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International Journal of Medical Sciences
Journal of Cancer
Theranostics
Journal of Genomics
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Editor-in-Chief: Chuxia Deng, PhD, National Institutes
of Health*, Bethesda, MD
* Dr. Deng is serving in his personal capacity.
Editor-in-Chief's Profile
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- Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (full index information)
- Full texts of articles in PubMed
Central, Europe PMC, and PMC Canada.
- Rapid review and publication.
- (For NIH-funded researchers) Save time by submitting your paper to us - this journal is in full compliance with NIH Public Access Requirement.
- High visibility of articles over the Internet.
- This Journal is ranked among the top 2.1% of journals (29/1380) according to SCImago in the area of
Agricultural and Biological Sciences ...details
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| Most Cited Paper Award in 2013: Winners of this year are Guan Yang and Xiao Yang from Institute of Biotechnology, AMMS, Beijing, for the paper "Smad4-mediated TGF-β signaling in tumorigenesis", cited by 42. Winners of previous years were Tina M. Thornton and Mercedes Rincon from University of Vermont (2012), Hong-Bo Shao et al. from Chinese Academy of Sciences (2011), and Joan K. Lunney from United States Department of Agriculture (2010). ...details |
| The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details |
| Top cited papers:
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| The periodontal ligament (PDL) is a fibrous connective tissue that attaches the tooth to the alveolar bone. We previously demonstrated the ability of PDL fibroblast-like cells to construct an endothelial cell (EC) marker-positive blood vessel-like structure, indicating the potential of fibroblastic lineage cells in PDL tissue as precursors of endothelial progenitor cells (EPCs) to facilitate the construction of a vascular system around damaged PDL tissue. A vascular regeneration around PDL tissue needs proliferation of vascular progenitor cells and the subsequent differentiation of the cells. Transforming growth factor-β (TGF-β) is known as an inducer of endothelial-mesenchymal transition (EndMT), however, it remains to be clarified what kinds of TGF-β signals affect growth and mesenchymal differentiation of PDL-derived EPC-like fibroblastic cells. Here, we demonstrated that TGF-β1 not only suppressed the proliferation of the PDL-derived EPC-like fibroblastic cells, but also induced smooth muscle cell (SMC) markers expression in the cells. ...details |
| Pancreatitis occurs when digestive enzymes are activated in the pancreas. Severe pancreatitis has a 10-30% mortality rate. No specific treatments for pancreatitis exist now. Here, Feng et al. discovered that interleukin-22 (IL-22) may have therapeutic potential in treating acute and chronic pancreatitis. Wild-type and IL-22 knockout mice were equally susceptible to ceru-lein-induced acute and chronic pancreatitis, whereas liver-specific IL-22 transgenic mice were completely resistant to cerulein-induced elevation of serum digestive enzymes, pancreatic necrosis and apoptosis, and inflammatory cell infiltration. Treatment of wild-type mice with recombinant IL-22 or adenovirus IL-22 markedly attenuated the severity of cerulein-induced acute and chronic pancreatitis. ...details |
| Kaposi sarcoma-associated herpesvirus (KSHV) is a causative agent for Kaposi sarcoma and primary effusion lymphoma. KSHV encodes a viral ORF57 (also named Mta) to regulate viral gene expression by enhancing viral RNA splicing and stability. In this study, we identified viral PAN RNA, a long non-coding polyadenylated nuclear RNA, as a main target of ORF57 by a genome-wide CLIP (cross-linking and immunoprecipitation) approach. KSHV genome lacking ORF57 expresses only a minimal amount of PAN. In cell cotransfection, ORF57 increased PAN expression by 20-30-fold. ...details |
| Mouse protein tyrosine phosphatase PTPBR7 is a receptor-like, transmembrane protein that is localized on the surface of neuronal cells. Its protein phosphatase activity is reduced upon multimerization, and PTPBR7-deficient mice display motor coordination defects. Extracellular molecules that may influence PTPBR7 activity, however, remain to be determined. We here show that the PTPBR7 extracellular domain binds to highly myelinated regions in mouse brain, in particular the white matter tracks in cerebellum. PTPBR7 deficiency does not alter this binding pattern, as witnessed by RAP in situ staining of Ptprr-/- mouse brain sections. ...details |
Research Paper
Candidate Chemosensory Genes in the Stemborer Sesamia nonagrioides
Nicolas Glaser, Aurore Gallot, Fabrice Legeai, Nicolas Montagné, Erwan Poivet, Myriam Harry, Paul-André Calatayud, Emmanuelle Jacquin-Joly
Int. J. Biol. Sci. 2013; 9(5): 481-495. doi:10.7150/ijbs.6109
[Abstract]
[Full text]
[PDF] Erratum
miR-21 Promotes Keratinocyte Migration and Re-epithelialization during Wound Healing
Xue Yang, Jun Wang, Shui-Long Guo, Kai-Ji Fan, Jun Li, You-Liang Wang, Yan Teng, Xiao Yang
Int. J. Biol. Sci. 2013; 9(5): 480. doi:10.7150/ijbs.9.480
[Abstract]
[Full text]
[PDF] Research Paper
Enrichment of Prostate Cancer Stem-Like Cells from Human Prostate Cancer Cell Lines by Culture in Serum-Free Medium and Chemoradiotherapy
Lei Wang, Xing Huang, Xinmin Zheng, Xinghuan Wang, Shiwen Li, Lin Zhang, Zhonghua Yang, Zhiping Xia
Int. J. Biol. Sci. 2013; 9(5): 472-479. doi:10.7150/ijbs.5855
[Abstract]
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Karyotypic and Molecular Genetic Changes Associated With Fetal Cardiovascular Abnormalities: Results of a Retrospective 4-Year Ultrasonic Diagnosis Study
Bihui Bao, Yu Wang, Hua Hu, Hong Yao, Yuyan Li, Shuai Tang, Lihong Zheng, Yan Xu, Zhiqing Liang
Int. J. Biol. Sci. 2013; 9(5): 463-471. doi:10.7150/ijbs.5404
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[PMC] Research Paper
Overexpression of microRNA-1 Causes Atrioventricular Block in Rodents
Yong Zhang, Lihua Sun, Yan Zhang, Haihai Liang, Xuelian Li, Ruijun Cai, Lu Wang, Weijie Du, Ruixue Zhang, Jing Li, Zhiguo Wang, Ning Ma, Xidi Wang, Zhimin Du, Baofeng Yang, Xu Gao, Hongli Shan
Int. J. Biol. Sci. 2013; 9(5): 455-462. doi:10.7150/ijbs.4630
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[PMC] Research Paper
Nanos3 Gene Targeting in Medaka ES Cells
Guijun Guan, Yan Yan, Tiansheng Chen, Meisheng Yi, Hong Ni, Kiyoshi Naruse, Yoshitaka Nagahama, Yunhan Hong
Int. J. Biol. Sci. 2013; 9(5): 444-454. doi:10.7150/ijbs.6507
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[PMC] Review
The C-Kit Receptor-Mediated Signal Transduction and Tumor-Related Diseases
Jing Liang, Yan-Ling Wu, Bing-Jia Chen, Wen Zhang, Yoshimasa Tanaka, Hiroshi Sugiyama
Int. J. Biol. Sci. 2013; 9(5): 435-443. doi:10.7150/ijbs.6087
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[PMC] Research Paper
PIG3 Functions in DNA Damage Response through Regulating DNA-PKcs Homeostasis
Bing Li, Zeng-Fu Shang, Jiao-Jiao Yin, Qin-Zhi Xu, Xiao-Dan Liu, Yu Wang, Shi-Meng Zhang, Hua Guan, Ping-Kun Zhou
Int. J. Biol. Sci. 2013; 9(4): 425-434. doi:10.7150/ijbs.6068
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[PMC] Research Paper
PairMotif+: A Fast and Effective Algorithm for De Novo Motif Discovery in DNA sequences
Qiang Yu, Hongwei Huo, Yipu Zhang, Hongzhi Guo, Haitao Guo
Int. J. Biol. Sci. 2013; 9(4): 412-424. doi:10.7150/ijbs.5786
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[PMC] Research Paper
A Novel Aurora-A Inhibitor, BPR1K0609S1, Sensitizes Colorectal Tumor cells to 5-Fluorofracil (5-FU) Treatment
Yoshimi Shionome, Wen-Hsing Lin, Hui-Yi Shiao, Hsing-Pang Hsieh, John Tsu-An Hsu, Toru Ouchi
Int. J. Biol. Sci. 2013; 9(4): 403-411. doi:10.7150/ijbs.5806
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Modulation of Cell Cycle Progression by 5-Azacytidine Is Associated with Early Myogenesis Induction in Murine Myoblasts
Anna Montesano, Livio Luzi, Pamela Senesi, Ileana Terruzzi
Int. J. Biol. Sci. 2013; 9(4): 391-402. doi:10.7150/ijbs.4729
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Dpysl4 Is Involved in Tooth Germ Morphogenesis through Growth Regulation, Polarization and Differentiation of Dental Epithelial Cells
Masato Yasukawa, Kentaro Ishida, Yohei Yuge, Mai Hanaoka, Yoko Minami, Miho Ogawa, Takashi Sasaki, Masahiro Saito, Takashi Tsuji
Int. J. Biol. Sci. 2013; 9(4): 382-390. doi:10.7150/ijbs.5510
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Silencing the HaHR3 Gene by Transgenic Plant-mediated RNAi to Disrupt Helicoverpa armigera Development
Yehui Xiong, Hongmei Zeng, Yuliang Zhang, Dawei Xu, Dewen Qiu
Int. J. Biol. Sci. 2013; 9(4): 370-381. doi:10.7150/ijbs.5929
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Complete Mitochondrial Genome Sequence Data Provides Genetic Evidence That the Brown Dog Tick Rhipicephalus sanguineus (Acari: Ixodidae) Represents a Species Complex
Guo-Hua Liu, Fen Chen, Yi-Zhou Chen, Hui-Qun Song, Rui-Qing Lin, Dong-Hui Zhou, Xing-Quan Zhu
Int. J. Biol. Sci. 2013; 9(4): 361-369. doi:10.7150/ijbs.6081
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Genomic Profiling Reveals the Potential Role of TCL1A and MDR1 Deficiency in Chemotherapy-Induced Cardiotoxicity
Timothy A. McCaffrey, Constantine Tziros, Jannet Lewis, Richard Katz, Robert Siegel, William Weglicki, Jay Kramer, I. Tong Mak, Ian Toma, Liang Chen, Elizabeth Benas, Alexander Lowitt, Shruti Rao, Linda Witkin, Yi Lian, Yinglei Lai, Zhaoqing Yang, Sidney W. Fu
Int. J. Biol. Sci. 2013; 9(4): 350-360. doi:10.7150/ijbs.6058
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Endosulfan-Induced Biomarkers in Japanese Rice Fish (Oryzias latipes) Analyzed by SELDI-TOF-MS
Sung-Eun Lee, Choi Young-Woong, Hyoung-ho Mo, Jino Son, Kyeonghun Park, Kijong Cho
Int. J. Biol. Sci. 2013; 9(4): 343-349. doi:10.7150/ijbs.5501
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[PMC] More ...
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