International Journal of Biological Sciences

Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

Impact factor is 4.057 according to 2018 release of Journal Citation Reports®. 5 Year Impact factor is 4.950. Congratulations!
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Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (full index information)
Full texts of articles in PubMed Central and Europe PMC.
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Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details

Top cited papers:

G Chen et al. TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation. Cited by 237
BF Zamarron & W Chen. Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression. Cited by 172
TM Thornton & M Rincon. Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival. Cited by 200
HB Shao et al. Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells. Cited by 247
JK Lunney. Advances in Swine Biomedical Model Genomics. Cited by 255
DP Siderovski & FS Willard. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Cited by 241

The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details

Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details

Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details

In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details

Research Paper
A Mathematical Modelling of Initiation of Dendritic Cells-Induced T Cell Immune Response
Wen-zhu Huang, Wen-hui Hu, Yun Wang, Jin Chen, Zu-quan Hu, Jing Zhou, Lina Liu, Wei Qiu, Fu-zhou Tang, Shi-chao Zhang, Yan Ouyang, Yuan-nong Ye, Guo-qiang Xu, Jin-hua Long, Zhu Zeng
Int. J. Biol. Sci. 2019; 15(7): 1396-1403. doi:10.7150/ijbs.33412
[Abstract] [Full text] [PDF]

Research Paper
P11 Loss-of-Function is Associated with Decreased Cell Proliferation and Neurobehavioral Disorders in Mice
Guosheng Liu, Yabo Wang, Weixin Zheng, Hanhua Cheng, Rongjia Zhou
Int. J. Biol. Sci. 2019; 15(7): 1383-1395. doi:10.7150/ijbs.33773
[Abstract] [Full text] [PDF]

Research Paper
Exosomal Micro RNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation
Hailong Yan, Ye Gao, Qiang Ding, Jiao Liu, Yan Li, Miaohan Jin, Han Xu, Sen Ma, Xiaolong Wang, Wenxian Zeng, Yulin Chen
Int. J. Biol. Sci. 2019; 15(7): 1368-1382. doi:10.7150/ijbs.33233
[Abstract] [Full text] [PDF]

Research Paper
Huaier polysaccharide inhibits the stem-like characteristics of ERα-36^high triple negative breast cancer cells via inactivation of the ERα-36 signaling pathway
Baoquan Hu, Wenting Yan, Minghao Wang, Xiang Cui, Ying Hu, Qingqiu Chen, Yi Zhang, Xiaowei Qi, Jun Jiang
Int. J. Biol. Sci. 2019; 15(7): 1358-1367. doi:10.7150/ijbs.27360
[Abstract] [Full text] [PDF]

Review
Role of Pyroptosis in Cardiovascular Diseases and its Therapeutic Implications
Cheng Zeng, Renqing Wang, Hongmei Tan
Int. J. Biol. Sci. 2019; 15(7): 1345-1357. doi:10.7150/ijbs.33568
[Abstract] [Full text] [PDF]

Research Paper
Prognostic Score Predicts Survival in HPV-Negative Head and Neck Squamous Cell Cancer Patients
Xu Qian, Duc T. Nguyen, Yue Dong, Branko Sinikovic, Andreas M. Kaufmann, Jeffrey N. Myers, Andreas E. Albers, Edward A. Graviss
Int. J. Biol. Sci. 2019; 15(7): 1336-1344. doi:10.7150/ijbs.33329
[Abstract] [Full text] [PDF]

Research Paper
Combined Features Based on Preoperative Controlling Nutritional Status Score and Circulating Tumour Cell Status Predict Prognosis for Colorectal Cancer Patients Treated with Curative Resection
Chaogang Yang, Chen Wei, Shuyi Wang, Song Han, Dongdong Shi, Chunxiao Zhang, Xiaobin Lin, Rongzhang Dou, Bin Xiong
Int. J. Biol. Sci. 2019; 15(6): 1325-1335. doi:10.7150/ijbs.33671
[Abstract] [Full text] [PDF]

Research Paper
CSN6 Promotes the Migration and Invasion of Cervical Cancer Cells by Inhibiting Autophagic Degradation of Cathepsin L
Zun Mao, Miao-Miao Sang, Cheng Chen, Wen-Tao Zhu, Yu-Sen Gong, Dong‑Sheng Pei
Int. J. Biol. Sci. 2019; 15(6): 1310-1324. doi:10.7150/ijbs.32987
[Abstract] [Full text] [PDF]

Research Paper
Novel Role of Heterogeneous Nuclear Ribonucleoprotein E1 in Regulation of Apoptosis and Autophagy by a Triazole Derivative in Vascular Endothelial Cells
Ning Meng, Yan Gong, Xin Mu, Yan Hong Wang, Le Su, Cheng Shi Jiang, Hua Zhang
Int. J. Biol. Sci. 2019; 15(6): 1299-1309. doi:10.7150/ijbs.32677
[Abstract] [Full text] [PDF]

Review
Emerging Roles of p53 Related lncRNAs in Cancer Progression: A Systematic Review
Tian Lin, Ping-Fu Hou, Sen Meng, Fang Chen, Tao Jiang, Min-Le Li, Mei-Lin Shi, Jin-Jin Liu, Jun-Nian Zheng, Jin Bai
Int. J. Biol. Sci. 2019; 15(6): 1287-1298. doi:10.7150/ijbs.33218
[Abstract] [Full text] [PDF]

Research Paper
A CRISPR Interference of CBP and p300 Selectively Induced Synthetic Lethality in Bladder Cancer Cells In Vitro
Jianfa Li, ChenChen Huang, Tiefu Xiong, Changshui Zhuang, Chengle Zhuang, Yawen Li, Jing Ye, Yaoting Gui
Int. J. Biol. Sci. 2019; 15(6): 1276-1286. doi:10.7150/ijbs.32332
[Abstract] [Full text] [PDF]

Review
Recent Advances in Studies of Molecular Hydrogen against Sepsis
Peng Qiu, Yang Liu, Jin Zhang
Int. J. Biol. Sci. 2019; 15(6): 1261-1275. doi:10.7150/ijbs.30741
[Abstract] [Full text] [PDF]

Research Paper
Nuclear CD44 Mediated by Importin β Participated in Naïve Genes Transcriptional Regulation in C3A-iCSCs
Ming Su, Peipei Wang, Xuan Wang, Mingzhi Zhang, Shiruo Wei, Kaiyu Liu, Shuo Han, Xu Han, Yue Deng, Li Shen
Int. J. Biol. Sci. 2019; 15(6): 1252-1260. doi:10.7150/ijbs.28235
[Abstract] [Full text] [PDF]

Research Paper
Epigenetic Down-Regulation of Sirt 1 via DNA Methylation and Oxidative Stress Signaling Contributes to the Gestational Diabetes Mellitus-Induced Fetal Programming of Heart Ischemia-Sensitive Phenotype in Late Life
Zewen Chen, Lei Gong, Peng Zhang, Yong Li, Bailin Liu, Lubo Zhang, Jian Zhuang, Daliao Xiao
Int. J. Biol. Sci. 2019; 15(6): 1240-1251. doi:10.7150/ijbs.33044
[Abstract] [Full text] [PDF]

Research Paper
Aplnra/b Sequentially Regulate Organ Left-Right Patterning via Distinct Mechanisms
Chengke Zhu, Zhenghua Guo, Yu Zhang, Min Liu, Bingyu Chen, Kang Cao, Yongmei Wu, Min Yang, Wenqing Yin, Haixia Zhao, Haoran Tai, Yu Ou, Xiaoping Yu, Chi Liu, Shurong Li, Bingyin Su, Yi Feng, Sizhou Huang
Int. J. Biol. Sci. 2019; 15(6): 1225-1239. doi:10.7150/ijbs.30100
[Abstract] [Full text] [PDF]

Research Paper
The Nuclear Export and Ubiquitin-Proteasome-Dependent Degradation of PPARγ Induced By Angiotensin II
Li Sun, Ka Bian
Int. J. Biol. Sci. 2019; 15(6): 1215-1224. doi:10.7150/ijbs.29741
[Abstract] [Full text] [PDF]

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