International Journal of Biological Sciences
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ISSN 1449-2288

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Theranostics

International Journal of Medical Sciences

Journal of Cancer

Oncomedicine

Journal of Genomics

Journal of Bone and Joint Infection (JBJI)

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Journal of Genomics now in PubMed/PubMed Central. Submit manuscript...

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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

new Latest impact factor is 3.982. 5 year IF is 4.454.
new Cover suggestion ...details
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Most Cited Paper Award: Winners of this year are Yan-Cun Liu, Xian-Biao Zou, Yan-Fen Chai, Yong-Ming Yao, for the paper "Macrophage Polarization in Inflammatory Diseases". Details...
The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details
Top cited papers:
Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...
The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details
Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details
Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details
The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details
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Research Paper
Recapitulating and Correcting Marfan Syndrome in a Cellular Model
Jung Woo Park, Li Yan, Chris Stoddard, Xiaofang Wang, Zhichao Yue, Leann Crandall, Tiwanna Robinson, Yuxiao Chang, Kyle Denton, Enqin Li, Bin Jiang, Zhenwu Zhang, Kristen Martins-Taylor, Siu-Pok Yee, Hong Nie, Feng Gu, Wei Si, Ting Xie, Lixia Yue, Ren-He Xu
Int. J. Biol. Sci. 2017; 13(5): 588-603. doi:10.7150/ijbs.19517
[Abstract] [Full text] [PDF]


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Research Paper
Aldehyde Dehydrogenases 1A2 Expression and Distribution are Potentially Associated with Neuron Death in Spinal Cord of Tg(SOD1*G93A)1Gur Mice
Huiting Liang, Chengsi Wu, Youqing Deng, Lei Zhu, Jie Zhang, Weiming Gan, Chunyan Tang, Renshi Xu
Int. J. Biol. Sci. 2017; 13(5): 574-587. doi:10.7150/ijbs.19150
[Abstract] [Full text] [PDF]


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Research Paper
DNA Methylation Mediated Down-Regulation of miR-370 Regulates Cell Growth through Activation of the Wnt/β-Catenin Signaling Pathway in Human Osteosarcoma Cells
Wentao Zhang, Ning Duan, Qian Zhang, Tao Song, Zhong Li, Caiguo Zhang, Xun Chen, Kunzheng Wang
Int. J. Biol. Sci. 2017; 13(5): 561-573. doi:10.7150/ijbs.19032
[Abstract] [Full text] [PDF]


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Review
Multifaceted Regulation of Gene Expression by the Apoptosis- and Splicing-Associated Protein Complex and Its Components
Bhagyashree Deka, Kusum Kumari Singh
Int. J. Biol. Sci. 2017; 13(5): 545-560. doi:10.7150/ijbs.18649
[Abstract] [Full text] [PDF]


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Research Paper
Increased expression of thyroid hormone responsive protein (THRSP) is the result but not the cause of higher intramuscular fat content in cattle
Lisa Schering, Elke Albrecht, Katrin Komolka, Christa Kühn, Steffen Maak
Int. J. Biol. Sci. 2017; 13(5): 532-544. doi:10.7150/ijbs.18775
[Abstract] [Full text] [PDF]


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Research Paper
Cold Inducible RNA Binding Protein Is Involved in Chronic Hypoxia Induced Neuron Apoptosis by Down-Regulating HIF-1α Expression and Regulated By microRNA-23a
Xiaoming Chen, Xinqin Liu, Bin Li, Qian Zhang, Jiye Wang, Wenbin Zhang, Wenjing Luo, Jingyuan Chen
Int. J. Biol. Sci. 2017; 13(4): 518-531. doi:10.7150/ijbs.17800
[Abstract] [Full text] [PDF]


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Research Paper
Targeting HSP90-HDAC6 Regulating Network Implicates Precision Treatment of Breast Cancer
Shiyi Yu, Xiuxiu Cai, Chenxi Wu, Yan Liu, Jun Zhang, Xue Gong, Xin Wang, Xiaoli Wu, Tao Zhu, Lin Mo, Jun Gu, Zhenghong Yu, Jinfei Chen, Jean Paul Thiery, Renjie Chai, Liming Chen
Int. J. Biol. Sci. 2017; 13(4): 505-517. doi:10.7150/ijbs.18834
[Abstract] [Full text] [PDF]


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Research Paper
Deguelin Attenuates Allergic Airway Inflammation via Inhibition of NF-κb Pathway in Mice
Zhang Bao, Pei Zhang, Yinan Yao, Guohua Lu, Zhongkai Tong, Bing Yan, Lingfang Tu, Guangdie Yang, Jianying Zhou
Int. J. Biol. Sci. 2017; 13(4): 492-504. doi:10.7150/ijbs.17238
[Abstract] [Full text] [PDF]


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Research Paper
Ethyl acetate fraction of Huogu formula inhibits adipogenic differentiation of bone marrow stromal cells via the BMP and Wnt signaling pathways
Xiangying Kong, Xiaomin Li, Cun Zhang, Liuluan Zhu, Chunfang Liu, Qingxia Qin, Cuiling Liu, Qianqian Wang, Jia Zhu, Xuan Wu, Hongye Wan, Weiheng Chen, Na Lin
Int. J. Biol. Sci. 2017; 13(4): 480-491. doi:10.7150/ijbs.18430
[Abstract] [Full text] [PDF]


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Research Paper
Dipalmitoylphosphatidic acid inhibits tumor growth in triple-negative breast cancer
Qian-Qian Zhang, Jian Chen, Da-Lei Zhou, You-Fa Duan, Cui-Ling Qi, Jiang-Chao Li, Xiao-Dong He, Min Zhang, Yong-Xia Yang, Lijing Wang
Int. J. Biol. Sci. 2017; 13(4): 471-479. doi:10.7150/ijbs.16290
[Abstract] [Full text] [PDF]


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Research Paper
Characterization of Cytosine Methylation and the DNA Methyltransferases of Toxoplasma gondii
Haixia Wei, Shichen Jiang, Longfei Chen, Cheng He, Shuizhen Wu, Hongjuan Peng
Int. J. Biol. Sci. 2017; 13(4): 458-470. doi:10.7150/ijbs.18644
[Abstract] [Full text] [PDF]


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Review
The role of germ cell loss during primordial follicle assembly: a review of current advances
Yuan-Chao Sun, Xiao-Feng Sun, Paul W. Dyce, Wei Shen, Hong Chen
Int. J. Biol. Sci. 2017; 13(4): 449-457. doi:10.7150/ijbs.18836
[Abstract] [Full text] [PDF]


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Research Paper
Estradiol Suppresses TLR4-triggered Apoptosis of Decidual Stromal Cells and Drives an Anti-inflammatory TH2 Shift by Activating SGK1
Yiyun Lou, Minhao Hu, Qijing Wang, Mu Yuan, Ning Wang, Fang Le, Lejun Li, Shisi Huang, Liya Wang, Xiangrong Xu, Fan Jin
Int. J. Biol. Sci. 2017; 13(4): 434-448. doi:10.7150/ijbs.18278
[Abstract] [Full text] [PDF]


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Review
Role of Epigenetics in Uveal Melanoma
Yongyun Li, Renbing Jia, Shengfang Ge
Int. J. Biol. Sci. 2017; 13(4): 426-433. doi:10.7150/ijbs.18331
[Abstract] [Full text] [PDF]


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Research Paper
MiR-696 Regulates C2C12 Cell Proliferation and Differentiation by Targeting CNTFRα
Han Wang, Lei Shi, Tingting Liang, BinBin Wang, WangJun Wu, Guosheng Su, Julong Wei, Pinghua Li, Ruihua Huang
Int. J. Biol. Sci. 2017; 13(4): 413-425. doi:10.7150/ijbs.17508
[Abstract] [Full text] [PDF]


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Review
Photoacoustic-Based Multimodal Nanoprobes: from Constructing to Biological Applications
Duyang Gao, Zhen Yuan
Int. J. Biol. Sci. 2017; 13(4): 401-412. doi:10.7150/ijbs.18750
[Abstract] [Full text] [PDF]

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