Omentin-1 ameliorates the progress of osteoarthritis by promoting IL-4-dependent anti-inflammatory responses and M2 macrophage polarization

Ko, Chih-Yuan; Lin, Yen-You; Achudhan, David; Chang, Jun-Way; Liu, Shan-Chi; Lai, Chao-Yang; Huang, Yuan-Li; Tsai, Chun-Hao; Fong, Yi-Chin; Chen, Hsien-Te; Lee, Kun-Tsan; Huang, Chien-Chung; Chang, Ting-Kuo; Tang, Chih-Hsin

doi:10.7150/ijbs.86701

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Int J Biol Sci 2023; 19(16):5275-5289. doi:10.7150/ijbs.86701 This issue Cite

Research Paper

Omentin-1 ameliorates the progress of osteoarthritis by promoting IL-4-dependent anti-inflammatory responses and M2 macrophage polarization

Chih-Yuan Ko^1,2#, Yen-You Lin^3#, David Achudhan¹, Jun-Way Chang⁴, Shan-Chi Liu^5,6, Chao-Yang Lai⁷, Yuan-Li Huang⁷, Chun-Hao Tsai^8,2, Yi-Chin Fong^8,2,9, Hsien-Te Chen^8,2, Kun-Tsan Lee^10,11, Chien-Chung Huang^12,13, Ting-Kuo Chang^14,15✉, Chih-Hsin Tang^{1,3,7,16,17✉}

1. Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
2. Department of Orthopedic Surgery, China Medical University Hospital, Taichung, Taiwan.
3. Department of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan.
4. Program of Biotechnology and Biomedical Industry, China Medical University, Taichung, Taiwan.
5. Department of Medical Education and Research, China Medical University Beigang Hospital, Yunlin County, Taiwan.
6. Institute of Biomedical Sciences, Mackay Medical College, New Taipei City, Taiwan.
7. Department of Medical Laboratory Science and Biotechnology, College of Medical and Health Science, Asia University, Taichung, Taiwan.
8. Department of Sports Medicine, College of Health Care, China Medical University, Taichung, Taiwan.
9. Department of Orthopedic Surgery, China Medical University Beigang Hospital, Yunlin, Taiwan.
10. Department of Post-Baccalaureate medicine, National Chung-Hsing University, Taichung, Taiwan.
11. Department of Orthopedics, Taichung Veterans General Hospital, Taichung, Taiwan.
12. School of Medicine, China Medical University, Taichung, Taiwan.
13. Division of Immunology and Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
14. Department of Medicine, Mackay Medical College, New Taipei, Taiwan.
15. Division of Spine Surgery, Department of Orthopedic Surgery, MacKay Memorial Hospital, New Taipei, Taiwan.
16. Chinese Medicine Research Center, China Medical University, Taichung, Taiwan.
17. Department of Medical Research, China Medical University Hsinchu Hospital, Hsinchu, Taiwan.
#These authors contributed equally to this work.

Citation:

Ko CY, Lin YY, Achudhan D, Chang JW, Liu SC, Lai CY, Huang YL, Tsai CH, Fong YC, Chen HT, Lee KT, Huang CC, Chang TK, Tang CH. Omentin-1 ameliorates the progress of osteoarthritis by promoting IL-4-dependent anti-inflammatory responses and M2 macrophage polarization. Int J Biol Sci 2023; 19(16):5275-5289. doi:10.7150/ijbs.86701. https://www.ijbs.com/v19p5275.htm

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Abstract

Osteoarthritis (OA) is a prevalent joint disease commonly associated with aging and obesity, which can lead to pain, stiffness, joint dysfunction, and disability. Omentin-1 (also called intelectin-1) is a newly discovered adipokine, which plays a protective role in suppressing the secretion of pro-inflammatory cytokines. Based on data from the Gene Expression Omnibus (GEO) dataset and clinical samples obtained at our institution revealed, determined that omentin-1 and IL-4 (an anti-inflammatory cytokine) levels were significantly lower in OA patients than in normal controls. Omentin-1 was shown to induce IL-4-depedent anti-inflammatory responses and M2 macrophage polarization in OA synovial fibroblasts via the PI3K, ERK, and AMPK pathways. Administering omentin-1 was shown to block cartilage degradation and bone erosion resulting from anterior cruciate ligament transection by inhibiting the production of pro-inflammatory cytokines and promoting M2 macrophage polarization in vivo. Our findings indicate omentin-1 as a promising therapeutic avenue for the treatment for OA.

Keywords: Omentin-1, Osteoarthritis, IL-4, M2 macrophage, Anti-inflammation

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APA

Ko, C.Y., Lin, Y.Y., Achudhan, D., Chang, J.W., Liu, S.C., Lai, C.Y., Huang, Y.L., Tsai, C.H., Fong, Y.C., Chen, H.T., Lee, K.T., Huang, C.C., Chang, T.K., Tang, C.H. (2023). Omentin-1 ameliorates the progress of osteoarthritis by promoting IL-4-dependent anti-inflammatory responses and M2 macrophage polarization. International Journal of Biological Sciences, 19(16), 5275-5289. https://doi.org/10.7150/ijbs.86701.

ACS

Ko, C.Y.; Lin, Y.Y.; Achudhan, D.; Chang, J.W.; Liu, S.C.; Lai, C.Y.; Huang, Y.L.; Tsai, C.H.; Fong, Y.C.; Chen, H.T.; Lee, K.T.; Huang, C.C.; Chang, T.K.; Tang, C.H. Omentin-1 ameliorates the progress of osteoarthritis by promoting IL-4-dependent anti-inflammatory responses and M2 macrophage polarization. Int. J. Biol. Sci. 2023, 19 (16), 5275-5289. DOI: 10.7150/ijbs.86701.

NLM

CSE

Ko CY, Lin YY, Achudhan D, Chang JW, Liu SC, Lai CY, Huang YL, Tsai CH, Fong YC, Chen HT, Lee KT, Huang CC, Chang TK, Tang CH. 2023. Omentin-1 ameliorates the progress of osteoarthritis by promoting IL-4-dependent anti-inflammatory responses and M2 macrophage polarization. Int J Biol Sci. 19(16):5275-5289.

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