Int J Biol Sci 2012; 8(10):1420-1430. doi:10.7150/ijbs.5273
Immunotherapies: The Blockade of Inhibitory Signals
1. Virus Inspection Department of Zhejiang Provincial Center for Disease Control and Prevention, 630 Xincheng Road, Hangzhou, 310051, China.
T lymphocytes require signaling by the T cell receptor and by nonclonotypic cosignaling receptors. The costimulatory and inhibitory signals profoundly influence the course of immune responses by amplifying or reducing the transcriptional effects of T cell receptor triggering. The inhibitory receptors such as CTLA-4, PD-1, and BTLA have recently drawn much attention as potential targets for immunotherapies. This review focuses on the progress that has been made with the mentioned receptors in the field of immunotherapies for autoimmune diseases, malignancies, infectious diseases, and transplantation.
Keywords: Inhibitory receptors, CTLA-4, PD-1, BTLA, immunotherapy.
This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Wu YL, Liang J, Zhang W, Tanaka Y, Sugiyama H. Immunotherapies: The Blockade of Inhibitory Signals. Int J Biol Sci 2012; 8(10):1420-1430. doi:10.7150/ijbs.5273. Available from http://www.ijbs.com/v08p1420.htm