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Research Paper
Downregulation of miR-199a-3p mediated by the CtBP2-HDAC1-FOXP3 transcriptional complex contributes to acute lung injury by targeting NLRP1
Zhi Chen, Wei-Hua Dong, Qiang Chen, Qiu-Gen Li, Zhong-Min Qiu
Int. J. Biol. Sci. 2019; 15(12): 2627-2640. doi:10.7150/ijbs.37133
[Abstract] [Full text] [PDF]


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Research Paper
MiR-93 regulates vascular smooth muscle cell proliferation, and neointimal formation through targeting Mfn2
Shengdong Feng, Lu Gao, Dianhong Zhang, Xinyu Tian, Lingyao Kong, Huiting Shi, Leiming Wu, Zhen Huang, Binbin Du, Cui Liang, Yanzhou Zhang, Rui Yao
Int. J. Biol. Sci. 2019; 15(12): 2615-2626. doi:10.7150/ijbs.36995
[Abstract] [Full text] [PDF]


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Research Paper
Osimertinib and pterostilbene in EGFR-mutation-positive non-small cell lung cancer (NSCLC)
Jillian Wilhelmina Paulina Bracht, Niki Karachaliou, Jordi Berenguer, Carlos Pedraz-Valdunciel, Martyna Filipska, Carles Codony-Servat, Jordi Codony-Servat, Rafael Rosell
Int. J. Biol. Sci. 2019; 15(12): 2607-2614. doi:10.7150/ijbs.32889
[Abstract] [Full text] [PDF]


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Research Paper
Phosphorylase Kinase β Represents a Novel Prognostic Biomarker and Inhibits Malignant Phenotypes of Liver Cancer Cell
Wenjing Yang, Chunyan Zhang, Yihao Li, Anli Jin, Yunfan Sun, Xinrong Yang, Beili Wang, Wei Guo
Int. J. Biol. Sci. 2019; 15(12): 2596-2606. doi:10.7150/ijbs.33278
[Abstract] [Full text] [PDF]


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Research Paper
Muscle Injury Associated Elevated Oxidative Stress and Abnormal Myogenesis in Patients with Idiopathic Scoliosis
Jiong Li, Mingxing Tang, Guanteng Yang, Longjie Wang, Qile Gao, Hongqi Zhang
Int. J. Biol. Sci. 2019; 15(12): 2584-2595. doi:10.7150/ijbs.33340
[Abstract] [Full text] [PDF]


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Review
Research Advances in CKLF-like MARVEL Transmembrane Domain-containing Family in Non-small Cell Lung Cancer
Keheng Wu, Xiaoman Li, Huadi Gu, Qiao Yang, Yingying Liu, Liang Wang
Int. J. Biol. Sci. 2019; 15(12): 2576-2583. doi:10.7150/ijbs.33733
[Abstract] [Full text] [PDF]


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Research Paper
EGF suppresses the expression of miR-124a in pancreatic β cell lines via ETS2 activation through the MEK and PI3K signaling pathways
Lin Yang, Yuansen Zhu, Delin Kong, Jiawei Gong, Wen Yu, Yang Liang, Yuzhe Nie, Chun-Bo Teng
Int. J. Biol. Sci. 2019; 15(12): 2561-2575. doi:10.7150/ijbs.34985
[Abstract] [Full text] [PDF]


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Review
Current Progress in CAR-T Cell Therapy for Solid Tumors
Shuo Ma, Xinchun Li, Xinyue Wang, Liang Cheng, Zhong Li, Changzheng Zhang, Zhenlong Ye, Qijun Qian
Int. J. Biol. Sci. 2019; 15(12): 2548-2560. doi:10.7150/ijbs.34213
[Abstract] [Full text] [PDF]


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Research Paper
microRNA-1 Regulates NCC Migration and Differentiation by Targeting sec63
Dongyue Wang, Yajuan Weng, Shuyu Guo, Wenhao Qin, Jieli Ni, Lei Yu, Yuxin Zhang, Qingshun Zhao, Jingjing Ben, Junqing Ma
Int. J. Biol. Sci. 2019; 15(12): 2538-2547. doi:10.7150/ijbs.35357
[Abstract] [Full text] [PDF]


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Research Paper
GATA Binding Protein 3 Boosts Extracellular ATP Hydrolysis and Inhibits Metastasis of Breast Cancer by Up-regulating Ectonucleoside Triphosphate Diphosphohydrolase 3
Meifang Li, Yuzhu Qi, Min Chen, Zun Wang, De Zeng, Yingsheng Xiao, Shaozhong Li, Haoyu Lin, Xiaolong Wei, Guojun Zhang
Int. J. Biol. Sci. 2019; 15(12): 2522-2537. doi:10.7150/ijbs.35563
[Abstract] [Full text] [PDF]


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Review
Matrix Mechanics as Regulatory Factors and Therapeutic Targets in Hepatic Fibrosis
Guobao Chen, Bin Xia, Qiang Fu, Xiang Huang, Fuping Wang, Zhongmin Chen, Yonggang Lv
Int. J. Biol. Sci. 2019; 15(12): 2509-2521. doi:10.7150/ijbs.37500
[Abstract] [Full text] [PDF]


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Research Paper
Xanthohumol inhibits colorectal cancer cells via downregulation of Hexokinases II-mediated glycolysis
Wenbin Liu, Wei Li, Haidan Liu, Xinfang Yu
Int. J. Biol. Sci. 2019; 15(11): 2497-2508. doi:10.7150/ijbs.37481
[Abstract] [Full text] [PDF]


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Research Paper
Circ-HIPK3 Strengthens the Effects of Adrenaline in Heart Failure by MiR-17-3p - ADCY6 Axis
Yunfei Deng, Jun Wang, Guojin Xie, Xiaochen Zeng, Hongli Li
Int. J. Biol. Sci. 2019; 15(11): 2484-2496. doi:10.7150/ijbs.36149
[Abstract] [Full text] [PDF]


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Research Paper
Protective Effect of Lactobacillus rhamnosus GG and its Supernatant against Myocardial Dysfunction in Obese Mice Exposed to Intermittent Hypoxia is Associated with the Activation of Nrf2 Pathway
Hui Xu, Jiqun Wang, Jun Cai, Wenke Feng, Yonggang Wang, Quan Liu, Lu Cai
Int. J. Biol. Sci. 2019; 15(11): 2471-2483. doi:10.7150/ijbs.36465
[Abstract] [Full text] [PDF]


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Review
Exosomes in Coronary Artery Disease
Xiao-Fei Gao, Zhi-Mei Wang, Feng Wang, Yue Gu, Jun-Jie Zhang, Shao-Liang Chen
Int. J. Biol. Sci. 2019; 15(11): 2461-2470. doi:10.7150/ijbs.36427
[Abstract] [Full text] [PDF]


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Research Paper
Rictor ablation in BMSCs inhibits bone metastasis of TM40D cells by attenuating osteolytic destruction and CAF formation
Zibo Liu, Hui Wang, Jialing He, Xiaoqin Yuan, Weiwei Sun
Int. J. Biol. Sci. 2019; 15(11): 2448-2460. doi:10.7150/ijbs.37241
[Abstract] [Full text] [PDF]

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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau

Editor-in-Chief's Profile

Impact factor is 4.067 according to 2019 release of Journal Citation Reports®.
new Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details
Top cited papers:
The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details
Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details
Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details
In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details