International Journal of Biological Sciences

Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

Impact factor is 3.873 according to 2017 release of Journal Citation Reports®. Congratulations!

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Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (full index information)
Full texts of articles in PubMed Central, Europe PMC, and PMC Canada.
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Most Cited Paper Award: Winners of this year are Yan-Cun Liu, Xian-Biao Zou, Yan-Fen Chai, Yong-Ming Yao, for the paper "Macrophage Polarization in Inflammatory Diseases". Details...

The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details

Top cited papers:

G Chen et al. TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation. Cited by 237
BF Zamarron & W Chen. Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression. Cited by 172
TM Thornton & M Rincon. Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival. Cited by 200
HB Shao et al. Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells. Cited by 247
JK Lunney. Advances in Swine Biomedical Model Genomics. Cited by 255
DP Siderovski & FS Willard. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Cited by 241

Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...

The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details

Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details

Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details

The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details

Research Paper
Stroma-derived Fibrinogen-like Protein 2 Activates Cancer-associated Fibroblasts to Promote Tumor Growth in Lung Cancer
Ying Zhu, Longhui Zhang, Haoran Zha, Fei Yang, Chunyan Hu, Lin Chen, Bo Guo, Bo Zhu
Int. J. Biol. Sci. 2017; 13(6): 804-814. doi:10.7150/ijbs.19398
[Abstract] [Full text] [PDF]

Research Paper
Berberine Reverses Hypoxia-induced Chemoresistance in Breast Cancer through the Inhibition of AMPK- HIF-1α
Yue Pan, Dan Shao, Yawei Zhao, Fan Zhang, Xiao Zheng, Yongfei Tan, Kan He, Jing Li, Li Chen
Int. J. Biol. Sci. 2017; 13(6): 794-803. doi:10.7150/ijbs.18969
[Abstract] [Full text] [PDF]

Research Paper
Dioscin Induces Gallbladder Cancer Apoptosis by Inhibiting ROS-Mediated PI3K/AKT Signalling
Xiaoling Song, Zheng Wang, Haibin Liang, Wenjie Zhang, Yuanyuan Ye, HuaiFeng Li, Yunping Hu, Yijian Zhang, Hao Weng, Jianhua Lu, Xuefeng Wang, Maolan Li, Yingbin Liu, Jun Gu
Int. J. Biol. Sci. 2017; 13(6): 782-793. doi:10.7150/ijbs.18732
[Abstract] [Full text] [PDF]

Review
Angiomotin Family Members: Oncogenes or Tumor Suppressors?
Meng Lv, Yanwei Shen, Jiao Yang, Shuting Li, Biyuan Wang, Zheling Chen, Pan Li, Peijun Liu, Jin Yang
Int. J. Biol. Sci. 2017; 13(6): 772-781. doi:10.7150/ijbs.19603
[Abstract] [Full text] [PDF]

Research Paper
Two Olfactory Pathways to Detect Aldehydes on Locust Mouthpart
Liwei Zhang, Hongwei Li, Long Zhang
Int. J. Biol. Sci. 2017; 13(6): 759-771. doi:10.7150/ijbs.19820
[Abstract] [Full text] [PDF]

Research Paper
Oncogenic Protein Kinase D3 Regulating Networks in Invasive Breast Cancer
Yan Liu, Jian Li, Jun Zhang, Zhenghong Yu, Shiyi Yu, Lele Wu, Yuzhi Wang, Xue Gong, Chenxi Wu, Xiuxiu Cai, Lin Mo, Mingya Wang, Jun Gu, Liming Chen
Int. J. Biol. Sci. 2017; 13(6): 748-758. doi:10.7150/ijbs.18472
[Abstract] [Full text] [PDF]

Research Paper
Genome-wide Identification and Expression Analysis of Amino Acid Transporters in the Whitefly, Bemisia tabaci (Gennadius)
Jixing Xia, Zezhong Yang, Cheng Gong, Wen Xie, Huipeng Pan, Zhaojiang Guo, Huixin Zheng, Xin Yang, Xiaodong Sun, Shi Kang, Fengshan Yang, Qingjun Wu, Shaoli Wang, Bin Cong, Xianfeng Teng, Youjun Zhang
Int. J. Biol. Sci. 2017; 13(6): 735-747. doi:10.7150/ijbs.18153
[Abstract] [Full text] [PDF]

Research Paper
Exosomes from Melatonin Treated Hepatocellularcarcinoma Cells Alter the Immunosupression Status through STAT3 Pathway in Macrophages
Liang Cheng, Jiatao Liu, Qingqing Liu, Yu Liu, Lulu Fan, Fang Wang, Hanqing Yu, Yuhuan Li, Lijia Bu, Xiaoqiu Li, Wei Wei, Hua Wang, Guoping Sun
Int. J. Biol. Sci. 2017; 13(6): 723-734. doi:10.7150/ijbs.19642
[Abstract] [Full text] [PDF]

Review
Mechanism of ribosome translation through mRNA secondary structures
Ping Xie, Hong Chen
Int. J. Biol. Sci. 2017; 13(6): 712-722. doi:10.7150/ijbs.19508
[Abstract] [Full text] [PDF]

Research Paper
Eupafolin Exhibits Potent Anti-Angiogenic and Antitumor Activity in Hepatocellular Carcinoma
Honglei Jiang, Dan Wu, Dong Xu, Hao Yu, Zheming Zhao, Dongyan Ma, Junzhe Jin
Int. J. Biol. Sci. 2017; 13(6): 701-711. doi:10.7150/ijbs.17534
[Abstract] [Full text] [PDF]

Research Paper
MicroRNA-142-3p and let-7g Negatively Regulates Augmented IL-6 Production in Neonatal Polymorphonuclear Leukocytes
Hsin-Chun Huang, Hong-Ren Yu, Te-Yao Hsu, I-Lun Chen, Hui-Chen Huang, Jen-Chieh Chang, Kuender D. Yang
Int. J. Biol. Sci. 2017; 13(6): 690-700. doi:10.7150/ijbs.17030
[Abstract] [Full text] [PDF]

Research Paper
Sleep Duration and Patterns in Chinese Older Adults: a Comprehensive Meta-analysis
Li Lu, Shi-Bin Wang, Wen-Wang Rao, Gabor S. Ungvari, Chee H. Ng, Helen F.K. Chiu, Juan Zhang, Changgui Kou, Fu-Jun Jia, Yu-Tao Xiang
Int. J. Biol. Sci. 2017; 13(6): 682-689. doi:10.7150/ijbs.19695
[Abstract] [Full text] [PDF]

Research Paper
PPARD is an Inhibitor of Cartilage Growth in External Ears
Zhen Zhang, Yanyu Duan, Zhongping Wu, Hui Zhang, Jun Ren, Lusheng Huang
Int. J. Biol. Sci. 2017; 13(5): 669-681. doi:10.7150/ijbs.19714
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Andrographolide Inhibits Angiogenesis by Inhibiting the Mir-21-5p/TIMP3 Signaling Pathway
Jianwei Dai, Yuyin Lin, Youfa Duan, Zixuan Li, Dalei Zhou, Wensheng Chen, Lijing Wang, Qian-Qian Zhang
Int. J. Biol. Sci. 2017; 13(5): 660-668. doi:10.7150/ijbs.19194
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Ezh2 Acts as a Tumor Suppressor in Kras-driven Lung Adenocarcinoma
Yanxiao Wang, Ning Hou, Xuan Cheng, Jishuai Zhang, Xiaohong Tan, Chong Zhang, Yuling Tang, Yan Teng, Xiao Yang
Int. J. Biol. Sci. 2017; 13(5): 652-659. doi:10.7150/ijbs.19108
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Dual Delivery of NGF and bFGF Coacervater Ameliorates Diabetic Peripheral Neuropathy via Inhibiting Schwann Cells Apoptosis
Rui Li, Jianfeng Ma, Yanqing Wu, Matthew Nangle, Shuang Zou, Yiyang Li, Jiayu Yin, Yingzheng Zhao, Helin Xu, Hongyu Zhang, Xiaokun Li, Qing song Ye, Jian Wang, Jian Xiao
Int. J. Biol. Sci. 2017; 13(5): 640-651. doi:10.7150/ijbs.18636
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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