Int J Biol Sci 2015; 11(1):31-37. doi:10.7150/ijbs.10615
Epithelial Cell Polarity Determinant CRB3 in Cancer Development
1. Center for Translational Medicine, the First Affiliated Hospital of Xi'an Jiaotong University
2. Department of Surgical Oncology, the First Affiliated Hospital of Xi'an Jiaotong University
Cell polarity, which is defined as asymmetry in cell shape, organelle distribution and cell function, is essential in numerous biological processes, including cell growth, cell migration and invasion, molecular transport, and cell fate. Epithelial cell polarity is mainly regulated by three conserved polarity protein complexes, the Crumbs (CRB) complex, partitioning defective (PAR) complex and Scribble (SCRIB) complex. Research evidence has indicated that dysregulation of cell polarity proteins may play an important role in cancer development. Crumbs homolog 3 (CRB3), a member of the CRB complex, may act as a cancer suppressor in mouse kidney epithelium and mouse mammary epithelium. In this review, we focus on the current data available on the roles of CRB3 in cancer development.
Keywords: apical-basal polarity, CRB3, EMT, cancer
Li P, Mao X, Ren Y, Liu P. Epithelial Cell Polarity Determinant CRB3 in Cancer Development. Int J Biol Sci 2015; 11(1):31-37. doi:10.7150/ijbs.10615. Available from http://www.ijbs.com/v11p0031.htm