COX2-ATP Synthase Regulates Spine Follicle Size in Hedgehogs

Zhang, Man; Wang, Mengyue; Jiang, Jingwei; Liu, Weiwei; Zhou, Siyi; Wang, Dehuan; Wang, Miaomiao; Zhao, Zixian; Xu, Zhiling; Wu, Wang; Lin, Xia; Zhang, Jinwei; Xu, Wei; Tang, Qu; Zhan, Rixing; Liu, Wanqian; Yang, Li; Zhou, Xun; Zhou, Wei; Lei, Mingxing

doi:10.7150/ijbs.83387

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Int J Biol Sci 2023; 19(15):4763-4777. doi:10.7150/ijbs.83387 This issue Cite

Research Paper

COX2-ATP Synthase Regulates Spine Follicle Size in Hedgehogs

Man Zhang¹, Mengyue Wang¹, Jingwei Jiang¹, Weiwei Liu¹, Siyi Zhou¹, Dehuan Wang¹, Miaomiao Wang¹, Zixian Zhao¹, Zhiling Xu¹, Wang Wu^1,2, Xia Lin^1,2, Jinwei Zhang^1,3, Wei Xu³, Qu Tang^2✉, Rixing Zhan⁴, Wanqian Liu¹, Li Yang¹, Xun Zhou^3✉, Wei Zhou^5✉, Mingxing Lei^1✉

1. 111 Project Laboratory of Biomechanics and Tissue Repair & Key Laboratory of Biorheological Science and Technology of Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China.
2. Three Gorges Hospital, Chongqing University, Chongqing 404000, China.
3. Department of Dermatology and Cosmetology, The First Affiliated Hospital of Chongqing College of Traditional Chinese Medicine, Chongqing 400021, China.
4. Institute of Burn Research, State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China.
5. Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing 400030, China.

Citation:

Zhang M, Wang M, Jiang J, Liu W, Zhou S, Wang D, Wang M, Zhao Z, Xu Z, Wu W, Lin X, Zhang J, Xu W, Tang Q, Zhan R, Liu W, Yang L, Zhou X, Zhou W, Lei M. COX2-ATP Synthase Regulates Spine Follicle Size in Hedgehogs. Int J Biol Sci 2023; 19(15):4763-4777. doi:10.7150/ijbs.83387. https://www.ijbs.com/v19p4763.htm

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Abstract

Skin evolves essential appendages with adaptive patterns that synergistically insulate the body from environmental insults. How similar appendages in different animals generate diversely-sized appendages remain elusive. Here we used hedgehog spine follicles and mouse hair follicles as models to investigate how similar follicles form in different sizes postnatally. Histology and immunostaining show that the spine follicles have a significantly greater size than the hair follicles. By RNA-sequencing analysis, we found that ATP synthases are highly expressed in hedgehog skin compared to mouse skin. Inhibition of ATP synthase resulted in smaller spine follicle formation during regeneration. We also identified that the mitochondrial gene COX2 functions upstream of ATP synthase that influences energy metabolism and cell proliferation to control the size of the spine follicles. Our study identified molecules that function differently in forming diversely-sized skin appendages across different animals, allowing them to adapt to the living environment and benefit from self-protection.

Keywords: ATP synthase, COX2, Hair follicle, Size control, Cell proliferation

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APA

Zhang, M., Wang, M., Jiang, J., Liu, W., Zhou, S., Wang, D., Wang, M., Zhao, Z., Xu, Z., Wu, W., Lin, X., Zhang, J., Xu, W., Tang, Q., Zhan, R., Liu, W., Yang, L., Zhou, X., Zhou, W., Lei, M. (2023). COX2-ATP Synthase Regulates Spine Follicle Size in Hedgehogs. International Journal of Biological Sciences, 19(15), 4763-4777. https://doi.org/10.7150/ijbs.83387.

ACS

Zhang, M.; Wang, M.; Jiang, J.; Liu, W.; Zhou, S.; Wang, D.; Wang, M.; Zhao, Z.; Xu, Z.; Wu, W.; Lin, X.; Zhang, J.; Xu, W.; Tang, Q.; Zhan, R.; Liu, W.; Yang, L.; Zhou, X.; Zhou, W.; Lei, M. COX2-ATP Synthase Regulates Spine Follicle Size in Hedgehogs. Int. J. Biol. Sci. 2023, 19 (15), 4763-4777. DOI: 10.7150/ijbs.83387.

NLM

CSE

Zhang M, Wang M, Jiang J, Liu W, Zhou S, Wang D, Wang M, Zhao Z, Xu Z, Wu W, Lin X, Zhang J, Xu W, Tang Q, Zhan R, Liu W, Yang L, Zhou X, Zhou W, Lei M. 2023. COX2-ATP Synthase Regulates Spine Follicle Size in Hedgehogs. Int J Biol Sci. 19(15):4763-4777.

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