Int J Biol Sci 2011; 7(4):403-409. doi:10.7150/ijbs.7.403


Ovarian Germline Stem Cells in the Teleost Fish, Medaka (Oryzias latipes)

Shuhei Nakamura1, Kayo Kobayashi1, Toshiya Nishimura1,2, Minoru Tanaka1,2 ✉

1. Laboratory of Molecular Genetics for Reproduction, National Institute for Basic Biology, Okazaki 444-8787, Japan.
2. Department of Basic Biology, Graduate University for Advanced Studies (SOKENDAI), Okazaki, Aichi 444-8585, Japan.


In the mammalian testis germline stem cells keep producing many sperms, while there is no direct evidence for the presence of germline stem cells in the ovary. It is widely accepted in mammals that the mature oocytes are supplied from a pool of primordial follicles in the adult ovary. In other vertebrates, such as fish, however, there has been no investigation on the mechanism underlying the high egg-producing ability. In this review, we introduce the recently identified ovarian germline stem cells and the surrounding unique structure in teleost fish, medaka (Oryzias latipes) [Nakamura S et al. Science. 2010; 328: 1561-1563]. We also discuss about the expression and function of sox9 that characterizes this unique structure.

Keywords: medaka, germline stem cells, sox9

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How to cite this article:
Nakamura S, Kobayashi K, Nishimura T, Tanaka M. Ovarian Germline Stem Cells in the Teleost Fish, Medaka (Oryzias latipes). Int J Biol Sci 2011; 7(4):403-409. doi:10.7150/ijbs.7.403. Available from