International Journal of Biological Sciences
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ISSN 1449-2288

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Theranostics

International Journal of Medical Sciences

Journal of Cancer

Oncomedicine

Journal of Genomics

Journal of Bone and Joint Infection (JBJI)

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Journal of Genomics now in PubMed/PubMed Central. Submit manuscript...

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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

new Latest impact factor is 3.982. 5 year IF is 4.454.
new Cover suggestion ...details
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Most Cited Paper Award: Winners of this year are Zhi-Yuan Xu et al, for the paper "Knockdown of Long Non-coding RNA HOTAIR Suppresses Tumor Invasion and Reverses Epithelial-mesenchymal Transition in Gastric Cancer". Details...
The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details
Top cited papers:
Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...
The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details
Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details
Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details
The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details
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Research Paper
The Correlation Between PARP1 and BRCA1 in AR Positive Triple-negative Breast Cancer
Jiayan Luo, Juan Jin, Fang Yang, Zijia Sun, Wenwen Zhang, Yaqin Shi, Jing Xu, Xiaoxiang Guan
Int. J. Biol. Sci. 2016; 12(12): 1500-1510. doi:10.7150/ijbs.16176
[Abstract] [Full text] [PDF]


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Research Paper
LIS1 Regulates Osteoclastogenesis through Modulation of M-SCF and RANKL Signaling Pathways and CDC42
Shiqiao Ye, Toshifumi Fujiwara, Jian Zhou, Kottayil I Varughese, Haibo Zhao
Int. J. Biol. Sci. 2016; 12(12): 1488-1499. doi:10.7150/ijbs.15583
[Abstract] [Full text] [PDF]


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Research Paper
Exosomes Derived from Human Endothelial Progenitor Cells Accelerate Cutaneous Wound Healing by Promoting Angiogenesis Through Erk1/2 Signaling
Jieyuan Zhang, Chunyuan Chen, Bin Hu, Xin Niu, Xiaolin Liu, Guowei Zhang, Changqing Zhang, Qing Li, Yang Wang
Int. J. Biol. Sci. 2016; 12(12): 1472-1487. doi:10.7150/ijbs.15514
[Abstract] [Full text] [PDF]


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Research Paper
Autophagy activation protects shock wave induced renal tubular epithelial cell apoptosis may through modulation of Akt/ GSK-3β pathway
Qingzhi Long, Xiang Li, Hui He, Dalin He
Int. J. Biol. Sci. 2016; 12(12): 1461-1471. doi:10.7150/ijbs.16864
[Abstract] [Full text] [PDF]


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Research Paper
Pathological Characterization Of IFNAR(-/-) Mice Infected With Bluetongue Virus Serotype 4
Alejandro Marín-López, Roberto Bermúdez, Eva Calvo-Pinilla, Sandra Moreno, Alejandro Brun, Javier Ortego
Int. J. Biol. Sci. 2016; 12(12): 1448-1460. doi:10.7150/ijbs.14967
[Abstract] [Full text] [PDF]


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Research Paper
MiR-99a and MiR-491 Regulate Cisplatin Resistance in Human Gastric Cancer Cells by Targeting CAPNS1
Yajie Zhang, Wenxia Xu, Pan Ni, Aiping Li, Jianwei Zhou, Shan Xu
Int. J. Biol. Sci. 2016; 12(12): 1437-1447. doi:10.7150/ijbs.16529
[Abstract] [Full text] [PDF]


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Review
CRISPR-Cas9: from Genome Editing to Cancer Research
Si Chen, Heng Sun, Kai Miao, Chu-Xia Deng
Int. J. Biol. Sci. 2016; 12(12): 1427-1436. doi:10.7150/ijbs.17421
[Abstract] [Full text] [PDF]


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Research Paper
Catalpol Protects Pre-Myelinating Oligodendrocytes against Ischemia-induced Oxidative Injury through ERK1/2 Signaling Pathway
Qiyan Cai, Teng Ma, Chengren Li, Yanping Tian, Hongli Li
Int. J. Biol. Sci. 2016; 12(12): 1415-1426. doi:10.7150/ijbs.16823
[Abstract] [Full text] [PDF]


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Research Paper
Distributed Features of Vimentin-Containing Neural Precursor Cells in Olfactory Bulb of SOD1G93A Transgenic Mice: a Study about Resource of Endogenous Neural Stem Cells
Chunyan Tang, Lei Zhu, Weiming Gan, Huiting Liang, Jiao Li, Jie Zhang, Xiong Zhang, Yi Lu, Renshi Xu
Int. J. Biol. Sci. 2016; 12(12): 1405-1414. doi:10.7150/ijbs.16696
[Abstract] [Full text] [PDF]


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Research Paper
Conserved chemosensory proteins in the proboscis and eyes of Lepidoptera
Jiao Zhu, Immacolata Iovinella, Francesca Romana Dani, Yu-Ling Liu, Ling-Qiao Huang, Yang Liu, Chen-Zhu Wang, Paolo Pelosi, Guirong Wang
Int. J. Biol. Sci. 2016; 12(11): 1394-1404. doi:10.7150/ijbs.16517
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Genetic Variant in Flavin-Containing Monooxygenase 3 Alters Lipid Metabolism in Laying Hens in a Diet-Specific Manner
Jing Wang, Cheng Long, Haijun Zhang, Yanan Zhang, Hao Wang, Hongyuan Yue, Xiaocui Wang, Shugeng Wu, Guanghai Qi
Int. J. Biol. Sci. 2016; 12(11): 1382-1393. doi:10.7150/ijbs.16472
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Review
Insights into the Nanog gene: A propeller for stemness in primitive stem cells
Wei Zhang, Yi Sui, Jun Ni, Tao Yang
Int. J. Biol. Sci. 2016; 12(11): 1372-1381. doi:10.7150/ijbs.16349
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Aloe-emodin suppresses hypoxia-induced retinal angiogenesis via inhibition of HIF-1α/VEGF pathway
Jianming Wu, Xiao Ke, Wei Wang, Hongcheng Zhang, Na Ma, Wei Fu, Manxi Zhao, Xiaoping Gao, Xiaofeng Hao, Zhirong Zhang
Int. J. Biol. Sci. 2016; 12(11): 1363-1371. doi:10.7150/ijbs.16334
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
IL28B SNP rs12979860 is the Critical Predictor for Sustained Viral Response in Chinese Children Aged 1 to 6 Years with Chronic Hepatitis C
Yan-Wei Zhong, Hong-Fei Zhang, Yan-Min Shi, Yong-Li Li, Fang Chu, Zhi-Qiang Xu, Da-Wei Chen, Yu Gan, Fu-Chuan Wang, Mei-Lei Gu, Yi Dong, Shi-Shu Zhu, Ce Shi, Hua-Hao Fan, Xiu-Chang Zhang, Min Zhang
Int. J. Biol. Sci. 2016; 12(11): 1357-1362. doi:10.7150/ijbs.16220
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Ginsenoside Rg1 Protects against Oxidative Stress-induced Neuronal Apoptosis through Myosin IIA-actin Related Cytoskeletal Reorganization
Yan Wang, Qian Liu, Yingqiong Xu, Yuanyuan Zhang, Yanni Lv, Yisha Tan, Nan Jiang, Guosheng Cao, Xiaonan Ma, Jingrong Wang, Zhengyu Cao, Boyang Yu, Junping Kou
Int. J. Biol. Sci. 2016; 12(11): 1341-1356. doi:10.7150/ijbs.15992
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Review
The Evolving Functions of Autophagy in Ocular Health: A Double-edged Sword
Peiwei Chai, Hongyan Ni, He Zhang, Xianqun Fan
Int. J. Biol. Sci. 2016; 12(11): 1332-1340. doi:10.7150/ijbs.16245
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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