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Int J Biol Sci 2011; 7(9):1412-1426. doi:10.7150/ijbs.7.1412

Review

Mechanisms Underlying the Induction of Regulatory T cells and Its Relevance in the Adaptive Immune Response in Parasitic Infections

Laura Adalid-Peralta1,2, Gladis Fragoso3, Agnes Fleury1,2, Edda Sciutto2,3✉

1. Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez
2. Unidad Periférica para el estudio de neuroinflamación del Instituto de Investigaciones Biomédicas de la UNAM en el INNN, Insurgentes Sur 3877, Col. La Fama, México, D.F. 14269, México
3. Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México, D.F, 04510, México

Abstract

To fulfill its function, the immune system must detect and interpret a wide variety of signals and adjust the magnitude, duration, and specific traits of each response during the complex host-parasite relationships in parasitic infections. Inflammation must be tightly regulated since uncontrolled inflammation may be as destructive as the triggering stimulus and leads to immune-mediated tissue injury.

During recent years, increasing evidence points to regulatory T cells (Tregs) as key anti-inflammatory cells, critically involved in limiting the inflammatory response. Herein, we review the published information on the induction of Tregs and summarize the most recent findings on Treg generation in parasitic diseases.

Keywords: regulatory T cells, parasitic infections, inflammation, dendritic cell, regulation, immune response, cytokines, malaria, Leishmania, Trypanosoma, Schistosoma, nematodes.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Adalid-Peralta L, Fragoso G, Fleury A, Sciutto E. Mechanisms Underlying the Induction of Regulatory T cells and Its Relevance in the Adaptive Immune Response in Parasitic Infections. Int J Biol Sci 2011; 7(9):1412-1426. doi:10.7150/ijbs.7.1412. Available from http://www.ijbs.com/v07p1412.htm