International Journal of Biological Sciences

Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

Impact factor is 3.873 according to 2017 release of Journal Citation Reports®. Congratulations!

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Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (full index information)
Full texts of articles in PubMed Central, Europe PMC, and PMC Canada.
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Most Cited Paper Award: Winners of this year are Yan-Cun Liu, Xian-Biao Zou, Yan-Fen Chai, Yong-Ming Yao, for the paper "Macrophage Polarization in Inflammatory Diseases". Details...

The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details

Top cited papers:

G Chen et al. TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation. Cited by 237
BF Zamarron & W Chen. Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression. Cited by 172
TM Thornton & M Rincon. Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival. Cited by 200
HB Shao et al. Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells. Cited by 247
JK Lunney. Advances in Swine Biomedical Model Genomics. Cited by 255
DP Siderovski & FS Willard. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Cited by 241

Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...

The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details

Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details

Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details

The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details

Research Paper
DNA Methylation Mediated Downregulation of miR-449c Controls Osteosarcoma Cell Cycle Progression by Directly Targeting Oncogene c-Myc
Qing Li, Hua Li, Xueling Zhao, Bing Wang, Lin Zhang, Caiguo Zhang, Fan Zhang
Int. J. Biol. Sci. 2017; 13(8): 1038-1050. doi:10.7150/ijbs.19476
[Abstract] [Full text] [PDF]

Research Paper
FGFR3 deficient mice have accelerated fracture repair
Yangli Xie, Fengtao Luo, Wei Xu, Zuqiang Wang, Xianding Sun, Meng Xu, Junlan Huang, Dali Zhang, Qiaoyan Tan, Bo Chen, Wanling Jiang, Xiaolan Du, Lin Chen
Int. J. Biol. Sci. 2017; 13(8): 1029-1037. doi:10.7150/ijbs.19309
[Abstract] [Full text] [PDF]

Research Paper
Functional Analysis of a Novel FOXL2 Indel Mutation in Chinese Families with Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Type I
Peiwei Chai, Fang Li, Jiayan Fan, Ruobin Jia, He Zhang, Xianqun Fan
Int. J. Biol. Sci. 2017; 13(8): 1019-1028. doi:10.7150/ijbs.19532
[Abstract] [Full text] [PDF]

Review
Linker Histone in Diseases
Xin Ye, ChuanLin Feng, Tian Gao, Guanqun Mu, Weiguo Zhu, Yang Yang
Int. J. Biol. Sci. 2017; 13(8): 1008-1018. doi:10.7150/ijbs.19891
[Abstract] [Full text] [PDF]

Research Paper
Osthole Promotes Bone Fracture Healing through Activation of BMP Signaling in Chondrocytes
Pinger Wang, Jun Ying, Cheng Luo, Xing Jin, Shanxing Zhang, Taotao Xu, Lei Zhang, Meng Mi, Di Chen, Peijian Tong, Hongting Jin
Int. J. Biol. Sci. 2017; 13(8): 996-1007. doi:10.7150/ijbs.19986
[Abstract] [Full text] [PDF]

Research Paper
Intracellular Insulin and Impaired Autophagy in a Zebrafish model and a Cell Model of Type 2 diabetes
Xiang-Hui Meng, Bo Chen, Jing-Pu Zhang
Int. J. Biol. Sci. 2017; 13(8): 985-995. doi:10.7150/ijbs.19249
[Abstract] [Full text] [PDF]

Research Paper
The Overexpression of CARM1 Promotes Human Osteosarcoma Cell Proliferation through the pGSK3β/β-Catenin/cyclinD1 Signaling Pathway
Shijie Li, Dongdong Cheng, Bin Zhu, Qingcheng Yang
Int. J. Biol. Sci. 2017; 13(8): 976-984. doi:10.7150/ijbs.19191
[Abstract] [Full text] [PDF]

Research Paper
Vasopressin Mediates the Renal Damage Induced by Limited Fructose Rehydration in Recurrently Dehydrated Rats
Fernando E. García-Arroyo, Edilia Tapia, Mónica G Blas-Marron, Guillermo Gonzaga, Octaviano Silverio, Magdalena Cristóbal, Horacio Osorio, Abraham S. Arellano-Buendía, Cecilia Zazueta, Omar Emiliano Aparicio-Trejo, Juan G. Reyes-García, José Pedraza-Chaverri, Virgilia Soto, Carlos Roncal-Jiménez, Richard J. Johnson, Laura G Sánchez-Lozada
Int. J. Biol. Sci. 2017; 13(8): 961-975. doi:10.7150/ijbs.20074
[Abstract] [Full text] [PDF]

Review
Current Progresses of Single Cell DNA Sequencing in Breast Cancer Research
Jianlin Liu, Ragini Adhav, Xiaoling Xu
Int. J. Biol. Sci. 2017; 13(8): 949-960. doi:10.7150/ijbs.19627
[Abstract] [Full text] [PDF]

Research Paper
Structure elucidation and antitumor activity of a new polysaccharide from Maerkang Tricholoma matsutake
Yiling Hou, Xiang Ding, Wanru Hou, Bo Song, Xianghui Yan
Int. J. Biol. Sci. 2017; 13(7): 935-948. doi:10.7150/ijbs.18953
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Acetylation of hMOF Modulates H4K16ac to Regulate DNA Repair Genes in Response to Oxidative Stress
Jianing Zhong, Liying Ji, Huiqian Chen, Xianfeng Li, Jian'an Zhang, Xingxing Wang, Weilin Wu, Ying Xu, Fei Huang, Wanshi Cai, Zhong Sheng Sun
Int. J. Biol. Sci. 2017; 13(7): 923-934. doi:10.7150/ijbs.17260
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
In Search for Pheromone Receptors: Certain Members of the Odorant Receptor Family in the Desert Locust Schistocerca gregaria (Orthoptera: Acrididae) Are Co-expressed with SNMP1
Pablo Pregitzer, Xingcong Jiang, Ewald Grosse-Wilde, Heinz Breer, Jürgen Krieger, Joerg Fleischer
Int. J. Biol. Sci. 2017; 13(7): 911-922. doi:10.7150/ijbs.18402
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Lycium Barbarum Polysaccharides Decrease Hyperglycemia-Aggravated Ischemic Brain Injury through Maintaining Mitochondrial Fission and Fusion Balance
Wen-Jing Liu, Hai-Feng Jiang, Faisal UL Rehman, Jing-Wen Zhang, Yue Chang, Li Jing, Jian-Zhong Zhang
Int. J. Biol. Sci. 2017; 13(7): 901-910. doi:10.7150/ijbs.18404
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Crosstalk between Mitochondrial Fission and Oxidative Stress in Paraquat-Induced Apoptosis in Mouse Alveolar Type II Cells
Guangju Zhao, Kaiqiang Cao, Changqin Xu, Aifang Sun, Wang Lu, Yi Zheng, Haixiao Li, Guangliang Hong, Bing Wu, Qiaomeng Qiu, Zhongqiu Lu
Int. J. Biol. Sci. 2017; 13(7): 888-900. doi:10.7150/ijbs.18468
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Inhibition of mTOR signaling Confers Protection against Cerebral Ischemic Injury in Acute Hyperglycemic Rats
Changchun Hei, Ping Liu, Xiao Yang, Jianguo Niu, P. Andy Li
Int. J. Biol. Sci. 2017; 13(7): 878-887. doi:10.7150/ijbs.18976
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Exposure to Concentrated Ambient Fine Particulate Matter Induces Vascular Endothelial Dysfunction via miR-21
Jianwei Dai, Wensheng Chen, Yuyin Lin, Shiwen Wang, Xiaolan Guo, Qian-Qian Zhang
Int. J. Biol. Sci. 2017; 13(7): 868-877. doi:10.7150/ijbs.19868
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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