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Int J Biol Sci 2008; 4(4):245. doi:10.7150/ijbs.4.245

Letter To The Editor

In reply to Zou et al. “New amyloid plaques or a game of hide-and-seek?”

Bradley Hyman Corresponding address

Massachusetts General Hospital, MassGeneral Institute for Neurodegeneration, Charlestown MA 02129, USA

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See for full terms and conditions.
How to cite this article:
Hyman B. In reply to Zou et al. “New amyloid plaques or a game of hide-and-seek?”. Int J Biol Sci 2008; 4(4):245. doi:10.7150/ijbs.4.245. Available from

Letter in Int J Biol Sci, Volume 4, 200


Reply to the article: Zou K, Maeda T, Michikawa M, Komano H. New amyloid plaques or a game of hide-and-seek? Int J Biol Sci 2008; 4:200-201.

We appreciate, but disagree with, Zou et al's comments regarding potential technical issues in the in vivo imaging. Our control experiments, including explicit criteria for inclusion and exclusion of new plaques, the presence of other plaques in the field that are observed by the dyes, the use of different freely diffusible well characterized dyes (both topical application and intraperitoneal application for a dye that that we have previously formally demonstrated to readily cross the blood brain barrier) and concurrent imaging of neurites and blood vessels to ensure quality of imaging per se all, in our opinion, argue against their concerns.

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Corresponding address Correspondence to: Bradley Hyman MD PhD, John B Penney Jr Professor of Neurology Harvard Medical School, Massachusetts General Hospital, MassGeneral Institute for Neurodegeneration Rm 2009, 114 16th Street, Charlestown MA 02129.

Published 2008-8-8