Int J Biol Sci
2007; 3(7):471-476.
doi:10.7150/ijbs.3.471 This issueCite
Research Paper
The Growth-hormone inducible transmembrane protein (Ghitm) belongs to the Bax inhibitory protein-like family
Kerstin Reimers*, Claudia YU Choi*, Vesna Bucan, Peter M Vogt
Department for Plastic, Hand and Reconstructive Surgery, Medical School Hannover, Podbielskistraße 380, D-30659 Hannover, Germany *These authors contributed equally.
Citation:
Reimers K, Choi CYU, Bucan V, Vogt PM. The Growth-hormone inducible transmembrane protein (Ghitm) belongs to the Bax inhibitory protein-like family. Int J Biol Sci 2007; 3(7):471-476. doi:10.7150/ijbs.3.471. https://www.ijbs.com/v03p0471.htm
The conserved protein domain UPF0005 is a protein family signature distributed among many species including fungi and bacteria. Although of unknown functionality this motif has been found in newly identified antiapoptotic proteins comprising the BI-1 family, namely Bax-inhibitory Protein-1 (BI-1), Lifeguard (LFG), and h-GAAP. In a search for vertebrate proteins presumably belonging to the BI-1 family, we found that Growth-hormone inducible transmembrane protein (Ghitm) is another prospective member of the BI-1 family. Here we characterise Ghitm in a first analysis regarding its phylogeny, expression in cancer cell lines, and proteomical properties.
Keywords: protein family, Bax-inhibitor, programmed cell death, bioinformatics, apoptosis inhibitors, transmembrane protein
Citation styles
APA
Reimers, K., Choi, C.YU., Bucan, V., Vogt, P.M. (2007). The Growth-hormone inducible transmembrane protein (Ghitm) belongs to the Bax inhibitory protein-like family. International Journal of Biological Sciences, 3(7), 471-476. https://doi.org/10.7150/ijbs.3.471.
ACS
Reimers, K.; Choi, C.YU.; Bucan, V.; Vogt, P.M. The Growth-hormone inducible transmembrane protein (Ghitm) belongs to the Bax inhibitory protein-like family. Int. J. Biol. Sci. 2007, 3 (7), 471-476. DOI: 10.7150/ijbs.3.471.
NLM
Reimers K, Choi CYU, Bucan V, Vogt PM. The Growth-hormone inducible transmembrane protein (Ghitm) belongs to the Bax inhibitory protein-like family. Int J Biol Sci 2007; 3(7):471-476. doi:10.7150/ijbs.3.471. https://www.ijbs.com/v03p0471.htm
CSE
Reimers K, Choi CYU, Bucan V, Vogt PM. 2007. The Growth-hormone inducible transmembrane protein (Ghitm) belongs to the Bax inhibitory protein-like family. Int J Biol Sci. 3(7):471-476.