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Int J Biol Sci 2010; 6(7):716-718. doi:10.7150/ijbs.6.716

Commentary

Role of clusters in insulin-regulated GLUT4 trafficking in adipose cells: A new paradigm?

Jian Yang

1. EDMNS, Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, MD, USA.
2. Department of Physiology, University of South Alabama College of Medicine, Mobile, AL, USA.

Abstract

Insulin stimulates glucose transport in muscle and adipose cells by stimulating translocation of glucose transporter 4 (GLUT4) to the plasma membrane. In a recent Cell Metabolism paper, Stenkula et al. found that insulin controls the spatial distribution of GLUT4 on the surface of isolated adipose cells through regulation of their post-fusion dispersal. The presence of GLUT4 in plasma membrane-associated clusters is suggestive of a new paradigm in membrane protein recycling.

Keywords: Adipocyte, GLUT4, exocytosis, endocytosis, insulin resistance

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How to cite this article:
Yang J. Role of clusters in insulin-regulated GLUT4 trafficking in adipose cells: A new paradigm?. Int J Biol Sci 2010; 6(7):716-718. doi:10.7150/ijbs.6.716. Available from http://www.ijbs.com/v06p0716.htm