International Journal of Biological Sciences

Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

Impact factor is 3.873 according to 2017 release of Journal Citation Reports®. Congratulations!

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Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (full index information)
Full texts of articles in PubMed Central, Europe PMC, and PMC Canada.
(For NIH-funded researchers) Save time by submitting your paper to us - this journal is in full compliance with NIH Public Access Requirement.

Most Cited Paper Award: Winners of this year are Yan-Cun Liu, Xian-Biao Zou, Yan-Fen Chai, Yong-Ming Yao, for the paper "Macrophage Polarization in Inflammatory Diseases". Details...

Special Issue on Computational Resources and Methods in Biological Sciences. Guest editors:
Prof. Jian Huang, Dr. Hao Lin, Prof. Shaoliang Peng.

The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details

Top cited papers:

G Chen et al. TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation. Cited by 237
BF Zamarron & W Chen. Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression. Cited by 172
TM Thornton & M Rincon. Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival. Cited by 200
HB Shao et al. Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells. Cited by 247
JK Lunney. Advances in Swine Biomedical Model Genomics. Cited by 255
DP Siderovski & FS Willard. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Cited by 241

Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...

The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details

Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details

Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details

The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details

Research Paper
Identification and Analysis of P53-Mediated Competing Endogenous RNA Network in Human Hepatocellular Carcinoma
Yiming Zhang, Ran Kang, Wenrong Liu, Yalan Yang, Ruofan Ding, Qingqing Huang, Junhua Meng, Lili Xiong, Zhiyun Guo
Int. J. Biol. Sci. 2017; 13(9): 1213-1221. doi:10.7150/ijbs.21502
[Abstract] [Full text] [PDF]

Research Paper
ATP2B1 gene Silencing Increases Insulin Sensitivity through Facilitating Akt Activation via the Ca²⁺/calmodulin Signaling Pathway and Ca²⁺-associated eNOS Activation in Endothelial Cells
Yang Long, Ji-yi Xia, Shao-wei Chen, Chen-lin Gao, Guan-nan Liang, Xue-mei He, Jian Wu, Chun-xia Jiang, Xin Liu, Wei Huang, Qin Wan, Yong Xu
Int. J. Biol. Sci. 2017; 13(9): 1203-1212. doi:10.7150/ijbs.19666
[Abstract] [Full text] [PDF]

Research Paper
Chronic Osteomyelitis Increases the Incidence of Type 2 Diabetes in Humans and Mice
Yicun Wang, Jun Wang, Zhantao Deng, Jiewen Jin, Hui Jiang, Jia Meng, Haidong Xu, Jianning Zhao, Guojing Sun, Hongbo Qian
Int. J. Biol. Sci. 2017; 13(9): 1192-1202. doi:10.7150/ijbs.21379
[Abstract] [Full text] [PDF]

Research Paper
Antisense lncRNA FOXF1-AS1 Promotes Migration and Invasion of Osteosarcoma Cells Through the FOXF1/MMP-2/-9 Pathway
Zhu Kun-Peng, Zhang Chun-Lin, Ma Xiao-Long
Int. J. Biol. Sci. 2017; 13(9): 1180-1191. doi:10.7150/ijbs.21722
[Abstract] [Full text] [PDF]

Research Paper
High PD-L1 Expression Is Closely Associated With Tumor-Infiltrating Lymphocytes and Leads to Good Clinical Outcomes in Chinese Triple Negative Breast Cancer Patients
NiJiati AiErken, Hui-juan Shi, Yu Zhou, Nan Shao, Jin Zhang, Yawei Shi, Zhong-yu Yuan, Ying Lin
Int. J. Biol. Sci. 2017; 13(9): 1172-1179. doi:10.7150/ijbs.20868
[Abstract] [Full text] [PDF]

Review
Fibroblast Growth Factor Receptor 2 Signaling in Breast Cancer
Haipeng Lei, Chu-Xia Deng
Int. J. Biol. Sci. 2017; 13(9): 1163-1171. doi:10.7150/ijbs.20792
[Abstract] [Full text] [PDF]

Research Paper
Skeletal Muscle-Specific Overexpression of PGC-1α Induces Fiber-Type Conversion through Enhanced Mitochondrial Respiration and Fatty Acid Oxidation in Mice and Pigs
Lin Zhang, Ying Zhou, Wangjun Wu, Liming Hou, Hongxing Chen, Bo Zuo, Yuanzhu Xiong, Jinzeng Yang
Int. J. Biol. Sci. 2017; 13(9): 1152-1162. doi:10.7150/ijbs.20132
[Abstract] [Full text] [PDF]

Research Paper
Effect of Population Size and Mutation Rate on the Evolution of RNA Sequences on an Adaptive Landscape Determined by RNA Folding
Ali R. Vahdati, Kathleen Sprouffske, Andreas Wagner
Int. J. Biol. Sci. 2017; 13(9): 1138-1151. doi:10.7150/ijbs.19436
[Abstract] [Full text] [PDF]

Research Paper
Host Cell Vimentin Restrains Toxoplasma gondii Invasion and Phosphorylation of Vimentin is Partially Regulated by Interaction with TgROP18
Cheng He, Ling Kong, Lijuan Zhou, Jing Xia, Haixia Wei, Min Liu, Hongjuan Peng
Int. J. Biol. Sci. 2017; 13(9): 1126-1137. doi:10.7150/ijbs.21247
[Abstract] [Full text] [PDF]

Review
The Emerging Roles of Microparticles in Diabetic Nephropathy
Chen Chen Lu, Kun Ling Ma, Xiong Zhong Ruan, Bi Cheng Liu
Int. J. Biol. Sci. 2017; 13(9): 1118-1125. doi:10.7150/ijbs.21140
[Abstract] [Full text] [PDF]

Review
Mesenchymal Stem Cell-Dependent Modulation of Liver Diseases
Marina Gazdic, Aleksandar Arsenijevic, Bojana Simovic Markovic, Ana Volarevic, Ivanka Dimova, Valentin Djonov, Nebojsa Arsenijevic, Miodrag Stojkovic, Vladislav Volarevic
Int. J. Biol. Sci. 2017; 13(9): 1109-1117. doi:10.7150/ijbs.20240
[Abstract] [Full text] [PDF]

Review
In Utero Alcohol Exposure and the Alteration of Histone Marks in the Developing Fetus: An Epigenetic Phenomenon of Maternal Drinking
Chanchal Mandal, Debasish Halder, Kyoung Hwa Jung, Young Gyu Chai
Int. J. Biol. Sci. 2017; 13(9): 1100-1108. doi:10.7150/ijbs.21047
[Abstract] [Full text] [PDF]

Review
Structural Maintenance of Chromosomes protein 1: Role in Genome Stability and Tumorigenesis
Fei Yi, Zhuo Wang, Jingwei Liu, Ying Zhang, Zhijun Wang, Hongde Xu, Xiaoman Li, Ning Bai, Liu Cao, Xiaoyu Song
Int. J. Biol. Sci. 2017; 13(8): 1092-1099. doi:10.7150/ijbs.21206
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Spatiotemporal Expression of Wnt/β-catenin Signaling during Morphogenesis and Odontogenesis of Deciduous Molar in Miniature Pig
Xiaoshan Wu, Yan Li, Fu Wang, Lei Hu, Yang Li, Jinsong Wang, Chunmei Zhang, Songlin Wang
Int. J. Biol. Sci. 2017; 13(8): 1082-1091. doi:10.7150/ijbs.20905
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Activation of Nrf2 Attenuates Pulmonary Vascular Remodeling via Inhibiting Endothelial-to-Mesenchymal Transition: an Insight from a Plant Polyphenol
Yucai Chen, Tianyi Yuan, Huifang Zhang, Yu Yan, Danshu Wang, Lianhua Fang, Yang Lu, Guanhua Du
Int. J. Biol. Sci. 2017; 13(8): 1067-1081. doi:10.7150/ijbs.20316
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Alkbh4 and Atrn Act Maternally to Regulate Zebrafish Epiboly
Qingrui Sun, Xingfeng Liu, Bo Gong, Di Wu, Anming Meng, Shunji Jia
Int. J. Biol. Sci. 2017; 13(8): 1051-1066. doi:10.7150/ijbs.19203
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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