International Journal of Biological Sciences

Impact factor
4.057

ISSN 1449-2288

News feeds of IJBS published articles
Manuscript login
Account
Submit

open access Global reach, higher impact

Journal of Genomics in PubMed Central. Submit manuscript now...

Theranostics

International Journal of Medical Sciences

Journal of Cancer

Journal of Genomics

Journal of Bone and Joint Infection (JBJI)

Oncomedicine

Journal of Biomedicine

Nanotheranostics

PubMed Central Indexed in Journal Impact Factor

Int J Biol Sci 2018; 14(10):1245-1255. doi:10.7150/ijbs.24347

Research Paper

Alcohol accumulation promotes esophagitis via pyroptosis activation

Fengjiao Wang1*, Gang Li2*, Jinfeng Ning1, Lantao Chen1, Hai Xu1, Xianglong Kong1, Jianlong Bu1, Weiwei Zhao3, Zhengtian Li4, Xiuyun Wang5, Xiaoguang Li6, Jianqun Ma1✉

1. Department of Thoracic Surgery, Harbin Medical University Cancer Hospital, Harbin, 150001, China
2. Department of General Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150000, China
3. Department of Epidemiology and Biostatistics, School of Public Health, Harbin Medical University, Harbin, 150086, China
4. Department of General Surgery, the First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China
5. Department of Abdominal Ultrasound, First Hospital of Harbin Medical University, Harbin, 150001, China
6. Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
*Authors share co-first authorship.

Abstract

Gastroesophageal reflux impairs the mucosal barrier in the distal esophagus, allowing chronic exposure of the squamous epithelium to multitudinous stimulations and inducing chronic inflammation. Esophagitis is a response to inflammation of the esophageal squamous mucosa. Our study clarified that alcohol accumulation could aggravate the progress of esophagitis by inducing pyroptosis; however, Ac-YVAD-CMK, an inhibitor of caspase-1, could effectively suppress the expression of IL-1β and IL-18 both in vivo and in vitro, reducing the inflammatory response, which is promised to be an agent to inhibit the progression of esophagitis. Additionally, caspase-1-derived pyroptosis is involved in esophageal cancer.

Keywords: alcohol, esophagitis, pyroptosis, caspase-1, Ac-YVAD-CMK

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Wang F, Li G, Ning J, Chen L, Xu H, Kong X, Bu J, Zhao W, Li Z, Wang X, Li X, Ma J. Alcohol accumulation promotes esophagitis via pyroptosis activation. Int J Biol Sci 2018; 14(10):1245-1255. doi:10.7150/ijbs.24347. Available from http://www.ijbs.com/v14p1245.htm