International Journal of Biological Sciences

Impact factor
3.873

ISSN 1449-2288

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Journal of Biomedicinenew

Theranostics

International Journal of Medical Sciences

Journal of Cancer

Oncomedicine

Journal of Genomics

Journal of Bone and Joint Infection (JBJI)

Nanotheranostics

PubMed Central Indexed in Journal Impact Factor
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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

Impact factor is 3.873 (five year impact factor 4.689) according to 2017 release of Journal Citation ReportsĀ®.
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Most Cited Paper Award: Winners of this year are Yan-Cun Liu, Xian-Biao Zou, Yan-Fen Chai, Yong-Ming Yao, for the paper "Macrophage Polarization in Inflammatory Diseases". Details...
Special Issue on Computational Resources and Methods in Biological Sciences. Guest editors:
Prof. Jian Huang, Dr. Hao Lin, Prof. Shaoliang Peng.
The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details
Top cited papers:
Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...
The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details
Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details
Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details
The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details
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Research Paper
MicroRNA-21-5p mediates TGF-β-regulated fibrogenic activation of spinal fibroblasts and the formation of fibrotic scars after spinal cord injury
Wenzhao Wang, Ronghan Liu, Yanlin Su, Hongfei Li, Wei Xie, Bin Ning
Int. J. Biol. Sci. 2018; 14(2): 178-188. doi:10.7150/ijbs.24074
[Abstract] [Full text] [PDF]


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Research Paper
Loss of p21 promoted tumorigenesis in the background of telomere dysfunctions induced by TRF2 and Wrn deficiency
Xiaoyu Si, Chihao Shao, Jing Li, Shuting Jia, Wenru Tang, Jihong Zhang, Julun Yang, Xiaoming Wu, Ying Luo
Int. J. Biol. Sci. 2018; 14(2): 165-177. doi:10.7150/ijbs.23477
[Abstract] [Full text] [PDF]


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Research Paper
Analysis of early stage osteonecrosis of the human femoral head and the mechanism of femoral head collapse
Cheng Wang, Haoye Meng, Yu Wang, Bin Zhao, Chenyang Zhao, Weijia Sun, Yun Zhu, Bingxing Han, Xueling Yuan, Ruoxi Liu, Xin Wang, Aiyuan Wang, Quanyi Guo, Jiang Peng, Shibi Lu
Int. J. Biol. Sci. 2018; 14(2): 156-164. doi:10.7150/ijbs.18334
[Abstract] [Full text] [PDF]


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Research Paper
NLRP12 Promotes Mouse Neutrophil Differentiation through Regulation of Non-canonical NF-κB and MAPKERK1/2 Signaling
Qian Wang, Furao Liu, Meichao Zhang, Pingting Zhou, Ci Xu, Yanyan Li, Lei Bian, Yuanhua Liu, Yuan Yao, Fei Wang, Yong Fang, Dong Li
Int. J. Biol. Sci. 2018; 14(2): 147-155. doi:10.7150/ijbs.23231
[Abstract] [Full text] [PDF]


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Research Paper
A Prognostic Model Based on Circulating Tumour Cells is Useful for Identifying the Poorest Survival Outcome in Patients with Metastatic Colorectal Cancer
Wen-Chi Chou, Min-Hsien Wu, Pei-Hung Chang, Hung-Chih Hsu, Gwo-jyh Chang, Wen-Kuan Huang, Chiao-En Wu, Jason Chia-Hsun Hsieh
Int. J. Biol. Sci. 2018; 14(2): 137-146. doi:10.7150/ijbs.23182
[Abstract] [Full text] [PDF]


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Research Paper
Ten hub genes associated with progression and prognosis of pancreatic carcinoma identified by co-expression analysis
Zhou Zhou, Yian Cheng, Yinan Jiang, Shi Liu, Meng Zhang, Jing Liu, Qiu Zhao
Int. J. Biol. Sci. 2018; 14(2): 124-136. doi:10.7150/ijbs.22619
[Abstract] [Full text] [PDF]


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Research Paper
The role of TGF-β/SMAD4 signaling in cancer
Ming Zhao, Lopa Mishra, Chu-Xia Deng
Int. J. Biol. Sci. 2018; 14(2): 111-123. doi:10.7150/ijbs.23230
[Abstract] [Full text] [PDF]


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Research Paper
MiR-21-mediated Metabolic Alteration of Cancer-associated Fibroblasts and Its Effect on Pancreatic Cancer Cell Behavior
Shuo Chen, Xi Chen, Tao Shan, Jiancang Ma, Wanrun Lin, Wei Li, Ya'an Kang
Int. J. Biol. Sci. 2018; 14(1): 100-110. doi:10.7150/ijbs.22555
[Abstract] [Full text] [PDF]


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Research Paper
Comparison of microRNA Profiles between Bovine Mammary Glands Infected with Staphylococcus aureus and Escherichia coli
Zhuo-Ma Luoreng, Xing-Ping Wang, Chu-Gang Mei, Lin-Sen Zan
Int. J. Biol. Sci. 2018; 14(1): 87-99. doi:10.7150/ijbs.22498
[Abstract] [Full text] [PDF]


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Research Paper
Fam60al as a novel factor involved in reprogramming of somatic cell nuclear transfer in zebrafish (Danio rerio)
Hongling Hu, Binbin Tao, Ji Chen, Zuoyan Zhu, Wei Hu
Int. J. Biol. Sci. 2018; 14(1): 78-86. doi:10.7150/ijbs.22426
[Abstract] [Full text] [PDF]


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Research Paper
Aryl Hydrocarbon Receptor Activation Modulates Intestinal Epithelial Barrier Function by Maintaining Tight Junction Integrity
Min Yu, Qimeng Wang, Yuanhang Ma, Liangzi Li, Kun Yu, Zhicao Zhang, Guoqing Chen, Xiangsheng Li, Weidong Xiao, Pengyuan Xu, Hua Yang
Int. J. Biol. Sci. 2018; 14(1): 69-77. doi:10.7150/ijbs.22259
[Abstract] [Full text] [PDF]


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Research Paper
Angiotensin 1-7 Overexpression Mediated by a Capsid-optimized AAV8 Vector Leads to Significant Growth Inhibition of Hepatocellular Carcinoma In vivo
Yingying Mao, Nana Pei, Xinglu Chen, Huiying Chen, Renhe Yan, Na Bai, Andrew Li, Jinlong Li, Yanling Zhang, Hongyan Du, Baihong Chen, Colin Sumners, Xuejun Wang, Shengqi Wang, Hongwei Li
Int. J. Biol. Sci. 2018; 14(1): 57-68. doi:10.7150/ijbs.22235
[Abstract] [Full text] [PDF]


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Research Paper
Dioscin overcome TKI resistance in EGFR-mutated lung adenocarcinoma cells via down-regulation of tyrosine phosphatase SHP2 expression
Yao-Chen Wang, De-Wei Wu, Tzu-Chin Wu, Lee Wang, Chih-Yi Chen, Huei Lee
Int. J. Biol. Sci. 2018; 14(1): 47-56. doi:10.7150/ijbs.22209
[Abstract] [Full text] [PDF]


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Research Paper
The metabonomics study of P-selectin glycoprotein ligand-1 (PSGL-1) deficiency inhibiting the progression of atherosclerosis in LDLR-/- mice
Binglin Li, Xin Lu, Jia Wang, Xiaodong He, Quliang Gu, Lijing Wang, Yongxia Yang
Int. J. Biol. Sci. 2018; 14(1): 36-46. doi:10.7150/ijbs.23082
[Abstract] [Full text] [PDF]


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Research Paper
Human Papillomavirus Types 16 and 18 Early-expressed Proteins Differentially Modulate the Cellular Redox State and DNA Damage
Alfredo Cruz-Gregorio, Joaquín Manzo-Merino, María Cecilia Gonzaléz-García, José Pedraza-Chaverri, Omar Noel Medina-Campos, Mahara Valverde, Emilio Rojas, María Alexandra Rodríguez-Sastre, Claudia María García-Cuellar, Marcela Lizano
Int. J. Biol. Sci. 2018; 14(1): 21-35. doi:10.7150/ijbs.21547
[Abstract] [Full text] [PDF]


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Research Paper
Disruption of Gen1 Causes Congenital Anomalies of the Kidney and Urinary Tract in Mice
Herui Wang, Chi Zhang, Xiaowen Wang, Yaru Lian, Bin Guo, Miao Han, Xiaoe Zhang, Xiaoting Zhu, Sixian Xu, Zengli Guo, Yunli Bi, Qian Shen, Xiang Wang, Jiaojiao Liu, Yuan Zhuang, Ting Ni, Hong Xu, Xiaohui Wu
Int. J. Biol. Sci. 2018; 14(1): 10-20. doi:10.7150/ijbs.22768
[Abstract] [Full text] [PDF]

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