Int J Biol Sci 2015; 11(2):168-175. doi:10.7150/ijbs.10464
Biology of IL-27 and its Role in the Host Immunity against Mycobacterium Tuberculosis
1. Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China.
IL-27, a heterodimeric cytokine of IL-12 family, regulates both innate and adaptive immunity largely via Jak-Stat signaling. IL-27 can induce IFN-γ and inflammatory mediators from T lymphocytes and innate immune cells. IL-27 has unique anti-inflammatory properties via both Tr1 cells dependent and independent mechanisms. Here the role and biology of IL-27 in innate and adaptive immunity are summarized, with special interest with immunity against Mycobacterium tuberculosis.
Keywords: IL-27, IL-27Rα, IL-12 family, Mycobacterium tuberculosis, Immunity
This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Abdalla AE, Li Q, Xie L, Xie J. Biology of IL-27 and its Role in the Host Immunity against Mycobacterium Tuberculosis. Int J Biol Sci 2015; 11(2):168-175. doi:10.7150/ijbs.10464. Available from http://www.ijbs.com/v11p0168.htm