Int J Biol Sci 2018; 14(10):1232-1244. doi:10.7150/ijbs.24612


Review of Drug Repositioning Approaches and Resources

Hanqing Xue, Jie Li*,✉, Haozhe Xie, Yadong Wang

School of Computer Science and Technology, Harbin Institute of Technology, 150001, Harbin, China
*Co-first author


Drug discovery is a time-consuming, high-investment, and high-risk process in traditional drug development. Drug repositioning has become a popular strategy in recent years. Different from traditional drug development strategies, the strategy is efficient, economical and riskless. There are usually three kinds of approaches: computational approaches, biological experimental approaches, and mixed approaches, all of which are widely used in drug repositioning. In this paper, we reviewed computational approaches and highlighted their characteristics to provide references for researchers to develop more powerful approaches. At the same time, the important findings obtained using these approaches are listed. Furthermore, we summarized 76 important resources about drug repositioning. Finally, challenges and opportunities in drug repositioning are discussed from multiple perspectives, including technology, commercial models, patents and investment.

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How to cite this article:
Xue H, Li J, Xie H, Wang Y. Review of Drug Repositioning Approaches and Resources. Int J Biol Sci 2018; 14(10):1232-1244. doi:10.7150/ijbs.24612. Available from