International Journal of Biological Sciences
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ISSN 1449-2288

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Editor-in-Chief: Chuxia Deng, PhD, National Institutes of Health*, Bethesda, MD
* Dr. Deng is serving in his personal capacity.
Editor-in-Chief's Profile
Impact factor: 3.168; 5-year journal impact factor: 3.436.
new Most Cited Paper Award: Winners are Brian F. Zamarron and WanJun Chen from National Institute of Dental and Craniofacial Research, NIH, for the paper "Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression". A certificate and $US 1000 have been issued. Winners of previous years.
The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details
Top cited papers:
Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. In a relatively significant number of PCa patients, the AR is overexpressed, mutated or genomically amplified. In addition, the failure of androgen-deprivation therapy (ADT) and recurrence of PCa with lethal phenotypes highlighted the importance of intratumoral (intracrine) androgen biosynthesis and metabolic pathways.
The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). In treated cells we also observed the conversion of the cytosolic form of the autophagosome marker LC3-I into LC3-II (the lipidated form located on the autophagosome membrane) and the enhanced incorporation of monodansylcadaverine and acridine orange, two markers of the autophagic compartments such as autolysosomes....details
Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans and it is an economic factor in pork production. Linkage, association, and expression analyses independently contributed to the identification of trait-associated molecular pathways and genes. ...details
Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. Because γδT cells express both natural killer receptors such as NKG2D and γδ T cell receptors, they are considered to represent a link between innate and adaptive immunity. ... ...details
The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. In this study, we have identified the genes of S. gregaria which encode homologues of co-receptors for the variant ionotropic receptors, the subtypes IR8a and IR25a. ...details
IJBS issue cover

Research Paper
Intermittent Hypothermia Is Neuroprotective in an in vitro Model of Ischemic Stroke
Sui-yi Xu, Ya-fang Hu, Wei-pin Li, Yong-ming Wu, Zhong Ji, Sheng-nan Wang, Ke Li, Su-yue Pan
Int. J. Biol. Sci. 2014; 10(8): 873-881. doi:10.7150/ijbs.8868
[Abstract] [Full text] [PDF]

Research Paper
Chondrocyte-specific Knockout of Cbfβ Reveals the Indispensable Function of Cbfβ in Chondrocyte Maturation, Growth Plate Development and Trabecular Bone Formation in Mice
Mengrui Wu, Yi-Ping Li, Guochun Zhu, Yun Lu, Yiping Wang, Joel Jules, Matthew McConnell, Rosa Serra, Jian-Zhong Shao, Wei Chen
Int. J. Biol. Sci. 2014; 10(8): 861-872. doi:10.7150/ijbs.8521
[Abstract] [Full text] [PDF]

Research Paper
Identification of Candidate Olfactory Genes in Chilo suppressalis by Antennal Transcriptome Analysis
Depan Cao, Yang Liu, Jinjin Wei, Xinyan Liao, William B. Walker, Jianhong Li, Guirong Wang
Int. J. Biol. Sci. 2014; 10(8): 846-860. doi:10.7150/ijbs.9297
[Abstract] [Full text] [PDF]

Research Paper
Establishment and Characterization of a Highly Tumorigenic African American Prostate Cancer Cell Line, E006AA-hT
Shahriar Koochekpour, Stacey S. Willard, Mojgan Shourideh, Shafat Ali, Chunhong Liu, Gissou Azabdaftari, Mohammad Saleem, Kristopher Attwood
Int. J. Biol. Sci. 2014; 10(8): 834-845. doi:10.7150/ijbs.9406
[Abstract] [Full text] [PDF]

Research Paper
Characteristic Expression of Extracellular Matrix in Subcutaneous Adipose Tissue Development and Adipogenesis; Comparison with Visceral Adipose Tissue
Shinobu Mori, Satomi Kiuchi, Atsushi Ouchi, Tadashi Hase, Takatoshi Murase
Int. J. Biol. Sci. 2014; 10(8): 825-833. doi:10.7150/ijbs.8672
[Abstract] [Full text] [PDF]

Research Paper
A Small Molecule Agonist THIQ as a Novel Pharmacoperone for Intracellularly Retained Melanocortin-4 Receptor Mutants
Hui Huang, Ya-Xiong Tao
Int. J. Biol. Sci. 2014; 10(8): 817-824. doi:10.7150/ijbs.9625
[Abstract] [Full text] [PDF]

Research Paper
SAMD9L Inactivation Promotes Cell Proliferation via Facilitating G1-S Transition in Hepatitis B Virus-associated Hepatocellular Carcinoma
Qun Wang, Yang-Yang Zhai, Ji-Hong Dai, Kun-Yu Li, Qing Deng, Ze-Guang Han
Int. J. Biol. Sci. 2014; 10(8): 807-816. doi:10.7150/ijbs.9143
[Abstract] [Full text] [PDF]

Research Paper
Up-Regulated Lipocalin-2 in Pulmonary Hypertension Involving in Pulmonary Artery SMC Resistance to Apoptosis
Guoliang Wang, Xiaoyan Liu, Liukun Meng, Shenghua Liu, Li Wang, Jun Li, Chuanjue Cui, Jian Meng, Shengshou Hu, Yingjie Wei
Int. J. Biol. Sci. 2014; 10(7): 798-806. doi:10.7150/ijbs.9470
[Abstract] [Full text] [PDF]

Research Paper
Swainsonine Induces Apoptosis through Mitochondrial Pathway and Caspase Activation in Goat Trophoblasts
Yong Huang, Feng Dong, Qian Du, Hongling Zhang, Xiaomao Luo, Xiangjun Song, Xiaomin Zhao, Wenlong Zhang, Dewen Tong
Int. J. Biol. Sci. 2014; 10(7): 789-797. doi:10.7150/ijbs.9168
[Abstract] [Full text] [PDF]

Research Paper
A Novel Role of Exogenous Carbon Monoxide on Protecting Cardiac Function and Improving Survival against Sepsis via Mitochondrial Energetic Metabolism Pathway
Xu Wang, Weiting Qin, Xuefeng Qiu, Jie Cao, Dadong Liu, Bingwei Sun
Int. J. Biol. Sci. 2014; 10(7): 777-788. doi:10.7150/ijbs.9220
[Abstract] [Full text] [PDF]

Short Research Communication
Direct Evidence for Calcineurin Binding to the Exon-7 Loop of the Sodium-Bicarbonate Cotransporter NBCn1
Harindarpal S. Gill, Eric D. Roush, Lauren Dutcher, Samir Patel
Int. J. Biol. Sci. 2014; 10(7): 771-776. doi:10.7150/ijbs.9539
[Abstract] [Full text] [PDF]

Review
Targeting Histone Deacetylases for Cancer Therapy: From Molecular Mechanisms to Clinical Implications
Zhiming Li, Wei-Guo Zhu
Int. J. Biol. Sci. 2014; 10(7): 757-770. doi:10.7150/ijbs.9067
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Dimethyloxaloylglycine Improves Angiogenic Activity of Bone Marrow Stromal Cells in the Tissue-Engineered Bone
Hao Ding, Song Chen, Wen-Qi Song, You-Shui Gao, Jun-Jie Guan, Yang Wang, Yuan Sun, Chang-Qing Zhang
Int. J. Biol. Sci. 2014; 10(7): 746-756. doi:10.7150/ijbs.8535
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
MicroRNA-135a Inhibits Cell Proliferation by Targeting Bmi1 in Pancreatic Ductal Adenocarcinoma
Zheng Dang, Wei-hua Xu, Peng Lu, Nan Wu, Jie Liu, Bai Ruan, Liang Zhou, Wen-jie Song, Ke-feng Dou
Int. J. Biol. Sci. 2014; 10(7): 733-745. doi:10.7150/ijbs.8097
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Type-IV Antifreeze Proteins are Essential for Epiboly and Convergence in Gastrulation of Zebrafish Embryos
Qing Xiao, Jian-Hong Xia, Xiao-Juan Zhang, Zhi Li, Yang Wang, Li Zhou, Jian-Fang Gui
Int. J. Biol. Sci. 2014; 10(7): 715-732. doi:10.7150/ijbs.9126
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Targeting the Sheddase Activity of ADAM17 by an Anti-ADAM17 Antibody D1(A12) Inhibits Head and Neck Squamous Cell Carcinoma Cell Proliferation and Motility via Blockage of Bradykinin Induced HERs Transactivation
Yanchao Huang, Nathan Benaich, Christopher Tape, Hang Fai Kwok, Gillian Murphy
Int. J. Biol. Sci. 2014; 10(7): 702-714. doi:10.7150/ijbs.9326
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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