Photodynamic Therapy for Inflammatory and Cancerous Diseases of the Intestines: Molecular Mechanisms and Prospects for Application

Deng, Beiying; Wang, Kunpeng; Zhang, Lilong; Qiu, Zhendong; Dong, Weiguo; Wang, Weixing

doi:10.7150/ijbs.87492

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Theranostics

International Journal of Medical Sciences

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Int J Biol Sci 2023; 19(15):4793-4810. doi:10.7150/ijbs.87492 This issue Cite

Review

Photodynamic Therapy for Inflammatory and Cancerous Diseases of the Intestines: Molecular Mechanisms and Prospects for Application

Beiying Deng^1#, Kunpeng Wang^2#, Lilong Zhang², Zhendong Qiu², Weiguo Dong^1✉, Weixing Wang^2✉

1. Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.
2. Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
^# These authors have contributed equally to this work.

Citation:

Deng B, Wang K, Zhang L, Qiu Z, Dong W, Wang W. Photodynamic Therapy for Inflammatory and Cancerous Diseases of the Intestines: Molecular Mechanisms and Prospects for Application. Int J Biol Sci 2023; 19(15):4793-4810. doi:10.7150/ijbs.87492. https://www.ijbs.com/v19p4793.htm

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Abstract

Photodynamic therapy (PDT) is a minimally invasive treatment that effectively targets cancer and inflammatory diseases. It has gained recognition for its efficacy, low toxicity, and potential for repeated use. Colorectal cancer (CRC) and inflammatory bowel diseases (IBD), including Crohn's disease (CD), and ulcerative colitis (UC), impose a significant burden on global intestinal health, with increasing incidence and prevalence rates. PDT shows promise as an emerging approach for gastrointestinal disease treatment, particularly IBD and CRC. Extensive preclinical research has demonstrated the safety and effectiveness of PDT for IBD and CRC, while clinical studies are currently underway. This review provides an overview of the underlying mechanisms responsible for the anti-inflammatory and anti-tumor effects of PDT, offering insights into the clinical application of PDT in IBD and CRC treatment. It is expected that this review will serve as a valuable reference for future research on PDT for CRC and IBD, contributing to advancements in the treatment of inflammatory and cancerous diseases of the intestines.

Keywords: photodynamic therapy, inflammatory bowel diseases, colorectal cancer, reactive oxygen species, immunology, nanomedicine

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APA

Deng, B., Wang, K., Zhang, L., Qiu, Z., Dong, W., Wang, W. (2023). Photodynamic Therapy for Inflammatory and Cancerous Diseases of the Intestines: Molecular Mechanisms and Prospects for Application. International Journal of Biological Sciences, 19(15), 4793-4810. https://doi.org/10.7150/ijbs.87492.

ACS

Deng, B.; Wang, K.; Zhang, L.; Qiu, Z.; Dong, W.; Wang, W. Photodynamic Therapy for Inflammatory and Cancerous Diseases of the Intestines: Molecular Mechanisms and Prospects for Application. Int. J. Biol. Sci. 2023, 19 (15), 4793-4810. DOI: 10.7150/ijbs.87492.

NLM

CSE

Deng B, Wang K, Zhang L, Qiu Z, Dong W, Wang W. 2023. Photodynamic Therapy for Inflammatory and Cancerous Diseases of the Intestines: Molecular Mechanisms and Prospects for Application. Int J Biol Sci. 19(15):4793-4810.

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