International Journal of Biological Sciences
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ISSN 1449-2288

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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

new Latest impact factor is 4.372. Congratulations!
new Cover suggestion ...details
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Most Cited Paper Award: Winners of this year are Guiqian Chen et al, for the paper "TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation". Details...
The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details
Top cited papers:
Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...
The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details
Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details
Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details
The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details
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Research Paper
The Xanthine Derivative KMUP-1 Attenuates Serotonin-Induced Vasoconstriction and K+-Channel Inhibitory Activity via the PKC Pathway in Pulmonary Arteries
Zen-Kong Dai, Yu-Wei Liu, Jong-Hau Hsu, Jwu-Lai Yeh, Ing-Jun Chen, Jiunn-Ren Wu, Bin-Nan Wu
Int. J. Biol. Sci. 2015; 11(6): 633-642. doi:10.7150/ijbs.11127
[Abstract] [Full text] [PDF]


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Letter
The Promyelocytic Leukemia Protein Is Upregulated in Conditions of Obesity and Liver Steatosis
Arkaitz Carracedo, Déborah Rousseau, Nicholas Douris, Sonia Fernández-Ruiz, Natalia Martín-Martín, Dror Weiss, Kaitlyn Webster, Andrew C. Adams, Mercedes Vazquez-Chantada, Maria L. Martinez-Chantar, Rodolphe Anty, Albert Tran, Eleftheria Maratos-Flier, Philippe Gual, Pier Paolo Pandolfi
Int. J. Biol. Sci. 2015; 11(6): 629-632. doi:10.7150/ijbs.11615
[Abstract] [Full text] [PDF]


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Research Paper
Tamoxifen Inhibits ER-negative Breast Cancer Cell Invasion and Metastasis by Accelerating Twist1 Degradation
Gang Ma, Jianjun He, Yang Yu, Yixiang Xu, Xiaobin Yu, Jarrod Martinez, David M. Lonard, Jianming Xu
Int. J. Biol. Sci. 2015; 11(5): 618-628. doi:10.7150/ijbs.11380
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Review
DNA Methylation, Its Mediators and Genome Integrity
Huan Meng, Ying Cao, Jinzhong Qin, Xiaoyu Song, Qing Zhang, Yun Shi, Liu Cao
Int. J. Biol. Sci. 2015; 11(5): 604-617. doi:10.7150/ijbs.11218
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
1H NMR Based Serum Metabolic Profiles Associated with Pathological Progression of Pancreatic Islet β Cell Tumor in Rip1-Tag2 Mice
Yongxia Yang, Ying Liu, Lingyun Zheng, Qianqian Zhang, Quliang Gu, Linlin Wang, Lijing Wang
Int. J. Biol. Sci. 2015; 11(5): 595-603. doi:10.7150/ijbs.11058
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Recognition of Cytosolic DNA Attenuates Glucose Metabolism and Induces AMPK Mediated Energy Stress Response
Min Zheng, Linna Xie, Yaoji Liang, Suqin Wu, Huijuan Xu, Yuedong Zhang, Hekun Liu, Dexin Lin, Jiahuai Han, Kunping Lu
Int. J. Biol. Sci. 2015; 11(5): 587-594. doi:10.7150/ijbs.10945
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
The effects of Insulin Pre-Administration in Mice Exposed to Ethanol: Alleviating Hepatic Oxidative Injury through Anti-Oxidative, Anti-Apoptotic Activities and Deteriorating Hepatic Steatosis through SRBEP-1c Activation
Jiangzheng Liu, Xin Wang, Zhengwu Peng, Tao Zhang, Hao Wu, Weihua Yu, Deqing Kong, Ying Liu, Hua Bai, Rui Liu, Xiaodi Zhang, Chunxu Hai
Int. J. Biol. Sci. 2015; 11(5): 569-586. doi:10.7150/ijbs.11039
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
ER Stress and Autophagy Dysfunction Contribute to Fatty Liver in Diabetic Mice
Quan Zhang, Yan Li, Tingting Liang, Xuemian Lu, Chi Zhang, Xingkai Liu, Xin Jiang, Robert C. Martin, Mingliang Cheng, Lu Cai
Int. J. Biol. Sci. 2015; 11(5): 559-568. doi:10.7150/ijbs.10690
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Evidence for Fungal Infection in Cerebrospinal Fluid and Brain Tissue from Patients with Amyotrophic Lateral Sclerosis
Ruth Alonso, Diana Pisa, Ana Isabel Marina, Esperanza Morato, Alberto Rábano, Izaskun Rodal, Luis Carrasco
Int. J. Biol. Sci. 2015; 11(5): 546-558. doi:10.7150/ijbs.11084
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Brain-Derived Neurotrophic Factor Regulates TRPC3/6 Channels and Protects Against Myocardial Infarction in Rodents
Pengzhou Hang, Jing Zhao, Benzhi Cai, Shanshan Tian, Wei Huang, Jing Guo, Chuan Sun, Yue Li, Zhimin Du
Int. J. Biol. Sci. 2015; 11(5): 536-545. doi:10.7150/ijbs.10754
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
NOD2 is Involved in the Inflammatory Response after Cerebral Ischemia-Reperfusion Injury and Triggers NADPH Oxidase 2-Derived Reactive Oxygen Species
Huiqing Liu, Xinbing Wei, Lingjun Kong, Xiaoqian Liu, Li Cheng, Shi Yan, Xiumei Zhang, Lin Chen
Int. J. Biol. Sci. 2015; 11(5): 525-535. doi:10.7150/ijbs.10927
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Review
Modulation of Glucose Transporter Protein by Dietary Flavonoids in Type 2 Diabetes Mellitus
Fatemeh Hajiaghaalipour, Manizheh Khalilpourfarshbafi, Aditya Arya
Int. J. Biol. Sci. 2015; 11(5): 508-524. doi:10.7150/ijbs.11241
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
The Histone H3K9 Demethylase Kdm3b Is Required for Somatic Growth and Female Reproductive Function
Zhaoliang Liu, Xian Chen, Suoling Zhou, Lan Liao, Rui Jiang, Jianming Xu
Int. J. Biol. Sci. 2015; 11(5): 494-507. doi:10.7150/ijbs.11849
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Activation of TLR3 Induces Osteogenic Responses in Human Aortic Valve Interstitial Cells through the NF-κB and ERK1/2 Pathways
Qiong Zhan, Rui Song, Qingchun Zeng, Qingzhou Yao, Lihua Ao, Dingli Xu, David A. Fullerton, Xianzhong Meng
Int. J. Biol. Sci. 2015; 11(4): 482-493. doi:10.7150/ijbs.10905
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Stem Cell Transplantation Upregulates Sirt1 and Antioxidant Expression, Ameliorating Fatty Liver in Type 2 Diabetic Mice
Ming Li, Kequan Guo, Luca Vanella, Shigeru Taketani, Yasushi Adachi, Susumu Ikehara
Int. J. Biol. Sci. 2015; 11(4): 472-481. doi:10.7150/ijbs.10809
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Hints for Metal-Preference Protein Sequence Determinants: Different Metal Binding Features of the Five Tetrahymena thermophila Metallothioneins
Anna Espart, Maribel Marín, Selene Gil-Moreno, Òscar Palacios, Francisco Amaro, Ana Martín-González, Juan C. Gutiérrez, Mercè Capdevila, Sílvia Atrian
Int. J. Biol. Sci. 2015; 11(4): 456-471. doi:10.7150/ijbs.11060
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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