International Journal of Biological Sciences

Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

Impact factor is 4.057 according to 2018 release of Journal Citation Reports®. 5 Year Impact factor is 4.950. Congratulations!
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Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (full index information)
Full texts of articles in PubMed Central and Europe PMC.
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Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details

Top cited papers:

G Chen et al. TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation. Cited by 237
BF Zamarron & W Chen. Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression. Cited by 172
TM Thornton & M Rincon. Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival. Cited by 200
HB Shao et al. Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells. Cited by 247
JK Lunney. Advances in Swine Biomedical Model Genomics. Cited by 255
DP Siderovski & FS Willard. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Cited by 241

The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details

Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details

Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details

In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details

Research Paper
SMARCAD1 Promotes Pancreatic Cancer Cell Growth and Metastasis through Wnt/β-catenin-Mediated EMT
Furao Liu, Zebin Xia, Meichao Zhang, Jiping Ding, Yang Feng, Jianwei Wu, Yun Dong, Wei Gao, Zengwei Han, Yuanhua Liu, Yuan Yao, Dong Li
Int. J. Biol. Sci. 2019; 15(3): 636-646. doi:10.7150/ijbs.29562
[Abstract] [Full text] [PDF]

Research Paper
The KLF14 Transcription Factor Regulates Glycolysis by Downregulating LDHB in Colorectal Cancer
Guiyang Wu, Shichao Yuan, Zaiping Chen, Guoping Chen, Qinghao Fan, Hao Dong, Fubo Ye, Jing Li, Xiongwen Zhu
Int. J. Biol. Sci. 2019; 15(3): 628-635. doi:10.7150/ijbs.30652
[Abstract] [Full text] [PDF]

Research Paper
Activation of AMPK by metformin promotes renal cancer cell proliferation under glucose deprivation through its interaction with PKM2
Meihan Liu, Zhuo Zhang, Hui Wang, Xiaoliang Chen, Chunxiang Jin
Int. J. Biol. Sci. 2019; 15(3): 617-627. doi:10.7150/ijbs.29689
[Abstract] [Full text] [PDF]

Review
Obesity, Nonalcoholic Fatty Liver Disease and Adipocytokines Network in Promotion of Cancer
Rosa Divella, Antonio Mazzocca, Antonella Daniele, Carlo Sabbà, Angelo Paradiso
Int. J. Biol. Sci. 2019; 15(3): 610-616. doi:10.7150/ijbs.29599
[Abstract] [Full text] [PDF]

Research Paper
A novel role of Cx43-composed GJIC in PDT phototoxicity: an implication of Cx43 for the enhancement of PDT efficacy
Deng-Pan Wu, Li-Ru Bai, Yan-Fang Lv, Yan Zhou, Chun-Hui Ding, Si-Man Yang, Fan Zhang, Jin-Lan Huang
Int. J. Biol. Sci. 2019; 15(3): 598-609. doi:10.7150/ijbs.29582
[Abstract] [Full text] [PDF]

Research Paper
TRIB3 Promotes the Proliferation and Invasion of Renal Cell Carcinoma Cells via Activating MAPK Signaling Pathway
Baoan Hong, Jingcheng Zhou, Kaifang Ma, Jiufeng Zhang, Haibiao Xie, Kenan Zhang, Lei Li, Lin Cai, Ning Zhang, Zhongyuan Zhang, Kan Gong
Int. J. Biol. Sci. 2019; 15(3): 587-597. doi:10.7150/ijbs.29737
[Abstract] [Full text] [PDF]

Research Paper
miR-9 Enhances the Chemosensitivity of AML Cells to Daunorubicin by Targeting the EIF5A2/MCL-1 Axis
Yanhui Liu, Pingchong Lei, Hong Qiao, Kai Sun, Xiling Lu, Fengchang Bao, Runhong Yu, Cheng Lian, Yao Li, Wei Chen, Fei Xue
Int. J. Biol. Sci. 2019; 15(3): 579-586. doi:10.7150/ijbs.29775
[Abstract] [Full text] [PDF]

Research Paper
Inhibition of Heme Oxygenase-1 enhances hyperthermia-induced autophagy and antiviral effect
Yang Yang, He-Xiao Wang, Lan Zhang, Wei Huo, Xiao-Dong Li, Rui-Qun Qi, Xiao-Yu Song, Shi Wei, Xing-Hua Gao, Shuai Han, Liu Cao
Int. J. Biol. Sci. 2019; 15(3): 568-578. doi:10.7150/ijbs.29759
[Abstract] [Full text] [PDF]

Research Paper
Rosmarinic acid alleviates cardiomyocyte apoptosis via cardiac fibroblast in doxorubicin-induced cardiotoxicity
Xin Zhang, Jin-Xiu Zhu, Zhen-Guo Ma, Hai-Ming Wu, Si-Chi Xu, Peng Song, Chun-Yan Kong, Yu-Pei Yuan, Wei Deng, Qi-Zhu Tang
Int. J. Biol. Sci. 2019; 15(3): 556-567. doi:10.7150/ijbs.29907
[Abstract] [Full text] [PDF]

Research Paper
Cyclin G2 Inhibits the Warburg Effect and Tumour Progression by Suppressing LDHA Phosphorylation in Glioma
Sen Li, Jinlan Gao, Xinbin Zhuang, Chenyang Zhao, Xiaoyu Hou, Xuesha Xing, Chen Chen, Qi Liu, Shuang Liu, Yang Luo
Int. J. Biol. Sci. 2019; 15(3): 544-555. doi:10.7150/ijbs.30297
[Abstract] [Full text] [PDF]

Research Paper
RRM2 is a potential prognostic biomarker with functional significance in glioma
Hongzhi Sun, Bingya Yang, Hao Zhang, Jingwei Song, Yenan Zhang, Jicheng Xing, Zhihui Yang, Changyong Wei, Tuoye Xu, Zhennan Yu, Zhipeng Xu, Min Hou, Minjun Ji, Yansong Zhang
Int. J. Biol. Sci. 2019; 15(3): 533-543. doi:10.7150/ijbs.30114
[Abstract] [Full text] [PDF]

Research Paper
Combined Androgen receptor blockade overcomes the resistance of breast cancer cells to palbociclib
Wenfei Ji, Yaqin Shi, Xin Wang, Weiwei He, Lin Tang, Shengwang Tian, Hua Jiang, Yongqian Shu, Xiaoxiang Guan
Int. J. Biol. Sci. 2019; 15(3): 522-532. doi:10.7150/ijbs.30572
[Abstract] [Full text] [PDF]

Research Paper
Autophagy resists EMT process to maintain retinal pigment epithelium homeostasis
Hao Feng, Xin Zhao, Qiqiang Guo, Yanling Feng, Mengtao Ma, Wendong Guo, Xiang Dong, Chengsi Deng, Chunlu Li, Xiaoyu Song, Shuai Han, Liu Cao
Int. J. Biol. Sci. 2019; 15(3): 507-521. doi:10.7150/ijbs.30575
[Abstract] [Full text] [PDF]

Research Paper
CD9 regulates keratinocyte migration by negatively modulating the sheddase activity of ADAM17
Jie Liu, Guoqin Zhu, Naixin Jia, Weiyi Wang, Yuan Wang, Meifang Yin, Xuping Jiang, Yuesheng Huang, Jiaping Zhang
Int. J. Biol. Sci. 2019; 15(2): 493-506. doi:10.7150/ijbs.29404
[Abstract] [Full text] [PDF]

Research Paper
Generation of Pigs Resistant to Highly Pathogenic-Porcine Reproductive and Respiratory Syndrome Virus through Gene Editing of CD163
Jingyao Chen, Haitao Wang, Jianhui Bai, Wenjie Liu, Xiaojuan Liu, Dawei Yu, Tao Feng, Zhaolin Sun, Linlin Zhang, Linyuan Ma, Yiqing Hu, Yunlong Zou, Tan Tan, Jie Zhong, Man Hu, Xiaofei Bai, Dengke Pan, Yiming Xing, Yaofeng Zhao, Kegong Tian, Xiaoxiang Hu, Ning Li
Int. J. Biol. Sci. 2019; 15(2): 481-492. doi:10.7150/ijbs.25862
[Abstract] [Full text] [PDF]

Research Paper
IL-15 Generates IFN-γ-producing Cells Reciprocally Expressing Lymphoid-Myeloid Markers during Dendritic Cell Differentiation
Kee Woong Kwon, So Jeong Kim, Hongmin Kim, Woo Sik Kim, Soon Myung Kang, Eunsol Choi, Sang-Jun Ha, Joo-Heon Yoon, Sung Jae Shin
Int. J. Biol. Sci. 2019; 15(2): 464-480. doi:10.7150/ijbs.25743
[Abstract] [Full text] [PDF]

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