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Int J Biol Sci 2013; 9(6):550-556. doi:10.7150/ijbs.6257

Short Research Communication

Deep Sequencing of the Transcriptome Reveals Inflammatory Features of Porcine Visceral Adipose Tissue

Tao Wang*, Anan Jiang*, Yanqin Guo, Ya Tan, Guoqing Tang, Miaomiao Mai, Haifeng Liu, Jian Xiao, Mingzhou Li, Xuewei Li

Institute of Animal Genetics & Breeding, College of Animal Science & Technology, Sichuan Agricultural University, Ya'an, Sichuan, China.
* These authors contributed equally to this work.

Abstract

Functional differences in the different types of adipose tissue and the impact of their dysfunction on metabolism are associated with the regional distribution of adipose depots. Here we show a genome-wide comparison between the transcriptomes of one source of subcutaneous and two sources of visceral adipose tissue in the pig using an RNA-seq approach. We obtained ~32.3 million unique mapped reads which covered ~80.2% of the current annotated transcripts across these three sources of adipose tissue. We identified various genes differentially expressed between subcutaneous and visceral adipose tissue, which are potentially associated with the inflammatory features of visceral adipose tissue. These results are of benefit for understanding the phenotypic, metabolic and functional differences between different types of adipose tissue that are deposited in different body sites.

Keywords: subcutaneous adipose tissue, visceral adipose tissue, RNA-seq, inflammatory, fatty acid metabolism, pig.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Wang T, Jiang A, Guo Y, Tan Y, Tang G, Mai M, Liu H, Xiao J, Li M, Li X. Deep Sequencing of the Transcriptome Reveals Inflammatory Features of Porcine Visceral Adipose Tissue. Int J Biol Sci 2013; 9(6):550-556. doi:10.7150/ijbs.6257. Available from http://www.ijbs.com/v09p0550.htm