International Journal of Biological Sciences

Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

Latest impact factor is 3.982. 5 year IF is 4.454.

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Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (full index information)
Full texts of articles in PubMed Central, Europe PMC, and PMC Canada.
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Most Cited Paper Award: Winners of this year are Zhi-Yuan Xu et al, for the paper "Knockdown of Long Non-coding RNA HOTAIR Suppresses Tumor Invasion and Reverses Epithelial-mesenchymal Transition in Gastric Cancer". Details...

The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details

Top cited papers:

G Chen et al. TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation. Cited by 237
BF Zamarron & W Chen. Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression. Cited by 172
TM Thornton & M Rincon. Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival. Cited by 200
HB Shao et al. Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells. Cited by 247
JK Lunney. Advances in Swine Biomedical Model Genomics. Cited by 255
DP Siderovski & FS Willard. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Cited by 241

Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...

The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details

Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details

Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details

The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details

Research Paper
Indoxyl Sulfate Enhance the Hypermethylation of Klotho and Promote the Process of Vascular Calcification in Chronic Kidney Disease
Jing Chen, Xiaoyan Zhang, Han Zhang, Tongqiang Liu, Hui Zhang, Jie Teng, Jun Ji, Xiaoqiang Ding
Int. J. Biol. Sci. 2016; 12(10): 1236-1246. doi:10.7150/ijbs.15195
[Abstract] [Full text] [PDF]

Research Paper
Deficiency of DJ-1 Ameliorates Liver Fibrosis through Inhibition of Hepatic ROS Production and Inflammation
Yingxue Yu, Xuehua Sun, Jinyang Gu, Chang Yu, Yankai Wen, Yueqiu Gao, Qiang Xia, Xiaoni Kong
Int. J. Biol. Sci. 2016; 12(10): 1225-1235. doi:10.7150/ijbs.15154
[Abstract] [Full text] [PDF]

Research Paper
miR-628 Promotes Burn-Induced Skeletal Muscle Atrophy via Targeting IRS1
Yonghui Yu, Xiao Li, Lingying Liu, Jiake Chai, Zhang Haijun, Wanli Chu, Huinan Yin, Li Ma, Hongjie Duan, Mengjing Xiao
Int. J. Biol. Sci. 2016; 12(10): 1213-1224. doi:10.7150/ijbs.15496
[Abstract] [Full text] [PDF]

Research Paper
Dmp1 Null Mice Develop a Unique Osteoarthritis-like Phenotype
Qi Zhang, Shuxian Lin, Ying Liu, Baozhi Yuan, Steph E Harris, Jian Q. Feng
Int. J. Biol. Sci. 2016; 12(10): 1203-1212. doi:10.7150/ijbs.15833
[Abstract] [Full text] [PDF]

Research Paper
Expression of Iron Regulatory Protein 1 Is Regulated not only by HIF-1 but also pCREB under Hypoxia
Qian-Qian Luo, Zhong-Ming Qian, Yu-Fu Zhou, Meng-Wan Zhang, Dang Wang, Li Zhu, Ya Ke
Int. J. Biol. Sci. 2016; 12(10): 1191-1202. doi:10.7150/ijbs.16437
[Abstract] [Full text] [PDF]

Research Paper
Changes in the Expression of FUS/TLS in Spinal Cords of SOD1 G93A Transgenic Mice and Correlation with Motor-Neuron Degeneration
Jiao Li, Yi Lu, Huiting Liang, Chunyan Tang, Lei Zhu, Jie Zhang, Renshi Xu
Int. J. Biol. Sci. 2016; 12(10): 1181-1190. doi:10.7150/ijbs.16158
[Abstract] [Full text] [PDF]

Research Paper
A Metabolomic Approach (¹H HRMAS NMR Spectroscopy) Supported by Histology to Study Early Post-transplantation Responses in Islet-transplanted Livers
Kevin Vivot, Malika A. Benahmed, Elodie Seyfritz, William Bietiger, Karim Elbayed, Elisa Ruhland, Allan Langlois, Elisa Maillard, Michel Pinget, Nathalie Jeandidier, Jean-Pierre Gies, Izzie-Jacques Namer, Séverine Sigrist, Nathalie Reix
Int. J. Biol. Sci. 2016; 12(10): 1168-1180. doi:10.7150/ijbs.15189
[Abstract] [Full text] [PDF]

Research Paper
Class A Scavenger Receptor Exacerbates Osteoclastogenesis by an Interleukin-6-Mediated Mechanism through ERK and JNK Signaling Pathways
Shuyu Guo, Yuanyuan Ni, Jingjing Ben, Yang Xia, Tingting Zhou, Dongyue Wang, Jieli Ni, Hui Bai, Lin Wang, Junqing Ma, Qi Chen
Int. J. Biol. Sci. 2016; 12(10): 1155-1167. doi:10.7150/ijbs.14654
[Abstract] [Full text] [PDF]

Review
Epithelial Sodium Channels in Pulmonary Epithelial Progenitor and Stem Cells
Yang Liu, Bi-Jie Jiang, Run-Zhen Zhao, Hong-Long Ji
Int. J. Biol. Sci. 2016; 12(9): 1150-1154. doi:10.7150/ijbs.15747
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
The Overexpression of TDP-43 Protein in the Neuron and Oligodendrocyte Cells Causes the Progressive Motor Neuron Degeneration in the SOD1 G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
Yi Lu, Chunyan Tang, Lei Zhu, Jiao Li, Huiting Liang, Jie Zhang, Renshi Xu
Int. J. Biol. Sci. 2016; 12(9): 1140-1149. doi:10.7150/ijbs.15938
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Selection of Reference Genes for Expression Studies of Xenobiotic Adaptation in Tetranychus urticae
Mariany Ashanty Morales, Bianca Marie Mendoza, Laura Corley Lavine, Mark Daniel Lavine, Douglas Bruce Walsh, Fang Zhu
Int. J. Biol. Sci. 2016; 12(9): 1129-1139. doi:10.7150/ijbs.16319
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
Role of Osteopontin in Liver Diseases
Yankai Wen, Seogsong Jeong, Qiang Xia, Xiaoni Kong
Int. J. Biol. Sci. 2016; 12(9): 1121-1128. doi:10.7150/ijbs.16445
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Novel FOXC2 Mutation in Hereditary Distichiasis Impairs DNA-Binding Activity and Transcriptional Activation
Leilei Zhang, Jie He, Bing Han, Linna Lu, Jiayan Fan, He Zhang, Shengfang Ge, Yixiong Zhou, Renbing Jia, Xianqun Fan
Int. J. Biol. Sci. 2016; 12(9): 1114-1120. doi:10.7150/ijbs.13774
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
An Effective Molecular Target Site in Hepatitis B Virus S Gene for Cas9 Cleavage and Mutational Inactivation
Hao Li, Chunyu Sheng, Hongbo Liu, Guangze Liu, Xinying Du, Juan Du, Linsheng Zhan, Peng Li, Chaojie Yang, Lihua Qi, Jian Wang, Xiaoxia Yang, Leili Jia, Jing Xie, Ligui Wang, Rongzhang Hao, Dongping Xu, Yigang Tong, Yusen Zhou, Jianjun Zhou, Yansong Sun, Qiao Li, Shaofu Qiu, Hongbin Song
Int. J. Biol. Sci. 2016; 12(9): 1104-1113. doi:10.7150/ijbs.16064
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Cooperation of Doxycycline with Phytochemicals and Micronutrients Against Active and Persistent Forms of Borrelia sp
Anna Goc, Alexandra Niedzwiecki, Matthias Rath
Int. J. Biol. Sci. 2016; 12(9): 1093-1103. doi:10.7150/ijbs.16060
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
Cytoskeleton Molecular Motors: Structures and Their Functions in Neuron
Qingpin Xiao, Xiaohui Hu, Zhiyi Wei, Kin Yip Tam
Int. J. Biol. Sci. 2016; 12(9): 1083-1092. doi:10.7150/ijbs.15633
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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