International Journal of Biological Sciences

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Int J Biol Sci 2018; 14(4):390-397. doi:10.7150/ijbs.22243

Review

MicroRNAs associated with therapy of non-small cell lung cancer

Junmi Lu, Yuting Zhan, Juan Feng, Jiadi Luo, Songqing Fan

Department of Pathology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China

Abstract

Background & Objective: The incidence of non-small cell lung cancer (NSCLC) has been rising over the past several decades. Despite various therapeutic regimens and modern diagnostic techniques are developed, NSCLC still have an extremely poor prognosis due to drug resistance. Therefore, it is critical to find a novel precise diagnosis and effective treatment approach for NSCLC patients. MicroRNAs (MiRNAs) are a class of 18-25nt non-coding small RNAs, which have been shown to be involved profoundly in the pathogenesis such as cellular proliferation, differentiation, development, apoptosis and tumorigenesis in many human tumors including of NSCLC. We reviewed existing research literature regarding correlations between miRNAs and their target's response to anticancer treatment, and summarized the recent findings between miRNAs and therapy availability in NSCLC.

Keywords: NSCLC, microRNAs, targeted therapy, radio-chemotherapy

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Lu J, Zhan Y, Feng J, Luo J, Fan S. MicroRNAs associated with therapy of non-small cell lung cancer. Int J Biol Sci 2018; 14(4):390-397. doi:10.7150/ijbs.22243. Available from http://www.ijbs.com/v14p0390.htm