International Journal of Biological Sciences

Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

Impact factor is 3.873 (five year impact factor 4.689) according to 2017 release of Journal Citation Reports®.
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Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (full index information)
Full texts of articles in PubMed Central and Europe PMC.
(For NIH-funded researchers) Save time by submitting your paper to us - this journal is in full compliance with NIH Public Access Requirement.

Most Cited Paper Award: Winners of this year are Yan-Cun Liu, Xian-Biao Zou, Yan-Fen Chai, Yong-Ming Yao, for the paper "Macrophage Polarization in Inflammatory Diseases". Details...

Special Issue on Computational Resources and Methods in Biological Sciences. Guest editors:
Prof. Jian Huang, Dr. Hao Lin, Prof. Shaoliang Peng.

The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details

Top cited papers:

G Chen et al. TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation. Cited by 237
BF Zamarron & W Chen. Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression. Cited by 172
TM Thornton & M Rincon. Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival. Cited by 200
HB Shao et al. Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells. Cited by 247
JK Lunney. Advances in Swine Biomedical Model Genomics. Cited by 255
DP Siderovski & FS Willard. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Cited by 241

Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...

The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details

Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details

Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details

The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details

Research Paper
Apoptosis Induction by Iron Radiation via Inhibition of Autophagy in Trp53^+/- Mouse Testes: Is Chronic Restraint-Induced Stress a Modifying Factor?
Hongyan Li, Bing Wang, Hong Zhang, Takanori Katsube, Yi Xie, Lu Gan
Int. J. Biol. Sci. 2018; 14(9): 1109-1121. doi:10.7150/ijbs.22805
[Abstract] [Full text] [PDF]

Research Paper
Zika Virus Envelope Protein induces G2/M Cell Cycle Arrest and Apoptosis via an Intrinsic Cell Death Signaling Pathway in Neuroendocrine PC12 Cells
Jun Liu, Qingqing Li, Xiaoxin Li, Zhenzhen Qiu, Andrew Li, Wenhan Liang, Huangyao Chen, Xiangsheng Cai, Xinglu Chen, Xinyue Duan, Jingjing Li, Wangsheng Wu, Mingyu Xu, Yingying Mao, Huiying Chen, Jinlong Li, Weiwang Gu, Hongwei Li
Int. J. Biol. Sci. 2018; 14(9): 1099-1108. doi:10.7150/ijbs.26400
[Abstract] [Full text] [PDF]

Review
The Nrf2 Signaling in Retinal Ganglion Cells under Oxidative Stress in Ocular Neurodegenerative Diseases
Xiu-Fen Liu, Dan-Dan Zhou, Tian Xie, Ji-Long Hao, Tayyab Hamid Malik, Cheng-Bo Lu, Jing Qi, Om Prakash Pant, Cheng-Wei Lu
Int. J. Biol. Sci. 2018; 14(9): 1090-1098. doi:10.7150/ijbs.25996
[Abstract] [Full text] [PDF]

Research Paper
Phosphorylation of SMC1A promotes hepatocellular carcinoma cell proliferation and migration
Ying Zhang, Fei Yi, Liang Wang, Zhuo Wang, Naijin Zhang, Zhijun Wang, Ziwei Li, Xiaoyu Song, Shi Wei, Liu Cao
Int. J. Biol. Sci. 2018; 14(9): 1081-1089. doi:10.7150/ijbs.24692
[Abstract] [Full text] [PDF]

Research Paper
WDR1 Promotes Cell Growth and Migration and Contributes to Malignant Phenotypes of Non-small Cell Lung Cancer through ADF/cofilin-mediated Actin Dynamics
Baiyin Yuan, Ruirui Zhang, Jisheng Hu, Zhongying Liu, Chao Yang, Tongcun Zhang, Chenxi Zhang
Int. J. Biol. Sci. 2018; 14(9): 1067-1080. doi:10.7150/ijbs.23845
[Abstract] [Full text] [PDF]

Research Paper
CCL2-SQSTM1 positive feedback loop suppresses autophagy to promote chemoresistance in gastric cancer
Wenxia Xu, Qi Wei, Mengjiao Han, Bingluo Zhou, Hanying Wang, Jianbing Zhang, Qiang Wang, Jie Sun, Lifeng Feng, Shouyu Wang, Yang Ye, Xian Wang, Jianwei Zhou, Hongchuan Jin
Int. J. Biol. Sci. 2018; 14(9): 1054-1066. doi:10.7150/ijbs.25349
[Abstract] [Full text] [PDF]

Research Paper
Aberrant Levels of Cystatin C in Amyotrophic Lateral Sclerosis: a Systematic Review and Meta Analysis
Yu Zhu, Mi Yang, Fangjun Li, Menghua Li, Zhenzhen Xu, Fang Yang, Yue Liu, Wenzhi Chen, Yougen Zhang, Renshi Xu
Int. J. Biol. Sci. 2018; 14(9): 1041-1053. doi:10.7150/ijbs.25711
[Abstract] [Full text] [PDF]

Research Paper
Kupffer-derived matrix metalloproteinase-9 contributes to liver fibrosis resolution
Min Feng, Jie Ding, Min Wang, Jie Zhang, Xinhua Zhu, Wenxian Guan
Int. J. Biol. Sci. 2018; 14(9): 1033-1040. doi:10.7150/ijbs.25589
[Abstract] [Full text] [PDF]

Research Paper
Overexpression of Toll-like Receptor 4-linked Mitogen-activated Protein Kinase Signaling Contributes to Internalization of Escherichia coli in Sheep
Sutian Wang, Yang Cao, Shoulong Deng, Xiaojing Jiang, Jiahao Wang, Xiaosheng Zhang, Jinlong Zhang, Guoshi Liu, Zhengxing Lian
Int. J. Biol. Sci. 2018; 14(9): 1022-1032. doi:10.7150/ijbs.25275
[Abstract] [Full text] [PDF]

Research Paper
Mesenchymal Stem Cells Promote Tumor Progression via Inducing Stroma Remodeling on Rabbit VX2 Bladder Tumor Model
Jun Chen, Lin Ma, Nianzhao Zhang, Yaofeng Zhu, Keqin Zhang, Zhishun Xu, Qian Wang
Int. J. Biol. Sci. 2018; 14(9): 1012-1021. doi:10.7150/ijbs.25200
[Abstract] [Full text] [PDF]

Review
The role of FGF21 in type 1 diabetes and its complications
Jian Zhang, Wenya Weng, Kai Wang, Xuemian Lu, Lu Cai, Jian Sun
Int. J. Biol. Sci. 2018; 14(9): 1000-1011. doi:10.7150/ijbs.25026
[Abstract] [Full text] [PDF]

Research Paper
An Inhibitor of Casein Kinase 1ε/δ (PF670462) Prevents the Deterioration of Dextran Sodium Sulfate-induced Ulcerative Colitis Caused by UVB Eye Irradiation
Keiichi Hiramoto, Yurika Yamate, Emiko Kasahara, Eisuke F Sato
Int. J. Biol. Sci. 2018; 14(9): 992-999. doi:10.7150/ijbs.24558
[Abstract] [Full text] [PDF]

Research Paper
Improving Prediction of Self-interacting Proteins Using Stacked Sparse Auto-Encoder with PSSM profiles
Yan-Bin Wang, Zhu-Hong You, Li-Ping Li, De-Shuang Huang, Feng-Feng Zhou, Shan Yang
Int. J. Biol. Sci. 2018; 14(8): 983-991. doi:10.7150/ijbs.23817
[Abstract] [Full text] [PDF]

Research Paper
Predicting Potential Drugs for Breast Cancer based on miRNA and Tissue Specificity
Liang Yu, Jin Zhao, Lin Gao
Int. J. Biol. Sci. 2018; 14(8): 971-982. doi:10.7150/ijbs.23350
[Abstract] [Full text] [PDF]

Research Paper
RicyerDB: A Database For Collecting Rice Yield-related Genes with Biological Analysis
Jing Jiang, Fei Xing, Xiangxiang Zeng, Quan Zou
Int. J. Biol. Sci. 2018; 14(8): 965-970. doi:10.7150/ijbs.23328
[Abstract] [Full text] [PDF]

Research Paper
HBPred: a tool to identify growth hormone-binding proteins
Hua Tang, Ya-Wei Zhao, Ping Zou, Chun-Mei Zhang, Rong Chen, Po Huang, Hao Lin
Int. J. Biol. Sci. 2018; 14(8): 957-964. doi:10.7150/ijbs.24174
[Abstract] [Full text] [PDF]

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