Int J Biol Sci 2019; 15(4):726-737. doi:10.7150/ijbs.30369


Autophagy in Ovarian Follicular Development and Atresia

Jiawei Zhou1,2, Xianwen Peng1,2, Shuqi Mei1,2✉

1. Institute of Animal Science and Veterinary Medicine, Hubei Academy of Agricultural Sciences, Wuhan 430064, China
2. Hubei Key Lab for Animal Embryo Engineering and Molecular Breeding, Wuhan 430064, China


Autophagy is a mechanism that exists in all eukaryotes under a variety of physiological and pathological conditions. In the mammalian ovaries, less than 1% of follicles ovulate, whereas the remaining 99% undergo follicular atresia. Autophagy and apoptosis have been previously found to be involved in the regulation of both primordial follicular development as well as atresia. The relationship between autophagy, follicular development, and atresia have been summarized in this review with the aim to obtain a more comprehensive understanding of the role played by autophagy in follicular development and atresia.

Keywords: autophagy, follicular development, atresia, granulosa cells

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How to cite this article:
Zhou J, Peng X, Mei S. Autophagy in Ovarian Follicular Development and Atresia. Int J Biol Sci 2019; 15(4):726-737. doi:10.7150/ijbs.30369. Available from