International Journal of Biological Sciences

Impact factor

ISSN 1449-2288

News feeds of IJBS published articles
Manuscript login

open access Global reach, higher impact

Journal of Genomics - Submit manuscript now...


International Journal of Medical Sciences

Journal of Cancer

Journal of Genomics



Journal of Biomedicine

PubMed Central Indexed in Journal Impact Factor

Int J Biol Sci 2008; 4(5):283-290. doi:10.7150/ijbs.4.283


Advances in Susceptibility Genetics of Intervertebral Degenerative Disc Disease

Yin'gang Zhang1✉, Zhengming Sun1, Jiangtao Liu1, Xiong Guo2

1. Department of Orthopaedics of the First Affiliated Hospital, Medical College of Xi'an Jiaotong University, Xi'an, 710061, China
2. Key Laboratory of Environment and Genes Related Diseases of Ministry of Education, Xi'an Jiaotong University, Xi'an, 710061, China


The traditional view that the etiology of lumbar disc herniation is primarily due to age, gender, occupation, smoking and exposure to vehicular vibration dominated much of the last century. Recent research indicates that heredity may be largely responsible for the degeneration as well as herniation of intervertebral discs. Since 1998, genetic influences have been confirmed by the identification of several genes forms associated with disc degeneration. These researches are paving the way for a better understanding of the biologic mechanisms. Now, many researchers unanimously agree that lumbar disc herniation appears to be similar to other complex diseases, whose etiology has both environmental and hereditary influence, each with a part of contribution and relative risk. Then addressing the etiological of lumbar disc herniation, it is important to integrate heredity with the environment factors. For the purpose of this review, we have limited our discussion to several susceptibility genes associated with disc degeneration.

Keywords: Intervertebral disc Disease, Degeneration, Candidate Genes, Familial Aggregation

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See for full terms and conditions.
How to cite this article:
Zhang Y, Sun Z, Liu J, Guo X. Advances in Susceptibility Genetics of Intervertebral Degenerative Disc Disease. Int J Biol Sci 2008; 4(5):283-290. doi:10.7150/ijbs.4.283. Available from