International Journal of Biological Sciences
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ISSN 1449-2288

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Theranostics

International Journal of Medical Sciences

Journal of Cancer

Oncomedicine

Journal of Genomics

Journal of Bone and Joint Infection (JBJI)

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Journal of Genomics now in PubMed/PubMed Central. Submit manuscript...

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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

new Latest impact factor is 3.982. 5 year IF is 4.454.
new Cover suggestion ...details
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Most Cited Paper Award: Winners of this year are Yan-Cun Liu, Xian-Biao Zou, Yan-Fen Chai, Yong-Ming Yao, for the paper "Macrophage Polarization in Inflammatory Diseases". Details...
The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details
Top cited papers:
Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...
The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details
Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details
Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details
The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details
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Research Paper
Activated ClC-2 Inhibits p-Akt to Repress Myelination in GDM Newborn Rats
Feixiang He, Yuchen Peng, Zhi Yang, Zilu Ge, Yanping Tian, Teng Ma, Hongli Li
Int. J. Biol. Sci. 2017; 13(2): 179-188. doi:10.7150/ijbs.17716
[Abstract] [Full text] [PDF]


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Research Paper
Diallyl Trisulfide Inhibits Growth of NCI-H460 in Vitro and in Vivo, and Ameliorates Cisplatin-Induced Oxidative Injury in the Treatment of Lung Carcinoma in Xenograft Mice
Xiaoyan Jiang, Xiaosong Zhu, Na Liu, Hongya Xu, Zhongxi Zhao, Siying Li, Shanzhong Li, Jianhua Cai, Jimin Cao
Int. J. Biol. Sci. 2017; 13(2): 167-178. doi:10.7150/ijbs.16828
[Abstract] [Full text] [PDF]


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Research Paper
Regulatory Axis of miR-195/497 and HMGA1-Id3 Governs Muscle Cell Proliferation and Differentiation
Huiling Qiu, Jiasheng Zhong, Lan Luo, Zhixiong Tang, Nian Liu, Kang Kang, Li Li, Deming Gou
Int. J. Biol. Sci. 2017; 13(2): 157-166. doi:10.7150/ijbs.17440
[Abstract] [Full text] [PDF]


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Research Paper
17beta-estradiol Attenuates TNF-α-Induced Premature Senescence of Nucleus Pulposus Cells through Regulating the ROS/NF-κB Pathway
Pei Li, Yibo Gan, Yuan Xu, Liyuan Wang, Bin Ouyang, Chengmin Zhang, Lei Luo, Chen Zhao, Qiang Zhou
Int. J. Biol. Sci. 2017; 13(2): 145-156. doi:10.7150/ijbs.16770
[Abstract] [Full text] [PDF]


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Research Paper
Lipocalin-2 Promotes Endoplasmic Reticulum Stress and Proliferation by Augmenting Intracellular Iron in Human Pulmonary Arterial Smooth Muscle Cells
Guoliang Wang, Shenghua Liu, Li Wang, Liukun Meng, Chuanjue Cui, Hao Zhang, Shengshou Hu, Ning Ma, Yingjie Wei
Int. J. Biol. Sci. 2017; 13(2): 135-144. doi:10.7150/ijbs.17758
[Abstract] [Full text] [PDF]


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Research Paper
miR-15a-3p and miR-16-1-3p Negatively Regulate Twist1 to Repress Gastric Cancer Cell Invasion and Metastasis
Tao Wang, Jingjing Hou, Zengpeng Li, Zihan Zheng, Jie Wei, Dan Song, Tao Hu, Qiao Wu, James Y. Yang, Jian-chun Cai
Int. J. Biol. Sci. 2017; 13(1): 122-134. doi:10.7150/ijbs.14770
[Abstract] [Full text] [PDF]


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Research Paper
Involvement of Rictor/mTORC2 in cardiomyocyte differentiation of mouse embryonic stem cells in vitro
Bei Zheng, Jiadan Wang, Leilei Tang, Chao Tan, Zhe Zhao, Yi Xiao, Renshan Ge, Danyan Zhu
Int. J. Biol. Sci. 2017; 13(1): 110-121. doi:10.7150/ijbs.16312
[Abstract] [Full text] [PDF]


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Research Paper
The Effect of Estradiol on the Growth Plate Chondrocytes of Limb and Spine from Postnatal Mice in vitro: The Role of Estrogen-Receptor and Estradiol Concentration
Sheng Shi, Shuang Zheng, Xin-Feng Li, Zu-De Liu
Int. J. Biol. Sci. 2017; 13(1): 100-109. doi:10.7150/ijbs.17696
[Abstract] [Full text] [PDF]


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Research Paper
Metadata Analysis of Phanerochaete chrysosporium Gene Expression Data Identified Common CAZymes Encoding Gene Expression Profiles Involved in Cellulose and Hemicellulose Degradation
Ayyappa Kumar Sista Kameshwar, Wensheng Qin
Int. J. Biol. Sci. 2017; 13(1): 85-99. doi:10.7150/ijbs.17390
[Abstract] [Full text] [PDF]


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Research Paper
Inhibition of miRNA-210 reverses nicotine-induced brain hypoxic-ischemic injury in neonatal rats
Lei Wang, Jun Ke, Yong Li, Qinyi Ma, Chiranjib Dasgupta, Xiaohui Huang, Lubo Zhang, DaLiao Xiao
Int. J. Biol. Sci. 2017; 13(1): 76-84. doi:10.7150/ijbs.17278
[Abstract] [Full text] [PDF]


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Research Paper
Forsythoside A exerts antipyretic effect on yeast-induced pyrexia mice via inhibiting transient receptor potential vanilloid 1 function
Cuiling Liu, Hongchang Su, Hongye Wan, Qingxia Qin, Xuan Wu, Xiangying Kong, Na Lin
Int. J. Biol. Sci. 2017; 13(1): 65-75. doi:10.7150/ijbs.18045
[Abstract] [Full text] [PDF]


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Research Paper
The efficiency analysis of thrombolytic rt-PA combined with intravascular interventional therapy in patients with acute basilar artery occlusion
Zhao Xianxian, Yue Chengsong, Mei Qiang, Wei Fei, Shen Lin, Ding Huiyan, Gong Zili
Int. J. Biol. Sci. 2017; 13(1): 57-64. doi:10.7150/ijbs.16029
[Abstract] [Full text] [PDF]


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Review
The Protective Effect of Alpha 7 Nicotinic Acetylcholine Receptor Activation on Critical Illness and Its Mechanism
Chao REN, Ya-lin TONG, Jun-cong LI, Zhong-qiu LU, Yong-ming YAO
Int. J. Biol. Sci. 2017; 13(1): 46-56. doi:10.7150/ijbs.16404
[Abstract] [Full text] [PDF]


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Research Paper
Deformed Skull Morphology Is Caused by the Combined Effects of the Maldevelopment of Calvarias, Cranial Base and Brain in FGFR2-P253R Mice Mimicking Human Apert Syndrome
Fengtao Luo, Yangli Xie, Wei Xu, Junlan Huang, Siru Zhou, Zuqiang Wang, Xiaoqing Luo, Mi Liu, Lin Chen, Xiaolan Du
Int. J. Biol. Sci. 2017; 13(1): 32-45. doi:10.7150/ijbs.16287
[Abstract] [Full text] [PDF]


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Research Paper
Let-7a Is an Antihypertrophic Regulator in the Heart via Targeting Calmodulin
Xin Zhou, Fei Sun, Shenjian Luo, Wei Zhao, Ti Yang, Guiye Zhang, Ming Gao, Renzhong Lu, You Shu, Wei Mu, Yanan Zhuang, Fengzhi Ding, Chaoqian Xu, Yanjie Lu
Int. J. Biol. Sci. 2017; 13(1): 22-31. doi:10.7150/ijbs.16298
[Abstract] [Full text] [PDF]


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Research Paper
MicroRNA-135a Regulates Apoptosis Induced by Hydrogen Peroxide in Rat Cardiomyoblast Cells
Ning Liu, Yong-Feng Shi, Hong-Ying Diao, Yang-Xue Li, Yan Cui, Xian-Jing Song, Xin Tian, Tian-Yi Li, Bin Liu
Int. J. Biol. Sci. 2017; 13(1): 13-21. doi:10.7150/ijbs.16769
[Abstract] [Full text] [PDF]

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