In reply to Zou <i>et al</i>. “New amyloid plaques or a game of hide-and-seek?”

Hyman, Bradley

doi:10.7150/ijbs.4.245

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Int J Biol Sci 2008; 4(4):245. doi:10.7150/ijbs.4.245 This issue Cite

Letter To The Editor

In reply to Zou et al. “New amyloid plaques or a game of hide-and-seek?”

Bradley Hyman

Massachusetts General Hospital, MassGeneral Institute for Neurodegeneration, Charlestown MA 02129, USA

Citation:

Hyman B. In reply to Zou et al. “New amyloid plaques or a game of hide-and-seek?”. Int J Biol Sci 2008; 4(4):245. doi:10.7150/ijbs.4.245. https://www.ijbs.com/v04p0245.htm

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Letter in Int J Biol Sci, Volume 4, 200

Reply to the article: Zou K, Maeda T, Michikawa M, Komano H. New amyloid plaques or a game of hide-and-seek? Int J Biol Sci 2008; 4:200-201.

We appreciate, but disagree with, Zou et al's comments regarding potential technical issues in the in vivo imaging. Our control experiments, including explicit criteria for inclusion and exclusion of new plaques, the presence of other plaques in the field that are observed by the dyes, the use of different freely diffusible well characterized dyes (both topical application and intraperitoneal application for a dye that that we have previously formally demonstrated to readily cross the blood brain barrier) and concurrent imaging of neurites and blood vessels to ensure quality of imaging per se all, in our opinion, argue against their concerns.

Author contact

Correspondence to: Bradley Hyman MD PhD, John B Penney Jr Professor of Neurology Harvard Medical School, Massachusetts General Hospital, MassGeneral Institute for Neurodegeneration Rm 2009, 114 16th Street, Charlestown MA 02129.

Published 2008-8-8

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APA

Hyman, B. (2008). In reply to Zou et al. “New amyloid plaques or a game of hide-and-seek?”. International Journal of Biological Sciences, 4(4), 245. https://doi.org/10.7150/ijbs.4.245.

ACS

Hyman, B. In reply to Zou et al. “New amyloid plaques or a game of hide-and-seek?”. Int. J. Biol. Sci. 2008, 4 (4), 245. DOI: 10.7150/ijbs.4.245.

NLM

Hyman B. In reply to Zou et al. “New amyloid plaques or a game of hide-and-seek?”. Int J Biol Sci 2008; 4(4):245. doi:10.7150/ijbs.4.245. https://www.ijbs.com/v04p0245.htm

CSE

Hyman B. 2008. In reply to Zou et al. “New amyloid plaques or a game of hide-and-seek?”. Int J Biol Sci. 4(4):245.

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