International Journal of Biological Sciences

Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

Impact factor is 4.057 according to 2018 release of Journal Citation Reports®. 5 Year Impact factor is 4.950. Congratulations!
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Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (full index information)
Full texts of articles in PubMed Central and Europe PMC.
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The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details

Top cited papers:

G Chen et al. TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation. Cited by 237
BF Zamarron & W Chen. Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression. Cited by 172
TM Thornton & M Rincon. Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival. Cited by 200
HB Shao et al. Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells. Cited by 247
JK Lunney. Advances in Swine Biomedical Model Genomics. Cited by 255
DP Siderovski & FS Willard. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Cited by 241

Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...

The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details

Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details

Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details

The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details

Review
Novel CD44-downstream signaling pathways mediating breast tumor invasion
Allal Ouhtit, Balsam Rizeq, Haissam Abou Saleh, MD Mizanur Rahman, Hatem Zayed
Int. J. Biol. Sci. 2018; 14(13): 1782-1790. doi:10.7150/ijbs.23586
[Abstract] [Full text] [PDF]

Research Paper
Inhibition of AKT suppresses the initiation and progression of BRCA1-associated mammary tumors
Hye Jung Baek, Sun Eui Kim, Jong Kwang Kim, Dong Hoon Shin, Tae Hyun Kim, Kwang Gi Kim, Chu-Xia Deng, Sang Soo Kim
Int. J. Biol. Sci. 2018; 14(13): 1769-1781. doi:10.7150/ijbs.29242
[Abstract] [Full text] [PDF]

Research Paper
Inhibition of Estrogen Signaling Reduces the Incidence of BRCA1-associated Mammary Tumor Formation
Hye Jung Baek, Sun Eui Kim, Eun Kyung Choi, Jong Kwang Kim, Dong Hoon Shin, Eun Jung Park, Tae Hyun Kim, Joo-Young Kim, Kwang Gi Kim, Chu-Xia Deng, Sang Soo Kim
Int. J. Biol. Sci. 2018; 14(12): 1755-1768. doi:10.7150/ijbs.28142
[Abstract] [Full text] [PDF]

Review
Targeting phosphodiesterase 4 as a potential therapeutic strategy for enhancing neuroplasticity following ischemic stroke
Haitao Wang, Uma Gaur, Jiao Xiao, Bingtian Xu, Jiangping Xu, Wenhua Zheng
Int. J. Biol. Sci. 2018; 14(12): 1745-1754. doi:10.7150/ijbs.26230
[Abstract] [Full text] [PDF]

Research Paper
The small molecule NSM00191 specifically represses the TNF-α/NF-кB axis in foot and ankle rheumatoid arthritis
Xiaodong Wen, Xun Chen, Xiaojun Liang, Hongmou Zhao, Yi Li, Xiangxiang Sun, Jun Lu
Int. J. Biol. Sci. 2018; 14(12): 1732-1744. doi:10.7150/ijbs.24232
[Abstract] [Full text] [PDF]

Research Paper
TFmapper: A Tool for Searching Putative Factors Regulating Gene Expression Using ChIP-seq Data
Jianming Zeng, Gang Li
Int. J. Biol. Sci. 2018; 14(12): 1724-1731. doi:10.7150/ijbs.28850
[Abstract] [Full text] [PDF]

Research Paper
TGF-β/SMAD4-Regulated LncRNA-LINP1 Inhibits Epithelial-Mesenchymal Transition in Lung Cancer
Chong Zhang, Yajing Hao, Yanxiao Wang, Jiaqian Xu, Yan Teng, Xiao Yang
Int. J. Biol. Sci. 2018; 14(12): 1715-1723. doi:10.7150/ijbs.27197
[Abstract] [Full text] [PDF]

Review
Alternative polyadenylation analysis in animals and plants: newly developed strategies for profiling, processing and validation
Yunqi Zhang, Shane A. Carrion, Yangzi Zhang, Xiaohui Zhang, Amy L. Zinski, Jennifer J. Michal, Zhihua Jiang
Int. J. Biol. Sci. 2018; 14(12): 1709-1714. doi:10.7150/ijbs.27168
[Abstract] [Full text] [PDF]

Research Paper
GLP-1 treatment protects endothelial cells from oxidative stress-induced autophagy and endothelial dysfunction
Xiangsheng Cai, Miaoqin She, Mingyu Xu, Huiying Chen, Jingjing Li, Xinglu Chen, Dianpeng Zheng, Jun Liu, Shangliang Chen, Jianbin Zhu, Xiaosong Xu, Ruiying Li, Jinlong Li, Shaolian Chen, Xiaorong Yang, Hongwei Li
Int. J. Biol. Sci. 2018; 14(12): 1696-1708. doi:10.7150/ijbs.27774
[Abstract] [Full text] [PDF]

Research Paper
Paired box 5 is a novel marker of breast cancers that is frequently downregulated by methylation
Xia Li, Jianbo Huang, Xinrong Luo, Dejuan Yang, Xuedong Yin, Weiyan Peng, Can Bi, Guosheng Ren, Tingxiu Xiang
Int. J. Biol. Sci. 2018; 14(12): 1686-1695. doi:10.7150/ijbs.27599
[Abstract] [Full text] [PDF]

Research Paper
The Pathogenesis of Atherosclerosis Based on Human Signaling Networks and Stem Cell Expression Data
Wan Li, Hao Huang, Lei Li, Li Wang, Yong Li, Yahui Wang, Shanshan Guo, Liansheng Li, Donghua Wang, Yuehan He, Lina Chen
Int. J. Biol. Sci. 2018; 14(12): 1678-1685. doi:10.7150/ijbs.27896
[Abstract] [Full text] [PDF]

Research Paper
BERMP: a cross-species classifier for predicting m⁶A sites by integrating a deep learning algorithm and a random forest approach
Yu Huang, Ningning He, Yu Chen, Zhen Chen, Lei Li
Int. J. Biol. Sci. 2018; 14(12): 1669-1677. doi:10.7150/ijbs.27819
[Abstract] [Full text] [PDF]

Research Paper
Epigenetic alterations of a novel antioxidant gene SLC22A3 predispose susceptible individuals to increased risk of esophageal cancer
Ji-Xian Xiong, Yan-Song Wang, Jingyi Sheng, Di Xiang, Tu-Xiong Huang, Bin-Bin Tan, Cui-Mian Zeng, Hua-Hui Li, Jiao Yang, Stephen J. Meltzer, Yuriko Mori, Yan-Ru Qin, Xin-Yuan Guan, Li Fu
Int. J. Biol. Sci. 2018; 14(12): 1658-1668. doi:10.7150/ijbs.28482
[Abstract] [Full text] [PDF]

Review
Cardiac fibrosis: new insights into the pathogenesis
Zhen-Guo Ma, Yu-Pei Yuan, Hai-Ming Wu, Xin Zhang, Qi-Zhu Tang
Int. J. Biol. Sci. 2018; 14(12): 1645-1657. doi:10.7150/ijbs.28103
[Abstract] [Full text] [PDF]

Review
Role of canonical Hedgehog signaling pathway in liver
Lili Gao, Zhenya Zhang, Peng Zhang, Minghua Yu, Tao Yang
Int. J. Biol. Sci. 2018; 14(12): 1636-1644. doi:10.7150/ijbs.28089
[Abstract] [Full text] [PDF]

Review
The Biological Roles of Translation Initiation Factor 3b
Xuefei Feng, Juan Li, Peijun Liu
Int. J. Biol. Sci. 2018; 14(12): 1630-1635. doi:10.7150/ijbs.26932
[Abstract] [Full text] [PDF]

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