Int J Biol Sci 2018; 14(10):1343-1360. doi:10.7150/ijbs.26111


Neutrophil Elastase Inhibitors and Chronic Kidney Disease

Elsa Bronze-da-Rocha, Alice Santos-Silva

UCIBIO/REQUIMTE, Laboratório de Bioquímica, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.


End-stage renal disease (ESRD), the last stage of chronic kidney disease (CKD), is characterized by chronic inflammation and oxidative stress. Neutrophils are the front line cells that mediate an inflammatory response against microorganisms as they can migrate, produce reactive oxygen species (ROS), secrete neutrophil serine proteases (NSPs), and release neutrophil extracellular traps (NETs). Serine proteases inhibitors regulate the activity of serine proteases and reduce neutrophil accumulation at inflammatory sites. This review intends to relate the role of neutrophil elastase in CKD and the effects of neutrophil elastase inhibitors in predicting or preventing inflammation.

Keywords: End-stage renal disease (ESRD), chronic kidney disease (CKD), neutrophil elastase, neutrophil elastase inhibitors, inflammation

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How to cite this article:
Bronze-da-Rocha E, Santos-Silva A. Neutrophil Elastase Inhibitors and Chronic Kidney Disease. Int J Biol Sci 2018; 14(10):1343-1360. doi:10.7150/ijbs.26111. Available from