kai Chen, Yueh-Ting Chiu, Dong-Hui Cheng, Masaoki Kawasumi, Shou-Yen Kao, Jeng-Fan Lo
Int. J. Biol. Sci. 2019; 15(5): 1080-1090. doi:10.7150/ijbs.31484
[Abstract] [Full text] [PDF]


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Research Paper
Cryptotanshinone Suppresses Non-Small Cell Lung Cancer via microRNA-146a-5p/EGFR Axis
Pengfei Qi, Yanli Li, Xiaomin Liu, Fatemeh A. Jafari, Xinju Zhang, Qiangling Sun, Zhongliang Ma
Int. J. Biol. Sci. 2019; 15(5): 1072-1079. doi:10.7150/ijbs.31277
[Abstract] [Full text] [PDF]


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Research Paper
Construing the Biochemical and Molecular Mechanism Underlying the In Vivo and In Vitro Chemotherapeutic Efficacy of Ruthenium-Baicalein Complex in Colon Cancer
Yixuan Wang, Li Bian, Tania Chakraborty, Torsha Ghosh, Pallakhi Chanda, Souvik Roy
Int. J. Biol. Sci. 2019; 15(5): 1052-1071. doi:10.7150/ijbs.31143
[Abstract] [Full text] [PDF]


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Research Paper
miR-30e-5p Mitigates Hypoxia-Induced Apoptosis in Human Stem Cell-Derived Cardiomyocytes by Suppressing Bim
Binhai Mo, Xiaodan Wu, Xiantao Wang, Jian Xie, Ziliang Ye, Lang Li
Int. J. Biol. Sci. 2019; 15(5): 1042-1051. doi:10.7150/ijbs.31099
[Abstract] [Full text] [PDF]


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Research Paper
FOXA1 is Prognostic of Triple Negative Breast Cancers by Transcriptionally Suppressing SOD2 and IL6
Xiaofeng Dai, Hongye Cheng, Xiao Chen, Ting Li, Jia Zhang, Guoyin Jin, Dongyan Cai, Zhaohui Huang
Int. J. Biol. Sci. 2019; 15(5): 1030-1041. doi:10.7150/ijbs.31009
[Abstract] [Full text] [PDF]


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Research Paper
Inflammatory and Senescent Phenotype of Pancreatic Stellate Cells Induced by Sqstm1 Downregulation Facilitates Pancreatic Cancer Progression
Chuxiao Shao, Chaoyong Tu, Xiangdong Cheng, Zhiyuan Xu, Xiaoguang Wang, Jian Shen, Kequn Chai, Wei Chen
Int. J. Biol. Sci. 2019; 15(5): 1020-1029. doi:10.7150/ijbs.27825
[Abstract] [Full text] [PDF]


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Research Paper
Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy
Fan Yang, Ying Qin, Yueqiu Wang, Songyan Meng, Huimin Xian, Hui Che, Jie Lv, Yang Li, Yahan Yu, Yunlong Bai, Lihong Wang
Int. J. Biol. Sci. 2019; 15(5): 1010-1019. doi:10.7150/ijbs.29680
[Abstract] [Full text] [PDF]


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Research Paper
FePt/GO Nanosheets Suppress Proliferation, Enhance Radiosensitization and Induce Autophagy of Human Non-Small Cell Lung Cancer Cells
Shijing Ma, Hongtao Miao, Yuan Luo, Yingming Sun, Xiaoli Tian, Feng Wang, Chengcheng You, Shan Peng, Guiliang Tang, Cui Yang, Wenjie Sun, Shuying Li, Yanling Mao, Jieyu Xu, Yu Xiao, Yan Gong, Hong Quan, Conghua Xie
Int. J. Biol. Sci. 2019; 15(5): 999-1009. doi:10.7150/ijbs.29805
[Abstract] [Full text] [PDF]


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Research Paper
Elevated CD163+/CD68+ Ratio at Tumor Invasive Front is Closely Associated with Aggressive Phenotype and Poor Prognosis in Colorectal Cancer
Chaogang Yang, Chen Wei, Shuyi Wang, Dongdong Shi, Chunxiao Zhang, Xiaobin Lin, Rongzhang Dou, Bin Xiong
Int. J. Biol. Sci. 2019; 15(5): 984-998. doi:10.7150/ijbs.29836
[Abstract] [Full text] [PDF]


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Research Paper
A Comprehensive Study of High Cholesterol Diet-Induced Larval Zebrafish Model: A Short-Time In Vivo Screening Method for Non-Alcoholic Fatty Liver Disease Drugs
Ji Ma, Hongli Yin, Maoru Li, Yang Deng, Owais Ahmad, Guohong Qin, Qiangqiang He, Jiajing Li, Kai Gao, Junyi Zhu, Bing Wang, Susu Wu, Tao Wang, Jing Shang
Int. J. Biol. Sci. 2019; 15(5): 973-983. doi:10.7150/ijbs.30013
[Abstract] [Full text] [PDF]


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Review
Prospect for Application of PARP Inhibitor in Patients with HER2 Negative Breast Cancer
Nan Shao, Yawei Shi, Liang Yu, Runyi Ye, Zhen Shan, Zhanqiang Zhang, Yunjian Zhang, Ying Lin
Int. J. Biol. Sci. 2019; 15(5): 962-972. doi:10.7150/ijbs.30721
[Abstract] [Full text] [PDF]


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Research Paper
KLF4-Mediated CDH3 Upregulation Suppresses Human Hepatoma Cell Growth and Migration via GSK-3β Signaling
Li Li, Shijun Yu, Qiong Wu, Ning Dou, Yandong Li, Yong Gao
Int. J. Biol. Sci. 2019; 15(5): 953-961. doi:10.7150/ijbs.30857
[Abstract] [Full text] [PDF]


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Research Paper
Estrogen Receptor Beta (ERβ) Mediated-CyclinD1 Degradation via Autophagy Plays an Anti-Proliferation Role in Colon Cells
Yong Wei, Can Huang, Haoyu Wu, Jian Huang
Int. J. Biol. Sci. 2019; 15(5): 942-952. doi:10.7150/ijbs.30930
[Abstract] [Full text] [PDF]

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