Int J Biol Sci
2023; 19(12):3816-3829.
doi:10.7150/ijbs.83134 This issueCite
Research Paper
FIBP interacts with transcription factor STAT3 to induce EME1 expression and drive radioresistance in lung adenocarcinoma
Yunhong Xu1,2*, Jun Li1,2*, Kuikui Zhu1,2*, Yulan Zeng1,2, Jing Chen1,2, Xiaorong Dong1,2, Sheng Zhang1,2✉, Shuangbing Xu1,2✉, Gang Wu1,2✉
1. Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. 2. Institute of Radiation Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. *These authors contributed equally to this work.
✉ Corresponding authors: Sheng Zhang or Shuangbing Xu or Gang Wu, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; E-mail: tonydppxcom or xsb723edu.cn or xhzlwgcom.
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Citation:
Xu Y, Li J, Zhu K, Zeng Y, Chen J, Dong X, Zhang S, Xu S, Wu G. FIBP interacts with transcription factor STAT3 to induce EME1 expression and drive radioresistance in lung adenocarcinoma. Int J Biol Sci 2023; 19(12):3816-3829. doi:10.7150/ijbs.83134. https://www.ijbs.com/v19p3816.htm
Cancer cells inevitably develop radioresistance during lung adenocarcinoma radiotherapy. However, the mechanisms are incompletely clarified. In this study, we show that FIBP protein expression in lung adenocarcinoma tissues is upregulated and associated with worse overall survival. Functionally, we find that depletion of FIBP inhibits lung adenocarcinoma progression and radioresistance in vitro and in vivo. Moreover, we uncover that FIBP interacts with STAT3 to enhance its transcriptional activity, thereby inducing the expression of the downstream target gene EME1. Importantly, we demonstrate that the biological effects of FIBP are partially dependent on EME1 in lung adenocarcinoma. Our work reveals that FIBP modulates the STAT3/EME1 axis to drive lung cancer progression and radioresistance, indicating that targeting FIBP may be a novel intervention strategy for lung adenocarcinoma radiotherapy.
Xu, Y., Li, J., Zhu, K., Zeng, Y., Chen, J., Dong, X., Zhang, S., Xu, S., Wu, G. (2023). FIBP interacts with transcription factor STAT3 to induce EME1 expression and drive radioresistance in lung adenocarcinoma. International Journal of Biological Sciences, 19(12), 3816-3829. https://doi.org/10.7150/ijbs.83134.
ACS
Xu, Y.; Li, J.; Zhu, K.; Zeng, Y.; Chen, J.; Dong, X.; Zhang, S.; Xu, S.; Wu, G. FIBP interacts with transcription factor STAT3 to induce EME1 expression and drive radioresistance in lung adenocarcinoma. Int. J. Biol. Sci. 2023, 19 (12), 3816-3829. DOI: 10.7150/ijbs.83134.
NLM
Xu Y, Li J, Zhu K, Zeng Y, Chen J, Dong X, Zhang S, Xu S, Wu G. FIBP interacts with transcription factor STAT3 to induce EME1 expression and drive radioresistance in lung adenocarcinoma. Int J Biol Sci 2023; 19(12):3816-3829. doi:10.7150/ijbs.83134. https://www.ijbs.com/v19p3816.htm
CSE
Xu Y, Li J, Zhu K, Zeng Y, Chen J, Dong X, Zhang S, Xu S, Wu G. 2023. FIBP interacts with transcription factor STAT3 to induce EME1 expression and drive radioresistance in lung adenocarcinoma. Int J Biol Sci. 19(12):3816-3829.
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