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Int J Biol Sci 2012; 8(6):778-790. doi:10.7150/ijbs.4538 This issue Cite

Review

Phosphate/Pyrophosphate and MV-related Proteins in Mineralisation: Discoveries from Mouse Models

Xiaoying Zhou, Yazhou Cui, Xiaoyan Zhou, Jinxiang Han✉

Shandong Academy of Medical Sciences, Shandong Medical Biotechnological Center, Key Laboratory for Rare Disease Research of Shandong Province, and Key Laboratory for Biotech Drugs of the Ministry of Health, Shandong, China.

✉ Corresponding author: Jinxiang Han, Ph.D., Shandong Academy of Medical Sciences, Shandong Medical Biotechnological Center, Key Laboratory for Rare Disease Research of Shandong Province, China, and Key Laboratory for Biotech Drugs of the Ministry of More

Citation:
Zhou X, Cui Y, Zhou X, Han J. Phosphate/Pyrophosphate and MV-related Proteins in Mineralisation: Discoveries from Mouse Models. Int J Biol Sci 2012; 8(6):778-790. doi:10.7150/ijbs.4538. https://www.ijbs.com/v08p0778.htm
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Abstract

During the process of matrix vesicle (MV)-mediated initiation of mineralisation, chondrocytes and osteoblasts mineralise the extracellular matrix by promoting the seeding of basic calcium phosphate crystals of hydroxyapatite (HA) along the collagen fibrils. This orchestrated process is carefully regulated by the balanced action of propagators and inhibitors of calcification. The primary antagonistic regulators of extracellular matrix mineralisation are phosphate (Pi) and inorganic pyrophosphate (PPi). Studies in mouse models and in humans have established critical roles for Pi/PPi homeostasis in biomineralisation. In this review, we present the regulators of Pi/PPi, as derived from animal models, and discuss their clinical relevance to physiological and pathological mineralisation.

Keywords: Mineralisation, Matrix vesicles, PPi, Pi, MV-related proteins, OPN.

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APA
Zhou, X., Cui, Y., Zhou, X., Han, J. (2012). Phosphate/Pyrophosphate and MV-related Proteins in Mineralisation: Discoveries from Mouse Models. International Journal of Biological Sciences, 8(6), 778-790. https://doi.org/10.7150/ijbs.4538.

ACS
Zhou, X.; Cui, Y.; Zhou, X.; Han, J. Phosphate/Pyrophosphate and MV-related Proteins in Mineralisation: Discoveries from Mouse Models. Int. J. Biol. Sci. 2012, 8 (6), 778-790. DOI: 10.7150/ijbs.4538.

NLM
Zhou X, Cui Y, Zhou X, Han J. Phosphate/Pyrophosphate and MV-related Proteins in Mineralisation: Discoveries from Mouse Models. Int J Biol Sci 2012; 8(6):778-790. doi:10.7150/ijbs.4538. https://www.ijbs.com/v08p0778.htm

CSE
Zhou X, Cui Y, Zhou X, Han J. 2012. Phosphate/Pyrophosphate and MV-related Proteins in Mineralisation: Discoveries from Mouse Models. Int J Biol Sci. 8(6):778-790.

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