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Int J Biol Sci 2009; 5(4):304-310. doi:10.7150/ijbs.5.304

Research Paper

Vesnarinone Represses the Fibrotic Changes in Murine Lung Injury Induced by Bleomycin

Minoru Inage 1, Hidenori Nakamura 1, Hiroshi Saito 1, Shuichi Abe 1, Toshihiko Hino 1, Noriaki Takabatake 1, Kyoko Terashita 1, Manabu Ogura 1, Shuichi Kato 1, Tetsumi Hosokawa 2, Makoto Sata 1, 3 ✉, Hitonobu Tomoike 1, 3

1. First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, JAPAN
2. Otsuka Pharmaceutical Company, Tokushima, JAPAN
3. Department of Internal Medicine, National Cardiovascular Center, Osaka, JAPAN

Abstract

We investigated the potential usefulness of vesnarinone, a novel cytokine inhibitor, for the treatment of lung fibrosis using a murine model of bleomycin (BLM)-induced pulmonary fibrosis. Mice were fed a control diet (n=42), or a diet containing low (n=42) or high (n=42) dose of vesnarinone. Dietary intake of vesnarinone minimized the BLM toxicity as reflected by significant decreases in numbers of inflammatory cells, KC, and soluble TNF receptors in the bronchoalveolar lavage fluid. A quantitative evaluation of histology demonstrated significantly mild lung parenchymal lesions in BLM-treated mice fed with diet containing high dose of vesnarinone than in the control diet group. Consistent with the histopathology, hydroxyproline levels in lung tissue from BLM-treated mice fed with diet containing vesnarinone were significantly lower than that from mice fed with control diet. We concluded that vesnarinone inhibits BLM-induced pulmonary fibrosis, at least in part, by the inhibition of acute lung injuries in the early phase.

Keywords: acute lung injury, bleomycin, chemokine, pulmonary fibrosis, vesnarinone

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How to cite this article:
Inage M, Nakamura H, Saito H, Abe S, Hino T, Takabatake N, Terashita K, Ogura M, Kato S, Hosokawa T, Sata M, Tomoike H. Vesnarinone Represses the Fibrotic Changes in Murine Lung Injury Induced by Bleomycin. Int J Biol Sci 2009; 5(4):304-310. doi:10.7150/ijbs.5.304. Available from http://www.ijbs.com/v05p0304.htm