ISSN: 1449-2288International Journal of Biological Sciences
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Int J Biol Sci 2023; 19(15):4834-4848. doi:10.7150/ijbs.87028 This issue Cite
Review
The bidirectional interplay between ncRNAs and methylation modifications in gastrointestinal tumors
1. Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
2. Henan Liver Transplantation Centre, China.
3. Henan Organ Transplantation Quality Control Centre, China.
4. Open and Key Laboratory for Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, China.
5. Henan Innovative Research Group for Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation, China.
Abstract
The aberrant expression of methylation and ncRNAs, two crucial regulators of epigenetic modifications, has been widely demonstrated in cancer. The complex interplay between them is essential in promoting malignant phenotype, poor prognosis, and drug resistance in GI tumors (including esophageal, gastric, colorectal, liver, and pancreatic cancers). Therefore, we summarize the interrelation process between ncRNAs and methylation modifications in GI tumors, including the detailed mechanism of methylation enzyme regulation of ncRNAs, the molecular mechanism of ncRNAs regulation of methylation modifications, and the correlation between the interactions between ncRNAs and methylation modifications and clinical features of tumors. Finally, we discuss the potential value of ncRNAs and methylation modifications in clinical diagnosis and therapy.
Keywords: ncRNAs, methylation, GI tumors, Mechanism, Biomarker and Therapy
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