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Int J Biol Sci 2014; 10(1):103-108. doi:10.7150/ijbs.7585


NOD2 Polymorphisms and Pulmonary Tuberculosis Susceptibility: A Systematic Review and Meta-Analysis

Chong Wang1, Zhong-Liang Chen1, Zhi-Fen Pan2, Li-Liang Wei3, Dan-Dan Xu1, Ting-Ting Jiang1, Xing Zhang1, Ze-Peng Ping1, Zhong-Jie Li1, Ji-Cheng Li1✉

1. Institute of Cell Biology, Zhejiang University, Hangzhou 310058, P.R. China
2. The First Hospital of Jiaxing, Jiaxing 314001, P.R. China
3. The Sixth Hospital of Shaoxing, Shaoxing 312000, P.R. China


The association between NOD2 and tuberculosis (TB) risk has been reported widely, but the results of previous studies remained controversial and ambiguous. To assess the association between NOD2 polymorphisms and TB risk, a meta-analysis was performed. A literature search was conducted by using the PubMed, Ovid, ISI Web of Knowledge, Elsevier ScienceDirect, and Chinese National Knowledge Infrastructure (CNKI). We identified the data from all articles estimating the association between NOD2 polymorphisms and TB risk. In total, 2,215 cases and 1,491 controls in 7 case-control studies were included. In meta-analysis, we found significant association between the Arg702Trp polymorphism and TB risk (OR = 0.43, 95% CI = 0.20-0.90, P = 0.02). However, no significant association was found between the Arg587Arg (OR = 1.31, 95% CI = 0.83-2.07, P = 0.25) and Gly908Arg (OR = 0.78, 95% CI = 0.21-2.87, P = 0.71) polymorphisms and TB risk. The present meta-analysis suggested that NOD2 Arg702Trp polymorphism was likely to be a protective factor for TB. However, the Arg587Arg and Gly908Arg polymorphisms might not be the genetic risk factors for TB susceptibility.

Keywords: NOD2, Single-nucleotide polymorphism, meta-analysis, tuberculosis

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See for full terms and conditions.
How to cite this article:
Wang C, Chen ZL, Pan ZF, Wei LL, Xu DD, Jiang TT, Zhang X, Ping ZP, Li ZJ, Li JC. NOD2 Polymorphisms and Pulmonary Tuberculosis Susceptibility: A Systematic Review and Meta-Analysis. Int J Biol Sci 2014; 10(1):103-108. doi:10.7150/ijbs.7585. Available from