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Research Paper
Mesoporous bioactive glass combined with graphene oxide scaffolds for bone repair
Wei Wang, Yang Liu, Chao Yang, Xin Qi, Shuangwu Li, Changsheng Liu, Xiaolin Li
Int. J. Biol. Sci. 2019; 15(10): 2156-2169. doi:10.7150/ijbs.35670
[Abstract] [Full text] [PDF]


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Research Paper
EFEMP2 suppresses epithelial-mesenchymal transition via Wnt/β-catenin signaling pathway in human bladder cancer
Qiang Zhou, Song Chen, Mengxin Lu, Yongwen Luo, Gang Wang, Yu Xiao, Lingao Ju, Xinghuan Wang
Int. J. Biol. Sci. 2019; 15(10): 2139-2155. doi:10.7150/ijbs.35541
[Abstract] [Full text] [PDF]


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Review
Radiation-induced heart disease: a review of classification, mechanism and prevention
Heru Wang, Jinlong Wei, Qingshuang Zheng, Lingbin Meng, Ying Xin, Xia Yin, Xin Jiang
Int. J. Biol. Sci. 2019; 15(10): 2128-2138. doi:10.7150/ijbs.35460
[Abstract] [Full text] [PDF]


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Research Paper
The Grass Carp Genomic Visualization Database (GCGVD): an informational platform for genome biology of grass carp
Min Tang, Ying Lu, Zhongmin Xiong, Ming Chen, Yufang Qin
Int. J. Biol. Sci. 2019; 15(10): 2119-2127. doi:10.7150/ijbs.32860
[Abstract] [Full text] [PDF]


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Research Paper
Extracellular Vesicles (EVs) from Lung Adenocarcinoma Cells Promote Human Umbilical Vein Endothelial Cell (HUVEC) Angiogenesis through Yes Kinase-associated Protein (YAP) Transport
Ying Wang, Liyang Dong, Hai Zhong, Linfei Yang, Qian Li, Chuan Su, Wei Gu, Yingying Qian
Int. J. Biol. Sci. 2019; 15(10): 2110-2118. doi:10.7150/ijbs.31605
[Abstract] [Full text] [PDF]


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Research Paper
5-aminolaevulinic acid-based photodynamic therapy inhibits ultraviolet B-induced skin photodamage
Hui Hua, Jia-wei Cheng, Wen-bo Bu, Juan Liu, Wei-wei Ma, Na Ni, Jian Shi, Bing-rong Zhou, Dan Luo
Int. J. Biol. Sci. 2019; 15(10): 2100-2109. doi:10.7150/ijbs.31583
[Abstract] [Full text] [PDF]


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Research Paper
Ciliary IFT80 regulates dental pulp stem cells differentiation by FGF/FGFR1 and Hh/BMP2 signaling
Xue Yuan, Min Liu, Xu Cao, Shuying Yang
Int. J. Biol. Sci. 2019; 15(10): 2087-2099. doi:10.7150/ijbs.27231
[Abstract] [Full text] [PDF]


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Research Paper
Deregulation of CSMD1 targeted by microRNA-10b drives gastric cancer progression through the NF-κB pathway
Xiang-Liu Chen, Lian-Lian Hong, Kai-Lai Wang, Xiang Liu, Jiu-Li Wang, Lan Lei, Zhi-Yuan Xu, Xiang-Dong Cheng, Zhi-Qiang Ling
Int. J. Biol. Sci. 2019; 15(10): 2075-2086. doi:10.7150/ijbs.23802
[Abstract] [Full text] [PDF]


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Research Paper
Trends in Alzheimer's Disease Research Based upon Machine Learning Analysis of PubMed Abstracts
Renchu Guan, Xiaojing Wen, Yanchun Liang, Dong Xu, Baorun He, Xiaoyue Feng
Int. J. Biol. Sci. 2019; 15(10): 2065-2074. doi:10.7150/ijbs.35743
[Abstract] [Full text] [PDF]


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Research Paper
Circular RNA CircEZH2 Suppresses Transmissible Gastroenteritis Coronavirus-induced Opening of Mitochondrial Permeability Transition Pore via Targeting MiR-22 in IPEC-J2
Xiaomin Zhao, Xuelian Ma, Jianxiong Guo, Mi Mi, Kaili Wang, Chuyi Zhang, Xiaoyi Tang, Lingling Chang, Yong Huang, Dewen Tong
Int. J. Biol. Sci. 2019; 15(10): 2051-2064. doi:10.7150/ijbs.36532
[Abstract] [Full text] [PDF]


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Research Paper
Vascular Protection of TPE-CA on Hyperhomocysteinemia-induced Vascular Endothelial Dysfunction through AA Metabolism Modulated CYPs Pathway
Hui Li, Zhenli Liu, Linlin Liu, Wen Li, Zhiwen Cao, Zhiqian Song, Qianqian Yang, Aiping Lu, Cheng Lu, Yuanyan Liu
Int. J. Biol. Sci. 2019; 15(10): 2037-2050. doi:10.7150/ijbs.35245
[Abstract] [Full text] [PDF]


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Review
Should we reconsider the apoptosis as a strategic player in tissue regeneration?
Bruna Codispoti, Irina Makeeva, Jamal Sied, Caterina Benincasa, Salvatore Scacco, Marco Tatullo
Int. J. Biol. Sci. 2019; 15(10): 2029-2036. doi:10.7150/ijbs.36362
[Abstract] [Full text] [PDF]


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Research Paper
Artemisinin Protects Human Retinal Pigmented Epithelial Cells Against Hydrogen Peroxide-induced Oxidative Damage by Enhancing the Activation of AMP-active Protein Kinase
Shuai Li, Shubhash Chandra chaudhary, Xia Zhao, Uma Gaur, Jiankang Fang, Fengxia Yan, Wenhua Zheng
Int. J. Biol. Sci. 2019; 15(9): 2016-2028. doi:10.7150/ijbs.30536
[Abstract] [Full text] [PDF]


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Research Paper
p53 Mutant p53N236S Induces Neural Tube Defects in Female Embryos Abnormal Cellular Proliferation, Differentiation and Apoptosis are Involved in the Gain of Function of p53N236S that Induces Female-specific Neural Tube Defects
Jinzhi Zhao, Yingbing Tian, Huihui Zhang, Lianhua Qu, Yu Chen, Qing Liu, Ying luo, Xiaoming Wu
Int. J. Biol. Sci. 2019; 15(9): 2006-2015. doi:10.7150/ijbs.31451
[Abstract] [Full text] [PDF]


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Research Paper
Deletion of CD163 Exon 7 Confers Resistance to Highly Pathogenic Porcine Reproductive and Respiratory Viruses on Pigs
Haitao Wang, Liangcai Shen, Jingyao Chen, Xiaojuan Liu, Tan Tan, Yiqing Hu, Xiaofei Bai, Yuexin Li, Kegong Tian, Ning Li, Xiaoxiang Hu
Int. J. Biol. Sci. 2019; 15(9): 1993-2005. doi:10.7150/ijbs.34269
[Abstract] [Full text] [PDF]


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Research Paper
Development and Validation of Tumor-educated Blood Platelets Integrin Alpha 2b (ITGA2B) RNA for Diagnosis and Prognosis of Non-small-cell Lung Cancer through RNA-seq
Shan Xing, Tao Zeng, Ning Xue, Yi He, Yan-zhen Lai, Hui-lan Li, Qi Huang, Shu-lin Chen, Wan-li Liu
Int. J. Biol. Sci. 2019; 15(9): 1977-1992. doi:10.7150/ijbs.36284
[Abstract] [Full text] [PDF]

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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau

Editor-in-Chief's Profile

Impact factor is 4.067 according to 2019 release of Journal Citation Reports®.
new Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details
Top cited papers:
The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details
Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details
Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details
In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details