International Journal of Biological Sciences

Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

Impact factor is 4.057 according to 2018 release of Journal Citation Reports®. 5 Year Impact factor is 4.950. Congratulations!
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Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (full index information)
Full texts of articles in PubMed Central and Europe PMC.
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The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details

Top cited papers:

G Chen et al. TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation. Cited by 237
BF Zamarron & W Chen. Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression. Cited by 172
TM Thornton & M Rincon. Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival. Cited by 200
HB Shao et al. Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells. Cited by 247
JK Lunney. Advances in Swine Biomedical Model Genomics. Cited by 255
DP Siderovski & FS Willard. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Cited by 241

Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...

The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details

Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details

Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details

The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details

Research Paper
Clopidogrel Reduces Fibronectin Accumulation and Improves Diabetes-Induced Renal Fibrosis
Zongyu Zheng, Tianjiao Ma, Xin Lian, Jialin Gao, Weigang Wang, Wenya Weng, Xuemian Lu, Weixia Sun, Yanli Cheng, Yaowen Fu, Madhavi J. Rane, Evelyne Gozal, Lu Cai
Int. J. Biol. Sci. 2019; 15(1): 239-252. doi:10.7150/ijbs.29063
[Abstract] [Full text] [PDF]

Research Paper
Psoralen Protects Chondrocytes, Exhibits Anti-Inflammatory Effects on Synoviocytes, and Attenuates Monosodium Iodoacetate-Induced Osteoarthritis
Chunli Wang, Mohanad Kh Al-ani, Yongqiang Sha, Qingjia Chi, Nianguo Dong, Li Yang, Kang Xu
Int. J. Biol. Sci. 2019; 15(1): 229-238. doi:10.7150/ijbs.28830
[Abstract] [Full text] [PDF]

Research Paper
Development and Validation of a Prognostic Nomogram in AFP-negative hepatocellular carcinoma
Xueping Wang, Minjie Mao, Zhonglian He, Lin Zhang, Huilan Li, Jianhua Lin, Yi He, Shuqin Dai, Wanming Hu, Wanli Liu
Int. J. Biol. Sci. 2019; 15(1): 221-228. doi:10.7150/ijbs.28720
[Abstract] [Full text] [PDF]

Research Paper
Establishing a prediction model for prostate cancer bone metastasis
Song Chen, Lu Wang, Kaiyu Qian, Wei Jiang, Haiqing Deng, Qiang Zhou, Gang Wang, Xuefeng Liu, Chin-Lee Wu, Yu Xiao, Xinghuan Wang
Int. J. Biol. Sci. 2019; 15(1): 208-220. doi:10.7150/ijbs.27537
[Abstract] [Full text] [PDF]

Research Paper
A Lung Sound Category Recognition Method Based on Wavelet Decomposition and BP Neural Network
Yan Shi, Yuqian Li, Maolin Cai, Xiaohua Douglas Zhang
Int. J. Biol. Sci. 2019; 15(1): 195-207. doi:10.7150/ijbs.29863
[Abstract] [Full text] [PDF]

Research Paper
PSPH Mediates the Metastasis and Proliferation of Non-small Cell Lung Cancer through MAPK Signaling Pathways
Li Liao, Mengxi Ge, Qiong Zhan, Ruofan Huang, Xiaoyu Ji, Xiaohua Liang, Xinli Zhou
Int. J. Biol. Sci. 2019; 15(1): 183-194. doi:10.7150/ijbs.29203
[Abstract] [Full text] [PDF]

Research Paper
GALNT6 Promotes Tumorigenicity and Metastasis of Breast Cancer Cell via β-catenin/MUC1-C Signaling Pathway
Yingge Mao, Yuqi Zhang, Sairong Fan, Lvao Chen, Lili Tang, Xiaoming Chen, Jianxin Lyu
Int. J. Biol. Sci. 2019; 15(1): 169-182. doi:10.7150/ijbs.29048
[Abstract] [Full text] [PDF]

Research Paper
Exosomes Derived from Human Induced Pluripotent Stem Cells-Endothelia Cells Promotes Postnatal Angiogenesis in Mice Bearing Ischemic Limbs
Meng Ye, Qihong Ni, Haozhe Qi, Xin Qian, Jiaquan Chen, Xiangjiang Guo, Maoran Li, Yiping Zhao, Guanhua Xue, Haoyu Deng, Lan Zhang
Int. J. Biol. Sci. 2019; 15(1): 158-168. doi:10.7150/ijbs.28392
[Abstract] [Full text] [PDF]

Research Paper
Sulforaphane Attenuates Angiotensin II-Induced Vascular Smooth Muscle Cell Migration via Suppression of NOX4/ROS/Nrf2 Signaling
Min Zhang, Yingjie Xu, Zhaohui Qiu, Li Jiang
Int. J. Biol. Sci. 2019; 15(1): 148-157. doi:10.7150/ijbs.28874
[Abstract] [Full text] [PDF]

Research Paper
Fibroblast Growth Factor 21 Attenuates Vascular Calcification by Alleviating Endoplasmic Reticulum Stress Mediated Apoptosis in Rats
Yuchen Shi, Shaoping Wang, Hongyu Peng, Yuan Lv, Wenzheng Li, Shujuan Cheng, Jinghua Liu
Int. J. Biol. Sci. 2019; 15(1): 138-147. doi:10.7150/ijbs.28873
[Abstract] [Full text] [PDF]

Research Paper
Calpain-2 Enhances Non-Small Cell Lung Cancer Progression and Chemoresistance to Paclitaxel via EGFR-pAKT Pathway
Fengkai Xu, Jie Gu, Chunlai Lu, Wei Mao, Lin Wang, Qiaoliang Zhu, Zhonghe Liu, Yiwei Chu, Ronghua Liu, Di Ge
Int. J. Biol. Sci. 2019; 15(1): 127-137. doi:10.7150/ijbs.28834
[Abstract] [Full text] [PDF]

Research Paper
COPI-Mediated Nuclear Translocation of EGFRvIII Promotes STAT3 Phosphorylation and PKM2 Nuclear Localization
Mingzhi Zhang, Haojie Sun, Yue Deng, Ming Su, Shiruo Wei, Peipei Wang, Lanlan Yu, Jinwen Liu, Jinhai Guo, Xuan Wang, Xu Han, Qihua He, Li Shen
Int. J. Biol. Sci. 2019; 15(1): 114-126. doi:10.7150/ijbs.28679
[Abstract] [Full text] [PDF]

Review
Remodeling the Microenvironment before Occurrence and Metastasis of Cancer
Xina Zhang, Juanjuan Xiang
Int. J. Biol. Sci. 2019; 15(1): 105-113. doi:10.7150/ijbs.28669
[Abstract] [Full text] [PDF]

Research Paper
Crosstalk between Epigenetic Modulations in Valproic Acid Deactivated Hepatic Stellate Cells: An Integrated Protein and miRNA Profiling Study
Peng Lu, Min Yan, Li He, Jing Li, Yuhua Ji, Juling Ji
Int. J. Biol. Sci. 2019; 15(1): 93-104. doi:10.7150/ijbs.28642
[Abstract] [Full text] [PDF]

Research Paper
G Protein-Coupled Estrogen Receptor 1 Inhibits Angiotensin II-Induced Cardiomyocyte Hypertrophy via the Regulation of PI3K-Akt-mTOR Signalling and Autophagy
Hui Pei, Wei Wang, Di Zhao, Hongyan Su, Guohai Su, Zhuo Zhao
Int. J. Biol. Sci. 2019; 15(1): 81-92. doi:10.7150/ijbs.28304
[Abstract] [Full text] [PDF]

Research Paper
Identification and Functional Characterization of a New Splicing Variant of EZH2 in the Central Nervous System
Danyang Li, Hui-Li Wang, Xiyao Huang, Xiaozhen Gu, Weizhen Xue, Yi Xu
Int. J. Biol. Sci. 2019; 15(1): 69-80. doi:10.7150/ijbs.28129
[Abstract] [Full text] [PDF]

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