Int J Biol Sci 2009; 5(5):438-443. doi:10.7150/ijbs.5.438


How Subchronic and Chronic Health Effects can be Neglected for GMOs, Pesticides or Chemicals

Gilles-Eric Séralini1,2 ✉, Joël Spiroux de Vendômois2, Dominique Cellier2,3, Charles Sultan2,4, Marcello Buiatti2,5, Lou Gallagher6, Michael Antoniou7, Krishna R. Dronamraju8

1. University of Caen, Institute of Biology, Biochemistry, Esplanade de la Paix 14032 Caen Cedex France.
2. CRIIGEN, 40 rue Monceau, 75008 Paris France
3. University of Rouen, LITIS EA 4108, 76821 Mont Saint-Aignan, France
4. University of Montpellier, School of Medicine, IGH, CNRS, France
5. University of Firenze, Italy
6. Institute for Environmental Science and Research, Ltd, Crown Research Institute, Porirua, New Zealand
7. King's College London School of Medicine, Dept. Medical and Molecular Genetics, London, United Kingdom
8. Foundation for Genetic Research, Houston, USA


Chronic health effects are increasing in the world such as cancers, hormonal, reproductive, nervous, or immune diseases, even in young people. During regulatory toxicological subchronic tests to prevent these on mammalian health, prior commercialization of chemicals, including pesticides and drugs, or GMOs, some statistically significant findings may be revealed. This discussion is about the need to investigate the relevant criteria to consider those as biologically significant. The sex differences and the non linear dose or time related effects should be considered in contrast to the claims of a Monsanto-supported expert panel about a GMO, the MON 863 Bt maize, but also for pesticides or drugs, in particular to reveal hormone-dependent diseases and first signs of toxicities.

Keywords: Pesticides, GMO, MON 863, side effects, toxicological tests.

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How to cite this article:
Séralini GE, de Vendômois JS, Cellier D, Sultan C, Buiatti M, Gallagher L, Antoniou M, Dronamraju KR. How Subchronic and Chronic Health Effects can be Neglected for GMOs, Pesticides or Chemicals. Int J Biol Sci 2009; 5(5):438-443. doi:10.7150/ijbs.5.438. Available from