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Int J Biol Sci 2011; 7(6):762-768. doi:10.7150/ijbs.7.762

Research Paper

Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells

Yu Nie, Bian-Mei Han, Xue-Bin Liu*, Jin-Jing Yang, Fang Wang, Xiang-Feng Cong, Xi Chen

Research Center for Cardiovascular Regenerative Medicine, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China
* This author now works in Department of Neural Stem Cell Transplantation, Armed Police General Hospital, Beijing, China.


The use of bone marrow mesenchymal stem cell- (MSC) transplantation therapy for cardiac diseases is limited due to poor survival of implanted cells. MicroRNAs (miRNAs) have been reported to be involved in regulating almost all cellular processes, including apoptosis. In this study, we found that the miRNA profile was altered during apoptosis induced by hypoxia and serum deprivation (hypoxia/SD). We further revealed that over-expression of miR-21, miR-23a and miR-210 could promote the survival of MSCs exposed to hypoxia/SD. In contrast, down-regulation of miR-21, miR-23a and miR-503 aggravated apoptosis of MSCs. It was indicated that these miRNAs may play important roles during MSC apoptosis induced by hypoxia/SD.

Keywords: Mesenchymal stem cells, MicroRNA, Hypoxia/serum deprivation, Apoptosis

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See for full terms and conditions.
How to cite this article:
Nie Y, Han BM, Liu XB, Yang JJ, Wang F, Cong XF, Chen X. Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells. Int J Biol Sci 2011; 7(6):762-768. doi:10.7150/ijbs.7.762. Available from