International Journal of Biological Sciences
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ISSN 1449-2288

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Journal of Genomics now in PubMed/PubMed Central. Submit manuscript...

International Journal of Medical Sciences

Journal of Cancer

Theranostics

Journal of Genomics

Journal of Bone and Joint Infection (JBJI)

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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

new Latest impact factor is 4.509. Congratulations!
new Cover suggestion ...details
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Most Cited Paper Award: Winners of this year are Guiqian Chen et al, for the paper "TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation". Details...
The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details
Top cited papers:
Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...
The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details
Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details
Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details
The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details
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Research Paper
Vitamin K2 Ameliorates Damage of Blood Vessels by Glucocorticoid: a Potential Mechanism for Its Protective Effects in Glucocorticoid-induced Osteonecrosis of the Femoral Head in a Rat Model
Yuelei Zhang, Junhui Yin, Hao Ding, Changqing Zhang, You-Shui Gao
Int. J. Biol. Sci. 2016; 12(7): 776-785. doi:10.7150/ijbs.15248
[Abstract] [Full text] [PDF]


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Research Paper
Inhibition of wnt/β-catenin Signaling in Hepatocellular Carcinoma by an Antipsychotic Drug Pimozide
Valerie Fako, Zhipeng Yu, Curtis J. Henrich, Tanya Ransom, Anuradha S. Budhu, Xin W. Wang
Int. J. Biol. Sci. 2016; 12(7): 768-775. doi:10.7150/ijbs.14718
[Abstract] [Full text] [PDF]


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Research Paper
A Novel Protein Elicitor (PeBA1) from Bacillus amyloliquefaciens NC6 Induces Systemic Resistance in Tobacco
Ningbo Wang, Mengjie Liu, Lihua Guo, Xiufen Yang, Dewen Qiu
Int. J. Biol. Sci. 2016; 12(6): 757-767. doi:10.7150/ijbs.14333
[Abstract] [Full text] [PDF]


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Research Paper
Chemoprevention of Low-Molecular-Weight Citrus Pectin (LCP) in Gastrointestinal Cancer Cells
Shi Wang, Pei Li, Sheng-Min Lu, Zhi-Qiang Ling
Int. J. Biol. Sci. 2016; 12(6): 746-756. doi:10.7150/ijbs.13988
[Abstract] [Full text] [PDF]


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Research Paper
Different Modulatory Mechanisms of Renal FXYD12 for Na+-K+-ATPase between Two Closely Related Medakas upon Salinity Challenge
Wen-Kai Yang, Chao-Kai Kang, An-Di Hsu, Chia-Hao Lin, Tsung-Han Lee
Int. J. Biol. Sci. 2016; 12(6): 730-745. doi:10.7150/ijbs.15066
[Abstract] [Full text] [PDF]


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Review
New Strategies for the Treatment of Solid Tumors with CAR-T Cells
Hao Zhang, Zhen-long Ye, Zhen-gang Yuan, Zheng-qiang Luo, Hua-jun Jin, Qi-jun qian
Int. J. Biol. Sci. 2016; 12(6): 718-729. doi:10.7150/ijbs.14405
[Abstract] [Full text] [PDF]


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Review
Interleukin-10 Family and Tuberculosis: An Old Story Renewed
Abualgasim Elgaili Abdalla, Nzungize Lambert, Xiangke Duan, Jianping Xie
Int. J. Biol. Sci. 2016; 12(6): 710-717. doi:10.7150/ijbs.13881
[Abstract] [Full text] [PDF]


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Research Paper
Ribose Accelerates Gut Motility and Suppresses Mouse Body Weight Gaining
Yan Liu, Tong-Ruei R Li, Cong Xu, Tian Xu
Int. J. Biol. Sci. 2016; 12(6): 701-709. doi:10.7150/ijbs.13635
[Abstract] [Full text] [PDF]


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Research Paper
Ubisol-Q10 Prevents Glutamate-Induced Cell Death by Blocking Mitochondrial Fragmentation and Permeability Transition Pore Opening
Santosh Kumari, Suresh L Mehta, Gaolin Z. Milledge, Xinyu Huang, Haining Li, P. Andy Li
Int. J. Biol. Sci. 2016; 12(6): 688-700. doi:10.7150/ijbs.13589
[Abstract] [Full text] [PDF]


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Research Paper
A Novel Role of Cab45-G in Mediating Cell Migration in Cancer Cells
Judong Luo, Zengpeng Li, Hong Zhu, Chenying Wang, Weibin Zheng, Yan He, Jianyuan Song, Wenjie Wang, Xifa Zhou, Xujing Lu, Shuyu Zhang, Jianming Chen
Int. J. Biol. Sci. 2016; 12(6): 677-687. doi:10.7150/ijbs.11037
[Abstract] [Full text] [PDF]


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Research Paper
Partial Müllerian Duct Retention in Smad4 Conditional Mutant Male Mice
Fabrice G. Petit, Chuxia Deng, Soazik P. Jamin
Int. J. Biol. Sci. 2016; 12(6): 667-676. doi:10.7150/ijbs.12300
[Abstract] [Full text] [PDF]


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Research Paper
RNA-Seq and iTRAQ Reveal the Dwarfing Mechanism of Dwarf Polish Wheat (Triticum polonicum L.)
Yi Wang, Xue Xiao, Xiaolu Wang, Jian Zeng, Houyang Kang, Xing Fan, Lina Sha, Haiqin Zhang, Yonghong Zhou
Int. J. Biol. Sci. 2016; 12(6): 653-666. doi:10.7150/ijbs.14577
[Abstract] [Full text] [PDF]


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Research Paper
Dimethyloxaloylglycine Promotes the Angiogenic Activity of Mesenchymal Stem Cells Derived from iPSCs via Activation of the PI3K/Akt Pathway for Bone Regeneration
Jieyuan Zhang, Junjie Guan, Xin Qi, Hao Ding, Hong Yuan, Zongping Xie, Chunyuan Chen, Xiaolin Li, Changqing Zhang, Yigang Huang
Int. J. Biol. Sci. 2016; 12(6): 639-652. doi:10.7150/ijbs.14025
[Abstract] [Full text] [PDF]


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Research Paper
In Vitro Antileukemia Activity of ZSTK474 on K562 and Multidrug Resistant K562/A02 Cells
Qianxiang Zhou, Yali Chen, Xi Chen, Wennan Zhao, Yuxu Zhong, Ran Wang, Meihua Jin, Yuling Qiu, Dexin Kong
Int. J. Biol. Sci. 2016; 12(6): 631-638. doi:10.7150/ijbs.14878
[Abstract] [Full text] [PDF]


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Research Paper
Modeling Energy Dynamics in Mice with Skeletal Muscle Hypertrophy Fed High Calorie Diets
Nichole D. Bond, Juen Guo, Kevin D. Hall, Alexandra C. McPherron
Int. J. Biol. Sci. 2016; 12(5): 617-630. doi:10.7150/ijbs.13525
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Ecological Trade-offs between Migration and Reproduction Are Mediated by the Nutrition-Sensitive Insulin-Signaling Pathway
Xinda Lin, Yun Yao, Bo Wang, Douglas J. Emlen, Laura Corley Lavine
Int. J. Biol. Sci. 2016; 12(5): 607-616. doi:10.7150/ijbs.14802
[Abstract] [Full text] [PDF]

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