Int J Biol Sci 2014; 10(9):983-989. doi:10.7150/ijbs.9442


The Role of Six1 in the Genesis of Muscle Cell and Skeletal Muscle Development

Wangjun Wu1, 2, ✉, Ruihua Huang1, 2, Qinghua Wu3, 4, Pinghua Li1, 2, Jie Chen1, Bojiang Li1, Honglin Liu 1,✉

1. Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China;
2. Huaian Academy of Nanjing Agricultural University, Huaian, Jiangsu, 223001, China;
3. College of Life Science, Yangtze University, Jingzhou, Hubei, 434023, China.
4. Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kradec Kralove, Hradec Kralove, Czech Republic.


The sine oculis homeobox 1 (Six1) gene encodes an evolutionarily conserved transcription factor. In the past two decades, much research has indicated that Six1 is a powerful regulator participating in skeletal muscle development. In this review, we summarized the discovery and structural characteristics of Six1 gene, and discussed the functional roles and molecular mechanisms of Six1 in myogenesis and in the formation of skeletal muscle fibers. Finally, we proposed areas of future interest for understanding Six1 gene function.

Keywords: Six1, Muscle, Muscle fiber, Muscle progenitors, Regulatory network, Molecular mechanism.

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How to cite this article:
Wu W, Huang R, Wu Q, Li P, Chen J, Li B, Liu H. The Role of Six1 in the Genesis of Muscle Cell and Skeletal Muscle Development. Int J Biol Sci 2014; 10(9):983-989. doi:10.7150/ijbs.9442. Available from